{"id":"https://openalex.org/W2200828348","doi":"https://doi.org/10.18103/mra.v0i3.158","title":"Successful and uncomplicated transfer of MRI Quantitative Chemical Shift Imaging (QCSI) technology for the detection of bone marrow fat signal fraction in type I Gaucher disease","display_name":"Successful and uncomplicated transfer of MRI Quantitative Chemical Shift Imaging (QCSI) technology for the detection of bone marrow fat signal fraction in type I Gaucher disease","publication_year":2015,"publication_date":"2015-05-19","ids":{"openalex":"https://openalex.org/W2200828348","doi":"https://doi.org/10.18103/mra.v0i3.158","mag":"2200828348"},"language":"en","primary_location":{"id":"doi:10.18103/mra.v0i3.158","doi":"https://doi.org/10.18103/mra.v0i3.158","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v0i3.158","pdf_url":"https://esmed.org/MRA/mra/article/download/158/55","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://esmed.org/MRA/mra/article/download/158/55","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031572283","display_name":"Annick Vanclooster","orcid":"https://orcid.org/0000-0003-0166-8865","observed_orcids":["https://orcid.org/0000-0003-0166-8865"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Annick Vanclooster","raw_affiliation_strings":["Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091091541","display_name":"Wouter Meersseman","orcid":"https://orcid.org/0000-0003-3170-1371","observed_orcids":["https://orcid.org/0000-0003-3170-1371"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Wouter Meersseman","raw_affiliation_strings":["Department of Pediatrics and Metabolic Center University Hospital Gasthuisberg University of Leuven Herestraat 49 , 3000 Leuven Belgium","Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Metabolic Center University Hospital Gasthuisberg University of Leuven Herestraat 49 , 3000 Leuven Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050567219","display_name":"Mario M. Maas","orcid":"https://orcid.org/0000-0001-6785-5167","observed_orcids":["https://orcid.org/0000-0001-6785-5167"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mario Maas","raw_affiliation_strings":["Academic Medical Centre Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Centre Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013483389","display_name":"Stefan Ghysels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stefan Ghysels","raw_affiliation_strings":["Department of radiology, University Hospital Leuven, Gasthuisberg, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of radiology, University Hospital Leuven, Gasthuisberg, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004803454","display_name":"Ronald R. Peeters","orcid":"https://orcid.org/0000-0002-7055-4039","observed_orcids":["https://orcid.org/0000-0002-7055-4039"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ronald Peeters","raw_affiliation_strings":["Department of radiology, University Hospital Leuven, Gasthuisberg, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of radiology, University Hospital Leuven, Gasthuisberg, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108769378","display_name":"Erik M. Akkerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik Akkerman","raw_affiliation_strings":["Academic Medical Centre Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Centre Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028321574","display_name":"David M Cassiman","orcid":"https://orcid.org/0000-0002-6154-0970","observed_orcids":["https://orcid.org/0000-0002-6154-0970"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David Cassiman","raw_affiliation_strings":["Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Centre, University Hospital Leuven, Gasthuisberg, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaucher-disease-type-1","display_name":"Gaucher disease type 1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dixon-imaging","display_name":"Dixon MRI","score":0.7059999704360962},{"id":"https://openalex.org/keywords/bone-marrow-fat-fraction","display_name":"bone marrow fat fraction","score":0.949999988079071},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.75},{"id":"https://openalex.org/keywords/technology-transfer","display_name":"technology transfer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/enzyme-replacement-therapy","display_name":"enzyme replacement therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-follow-up","display_name":"disease follow-up","score":0.6190000176429749},{"id":"https://openalex.org/keywords/bone-involvement","display_name":"bone involvement","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.673037052154541},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5683572888374329},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5143212080001831},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4526684880256653},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.43704456090927124},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.41830214858055115},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36701613664627075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.172830730676651},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09832480549812317},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18103/mra.v0i3.158","doi":"https://doi.org/10.18103/mra.v0i3.158","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v0i3.158","pdf_url":"https://esmed.org/MRA/mra/article/download/158/55","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/657116","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/bitstream/123456789/657116/2/158-1-634-1-10-20150602.pdf","pdf_url":"https://lirias.kuleuven.be/bitstream/123456789/657116/2/158-1-634-1-10-20150602.pdf","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18103/mra.v0i3.158","doi":"https://doi.org/10.18103/mra.v0i3.158","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v0i3.158","pdf_url":"https://esmed.org/MRA/mra/article/download/158/55","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2200828348.pdf","grobid_xml":"https://content.openalex.org/works/W2200828348.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1989812344","https://openalex.org/W2002193247","https://openalex.org/W2025584396","https://openalex.org/W2081808079","https://openalex.org/W2102761052","https://openalex.org/W2103010570","https://openalex.org/W2119593625","https://openalex.org/W2140545977","https://openalex.org/W2604213239","https://openalex.org/W4241153917"],"related_works":["https://openalex.org/W2525585414","https://openalex.org/W2119593625","https://openalex.org/W2025584396","https://openalex.org/W2099411973","https://openalex.org/W2041580499","https://openalex.org/W2102761052","https://openalex.org/W4324149386","https://openalex.org/W2792409134","https://openalex.org/W2409620306","https://openalex.org/W2002193247"],"abstract_inverted_index":{"Background":[0],"and":[1,28,70,78,114,138,151,190,202,210,217],"study":[2,85,258],"aim:":[3],"Dixon":[4,261],"Quantitative":[5],"Chemical":[6],"Shift":[7],"Imaging":[8],"(QCSI)":[9],"to":[10,43,63,111,135,162,177,223,271,280],"measure":[11],"lumbar":[12],"spine":[13],"bone":[14,32,172],"marrow":[15],"fat":[16],"signal":[17],"fraction":[18],"(FF),":[19],"is":[20,174,251,265],"considered":[21],"the":[22,26,52,59,64,84,94,103,116,122,160,181,274,286],"\u2018gold":[23],"standard\u2019":[24],"for":[25,108,120,171,276],"determination":[27],"follow":[29],"up":[30],"of":[31,93,102,144,169,226],"involvement":[33],"in":[34,48,97,149,152,200,242,244,253],"type":[35],"I":[36],"Gaucher":[37,281],"disease":[38,173],"(GD).":[39],"Since":[40],"there":[41],"used":[42],"be":[44],"only":[45],"one":[46,109,208,269],"centre":[47,270],"Europe":[49],"(AMC,":[50],"Amsterdam,":[51],"Netherlands)":[53],"offering":[54,273],"this":[55,278],"technique,":[56],"we":[57],"transferred":[58],"Amsterdam":[60,104,182,203],"QCSI":[61,95,250,262],"technology":[62,264],"University":[65],"Hospital":[66],"Gasthuisberg":[67],"(Leuven,":[68],"Belgium)":[69],"tested":[71],"it":[72],"on":[73],"9":[74,80],"Belgian":[75],"patients.":[76,246],"Patients":[77],"methods:":[79],"GD":[81],"patients":[82,154,186,192],"entered":[83],"from":[86,232,268],"November":[87],"2006":[88],"till":[89,235],"April":[90],"2010.":[91],"Installation":[92],"technique":[96,123,279],"Leuven":[98,150,201],"required":[99],"a":[100,125,139,224,239],"visit":[101],"MRI":[105,263,282],"physicist":[106],"(E.M.A.)":[107],"day,":[110],"install":[112],"software":[113],"train":[115],"local":[117],"team.":[118],"Requirements":[119],"running":[121],"are:":[124],"1.5":[126],"Tesla":[127],"MRI-scanner,":[128],"Siemens":[129],"or":[130],"General":[131],"Electric,":[132],"with":[133],"access":[134],"sequence":[136],"programming":[137],"dedicated":[140],"physicist.":[141],"A":[142],"total":[143],"22":[145],"scans":[146,156,199],"were":[147,157,187,204],"performed":[148,158,206],"2":[153],"parallel":[155,198],"at":[159,193],"AMC,":[161],"determine":[163],"reproducibility.":[164],"The":[165],"critical":[166],"cut-off":[167],"value":[168],"FF":[170,243],"23%,":[175],"according":[176],"data":[178],"published":[179],"by":[180],"group.":[183],"Results:":[184],"Four":[185],"scanned":[188],"once":[189],"five":[191],"least":[194],"3":[195,245],"times.":[196],"Two":[197],"each":[205],"within":[207],"week":[209],"showed":[211],"good":[212],"reproducibility":[213],"(40.7%":[214],"vs.":[215,219],"43.8%":[216],"41%":[218],"39%":[220],").":[221],"Due":[222],"shortage":[225],"enzyme,":[227],"enzyme":[228],"replacement":[229],"therapy":[230],"ceased":[231],"August":[233],"2009":[234],"January":[236],"2010,":[237],"causing":[238],"detectable":[240],"decrease":[241],"This":[247,257],"confirms":[248],"that":[249,260],"useful":[252],"clinical":[254],"follow-up.":[255],"Conclusion:":[256],"shows":[259],"successfully":[266],"transferable":[267],"another,":[272],"potential":[275],"spreading":[277],"expert":[283],"centres":[284],"throughout":[285],"world.":[287]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}