{"id":"https://openalex.org/W2200344714","doi":"https://doi.org/10.1161/circulationaha.115.016133","title":"Estrogen Metabolite 16\u03b1-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II\u2013Associated Pulmonary Arterial Hypertension Through MicroRNA-29\u2013Mediated Modulation of Cellular Metabolism","display_name":"Estrogen Metabolite 16\u03b1-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II\u2013Associated Pulmonary Arterial Hypertension Through MicroRNA-29\u2013Mediated Modulation of Cellular Metabolism","publication_year":2015,"publication_date":"2015-10-20","ids":{"openalex":"https://openalex.org/W2200344714","doi":"https://doi.org/10.1161/circulationaha.115.016133","mag":"2200344714","pmid":"https://pubmed.ncbi.nlm.nih.gov/26487756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4698046"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.115.016133","doi":"https://doi.org/10.1161/circulationaha.115.016133","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.115.016133","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4698046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101594771","display_name":"Xinping Chen","orcid":"https://orcid.org/0000-0002-7490-9036","observed_orcids":["https://orcid.org/0000-0002-7490-9036"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinping Chen","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031549141","display_name":"Megha H. Talati","orcid":"https://orcid.org/0000-0002-2892-8113","observed_orcids":["https://orcid.org/0000-0002-2892-8113"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megha Talati","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017870559","display_name":"Joshua P. Fessel","orcid":"https://orcid.org/0000-0003-0797-7693","observed_orcids":["https://orcid.org/0000-0003-0797-7693"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua P. Fessel","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056044508","display_name":"Anna Ryan Hemnes","orcid":"https://orcid.org/0000-0002-2755-5845","observed_orcids":["https://orcid.org/0000-0002-2755-5845"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna R. Hemnes","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058773601","display_name":"Santhi Gladson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santhi Gladson","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077289061","display_name":"Jaketa L. French","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaketa French","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012081646","display_name":"Sheila D. Shay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila Shay","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080744249","display_name":"Aaron W. Trammell","orcid":"https://orcid.org/0000-0002-6960-7711","observed_orcids":["https://orcid.org/0000-0002-6960-7711"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Trammell","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John A. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Phillips","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101944234","display_name":"Rizwan Hamid","orcid":"https://orcid.org/0000-0001-5063-7614","observed_orcids":["https://orcid.org/0000-0001-5063-7614"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rizwan Hamid","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009935328","display_name":"Joy D. Cogan","orcid":"https://orcid.org/0000-0001-8106-1216","observed_orcids":["https://orcid.org/0000-0001-8106-1216"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy D. Cogan","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113693862","display_name":"Elliott P. Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott P. Dawson","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069415050","display_name":"Kristie E. Womble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristie E. Womble","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051910732","display_name":"Lora K. Hedges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora K. Hedges","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth G. Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth G. Martinez","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105415221","display_name":"Lisa A Wheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Wheeler","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065762639","display_name":"James E. Loyd","orcid":"https://orcid.org/0000-0002-5042-7390","observed_orcids":["https://orcid.org/0000-0002-5042-7390"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Loyd","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071456081","display_name":"Susan J. Majka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan J. Majka","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042419219","display_name":"James D. West","orcid":"https://orcid.org/0000-0002-6004-0202","observed_orcids":["https://orcid.org/0000-0002-6004-0202"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James West","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030467856","display_name":"Eric D. Austin","orcid":"https://orcid.org/0000-0002-1709-9022","observed_orcids":["https://orcid.org/0000-0002-1709-9022"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210139231","display_name":"BioVentures (United States)","ror":"https://ror.org/03gs9sh82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139231"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Austin","raw_affiliation_strings":["From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Departments of Medicine (X.C., M.T., J.P.F., A.R.H., S.G., J.F., S.S., L.A.W., J.E.L., S.J.M., J.W.), Pharmacology (J.P.F.), Pediatrics (J.A.P., R.H., J..C., L.K.H.), and Pathology (E.G.M.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.); and Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Bioventures, Inc, Murfreesboro, TN (E.P.D., K.E.W.)","institution_ids":["https://openalex.org/I4210139231"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine, Houston, TX (A.T.)","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.2687,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.98592493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"133","issue":"1","first_page":"82","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.859000027179718},{"id":"https://openalex.org/keywords/16alpha-hydroxyestrone","display_name":"16\u03b1-hydroxyestrone","score":0.9509999752044678},{"id":"https://openalex.org/keywords/estrogen-metabolites","display_name":"estrogen metabolites","score":0.8790000081062317},{"id":"https://openalex.org/keywords/microrna-29","display_name":"microRNA-29","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bmpr2","display_name":"BMPR2","score":0.753000020980835},{"id":"https://openalex.org/keywords/heritable-pulmonary-arterial-hypertension","display_name":"heritable pulmonary arterial hypertension","score":0.8949999809265137},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8757491111755371},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6426206231117249},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6361975073814392},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.5303312540054321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5207145810127258},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.500220775604248},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49023205041885376},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4836479425430298},{"id":"https://openalex.org/C2781228645","wikidata":"https://www.wikidata.org/wiki/Q4941575","display_name":"Bone morphogenetic protein receptor","level":4,"score":0.47266635298728943},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.47065678238868713},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.44030922651290894},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4116480350494385},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35953497886657715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32861822843551636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0959557592868805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08546197414398193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07790783047676086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006894","descriptor_name":"Hydroxyestrones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006894","descriptor_name":"Hydroxyestrones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052006","descriptor_name":"Bone Morphogenetic Protein Receptors, Type II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/circulationaha.115.016133","doi":"https://doi.org/10.1161/circulationaha.115.016133","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.115.016133","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:26487756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26487756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4103044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4698046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4698046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4698046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4103044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4698046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2771027099","display_name":"Gender differences and endothelin responses in right ventricular afterload stress","funder_award_id":"K08HL093363","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3533921386","display_name":"Role of Lung MSC in Emphysema","funder_award_id":"R01HL116597","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3803024886","display_name":"Hormonal, Metabolic and Signaling Interactions in PAH","funder_award_id":"P01HL108800","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4240081654","display_name":"Variations in estrogen exposures may modify pulmonary arterial hypertension","funder_award_id":"K23HL098743","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5196458118","display_name":"Vanderbilt Center for Undiagnosed Diseases (VCUD)","funder_award_id":"U01HG007674","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5201076466","display_name":null,"funder_award_id":"L40 HL090173","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G520785742","display_name":"XFe96 Analyzer","funder_award_id":"1s10od018015-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6916765345","display_name":"Interventions Against the Molecular Etiology of BMPR2-induced PAH","funder_award_id":"R01HL095797","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7739515466","display_name":"Role of BMPR2 expression in HPAH; implications for novel therapeutic approaches","funder_award_id":"R01HL102020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7773456091","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR)","funder_award_id":"UL1TR000445","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000910126","display_name":"Interdisciplinary Training Program in Lung Research","funder_award_id":"T32HL094296","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G902097116","display_name":"Metabolic Reprogramming in Pulmonary Arterial Hypertension","funder_award_id":"K08HL121174","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W193425753","https://openalex.org/W1708068686","https://openalex.org/W1832095457","https://openalex.org/W1838133438","https://openalex.org/W1924364089","https://openalex.org/W1951670987","https://openalex.org/W1965971393","https://openalex.org/W1966590827","https://openalex.org/W1970846664","https://openalex.org/W1972453512","https://openalex.org/W1976770854","https://openalex.org/W1978214583","https://openalex.org/W1981493632","https://openalex.org/W1982657089","https://openalex.org/W1982886546","https://openalex.org/W1984693219","https://openalex.org/W1990875061","https://openalex.org/W1992092213","https://openalex.org/W2000456938","https://openalex.org/W2001630174","https://openalex.org/W2002247513","https://openalex.org/W2002925464","https://openalex.org/W2003155673","https://openalex.org/W2010105156","https://openalex.org/W2012422658","https://openalex.org/W2017027000","https://openalex.org/W2025309753","https://openalex.org/W2028325343","https://openalex.org/W2028827931","https://openalex.org/W2029509991","https://openalex.org/W2029640027","https://openalex.org/W2030350999","https://openalex.org/W2030579450","https://openalex.org/W2037568417","https://openalex.org/W2043127046","https://openalex.org/W2046314136","https://openalex.org/W2046448515","https://openalex.org/W2046792302","https://openalex.org/W2049604140","https://openalex.org/W2050594817","https://openalex.org/W2053765786","https://openalex.org/W2059843925","https://openalex.org/W2067360285","https://openalex.org/W2072445922","https://openalex.org/W2074318487","https://openalex.org/W2075756011","https://openalex.org/W2077065151","https://openalex.org/W2080024994","https://openalex.org/W2081742737","https://openalex.org/W2088829415","https://openalex.org/W2095314259","https://openalex.org/W2097076005","https://openalex.org/W2102181984","https://openalex.org/W2102923791","https://openalex.org/W2104369067","https://openalex.org/W2110241360","https://openalex.org/W2112137254","https://openalex.org/W2112488807","https://openalex.org/W2114863766","https://openalex.org/W2117339256","https://openalex.org/W2118452945","https://openalex.org/W2120379299","https://openalex.org/W2121014368","https://openalex.org/W2121580924","https://openalex.org/W2128940917","https://openalex.org/W2135580384","https://openalex.org/W2141262339","https://openalex.org/W2142645644","https://openalex.org/W2146796052","https://openalex.org/W2147791685","https://openalex.org/W2151922790","https://openalex.org/W2152083180","https://openalex.org/W2152216118","https://openalex.org/W2154332638","https://openalex.org/W2155295345","https://openalex.org/W2156432877","https://openalex.org/W2160234571","https://openalex.org/W2161520297","https://openalex.org/W2164216268","https://openalex.org/W2164418602","https://openalex.org/W2167383172","https://openalex.org/W2167910192","https://openalex.org/W2168349771","https://openalex.org/W2170075724","https://openalex.org/W2171273257","https://openalex.org/W2183644045","https://openalex.org/W3140907331"],"related_works":["https://openalex.org/W2003155673","https://openalex.org/W1897452238","https://openalex.org/W2421478670","https://openalex.org/W7165596628","https://openalex.org/W2063608650","https://openalex.org/W2743002665","https://openalex.org/W2111397592","https://openalex.org/W68878742","https://openalex.org/W1511113874","https://openalex.org/W7169641693"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pulmonary":[1,179],"arterial":[2],"hypertension":[3,59],"(PAH)":[4],"is":[5],"a":[6,251],"proliferative":[7],"disease":[8],"of":[9,54,64,73,79,125,172,222,226,234,238,247],"the":[10,20,86,220],"pulmonary":[11,58],"vasculature":[12],"that":[13,40,52],"preferentially":[14],"affects":[15],"women.":[16],"Estrogens":[17],"such":[18],"as":[19],"metabolite":[21],"16\u03b1-hydroxyestrone":[22],"(16\u03b1OHE)":[23],"may":[24],"contribute":[25],"to":[26,109,116,143],"PAH":[27,44],"pathogenesis,":[28],"and":[29,51,107,137,145,170,212,231,243,249],"alterations":[30],"in":[31,60,97,112,133,139,166,197,241,244],"cellular":[32],"energy":[33,83,174,235],"metabolism":[34,175],"associate":[35],"with":[36,82,105,152,157,177,194,214],"PAH.":[37],"We":[38],"hypothesized":[39],"16\u03b1OHE":[41,117,144,218],"promotes":[42,219],"heritable":[43],"(HPAH)":[45],"via":[46,224],"microRNA-29":[47],"(miR-29)":[48],"family":[49],"upregulation":[50,225],"antagonism":[53],"miR-29":[55,87,92,239],"would":[56],"attenuate":[57],"transgenic":[61],"mouse":[62,127],"models":[63],"Bmpr2":[65,98,113,126,154,186],"mutation.":[66],"METHODS":[67],"AND":[68],"RESULTS:":[69],"MicroRNA":[70],"array":[71],"profiling":[72],"human":[74],"lung":[75,128],"tissue":[76],"found":[77],"elevation":[78],"microRNAs":[80],"associated":[81],"metabolism,":[84],"including":[85],"family,":[88],"among":[89],"HPAH":[90,149,203,223,248],"patients.":[91],"expression":[93],"was":[94],"2-fold":[95],"higher":[96,111],"mutant":[99],"mice":[100,114,141,155],"lungs":[101,150,188],"at":[102],"baseline":[103],"compared":[104,151,176],"controls":[106],"4":[108,121],"8-fold":[110],"exposed":[115,142],"1.25":[118],"\u03bcg/h":[119],"for":[120,161],"weeks.":[122],"Blot":[123],"analyses":[124],"protein":[129,146],"showed":[130],"significant":[131],"reductions":[132],"peroxisome":[134],"proliferator-activated":[135],"receptor-\u03b3":[136],"CD36":[138],"those":[140],"derived":[147,184,201],"from":[148,185,202],"controls.":[153,178],"treated":[156],"anti-miR-29":[158,195,215],"(20-mg/kg":[159],"injections":[160],"6":[162],"weeks)":[163],"had":[164],"improvements":[165],"hemodynamic":[167],"profile,":[168],"histology,":[169],"markers":[171],"dysregulated":[173],"artery":[180],"smooth":[181],"muscle":[182],"cells":[183,200],"murine":[187],"demonstrated":[189],"mitochondrial":[190],"abnormalities,":[191],"which":[192,228],"improved":[193,213],"transfection":[196],"vitro;":[198],"endothelial-like":[199],"patient":[204],"induced":[205],"pluripotent":[206],"stem":[207],"cell":[208],"lines":[209],"were":[210],"similar":[211],"treatment.":[216],"CONCLUSIONS:":[217],"development":[221],"miR-29,":[227],"alters":[229],"molecular":[230],"functional":[232],"indexes":[233],"metabolism.":[236],"Antagonism":[237],"improves":[240],"vivo":[242],"vitro":[245],"features":[246],"reveals":[250],"possible":[252],"novel":[253],"therapeutic":[254],"target.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}