{"id":"https://openalex.org/W2200293537","doi":"https://doi.org/10.1016/b978-012124546-7/50438-1","title":"Protein Kinase Inhibitors","display_name":"Protein Kinase Inhibitors","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2200293537","doi":"https://doi.org/10.1016/b978-012124546-7/50438-1","mag":"2200293537"},"language":"en","primary_location":{"id":"doi:10.1016/b978-012124546-7/50438-1","doi":"https://doi.org/10.1016/b978-012124546-7/50438-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012124546-7/50438-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Cell Signaling","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1506706279","display_name":"Handbook of Cell Signaling"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086404962","display_name":"Alexander Levitzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Alexander Levitzki","raw_affiliation_strings":["Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086404962"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12505893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"451","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.15559999644756317,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.765999972820282},{"id":"https://openalex.org/keywords/tyrphostin","display_name":"tyrphostin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8080000281333923},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6420000195503235},{"id":"https://openalex.org/keywords/raf","display_name":"Raf","score":0.7929999828338623},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oncoprotein","display_name":"oncoprotein","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cancer-drug-targets","display_name":"cancer drug targets","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32004237174987793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2946125864982605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-012124546-7/50438-1","doi":"https://doi.org/10.1016/b978-012124546-7/50438-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012124546-7/50438-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Cell Signaling","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W48141842","https://openalex.org/W74896817","https://openalex.org/W773741071","https://openalex.org/W1494491432","https://openalex.org/W1495058242","https://openalex.org/W1544215724","https://openalex.org/W1558484175","https://openalex.org/W1566452430","https://openalex.org/W1592467150","https://openalex.org/W1604872463","https://openalex.org/W1608167574","https://openalex.org/W1650803198","https://openalex.org/W1659692600","https://openalex.org/W1725436419","https://openalex.org/W1925715381","https://openalex.org/W1966112698","https://openalex.org/W1966419887","https://openalex.org/W1970955548","https://openalex.org/W1984323202","https://openalex.org/W1984753951","https://openalex.org/W1988885513","https://openalex.org/W1994759421","https://openalex.org/W2009727780","https://openalex.org/W2013178046","https://openalex.org/W2016086822","https://openalex.org/W2019293169","https://openalex.org/W2020482981","https://openalex.org/W2020707154","https://openalex.org/W2020876160","https://openalex.org/W2023563217","https://openalex.org/W2024966528","https://openalex.org/W2025810127","https://openalex.org/W2026351725","https://openalex.org/W2028666409","https://openalex.org/W2033989981","https://openalex.org/W2036804890","https://openalex.org/W2039049403","https://openalex.org/W2051920082","https://openalex.org/W2052667147","https://openalex.org/W2052948798","https://openalex.org/W2053610974","https://openalex.org/W2057579354","https://openalex.org/W2058839845","https://openalex.org/W2061073136","https://openalex.org/W2062141151","https://openalex.org/W2066360911","https://openalex.org/W2066678149","https://openalex.org/W2068105365","https://openalex.org/W2073207471","https://openalex.org/W2079818105","https://openalex.org/W2082501870","https://openalex.org/W2082801302","https://openalex.org/W2084478971","https://openalex.org/W2085254573","https://openalex.org/W2087023176","https://openalex.org/W2088806906","https://openalex.org/W2090895449","https://openalex.org/W2091735622","https://openalex.org/W2101781016","https://openalex.org/W2102689964","https://openalex.org/W2110437560","https://openalex.org/W2118192897","https://openalex.org/W2118310862","https://openalex.org/W2122048408","https://openalex.org/W2127048642","https://openalex.org/W2134094496","https://openalex.org/W2140435084","https://openalex.org/W2142343355","https://openalex.org/W2143805046","https://openalex.org/W2144383844","https://openalex.org/W2144785546","https://openalex.org/W2145536892","https://openalex.org/W2153640566","https://openalex.org/W2158380484","https://openalex.org/W2160992446","https://openalex.org/W2163188200","https://openalex.org/W2164324220","https://openalex.org/W2166056434","https://openalex.org/W2170285778","https://openalex.org/W2199856175","https://openalex.org/W2296924449","https://openalex.org/W2318017968","https://openalex.org/W2397672408","https://openalex.org/W2403197314","https://openalex.org/W2404951799","https://openalex.org/W2412238156","https://openalex.org/W2466059562","https://openalex.org/W4317523379","https://openalex.org/W6603089146","https://openalex.org/W6635548412","https://openalex.org/W6636784571","https://openalex.org/W6636973741","https://openalex.org/W6681581084","https://openalex.org/W6684902706"],"related_works":["https://openalex.org/W2001415101","https://openalex.org/W1556540926","https://openalex.org/W203235444","https://openalex.org/W1966894257","https://openalex.org/W2103979765","https://openalex.org/W2094670537","https://openalex.org/W2262068421","https://openalex.org/W1530102655","https://openalex.org/W2160457163","https://openalex.org/W814013141"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}