{"id":"https://openalex.org/W2200855375","doi":null,"title":"Bone marrow transplantation for thalassemia. The USA experience.","display_name":"Bone marrow transplantation for thalassemia. The USA experience.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2200855375","mag":"2200855375","pmid":"https://pubmed.ncbi.nlm.nih.gov/8311166"},"language":"en","primary_location":{"id":"pmid:8311166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8311166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pediatric hematology/oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011479118","display_name":"M. Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Walters","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037247107","display_name":"Keith M. Sullivan","orcid":"https://orcid.org/0000-0002-1379-9216","observed_orcids":["https://orcid.org/0000-0002-1379-9216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Sullivan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112022814","display_name":"Richard J. O'Reilly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J O'Reilly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067712388","display_name":"Farid Boulad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Boulad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037708456","display_name":"J Brockstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Brockstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110123450","display_name":"Karl G. Blume","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Blume","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110878526","display_name":"Michael D. Amylon","orcid":"https://orcid.org/0009-0007-2028-7992","observed_orcids":["https://orcid.org/0009-0007-2028-7992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Amylon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113433230","display_name":"F. Leonard Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F L Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042600356","display_name":"Martin R. Klemperer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Klemperer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067158637","display_name":"John Graham\u2010Pole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Graham-Pole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.192,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.7696122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"1","first_page":"11","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalassemia-major","display_name":"thalassemia major","score":0.972000002861023},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hla-matched-sibling-donor","display_name":"matched sibling donor","score":0.7929999828338623},{"id":"https://openalex.org/keywords/unrelated-donor","display_name":"unrelated donor","score":0.5019999742507935},{"id":"https://openalex.org/keywords/haploidentical-donor","display_name":"haploidentical donor","score":0.968999981880188},{"id":"https://openalex.org/keywords/hla-mismatch","display_name":"HLA mismatch","score":0.6190000176429749},{"id":"https://openalex.org/keywords/busulfan","display_name":"busulfan","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9240000247955322},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/liver-iron-overload","display_name":"liver iron overload","score":0.5230000019073486},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.7649999856948853},{"id":"https://openalex.org/keywords/chelation","display_name":"chelation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.7710000276565552},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.824999988079071},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.8579447865486145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8245794773101807},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.7244693636894226},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6849007606506348},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.6188449859619141},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6163250803947449},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5781230330467224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5483506321907043},{"id":"https://openalex.org/C2994180119","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Bone marrow transplantation","level":3,"score":0.4576616883277893},{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.45355871319770813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43500664830207825},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35776782035827637},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22510802745819092},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8311166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8311166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pediatric hematology/oncology","raw_type":"Journal Article"},{"id":"mag:2200855375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8311166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4454968240","display_name":"IMMUNOLOGIC STUDIES IN STEM CELL GRAFTS FOR MALIGNANCIES","funder_award_id":"P01CA018221","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G470551214","display_name":"Stem Cell Transplantation: Basic/Clinical Research","funder_award_id":"P01HL036444","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000906164","display_name":"Adult Leukemia Research Center","funder_award_id":"P01CA018029","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2980000661","https://openalex.org/W2087218234","https://openalex.org/W2581110861","https://openalex.org/W178234560","https://openalex.org/W2069988626","https://openalex.org/W3147853225","https://openalex.org/W947537778","https://openalex.org/W2581177594","https://openalex.org/W2402227730","https://openalex.org/W2262129719"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"have":[2],"reviewed":[3],"the":[4,20,47,84,227,237,284,289,357],"results":[5],"of":[6,46,83,152,163,173,191,204,211,221,229,236,260,286,295,318,341,348,359],"bone":[7,327],"marrow":[8,88,104,117,179,242,328,360],"transplantation":[9,30,361],"in":[10,19,31,63,71,144,303,314],"30":[11,85],"patients":[12,27,35,64,86,111,134,153,175,207,239,261,319,332],"with":[13,65,146,188,326],"thalassemia":[14,212,222,322,363],"major":[15],"who":[16,28,177,240],"were":[17,41,55,112,135,154,252],"treated":[18],"United":[21],"States.":[22],"PATIENTS":[23],"AND":[24],"METHODS:":[25],"Ten":[26],"underwent":[29],"Seattle":[32],"and":[33,60,69,109,128,213,226,279,288,364],"20":[34],"from":[36,73,89,105,118,180,194,243],"five":[37,214],"other":[38,97],"U.S.":[39,349],"centers":[40,351],"identified":[42],"through":[43],"a":[44,90,119,161,189,336],"survey":[45],"International":[48],"Bone":[49],"Marrow":[50],"Transplant":[51],"Registry.":[52],"These":[53],"transplants":[54],"performed":[56,255],"between":[57,306],"November":[58],"1981":[59],"April":[61],"1992":[62],"diverse":[66],"ethnic":[67],"backgrounds":[68],"ranged":[70],"age":[72],"6":[74],"months":[75,196],"to":[76,197,355,365],"14":[77],"years":[78,200],"(median":[79],"4.0":[80],"years).":[81],"Twenty-seven":[82],"received":[87,102,178,241],"human":[91],"leukocyte":[92],"antigen":[93],"(HLA)-identical":[94],"sibling":[95],"or":[96,140,245],"family":[98,183],"member,":[99],"one":[100,235],"patient":[101],"HLA-matched":[103],"an":[106,181],"unrelated":[107,246],"donor,":[108],"two":[110],"given":[113,136,155],"haploidentical":[114],"but":[115],"HLA-mismatched":[116],"related":[120],"donor.":[121],"Cytoreductive":[122],"(preparative)":[123],"therapy":[124],"varied":[125],"among":[126],"institutions":[127],"pretransplant":[129],"risk":[130,264,271,308],"categories.":[131],"In":[132],"general,":[133],"busulfan":[137],"(12-24":[138],"mg/kg)":[139,143],"dimethylmyleran":[141],"(5":[142],"combination":[145],"cyclophosphamide":[147,168],"(120-240":[148],"mg/kg).":[149,170],"A":[150,269,344],"subset":[151],"total":[156],"body":[157],"irradiation":[158],"(TBI)":[159],"at":[160],"dose":[162],"720":[164],"cGy":[165],"followed":[166],"by":[167,275,283],"(120":[169],"RESULTS:":[171],"Sixteen":[172],"27":[174,206],"(59%)":[176],"HLA-identical":[182],"member":[184],"are":[185,333],"event-free":[186,230,304,334],"survivors,":[187,335],"duration":[190],"follow-up":[192],"ranging":[193],"2":[195],">":[198],"10":[199],"after":[201],"transplantation.":[202,329],"Six":[203],"these":[205],"(22%)":[208],"had":[209],"recurrence":[210,223,340],"(19%)":[215],"died.":[216],"The":[217,311],"estimated":[218],"actuarial":[219],"rate":[220,228],"was":[224,232,266,273,299],"24%":[225],"survival":[231,305],"57%.":[233],"Only":[234],"three":[238],"HLA-nonidentical":[244],"donors":[247],"survives":[248],"event-free.":[249],"Liver":[250],"biopsies":[251],"not":[253,267],"routinely":[254],"before":[256],"transplant.":[257],"Thus,":[258],"classification":[259,272],"into":[262],"Lucarelli":[263],"groups":[265],"possible.":[268],"modified":[270],"devised":[274],"using":[276],"liver":[277],"size":[278],"iron":[280],"status":[281],"assessed":[282],"regularity":[285],"chelation":[287],"serum":[290],"ferritin":[291],"level.":[292],"With":[293],"use":[294,358],"this":[296,315],"classification,":[297],"there":[298],"no":[300],"significant":[301,337],"difference":[302],"transplant":[307,350],"groups.":[309],"CONCLUSIONS:":[310],"findings":[312],"observed":[313],"small":[316],"series":[317],"confirms":[320],"that":[321],"can":[323],"be":[324,353],"cured":[325],"Although":[330],"most":[331],"number":[338],"experienced":[339],"their":[342],"disease.":[343],"cooperative":[345],"multicenter":[346],"trial":[347],"may":[352],"necessary":[354],"evaluate":[356],"for":[362],"determine":[366],"optimal":[367],"treatment.":[368]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}