{"id":"https://openalex.org/W2201236333","doi":"https://doi.org/10.1002/phar.1671","title":"Role of Histone Deacetylase Inhibitors in Relapsed Refractory Multiple Myeloma: A Focus on Vorinostat and Panobinostat","display_name":"Role of Histone Deacetylase Inhibitors in Relapsed Refractory Multiple Myeloma: A Focus on Vorinostat and Panobinostat","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2201236333","doi":"https://doi.org/10.1002/phar.1671","mag":"2201236333","pmid":"https://pubmed.ncbi.nlm.nih.gov/26684557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4995883"},"language":"en","primary_location":{"id":"doi:10.1002/phar.1671","doi":"https://doi.org/10.1002/phar.1671","is_oa":false,"landing_page_url":"https://doi.org/10.1002/phar.1671","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4995883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046310846","display_name":"Salma Afifi","orcid":"https://orcid.org/0000-0002-1556-1025","observed_orcids":["https://orcid.org/0000-0002-1556-1025"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Salma Afifi","raw_affiliation_strings":["Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063433959","display_name":"Angela Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Michael","raw_affiliation_strings":["Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043330126","display_name":"Mahshid Azimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahshid Azimi","raw_affiliation_strings":["Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012858479","display_name":"Mabel Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mabel Rodriguez","raw_affiliation_strings":["Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026740596","display_name":"Nikoletta K. Lendvai","orcid":"https://orcid.org/0000-0002-9849-4795","observed_orcids":["https://orcid.org/0000-0002-9849-4795"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikoletta Lendvai","raw_affiliation_strings":["Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082004555","display_name":"Ola Landgren","orcid":"https://orcid.org/0000-0001-6485-4839","observed_orcids":["https://orcid.org/0000-0001-6485-4839"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ola Landgren","raw_affiliation_strings":["Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046310846"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":1.3459,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.79348689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"35","issue":"12","first_page":"1173","last_page":"1188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":1.0},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6110000014305115},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/fda-approval","display_name":"FDA approval","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.961520254611969},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.825440526008606},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.8134210109710693},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6958689093589783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6785098314285278},{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.6099750399589539},{"id":"https://openalex.org/C2778524551","wikidata":"https://www.wikidata.org/wiki/Q7227206","display_name":"Pomalidomide","level":4,"score":0.5734880566596985},{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.5689495801925659},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5306462645530701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4606722593307495},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.4567417502403259},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44001615047454834},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.42636731266975403},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.36734098196029663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31910958886146545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11190018057823181},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.08759421110153198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077767","descriptor_name":"Panobinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/phar.1671","doi":"https://doi.org/10.1002/phar.1671","is_oa":false,"landing_page_url":"https://doi.org/10.1002/phar.1671","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:26684557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26684557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4995883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4995883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacotherapy","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4995883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4995883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacotherapy","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1135615481","https://openalex.org/W1511815964","https://openalex.org/W1525338014","https://openalex.org/W1963678818","https://openalex.org/W1964843472","https://openalex.org/W1965262464","https://openalex.org/W1973120064","https://openalex.org/W1974400343","https://openalex.org/W1981563918","https://openalex.org/W1983770251","https://openalex.org/W1984518316","https://openalex.org/W1988473759","https://openalex.org/W1991376723","https://openalex.org/W1992776819","https://openalex.org/W1994847517","https://openalex.org/W2007152893","https://openalex.org/W2010833137","https://openalex.org/W2023351948","https://openalex.org/W2026642838","https://openalex.org/W2027652423","https://openalex.org/W2028919540","https://openalex.org/W2040310677","https://openalex.org/W2052169053","https://openalex.org/W2066424427","https://openalex.org/W2068331698","https://openalex.org/W2070814954","https://openalex.org/W2072714194","https://openalex.org/W2073858771","https://openalex.org/W2079167171","https://openalex.org/W2080316252","https://openalex.org/W2088474788","https://openalex.org/W2095026025","https://openalex.org/W2095255742","https://openalex.org/W2096367061","https://openalex.org/W2099262276","https://openalex.org/W2103665811","https://openalex.org/W2103789449","https://openalex.org/W2104244233","https://openalex.org/W2104337841","https://openalex.org/W2106333492","https://openalex.org/W2111613209","https://openalex.org/W2118335184","https://openalex.org/W2129890171","https://openalex.org/W2133351180","https://openalex.org/W2140579395","https://openalex.org/W2142112710","https://openalex.org/W2142629029","https://openalex.org/W2144728882","https://openalex.org/W2146816088","https://openalex.org/W2149386327","https://openalex.org/W2150642119","https://openalex.org/W2168980644","https://openalex.org/W2169508075","https://openalex.org/W2170552969","https://openalex.org/W2171585059","https://openalex.org/W2184975107","https://openalex.org/W2264834016","https://openalex.org/W2267091465","https://openalex.org/W2318951702","https://openalex.org/W2550544585","https://openalex.org/W2551961385","https://openalex.org/W2592499318","https://openalex.org/W2979643211","https://openalex.org/W6734106785"],"related_works":["https://openalex.org/W1902022603","https://openalex.org/W2404833632","https://openalex.org/W4395037776","https://openalex.org/W2160359715","https://openalex.org/W2532328198","https://openalex.org/W3174960807","https://openalex.org/W2048439525","https://openalex.org/W2216387124","https://openalex.org/W2981252612","https://openalex.org/W3000746301"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1,76],"is":[2,9,89],"a":[3],"neoplastic":[4],"plasma":[5,15],"cell":[6],"disorder":[7],"that":[8],"characterized":[10],"by":[11],"clonal":[12],"proliferation":[13],"of":[14,52,74,102,113,118,154,171],"cells":[16],"in":[17,23,40,65,82,115,179],"the":[18,24,41,50,72,83,100,116,135,140,149,152,165],"bone":[19],"marrow,":[20],"monoclonal":[21],"protein":[22],"blood":[25],"and/or":[26],"urine,":[27],"and":[28,32,43,56,58,63,77,123,132,143,156,168,173,175],"associated":[29],"organ":[30],"dysfunction":[31],"biomarkers.":[33],"There":[34],"have":[35,70,78,109,125],"been":[36],"multiple":[37,75,97,110,119,130,158],"recent":[38],"advances":[39],"relapsed":[42,155],"refractory":[44,157],"setting.":[45],"Major":[46],"steps":[47],"forward":[48],"include":[49],"introduction":[51],"proteasome":[53],"inhibitors":[54,108],"(bortezomib":[55],"carfilzomib)":[57],"immunomodulatory":[59],"drugs":[60,69],"(thalidomide,":[61],"lenalidomide,":[62],"pomalidomide)":[64],"various":[66],"combinations.":[67],"These":[68],"changed":[71],"management":[73],"extended":[79],"overall":[80],"survival":[81],"past":[84],"decade.":[85],"Established":[86],"curative":[87],"therapy":[88],"not":[90],"yet":[91],"available":[92],"for":[93,151],"patients":[94],"diagnosed":[95],"with":[96,138],"myeloma,":[98,131],"supporting":[99],"development":[101],"new":[103],"treatment":[104,117,153],"targets.":[105],"Histone":[106],"deacetylase":[107],"proposed":[111],"mechanisms":[112],"action":[114],"myeloma.":[120,159],"Both":[121],"vorinostat":[122,172],"panobinostat":[124,174],"demonstrated":[126],"some":[127],"activity":[128],"against":[129],"due":[133],"to":[134],"benefits":[136],"reported":[137],"panobinostat,":[139],"U.S.":[141],"Food":[142],"Drug":[144],"Administration":[145],"has":[146],"recently":[147],"approved":[148],"drug":[150],"In":[160],"this":[161],"article,":[162],"we":[163],"describe":[164],"pharmacology,":[166],"efficacy,":[167],"toxicity":[169],"profile":[170],"their":[176],"possible":[177],"place":[178],"therapy.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}