{"id":"https://openalex.org/W2201658386","doi":"https://doi.org/10.1113/jp271198","title":"Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons","display_name":"Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons","publication_year":2015,"publication_date":"2015-11-13","ids":{"openalex":"https://openalex.org/W2201658386","doi":"https://doi.org/10.1113/jp271198","mag":"2201658386","pmid":"https://pubmed.ncbi.nlm.nih.gov/26563747","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4799965"},"language":"en","primary_location":{"id":"doi:10.1113/jp271198","doi":"https://doi.org/10.1113/jp271198","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp271198","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4799965","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Saikat Chakraborty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801410363","display_name":"Stony Brook University Hospital","ror":"https://ror.org/05wyq9e07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saikat Chakraborty","raw_affiliation_strings":["Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA","institution_ids":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083183210","display_name":"Mario J. Rebecchi","orcid":"https://orcid.org/0000-0001-5779-0275","observed_orcids":["https://orcid.org/0000-0001-5779-0275"]},"institutions":[{"id":"https://openalex.org/I2801410363","display_name":"Stony Brook University Hospital","ror":"https://ror.org/05wyq9e07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Rebecchi","raw_affiliation_strings":["Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA","institution_ids":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072968238","display_name":"Martin Kaczocha","orcid":"https://orcid.org/0000-0002-2527-1398","observed_orcids":["https://orcid.org/0000-0002-2527-1398"]},"institutions":[{"id":"https://openalex.org/I2801410363","display_name":"Stony Brook University Hospital","ror":"https://ror.org/05wyq9e07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Kaczocha","raw_affiliation_strings":["Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA","institution_ids":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075730123","display_name":"Michelino Puopolo","orcid":"https://orcid.org/0000-0002-4262-3009","observed_orcids":["https://orcid.org/0000-0002-4262-3009"]},"institutions":[{"id":"https://openalex.org/I2801410363","display_name":"Stony Brook University Hospital","ror":"https://ror.org/05wyq9e07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelino Puopolo","raw_affiliation_strings":["Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794 USA","institution_ids":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075730123"],"corresponding_institution_ids":["https://openalex.org/I2801410363","https://openalex.org/I4210102711","https://openalex.org/I59553526"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.3041,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76758528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"594","issue":"6","first_page":"1627","last_page":"1642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dopamine-d1-d5-receptors","display_name":"dopamine D1/D5 receptors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/skf-81297","display_name":"SKF 81297","score":0.9039999842643738},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.8119999766349792},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.3700000047683716},{"id":"https://openalex.org/keywords/nociceptor-excitability","display_name":"nociceptor excitability","score":0.6980000138282776},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.8569999933242798},{"id":"https://openalex.org/keywords/low-threshold-mechanoreceptors","display_name":"low-threshold mechanoreceptors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.4860000014305115},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9070000052452087},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.5249999761581421},{"id":"https://openalex.org/keywords/receptor-resensitization","display_name":"receptor resensitization","score":0.4699999988079071},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.7496762871742249},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6782938241958618},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.5801223516464233},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5781476497650146},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5603609681129456},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.45719990134239197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43597280979156494},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.42772117257118225},{"id":"https://openalex.org/C160262196","wikidata":"https://www.wikidata.org/wiki/Q5376331","display_name":"Endogenous agonist","level":5,"score":0.426848828792572},{"id":"https://openalex.org/C2779917531","wikidata":"https://www.wikidata.org/wiki/Q7389148","display_name":"SCH-23390","level":4,"score":0.4263584613800049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3748854696750641},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3688585162162781},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3587406277656555},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3386264741420746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2188868224620819},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1346375048160553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07534301280975342}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019257","descriptor_name":"Quinpirole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019257","descriptor_name":"Quinpirole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019257","descriptor_name":"Quinpirole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019257","descriptor_name":"Quinpirole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jp271198","doi":"https://doi.org/10.1113/jp271198","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp271198","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4799965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4799965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:26563747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26563747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4799965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4799965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W38478502","https://openalex.org/W257920779","https://openalex.org/W1497042115","https://openalex.org/W1507561445","https://openalex.org/W1511198581","https://openalex.org/W1529080374","https://openalex.org/W1557308980","https://openalex.org/W1571969265","https://openalex.org/W1663449815","https://openalex.org/W1665323890","https://openalex.org/W1701153260","https://openalex.org/W1831892029","https://openalex.org/W1883732752","https://openalex.org/W1912302639","https://openalex.org/W1919664406","https://openalex.org/W1946561635","https://openalex.org/W1952328179","https://openalex.org/W1952350508","https://openalex.org/W1965614726","https://openalex.org/W1965864495","https://openalex.org/W1967849926","https://openalex.org/W1967863888","https://openalex.org/W1968263372","https://openalex.org/W1968969894","https://openalex.org/W1969046291","https://openalex.org/W1970829598","https://openalex.org/W1970896847","https://openalex.org/W1976640346","https://openalex.org/W1977933460","https://openalex.org/W1979434196","https://openalex.org/W1980688348","https://openalex.org/W1981314372","https://openalex.org/W1983028125","https://openalex.org/W1984033377","https://openalex.org/W1984122626","https://openalex.org/W1984596133","https://openalex.org/W1985030046","https://openalex.org/W1985144092","https://openalex.org/W1986235007","https://openalex.org/W1986661851","https://openalex.org/W1987745165","https://openalex.org/W1988174555","https://openalex.org/W1989112484","https://openalex.org/W1990442137","https://openalex.org/W1990599248","https://openalex.org/W1991417446","https://openalex.org/W1991537855","https://openalex.org/W1994266757","https://openalex.org/W1996829657","https://openalex.org/W1997454260","https://openalex.org/W1997517400","https://openalex.org/W1998321019","https://openalex.org/W1999836929","https://openalex.org/W2000599651","https://openalex.org/W2002761019","https://openalex.org/W2004052351","https://openalex.org/W2004228890","https://openalex.org/W2006356077","https://openalex.org/W2007786915","https://openalex.org/W2013816675","https://openalex.org/W2020588358","https://openalex.org/W2023355644","https://openalex.org/W2025050719","https://openalex.org/W2027077773","https://openalex.org/W2034404400","https://openalex.org/W2037457592","https://openalex.org/W2039482493","https://openalex.org/W2039522435","https://openalex.org/W2041244325","https://openalex.org/W2041526142","https://openalex.org/W2044513817","https://openalex.org/W2045235636","https://openalex.org/W2045626430","https://openalex.org/W2046403343","https://openalex.org/W2047108298","https://openalex.org/W2049100687","https://openalex.org/W2050606005","https://openalex.org/W2050781058","https://openalex.org/W2052344768","https://openalex.org/W2052482154","https://openalex.org/W2053096012","https://openalex.org/W2053376101","https://openalex.org/W2053400182","https://openalex.org/W2056728969","https://openalex.org/W2061627146","https://openalex.org/W2062428853","https://openalex.org/W2062671000","https://openalex.org/W2063428082","https://openalex.org/W2063795822","https://openalex.org/W2068906489","https://openalex.org/W2069198383","https://openalex.org/W2071170359","https://openalex.org/W2073969441","https://openalex.org/W2074309813","https://openalex.org/W2074766111","https://openalex.org/W2074797643","https://openalex.org/W2075449089","https://openalex.org/W2082554893","https://openalex.org/W2085052553","https://openalex.org/W2085176886","https://openalex.org/W2086015992","https://openalex.org/W2089731207","https://openalex.org/W2090617423","https://openalex.org/W2091526526","https://openalex.org/W2091630314","https://openalex.org/W2092799738","https://openalex.org/W2097744565","https://openalex.org/W2099414466","https://openalex.org/W2099429157","https://openalex.org/W2103120820","https://openalex.org/W2107705149","https://openalex.org/W2109293109","https://openalex.org/W2116342741","https://openalex.org/W2119832782","https://openalex.org/W2120227437","https://openalex.org/W2121896543","https://openalex.org/W2122231383","https://openalex.org/W2131075809","https://openalex.org/W2134742719","https://openalex.org/W2138322683","https://openalex.org/W2140867988","https://openalex.org/W2141264170","https://openalex.org/W2147343991","https://openalex.org/W2147672258","https://openalex.org/W2150861334","https://openalex.org/W2154152084","https://openalex.org/W2161277838","https://openalex.org/W2162056974","https://openalex.org/W2162723169","https://openalex.org/W2164442872","https://openalex.org/W2241489926","https://openalex.org/W2305369714","https://openalex.org/W2423858645"],"related_works":["https://openalex.org/W1176865607","https://openalex.org/W2572428557","https://openalex.org/W2782378581","https://openalex.org/W2610976827","https://openalex.org/W2061735569","https://openalex.org/W2418235693","https://openalex.org/W2116147934","https://openalex.org/W2317160306","https://openalex.org/W1946202333","https://openalex.org/W7095762068"],"abstract_inverted_index":{"Key":[0],"points":[1],"Transient":[2],"receptor":[3,127,133,164],"potential":[4,128],"vanilloid":[5,129],"type":[6,130],"1":[7,131],"(TRPV1)":[8,132],"receptors":[9,263,341],"transduce":[10],"noxious":[11,122,370],"thermal":[12,19],"stimuli":[13],"and":[14,44,52,92,162,199,204,265],"are":[15],"responsible":[16],"for":[17,117,365],"the":[18,35,69,139,150,158,169,246,251,278,285,297,312,322,329],"hyperalgesia":[20],"associated":[21],"with":[22,293,305,320],"inflammatory":[23],"pain.":[24],"A":[25,288],"large":[26],"population":[27],"of":[28,71,80,105,141,152,160,196,209,229,250,274,325,338,353],"dorsal":[29,180],"root":[30,181],"ganglia":[31,182],"(DRG)":[32,183],"neurons,":[33,157],"including":[34],"C":[36,300],"low":[37],"threshold":[38],"mechanoreceptors":[39],"(C\u2010LTMRs),":[40],"express":[41],"tyrosine":[42],"hydroxylase,":[43],"probably":[45],"release":[46],"dopamine.":[47],"We":[48,101,349],"found":[49],"that":[50,103,223,336,351],"dopamine":[51,109,118,147,161,163,231,340,357,366],"SKF":[53,81,187,210,255,275,326],"81297":[54,82,188,211,256,276,327],"(an":[55,63,189,217,236],"agonist":[56,64,190,237],"at":[57,65,191,219,238],"D1/D5":[58,192,220,230,339],"receptors),":[59,67,193,221],"but":[60],"not":[61,282],"quinpirole":[62,235],"D2":[66,239],"downregulate":[68],"activity":[70,151,290,302],"TRPV1":[72,84,106,153,354],"channels":[73,85,107,154,355],"in":[74,110,138,155,358],"DRG":[75],"neurons.":[76,184],"The":[77,125,207,271],"inhibitory":[78,272,323],"effect":[79,208,244,273,324],"on":[83,89,168,245,268,277,328],"was":[86,212,225,257,281,291,303,318,332],"strongly":[87],"dependent":[88,267],"external":[90,269],"calcium":[91],"preferentially":[93,344],"linked":[94,345],"to":[95,119,346,367],"calcium\u2013calmodulin\u2010dependent":[96,313],"protein":[97,261,286,298,314],"kinase":[98,287,299,315],"II":[99,307,316],"(CaMKII).":[100],"suggest":[102,350],"modulation":[104,140,352],"by":[108,202,214,227,254,259,356],"nociceptive":[111,156,359],"neurons":[112,360],"may":[113,342,361],"represent":[114,362],"a":[115,135,363],"way":[116,364],"modulate":[120,149,368],"incoming":[121,369],"stimuli.":[123,371],"Abstract":[124],"transient":[126],"plays":[134],"key":[136],"role":[137],"nociceptor":[142],"excitability.":[143],"To":[144],"address":[145],"whether":[146],"can":[148],"effects":[159],"agonists":[165],"were":[166],"tested":[167],"capsaicin\u2010activated":[170,247,252,279,330],"current":[171,253,280,331],"recorded":[172],"from":[173],"acutely":[174],"dissociated":[175],"small":[176],"diameter":[177],"(<27":[178],"\u03bcm)":[179],"Dopamine":[185],"or":[186,295],"caused":[194],"inhibition":[195],"both":[197],"inward":[198],"outward":[200],"currents":[201],"\u223c60%":[203],"\u223c48%,":[205],"respectively.":[206],"reversed":[213],"SCH":[215],"23390":[216],"antagonist":[218],"confirming":[222],"it":[224],"mediated":[226,258],"activation":[228,337],"receptors.":[232],"In":[233,309],"contrast,":[234,310],"receptors)":[240],"had":[241],"no":[242],"significant":[243],"current.":[248],"Inhibition":[249],"G":[260],"coupled":[262],"(GPCRs),":[264],"highly":[266],"calcium.":[270],"affected":[283],"when":[284,296,311],"(PKA)":[289],"blocked":[292,304,319],"H89,":[294],"(PKC)":[301],"bisindolylmaleimide":[306],"(BIM).":[308],"(CaMKII)":[317],"KN\u201093,":[321],"greatly":[333],"reduced,":[334],"suggesting":[335],"be":[343],"CaMKII":[347],"activity.":[348]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}