{"id":"https://openalex.org/W2200997261","doi":"https://doi.org/10.1038/ncomms9695","title":"BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages","display_name":"BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages","publication_year":2015,"publication_date":"2015-11-02","ids":{"openalex":"https://openalex.org/W2200997261","doi":"https://doi.org/10.1038/ncomms9695","mag":"2200997261","pmid":"https://pubmed.ncbi.nlm.nih.gov/26522614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4659838"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms9695","doi":"https://doi.org/10.1038/ncomms9695","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms9695","pdf_url":"https://www.nature.com/articles/ncomms9695.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms9695.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055822030","display_name":"Alessandra Rosati","orcid":"https://orcid.org/0000-0001-6675-0857","observed_orcids":["https://orcid.org/0000-0001-6675-0857","https://orcid.org/0000-0002-9235-8987"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Rosati","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018944419","display_name":"Anna Maria Basile","orcid":"https://orcid.org/0000-0002-4523-8202","observed_orcids":["https://orcid.org/0000-0002-4523-8202"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Basile","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080723254","display_name":"Raffaella D\u2019Auria","orcid":"https://orcid.org/0000-0001-7758-8592","observed_orcids":["https://orcid.org/0000-0001-7758-8592"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella D\u2019Auria","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","Department of Pharmacy, Division of Biomedicine \u201cA. Leone\u201d, University of Salerno, Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Division of Biomedicine \u201cA. Leone\u201d, University of Salerno, Fisciano, 84084, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025696227","display_name":"Morena d\u2019Avenia","orcid":"https://orcid.org/0000-0001-6359-5871","observed_orcids":["https://orcid.org/0000-0001-6359-5871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morena d\u2019Avenia","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006138228","display_name":"Margot De Marco","orcid":"https://orcid.org/0000-0003-4134-1437","observed_orcids":["https://orcid.org/0000-0003-4134-1437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margot De Marco","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011914678","display_name":"Antonia Falco","orcid":"https://orcid.org/0009-0003-5721-6902","observed_orcids":["https://orcid.org/0009-0003-5721-6902"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonia Falco","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087277477","display_name":"Michelina Festa","orcid":"https://orcid.org/0009-0006-4551-2589","observed_orcids":["https://orcid.org/0009-0006-4551-2589"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michelina Festa","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017046089","display_name":"Luana Guerriero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luana Guerriero","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060693420","display_name":"Vittoria Iorio","orcid":"https://orcid.org/0000-0001-7826-4725","observed_orcids":["https://orcid.org/0000-0001-7826-4725"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittoria Iorio","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076170622","display_name":"Roberto Parente","orcid":"https://orcid.org/0000-0001-5639-3040","observed_orcids":["https://orcid.org/0000-0001-5639-3040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Parente","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010378389","display_name":"Maria Carmela Pascale","orcid":"https://orcid.org/0000-0002-4935-7903","observed_orcids":["https://orcid.org/0000-0002-4935-7903"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Pascale","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Division of Biomedicine \"A. Leone\", University of Salerno, Fisciano, Salerno 84084, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058335899","display_name":"Liberato Marzullo","orcid":"https://orcid.org/0000-0001-6133-4483","observed_orcids":["https://orcid.org/0000-0001-6133-4483"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Liberato Marzullo","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6133-4483","affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, 84084, Salerno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376970","display_name":"Renato Franco","orcid":"https://orcid.org/0000-0002-8340-3184","observed_orcids":["https://orcid.org/0000-0002-8340-3184","https://orcid.org/0000-0002-6424-7841"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Franco","raw_affiliation_strings":["Pathology Unit, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Unit, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021846516","display_name":"Claudio Arra","orcid":"https://orcid.org/0000-0003-3162-2091","observed_orcids":["https://orcid.org/0000-0003-3162-2091"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Arra","raw_affiliation_strings":["Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064994916","display_name":"Ant\u00f4nio Barbieri","orcid":"https://orcid.org/0000-0002-7788-6167","observed_orcids":["https://orcid.org/0000-0002-7788-6167"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Barbieri","raw_affiliation_strings":["Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077381350","display_name":"Domenica Rea","orcid":"https://orcid.org/0000-0002-7162-6735","observed_orcids":["https://orcid.org/0000-0002-7162-6735"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenica Rea","raw_affiliation_strings":["Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal facility, Istituto Nazionale Tumouri Fondazione \"G. Pascale\", Naples 81100, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089218309","display_name":"Giulio Menichini","orcid":"https://orcid.org/0000-0003-1858-3964","observed_orcids":["https://orcid.org/0000-0003-1858-3964"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Menichini","raw_affiliation_strings":["Reconstructive Microsurgery, Department of Oncology, Careggi University Hospital, Florence 50139, Italy","Department of Oncology, Reconstructive Microsurgery, Careggi University Hospital, Florence, 50139, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reconstructive Microsurgery, Department of Oncology, Careggi University Hospital, Florence 50139, Italy","institution_ids":["https://openalex.org/I4210115393"]},{"raw_affiliation_string":"Department of Oncology, Reconstructive Microsurgery, Careggi University Hospital, Florence, 50139, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009430102","display_name":"Michael Hahne","orcid":"https://orcid.org/0000-0002-3953-6430","observed_orcids":["https://orcid.org/0000-0002-3953-6430"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Hahne","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, CNRS UMR5535, Montpellier 34293, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, CNRS UMR5535, Montpellier 34293, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000969662","display_name":"Maarten F. Bijlsma","orcid":"https://orcid.org/0000-0001-6627-3229","observed_orcids":["https://orcid.org/0000-0001-6627-3229"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Bijlsma","raw_affiliation_strings":["Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam 1105AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013299634","display_name":"Daniela Barcaroli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Barcaroli","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044515513","display_name":"Gianluca Sala","orcid":"https://orcid.org/0000-0002-4494-915X","observed_orcids":["https://orcid.org/0000-0002-4494-915X"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Sala","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010675355","display_name":"Fabio F. di Mola","orcid":"https://orcid.org/0000-0001-9877-2946","observed_orcids":["https://orcid.org/0000-0001-9877-2946"]},"institutions":[{"id":"https://openalex.org/I4210149564","display_name":"Ospedale SS. Annunziata","ror":"https://ror.org/04hd4qy94","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149564"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Francesco di Mola","raw_affiliation_strings":["Division of Surgical Oncology, \"S.S. Annunziata\"Hospital, Chieti 66100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, \"S.S. Annunziata\"Hospital, Chieti 66100, Italy","institution_ids":["https://openalex.org/I4210149564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028617483","display_name":"Pierluigi Di Sebastiano","orcid":"https://orcid.org/0000-0002-9386-8241","observed_orcids":["https://orcid.org/0000-0002-9386-8241"]},"institutions":[{"id":"https://openalex.org/I4210149564","display_name":"Ospedale SS. Annunziata","ror":"https://ror.org/04hd4qy94","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149564"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierluigi di Sebastiano","raw_affiliation_strings":["Division of Surgical Oncology, \"S.S. Annunziata\"Hospital, Chieti 66100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, \"S.S. Annunziata\"Hospital, Chieti 66100, Italy","institution_ids":["https://openalex.org/I4210149564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088464195","display_name":"Jelena Todoric","orcid":"https://orcid.org/0000-0002-2669-3904","observed_orcids":["https://orcid.org/0000-0002-2669-3904"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelena Todoric","raw_affiliation_strings":["Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001192190","display_name":"Laura Antonucci","orcid":"https://orcid.org/0000-0001-8965-2432","observed_orcids":["https://orcid.org/0000-0001-8965-2432"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Antonucci","raw_affiliation_strings":["Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089727653","display_name":"Vincent Corvest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Corvest","raw_affiliation_strings":["CALIXAR, Bioparc, B\u00e2timent La\u00ebnnec, Lyon 69008, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CALIXAR, Bioparc, B\u00e2timent La\u00ebnnec, Lyon 69008, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006366809","display_name":"Anass Jawhari","orcid":"https://orcid.org/0000-0001-8170-0524","observed_orcids":["https://orcid.org/0000-0001-8170-0524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anass Jawhari","raw_affiliation_strings":["CALIXAR, Bioparc, B\u00e2timent La\u00ebnnec, Lyon 69008, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CALIXAR, Bioparc, B\u00e2timent La\u00ebnnec, Lyon 69008, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003013528","display_name":"Matthew A. Firpo","orcid":"https://orcid.org/0000-0002-7983-3982","observed_orcids":["https://orcid.org/0000-0002-7983-3982"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A Firpo","raw_affiliation_strings":["Department of Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA","Department of Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84132, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0002-7983-3982","affiliations":[{"raw_affiliation_string":"Department of Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"Department of Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84132, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072185005","display_name":"David A. Tuveson","orcid":"https://orcid.org/0000-0002-8017-2712","observed_orcids":["https://orcid.org/0000-0002-8017-2712"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Tuveson","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA","Cold Spring Harbor Laboratory, Cold Spring Harbor, 11724, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, 11724, New York, USA","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078594749","display_name":"Mario Capunzo","orcid":"https://orcid.org/0000-0002-2399-2650","observed_orcids":["https://orcid.org/0000-0002-2399-2650"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Capunzo","raw_affiliation_strings":["Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, 84081, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, 84081, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056315342","display_name":"Michael Karin","orcid":"https://orcid.org/0000-0002-2758-6473","observed_orcids":["https://orcid.org/0000-0002-2758-6473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Karin","raw_affiliation_strings":["Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UCSD, School of Medicine, San Diego, California 92093-0723, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction Departments of Pharmacology and Pathology, Laboratory of Gene Regulation and Signal Transduction, UCSD, School of Medicine, San Diego, 92093-0723, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017442589","display_name":"Vincenzo De Laurenzi","orcid":"https://orcid.org/0000-0002-7506-1743","observed_orcids":["https://orcid.org/0000-0002-7506-1743"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Vincenzo De Laurenzi","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Orali e Biotecnologiche, University \"G. d'Annunzio\" di Chieti-Pescara, Centro Studi sull'Invecchiamento, CeSI-MeT, Chieti 66100, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001382285","display_name":"Maria Caterina Turco","orcid":"https://orcid.org/0000-0002-7835-359X","observed_orcids":["https://orcid.org/0000-0002-7835-359X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Caterina Turco","raw_affiliation_strings":["BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","Department of Medicine and Surgery, University of Salerno, Baronissi, 84081, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOUNIVERSA s.r.l., Fisciano, Salerno 84084, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno 84081, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Baronissi, 84081, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5001382285","https://openalex.org/A5017442589"],"corresponding_institution_ids":["https://openalex.org/I131729948","https://openalex.org/I39387349"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.4919,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.96624275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"8695","last_page":"8695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.20029999315738678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bag3","display_name":"BAG3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumour-associated-macrophages","display_name":"tumour-associated macrophages","score":0.925000011920929},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ifitm2","display_name":"IFITM2","score":0.8560000061988831},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/p38-mapk-signalling","display_name":"p38 MAPK signalling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7681640386581421},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.710118293762207},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.6388790607452393},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5745789408683777},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5339998006820679},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5207788348197937},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.5103711485862732},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.48424264788627625},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4734249413013458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4110046625137329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3833436965942383},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3444805145263672},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3380788564682007},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3034686744213104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2545372247695923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2378581464290619},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2011629343032837},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.12245291471481323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1038/ncomms9695","doi":"https://doi.org/10.1038/ncomms9695","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms9695","pdf_url":"https://www.nature.com/articles/ncomms9695.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:26522614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26522614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4659838","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4659838/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:repository.cshl.edu:31962","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/31962/1/Tuveson_NatComm_2015a.pdf","pdf_url":"https://repository.cshl.edu/id/eprint/31962/1/Tuveson_NatComm_2015a.pdf","source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.5888","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.5888","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c8/76/ncomms9695.PMC4659838.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/2e634027-28d3-45c1-8300-192d8b82890f","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/bag3-promotes-pancreatic-ductal-adenocarcinoma-growth-by-activating-stromal-macrophages(2e634027-28d3-45c1-8300-192d8b82890f).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications, 6. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9695","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms9695","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1jr3f60b","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1jr3f60b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications, vol 6, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1jr3f60b","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1jr3f60b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 6, iss 1","raw_type":"article"},{"id":"pmh:oai:iris.unicampania.it:11591/352250","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/352250","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/a867be13-45de-4678-82b7-41b4b6649d45","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/a867be13-45de-4678-82b7-41b4b6649d45","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/ncomms9695","doi":"https://doi.org/10.1038/ncomms9695","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms9695","pdf_url":"https://www.nature.com/articles/ncomms9695.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1529346103","display_name":null,"funder_award_id":"15196","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G995807686","display_name":null,"funder_award_id":"AIRC IG-15196","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2200997261.pdf","grobid_xml":"https://content.openalex.org/works/W2200997261.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W160183570","https://openalex.org/W1968805631","https://openalex.org/W1971298987","https://openalex.org/W1971620413","https://openalex.org/W1976691320","https://openalex.org/W1981840935","https://openalex.org/W1986482237","https://openalex.org/W1986887896","https://openalex.org/W1994052960","https://openalex.org/W1996912024","https://openalex.org/W2004915012","https://openalex.org/W2010916968","https://openalex.org/W2012532871","https://openalex.org/W2015751470","https://openalex.org/W2021766591","https://openalex.org/W2023457562","https://openalex.org/W2027888296","https://openalex.org/W2032672595","https://openalex.org/W2033278321","https://openalex.org/W2047601357","https://openalex.org/W2051014195","https://openalex.org/W2059069515","https://openalex.org/W2065215232","https://openalex.org/W2071568678","https://openalex.org/W2075274809","https://openalex.org/W2076198632","https://openalex.org/W2078214659","https://openalex.org/W2084299788","https://openalex.org/W2085605492","https://openalex.org/W2087959519","https://openalex.org/W2088110734","https://openalex.org/W2089727089","https://openalex.org/W2104958095","https://openalex.org/W2107748627","https://openalex.org/W2118278569","https://openalex.org/W2120717826","https://openalex.org/W2135971454","https://openalex.org/W2136176800","https://openalex.org/W2136292231","https://openalex.org/W2137217704","https://openalex.org/W2151048225","https://openalex.org/W2152181022","https://openalex.org/W2158482235","https://openalex.org/W2160269498","https://openalex.org/W2161091841","https://openalex.org/W2164537670","https://openalex.org/W2164942973","https://openalex.org/W2167122992","https://openalex.org/W2329085126"],"related_works":["https://openalex.org/W2565757466","https://openalex.org/W2398833344","https://openalex.org/W2189902773","https://openalex.org/W2945109346","https://openalex.org/W3209782193","https://openalex.org/W4402100106","https://openalex.org/W2791600154","https://openalex.org/W2884727596","https://openalex.org/W3111826740","https://openalex.org/W4390103942"],"abstract_inverted_index":{"The":[0],"incidence":[1],"and":[2,29,38,52,58,73,80,100,120,123],"death":[3],"rate":[4],"of":[5,18,40,61,91],"pancreatic":[6],"ductal":[7],"adenocarcinoma":[8],"(PDAC)":[9],"have":[10],"increased":[11],"in":[12,35,96,104,117],"recent":[13],"years,":[14],"therefore":[15],"the":[16,59,81,89],"identification":[17],"novel":[19],"targets":[20],"for":[21],"treatment":[22],"is":[23],"extremely":[24],"important.":[25],"Interactions":[26],"between":[27],"cancer":[28],"stromal":[30],"cells":[31,47],"are":[32],"critically":[33],"involved":[34,116],"tumour":[36,98],"formation":[37,103],"development":[39],"metastasis.":[41],"Here":[42],"we":[43,86,111],"report":[44],"that":[45,75,88,125],"PDAC":[46,62,118],"secrete":[48],"BAG3,":[49],"which":[50],"binds":[51],"activates":[53],"macrophages,":[54],"inducing":[55],"their":[56],"activation":[57],"secretion":[60],"supporting":[63],"factors.":[64],"We":[65],"also":[66],"identify":[67,112],"IFITM-2":[68],"as":[69],"a":[70,113],"BAG3":[71],"receptor":[72],"show":[74,87,124],"it":[76],"signals":[77],"through":[78],"PI3K":[79],"p38":[82],"MAPK":[83],"pathways.":[84],"Finally,":[85],"use":[90],"an":[92,126],"anti-BAG3":[93,127],"antibody":[94,128],"results":[95],"reduced":[97],"growth":[99,119],"prevents":[101],"metastasis":[102],"three":[105],"different":[106],"mouse":[107],"models.":[108],"In":[109],"conclusion,":[110],"paracrine":[114],"loop":[115],"metastatic":[121],"spreading,":[122],"has":[129],"therapeutic":[130],"potential.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}