{"id":"https://openalex.org/W2201613825","doi":"https://doi.org/10.1016/j.phrs.2015.10.012","title":"Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension","display_name":"Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension","publication_year":2015,"publication_date":"2015-10-30","ids":{"openalex":"https://openalex.org/W2201613825","doi":"https://doi.org/10.1016/j.phrs.2015.10.012","mag":"2201613825","pmid":"https://pubmed.ncbi.nlm.nih.gov/26523876"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2015.10.012","doi":"https://doi.org/10.1016/j.phrs.2015.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2015.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661815002558/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1043661815002558/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015104391","display_name":"Thiago B Bruder-Nascimento","orcid":"https://orcid.org/0000-0001-5671-318X","observed_orcids":["https://orcid.org/0000-0001-5671-318X"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thiago Bruder-Nascimento","raw_affiliation_strings":["Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002032826","display_name":"Benjamin R. Butler","orcid":"https://orcid.org/0000-0001-7831-0111","observed_orcids":["https://orcid.org/0000-0001-7831-0111"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin R. Butler","raw_affiliation_strings":["Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070420062","display_name":"David J. Herren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Herren","raw_affiliation_strings":["Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064950429","display_name":"Michael W. Brands","orcid":"https://orcid.org/0000-0002-5005-1733","observed_orcids":["https://orcid.org/0000-0002-5005-1733"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Brands","raw_affiliation_strings":["Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067849248","display_name":"Kendra K. Bence","orcid":"https://orcid.org/0000-0002-5879-4726","observed_orcids":["https://orcid.org/0000-0002-5879-4726"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra K. Bence","raw_affiliation_strings":["Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052976343","display_name":"Eric J. Belin de Chantem\u00e8le","orcid":"https://orcid.org/0000-0002-0184-3830","observed_orcids":["https://orcid.org/0000-0002-0184-3830"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric J. Belin de Chantem\u00e8le","raw_affiliation_strings":["Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States. Electronic address: ebelindechanteme@gru.edu","Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States"],"raw_orcid":"https://orcid.org/0000-0002-0184-3830","affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States. Electronic address: ebelindechanteme@gru.edu","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052976343"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.7457,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.69280139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"102","issue":null,"first_page":"235","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.10599999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9879999756813049},{"id":"https://openalex.org/keywords/proopiomelanocortin-neurons","display_name":"proopiomelanocortin neurons","score":0.9829999804496765},{"id":"https://openalex.org/keywords/leptin-signaling","display_name":"leptin signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9110000133514404},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9589999914169312},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8715018033981323},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8707226514816284},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7849581837654114},{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.696281909942627},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.6349963545799255},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4898047149181366},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.42861056327819824},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.4217950999736786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.389530211687088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3613150417804718},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3431144952774048},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.08313244581222534}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2015.10.012","doi":"https://doi.org/10.1016/j.phrs.2015.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2015.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661815002558/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:26523876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26523876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2015.10.012","doi":"https://doi.org/10.1016/j.phrs.2015.10.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2015.10.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661815002558/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2201613825.pdf","grobid_xml":"https://content.openalex.org/works/W2201613825.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1601357256","https://openalex.org/W1975214074","https://openalex.org/W2013688437","https://openalex.org/W2024356478","https://openalex.org/W2043342443","https://openalex.org/W2059647625","https://openalex.org/W2066037847","https://openalex.org/W2070582535","https://openalex.org/W2072206476","https://openalex.org/W2074348556","https://openalex.org/W2087482176","https://openalex.org/W2097369652","https://openalex.org/W2097954820","https://openalex.org/W2101037051","https://openalex.org/W2105817828","https://openalex.org/W2105987351","https://openalex.org/W2109898272","https://openalex.org/W2118743996","https://openalex.org/W2132325669","https://openalex.org/W2133447451","https://openalex.org/W2142851934","https://openalex.org/W2144299243","https://openalex.org/W2144375073","https://openalex.org/W2156496741","https://openalex.org/W2167731943","https://openalex.org/W2301759851","https://openalex.org/W2565131984","https://openalex.org/W6697772603","https://openalex.org/W6730988893"],"related_works":["https://openalex.org/W1969835310","https://openalex.org/W2047971516","https://openalex.org/W2015872450","https://openalex.org/W2166890779","https://openalex.org/W2319604579","https://openalex.org/W2439106121","https://openalex.org/W2023381149","https://openalex.org/W2027444063","https://openalex.org/W1988098212","https://openalex.org/W2130768355"],"abstract_inverted_index":{"Protein":[0],"tyrosine":[1],"phosphatase":[2],"1b":[3],"(Ptp1b),":[4],"which":[5],"represses":[6],"leptin":[7,22,65,79,103,153],"signaling,":[8],"is":[9,42],"a":[10,133,174,184,227,235],"promising":[11],"therapeutic":[12,237],"target":[13,238],"for":[14,239],"obesity.":[15,249],"Genome":[16],"wide":[17],"deletion":[18,72,110,142,208],"of":[19,40,84,91,102,137,209,242],"Ptp1b,":[20],"increases":[21,56,165,219],"sensitivity,":[23],"protects":[24,214],"mice":[25,168,172],"from":[26,215],"obesity":[27],"and":[28,45,80,93,98,127,147,159,162,179,217,232,244],"diabetes,":[29],"but":[30,120,205],"alters":[31],"cardiovascular":[32,76,89,115,245],"function":[33],"by":[34,183],"increasing":[35,64],"blood":[36],"pressure":[37],"(BP).":[38],"Leptin-control":[39],"metabolism":[41],"centrally":[43],"mediated":[44],"involves":[46],"proopiomelanocortin":[47],"(POMC)":[48],"neurons.":[49],"Whether":[50],"these":[51,199],"neurons":[52,69,213],"contribute":[53],"to":[54,78,124,192],"leptin-mediated":[55],"in":[57,67,166,177,187,190,211,220],"BP":[58,122,164,181],"remain":[59],"unclear.":[60],"We":[61,86],"hypothesized":[62],"that":[63,131,207],"signaling":[66],"POMC":[68,212],"with":[70,107,196,248],"Ptp1b":[71,210],"will":[73],"sensitize":[74],"the":[75,88,240],"system":[77],"enhance":[81],"neurogenic":[82,135],"control":[83,136],"BP.":[85,138,221],"analyzed":[87],"phenotype":[90],"Ptp1b+/+":[92],"POMC-Ptp1b-/-":[94,167,171],"mice,":[95],"at":[96],"baseline":[97,114],"after":[99],"7":[100],"days":[101],"infusion":[104],"or":[105],"sympatho-activation":[106,195],"phenylephrine.":[108,197],"POMCPtp1b":[109],"did":[111],"not":[112],"alter":[113],"hemodynamics":[116],"(BP,":[117],"heart":[118],"rate)":[119],"reduced":[121,155],"response":[123,191],"ganglionic":[125],"blockade":[126],"plasma":[128],"catecholamine":[129],"levels":[130],"suggests":[132],"decreased":[134],"In":[139],"contrast,":[140],"POMC-Ptp1b":[141,233],"increased":[143,176],"vascular":[144,156,194],"adrenergic":[145,157,188,223],"reactivity":[146,158,189],"aortic":[148],"\u03b1-adrenergic":[149],"receptors":[150],"expression.":[151],"Chronic":[152],"treatment":[154,241],"blunted":[160,175],"diastolic":[161,178],"mean":[163,180],"only.":[169],"Similarly":[170],"exhibited":[173],"accompanied":[182],"gradual":[185],"reduction":[186],"chronic":[193],"Together":[198],"data":[200],"rule":[201],"out":[202],"our":[203],"hypothesis":[204],"suggest":[206],"leptin-":[216],"sympatho-mediated":[218],"Vascular":[222],"desensitization":[224],"appears":[225],"as":[226,234],"protective":[228],"mechanism":[229],"against":[230],"hypertension,":[231],"key":[236],"metabolic":[243],"dysfunctions":[246],"associated":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}