{"id":"https://openalex.org/W2201021533","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","title":"Randomized, phase II trial comparing carboplatin (C) and tri-weekly paclitaxel (tP) with C and weekly paclitaxel (wP) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC)","display_name":"Randomized, phase II trial comparing carboplatin (C) and tri-weekly paclitaxel (tP) with C and weekly paclitaxel (wP) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC)","publication_year":2008,"publication_date":"2008-05-20","ids":{"openalex":"https://openalex.org/W2201021533","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","mag":"2201021533"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.26.15_suppl.19046","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007143858","display_name":"Makoto Maemondo","orcid":"https://orcid.org/0000-0002-1950-1943","observed_orcids":["https://orcid.org/0000-0002-1950-1943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Maemondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065197178","display_name":"A. Inoue","orcid":"https://orcid.org/0000-0002-2954-2722","observed_orcids":["https://orcid.org/0000-0002-2954-2722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080846994","display_name":"Shunichi Sugawara","orcid":"https://orcid.org/0000-0002-3427-4558","observed_orcids":["https://orcid.org/0000-0002-3427-4558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Sugawara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038817476","display_name":"Takashi Ishida","orcid":"https://orcid.org/0000-0002-1060-0777","observed_orcids":["https://orcid.org/0000-0002-1060-0777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Ishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085358387","display_name":"Kazuhiro Usui","orcid":"https://orcid.org/0000-0002-4492-9327","observed_orcids":["https://orcid.org/0000-0002-4492-9327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Usui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080652822","display_name":"Takashige Abe","orcid":"https://orcid.org/0000-0002-5468-7632","observed_orcids":["https://orcid.org/0000-0002-5468-7632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Abe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076854153","display_name":"Mariko Kanbe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Kanbe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886712","display_name":"Hiroshi Watanabe","orcid":"https://orcid.org/0000-0002-1333-4806","observed_orcids":["https://orcid.org/0000-0002-1333-4806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077670186","display_name":"Yasuo Saijo","orcid":"https://orcid.org/0000-0003-4721-1270","observed_orcids":["https://orcid.org/0000-0003-4721-1270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Saijo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111464112","display_name":"T. Nukiwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Nukiwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"15_suppl","first_page":"19046","last_page":"19046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8989999890327454},{"id":"https://openalex.org/keywords/weekly-chemotherapy","display_name":"weekly chemotherapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.8690000176429749},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.902999997138977},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.4959999918937683},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety-comparison","display_name":"treatment safety and efficacy comparison","score":0.4950000047683716},{"id":"https://openalex.org/keywords/age-as-prognostic-factor","display_name":"age as prognostic factor","score":0.4869999885559082},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9100703001022339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7230309247970581},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.6265265941619873},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6264647841453552},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5900416374206543},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5076881647109985},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5000259876251221},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4844706058502197},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.46139025688171387},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4520835280418396},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.450821191072464},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4192364513874054},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39934101700782776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3730809688568115},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34264951944351196},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2954000234603882},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2205192744731903},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.06156167387962341},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2008.26.15_suppl.19046","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.19046","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140881907","https://openalex.org/W2600689008","https://openalex.org/W2119659897","https://openalex.org/W2999060407","https://openalex.org/W2999593797","https://openalex.org/W2589377315","https://openalex.org/W2297728735","https://openalex.org/W2965618088","https://openalex.org/W2146700613","https://openalex.org/W2241535667"],"abstract_inverted_index":{"19046":[0],"Background:":[1],"The":[2,117,221],"appropriate":[3],"platinum":[4],"doublet":[5],"regimen":[6,339],"for":[7,50,76,194,201,245,254,340],"elderly":[8,51,54,84,341],"pts":[9,88,142,171,183,191,198],"with":[10,89,158,343],"advanced":[11,38,90,344],"NSCLC":[12,91,345],"is":[13,322,346],"still":[14],"matter":[15],"of":[16,28,43,68,138,149,156,224,337],"debate.":[17],"Although":[18],"previous":[19],"randomized":[20,56,93],"trial":[21],"failed":[22],"to":[23,62,94,179,309,352],"show":[24],"a":[25],"survival":[26,130],"benefit":[27],"C":[29,34,44,69,73,96,106,319,329],"+":[30,35,45,70,74,100,110],"wP":[31,46,75,111,255,267,299,316,321],"against":[32],"standard":[33],"tP":[36,71,101,246,260,280,293,331],"in":[37,140,172,231,279,292,315,332],"NSCLC,":[39],"less":[40,326],"toxic":[41,327],"profile":[42],"may":[47],"be":[48,152],"favorable":[49],"population.":[52],"This":[53],"specific,":[55],"phase":[57],"II":[58],"study":[59],"was":[60,120,169,262,269,276,313],"conducted":[61],"evaluate":[63],"the":[64,153,166,190],"efficacy":[65],"and":[66,72,125,132,162,196,235,243,248,252,265,286,296,302,320,325,330],"safety":[67,195],"future":[77],"large":[78],"scale":[79],"trials.":[80],"Methods:":[81],"Previously":[82],"untreated":[83],"(\u226570":[85],"years":[86],"old)":[87],"were":[92,128,184,192,199,227,239,289],"receive":[95],"(AUC":[97,107],"6,":[98,108],"day1)":[99,104,109],"(200":[102],"mg/m2,":[103,113],"or":[105],"(70":[112],"day1,":[114],"8,":[115],"15).":[116],"primary":[118],"endpoint":[119],"overall":[121],"response":[122],"rate":[123],"(ORR),":[124],"secondary":[126],"endpoints":[127],"progression-free":[129],"(PFS)":[131],"toxicity":[133],"profile.":[134],"Assuming":[135],"that":[136],"ORR":[137,148],"40%":[139],"eligible":[141],"would":[143,151],"indicate":[144],"potential":[145],"usefulness":[146],"while":[147],"20%":[150],"lower":[154],"limit":[155],"interest,":[157],"alpha":[159],"=":[160,164],"0.05":[161],"beta":[163],"0.20,":[165],"estimated":[167],"accrual":[168],"36":[170],"each":[173],"arm.":[174,256,317],"Results:":[175],"From":[176],"November":[177],"2004":[178],"June":[180],"2007,":[181],"82":[182],"enrolled":[185],"from":[186],"12":[187],"institutions.":[188],"All":[189],"evaluable":[193,200],"81":[197],"efficacy.":[202],"Patient":[203],"characteristics":[204],"were:":[205],"Male/Female":[206],"69/13;":[207],"median":[208,222],"age":[209],"75":[210],"(range":[211,229],"70\u201387);":[212],"Performance":[213],"status":[214],"0/1":[215],"42/40;":[216],"Stage":[217],"IIIB/IV/postoperative":[218],"recurrence":[219],"26/47/9.":[220],"numbers":[223],"treatment":[225,305],"cycles":[226],"3":[228,273],"1\u20136)":[230],"both":[232],"arms.":[233],"ORRs":[234],"disease":[236,312],"control":[237],"rates":[238],"53%":[240],"(95%CI:":[241,250],"38\u201368)":[242],"88%":[244],"arm,":[247],"55%":[249],"40\u201370)":[251],"91%":[253],"Median":[257],"PFS":[258],"on":[259,266],"arm":[261,268,281,294,300],"4.3":[263],"months":[264],"4.9":[270],"months.":[271],"Grade":[272,283],"peripheral":[274],"neuropathy":[275],"observed":[277,314],"only":[278],"(25%).":[282],"3/4":[284],"neutropenia":[285,288],"febrile":[287],"more":[290],"frequent":[291],"(88%":[295],"10%)":[297],"than":[298,328],"(41%":[301],"2%).":[303],"One":[304],"related":[306],"death":[307],"due":[308],"interstitial":[310],"lung":[311],"Conclusions:":[318],"similarly":[323],"effective":[324],"this":[333,338],"study.":[334],"Further":[335],"evaluation":[336],"population":[342],"warranted":[347],"No":[348],"significant":[349],"financial":[350],"relationships":[351],"disclose.":[353]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}