{"id":"https://openalex.org/W2201655171","doi":null,"title":"Angiotensin-(1-7): a novel vasodilator of the coronary circulation.","display_name":"Angiotensin-(1-7): a novel vasodilator of the coronary circulation.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2201655171","mag":"2201655171","pmid":"https://pubmed.ncbi.nlm.nih.gov/9830510"},"language":"en","primary_location":{"id":"pmid:9830510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9830510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021293904","display_name":"K. Bridget Brosnihan","orcid":"https://orcid.org/0000-0002-1956-7897","observed_orcids":["https://orcid.org/0000-0002-1956-7897"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K B Brosnihan","raw_affiliation_strings":["Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA. bbrosnih@wfubmc.edu","Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157-1032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1032, USA. bbrosnih@wfubmc.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157-1032, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082661999","display_name":"P Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064049204","display_name":"Elisabeth Ann Tallant","orcid":"https://orcid.org/0000-0003-4162-4373","observed_orcids":["https://orcid.org/0000-0003-4162-4373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Tallant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010550865","display_name":"Carlos Maria Ferrario","orcid":"https://orcid.org/0000-0003-0792-6239","observed_orcids":["https://orcid.org/0000-0003-0792-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Ferrario","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.251,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.83009511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"227","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-1-7","display_name":"angiotensin-(1-7)","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8460000157356262},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bradykinin-b2-receptor","display_name":"bradykinin B2 receptor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.781000018119812},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.5870000123977661},{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.6050000190734863},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.47200000286102295},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.4300000071525574},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.6389999985694885},{"id":"https://openalex.org/keywords/angiotensin-i","display_name":"angiotensin I","score":0.5149999856948853},{"id":"https://openalex.org/keywords/candesartan","display_name":"candesartan","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.8103007078170776},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7473889589309692},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.738696277141571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6047899127006531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5874150395393372},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.5860217809677124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5686614513397217},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.5537763237953186},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.49522867798805237},{"id":"https://openalex.org/C2780036600","wikidata":"https://www.wikidata.org/wiki/Q415970","display_name":"Candesartan","level":4,"score":0.47863975167274475},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4680715799331665},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.46413251757621765},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.38083451986312866},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3395863175392151},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33116602897644043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22030624747276306}],"mesh":[{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9830510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9830510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological research","raw_type":"Journal Article"},{"id":"mag:2201655171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9830510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080248232","https://openalex.org/W2103115053","https://openalex.org/W2740033396","https://openalex.org/W2092343725","https://openalex.org/W2155118902","https://openalex.org/W1994250435","https://openalex.org/W1909552007","https://openalex.org/W2587514028","https://openalex.org/W2024416570","https://openalex.org/W2737815306"],"abstract_inverted_index":{"Angiotensin-(1-7)":[0],"[Ang-(1-7)]":[1],"possesses":[2],"novel":[3,265],"biological":[4],"functions":[5],"that":[6,237],"are":[7],"distinct":[8],"from":[9,233],"angiotensin":[10,246],"II":[11,20,29,206],"(Ang":[12],"II).":[13],"In":[14,211],"coronary":[15,116,260,281],"arteries,":[16],"the":[17,22,48,55,70,101,111,135,165,185,208,214,219,255],"octapeptide":[18],"Ang":[19,28,202,205],"and":[21,32,62,72,104,243,272],"heptapeptide":[23],"Ang-(1-7)":[24,33,37,76,133,137,141,181,238,250,268],"exert":[25],"opposing":[26],"actions.":[27],"elicits":[30,38],"vasoconstriction":[31],"is":[34,51,78,239],"a":[35,81,241,270,273],"vasodilator.":[36],"vasodilation":[39,77,150,186,279],"by":[40,54,80,130,188,225],"an":[41,90,96],"endothelium-dependent":[42],"release":[43,73],"of":[44,74,108,114,148,167,171,217,257,267,277],"nitric":[45],"oxide.":[46],"Further,":[47],"vasorelaxant":[49],"activity":[50],"markedly":[52],"attenuated":[53],"bradykinin":[56],"(BK)":[57],"B2":[58],"receptor":[59,92,98],"antagonist":[60,138],"icatibant":[61],"does":[63],"not":[64,183,223],"appear":[65],"to":[66,110,213,253],"be":[67],"associated":[68],"with":[69],"synthesis":[71],"prostaglandins.":[75],"mediated":[79],"non-AT1/AT2":[82],"receptor,":[83],"since":[84,180,200],"[Sar1Thr8]-Ang":[85,229],"II,":[86],"but":[87],"neither":[88,201],"candesartan,":[89,226],"AT1":[91],"antagonist,":[93,99],"nor":[94,204],"PD123319,":[95],"AT2":[97],"blocked":[100,224],"response.":[102,210],"Specific":[103],"high":[105],"affinity":[106],"binding":[107],"125I-Ang-(1-7)":[109],"endothelial":[112],"layer":[113],"canine":[115],"arteries":[117],"was":[118,126,160,176,196,222,251],"demonstrated":[119],"using":[120],"in":[121,164,259,280],"vitro":[122],"emulsion":[123],"autoradiography.":[124],"Binding":[125],"effectively":[127],"competed":[128],"for":[129,178,198,245],"either":[131,189],"unlabeled":[132],"or":[134,191,228],"specific":[136,177,197],"[D-Ala7]-Ang-(1-7).":[139],"Additionally,":[140],"potentiated":[142,174,220],"synergistically":[143],"BK-induced":[144],"vasodilation.":[145],"The":[146,173],"EC50":[147],"BK":[149,209],"(2.45":[151],"+/-":[152,157],"0.51":[153],"nmol/L":[154],"vs":[155],"0.37":[156],"0.08":[158],"nmol/L)":[159],"shifted":[161],"6.6-fold":[162],"left-ward":[163],"presence":[166],"2":[168],"mumol/L":[169],"concentration":[170],"Ang-(1-7).":[172],"response":[175,221],"BK,":[179],"did":[182],"augment":[184],"produced":[187],"acetylcholine":[190],"sodium":[192],"nitroprusside;":[193],"further,":[194],"it":[195],"Ang-(1-7),":[199,218],"I":[203],"augmented":[207],"contrast":[212],"vasodilator":[215,271],"actions":[216,266],"PD123319":[227],"II.":[230],"Novel":[231],"studies":[232,263],"our":[234],"group":[235],"demonstrate":[236],"both":[240],"substrate":[242],"inhibitor":[244],"converting":[247],"enzyme":[248],"(ACE).":[249],"shown":[252],"retard":[254],"degradation":[256],"125I-[Tyr0]-BK":[258],"rings.":[261],"These":[262],"describe":[264],"as":[269],"local":[274],"synergistic":[275],"modulator":[276],"kinin-induced":[278],"arteries.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
