{"id":"https://openalex.org/W2200147471","doi":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","title":"Effects of \u03b2-adrenoceptor stimulation on contractility, [Ca2+]i, and Ca2+current in diabetic rat cardiomyocytes","display_name":"Effects of \u03b2-adrenoceptor stimulation on contractility, [Ca2+]i, and Ca2+current in diabetic rat cardiomyocytes","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2200147471","doi":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","mag":"2200147471","pmid":"https://pubmed.ncbi.nlm.nih.gov/9841512"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1998.274.6.h1849","doi":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpheart.1998.274.6.H1849","source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpheart.1998.274.6.H1849","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Atsushi Tamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Tamada","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101659028","display_name":"Yuichi Hattori","orcid":"https://orcid.org/0000-0003-3852-3897","observed_orcids":["https://orcid.org/0000-0003-3852-3897"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Hattori","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006200134","display_name":"Hideki Houzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Houzen","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081656048","display_name":"Yoichi M. A. Yamada","orcid":"https://orcid.org/0000-0001-6103-0658","observed_orcids":["https://orcid.org/0000-0001-6103-0658"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Yamada","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038766114","display_name":"Ichiro Sakuma","orcid":"https://orcid.org/0000-0002-3863-0492","observed_orcids":["https://orcid.org/0000-0002-3863-0492"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Sakuma","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111820422","display_name":"Akira Kitabatake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Kitabatake","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110172965","display_name":"Morio Kanno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Morio Kanno","raw_affiliation_strings":["Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"1 Departments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":2.2521,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.89698358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"274","issue":"6","first_page":"H1849","last_page":"H1857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.781000018119812},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.847000002861023},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium","display_name":"sarcoplasmic reticulum calcium","score":0.8880000114440918},{"id":"https://openalex.org/keywords/caffeine-response","display_name":"caffeine response","score":0.7020000219345093},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8980000019073486},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9399999976158142},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inotropic-effect","display_name":"inotropic effect","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8842798471450806},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8679647445678711},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.814677357673645},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7777215242385864},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.6601747274398804},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.6455029845237732},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5890687108039856},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.4337526261806488},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4161701798439026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38104861974716187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3141128122806549},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1998.274.6.h1849","doi":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpheart.1998.274.6.H1849","source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9841512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9841512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/ajpheart.1998.274.6.h1849","doi":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.274.6.h1849","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpheart.1998.274.6.H1849","source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2200147471.pdf","grobid_xml":"https://content.openalex.org/works/W2200147471.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1963133482","https://openalex.org/W1964246559","https://openalex.org/W1967088741","https://openalex.org/W1974874590","https://openalex.org/W1979314367","https://openalex.org/W2001105552","https://openalex.org/W2002938395","https://openalex.org/W2003030446","https://openalex.org/W2028914697","https://openalex.org/W2034702981","https://openalex.org/W2055984902","https://openalex.org/W2064417777","https://openalex.org/W2070692648","https://openalex.org/W2071712163","https://openalex.org/W2073236248","https://openalex.org/W2075027945","https://openalex.org/W2082685333","https://openalex.org/W2091867363","https://openalex.org/W2122682053","https://openalex.org/W2135955653","https://openalex.org/W2136297988","https://openalex.org/W2136768937","https://openalex.org/W2142567715","https://openalex.org/W2162025110","https://openalex.org/W2164931274","https://openalex.org/W2165882508","https://openalex.org/W2210638598","https://openalex.org/W2223849105","https://openalex.org/W2235517549","https://openalex.org/W2280861697","https://openalex.org/W2341693999","https://openalex.org/W2395290016","https://openalex.org/W2409250285","https://openalex.org/W2411934600","https://openalex.org/W2412082900","https://openalex.org/W2415224743","https://openalex.org/W2426099782"],"related_works":["https://openalex.org/W2280861697","https://openalex.org/W2100824675","https://openalex.org/W2135955653","https://openalex.org/W7095685974","https://openalex.org/W7073621947","https://openalex.org/W2158766260","https://openalex.org/W1964246559","https://openalex.org/W2415638476","https://openalex.org/W1980336437","https://openalex.org/W2152075839"],"abstract_inverted_index":{"The":[0,27,46,85,128],"mechanism":[1],"of":[2,69,87,97,151,157,179,183],"the":[3,66,75,131,152,166,171,189],"diminished":[4,42,190],"inotropic":[5,47],"response":[6,90,116,173],"to":[7,51,91,117,188],"beta-adrenoceptor":[8],"stimulation":[9],"in":[10,15,22,29,43,65,89,106,119,125,130,135],"diabetic":[11,18,44,83,107,126,136],"hearts":[12],"was":[13,63,103],"studied":[14],"enzymatically":[16],"isolated":[17],"rat":[19],"ventricular":[20],"myocytes":[21,121,137,159],"comparison":[23],"with":[24],"age-matched":[25],"controls.":[26],"increases":[28],"contractions":[30],"and":[31,48,53,72,82,111,154,165,174],"intracellular":[32],"Ca2+":[33,77,101,184],"concentration":[34],"([Ca2+]i)":[35],"transients":[36],"produced":[37],"by":[38,140],"isoproterenol":[39,132],"were":[40,57,138],"markedly":[41,123],"myocytes.":[45,84,108,127],"[Ca2+]i":[49,88,115,155],"responses":[50,133,156],"forskolin":[52],"dibutyryl":[54],"cAMP":[55],"(DBcAMP)":[56],"also":[58],"reduced.":[59],"No":[60],"significant":[61],"difference":[62],"found":[64],"stimulating":[67],"effects":[68],"isoproterenol,":[70],"forskolin,":[71,110],"DBcAMP":[73,112],"on":[74],"L-type":[76],"current":[78],"(ICa)":[79],"between":[80],"control":[81,120],"rise":[86],"rapid":[92],"caffeine":[93,118],"application,":[94],"an":[95,149],"index":[96],"sarcoplasmic":[98],"reticulum":[99],"(SR)":[100],"content,":[102],"significantly":[104],"decreased":[105],"Isoproterenol,":[109],"enhanced":[113],"this":[114],"more":[122],"than":[124],"changes":[129],"observed":[134],"prevented":[139],"insulin":[141],"therapy.":[142],"We":[143],"conclude":[144],"that":[145],"1)":[146],"diabetes":[147],"causes":[148],"impairment":[150],"contractile":[153],"cardiac":[158],"when":[160],"stimulated":[161],"at":[162],"both":[163],"beta-adrenoceptors":[164],"postreceptor":[167],"level":[168],"without":[169],"affecting":[170],"ICa":[172],"2)":[175],"altered":[176],"SR":[177],"functions":[178],"uptake":[180],"and/or":[181],"release":[182],"may":[185],"primarily":[186],"contribute":[187],"beta-adrenergic":[191],"response.":[192]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
