{"id":"https://openalex.org/W2199960015","doi":null,"title":"Cancer stem cell vaccine expressing ESAT-6-gpi and IL-21 inhibits melanoma growth and metastases.","display_name":"Cancer stem cell vaccine expressing ESAT-6-gpi and IL-21 inhibits melanoma growth and metastases.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2199960015","mag":"2199960015","pmid":"https://pubmed.ncbi.nlm.nih.gov/26692931","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656764"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3652817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101835771","display_name":"Fengshu Zhao","orcid":"https://orcid.org/0000-0002-9722-0055","observed_orcids":["https://orcid.org/0000-0002-9722-0055"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengshu Zhao","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022467764","display_name":"Xiangfeng He","orcid":"https://orcid.org/0000-0003-2131-8221","observed_orcids":["https://orcid.org/0000-0003-2131-8221"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210105390","display_name":"Nantong Tumor Hospital","ror":"https://ror.org/01egmr022","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangfeng He","raw_affiliation_strings":["Department of Medical Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, 226361, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, 226361, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210105390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077381042","display_name":"Jianan Sun","orcid":"https://orcid.org/0009-0008-9002-8344","observed_orcids":["https://orcid.org/0009-0008-9002-8344"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianan Sun","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102817467","display_name":"Di Wu","orcid":"https://orcid.org/0000-0002-5151-6010","observed_orcids":["https://orcid.org/0000-0002-5151-6010"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051466221","display_name":"Meng Pan","orcid":"https://orcid.org/0000-0002-4380-2324","observed_orcids":["https://orcid.org/0000-0002-4380-2324"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Pan","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339715","display_name":"Miao Li","orcid":"https://orcid.org/0000-0002-9623-9379","observed_orcids":["https://orcid.org/0000-0002-9623-9379"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Li","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061320365","display_name":"Songyan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songyan Wu","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451771","display_name":"Rong Zhang","orcid":"https://orcid.org/0000-0001-5824-5447","observed_orcids":["https://orcid.org/0000-0001-5824-5447","https://orcid.org/0009-0004-9009-4481"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Zhang","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036616564","display_name":"Chunguang Yan","orcid":"https://orcid.org/0000-0002-6077-9189","observed_orcids":["https://orcid.org/0000-0002-6077-9189"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunguang Yan","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065009308","display_name":"Jun Dou","orcid":"https://orcid.org/0000-0001-6944-5874","observed_orcids":["https://orcid.org/0000-0001-6944-5874"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Dou","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0173,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72610796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"10","first_page":"1870","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/esat-6","display_name":"ESAT-6","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glycosylphosphatidylinositol","display_name":"glycosylphosphatidylinositol","score":0.9440000057220459},{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.9890000224113464},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":1.0},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.734000027179718},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7136345505714417},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6669646501541138},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5980921387672424},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.552925169467926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5200652480125427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44664156436920166},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.441854327917099},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.44146913290023804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4261625409126282},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.41146209836006165},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4073479175567627},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3823995292186737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2881479263305664},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2188073992729187},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10572978854179382},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08513644337654114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:3652817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26692931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26692931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4656764","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4656764/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2199960015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26692931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2582502188","doi":null,"is_oa":false,"landing_page_url":"http://or.nsfc.gov.cn/handle/00001903-5/385791","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3652817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W135120748","https://openalex.org/W938203404","https://openalex.org/W1519435967","https://openalex.org/W1844826649","https://openalex.org/W1902126494","https://openalex.org/W1922507831","https://openalex.org/W1962635928","https://openalex.org/W1965180311","https://openalex.org/W1985257314","https://openalex.org/W1994111355","https://openalex.org/W1995458608","https://openalex.org/W1998181914","https://openalex.org/W1998962361","https://openalex.org/W2007026865","https://openalex.org/W2010750162","https://openalex.org/W2029098600","https://openalex.org/W2034461318","https://openalex.org/W2035413967","https://openalex.org/W2042031899","https://openalex.org/W2046917463","https://openalex.org/W2052912081","https://openalex.org/W2064581203","https://openalex.org/W2066166771","https://openalex.org/W2067415629","https://openalex.org/W2068368560","https://openalex.org/W2069428724","https://openalex.org/W2076948707","https://openalex.org/W2081035306","https://openalex.org/W2081151500","https://openalex.org/W2088744617","https://openalex.org/W2098820114","https://openalex.org/W2101139369","https://openalex.org/W2103018035","https://openalex.org/W2129209894","https://openalex.org/W2135479684","https://openalex.org/W2137250828","https://openalex.org/W2148647134","https://openalex.org/W2155131748","https://openalex.org/W2164114377","https://openalex.org/W2168249402","https://openalex.org/W2287384543","https://openalex.org/W2317703908","https://openalex.org/W4213214835"],"related_works":["https://openalex.org/W2759461329","https://openalex.org/W1985257314","https://openalex.org/W1465808115","https://openalex.org/W6902260601","https://openalex.org/W4285282367","https://openalex.org/W2068368560","https://openalex.org/W3212875349","https://openalex.org/W3013355648","https://openalex.org/W2081151500","https://openalex.org/W3214121811"],"abstract_inverted_index":{"Tumor":[0],"vaccines":[1,32],"may":[2,166],"induce":[3],"antitumor":[4,22],"efficacy,":[5],"however,":[6],"weak":[7],"immunogenicity":[8,29],"of":[9,14,20,30,34,99,111,123,145,151,177],"tumor":[10,31],"antigens":[11],"is":[12],"one":[13],"the":[15,21,59,82,143,149,161,171],"prime":[16],"obstacles":[17],"for":[18,175],"excitation":[19],"immune":[23],"responses.":[24],"Therefore,":[25],"strategies":[26],"that":[27,81],"enhance":[28],"are":[33],"particular":[35],"interest.":[36],"In":[37],"this":[38,133],"study,":[39],"a":[40],"novel":[41],"melanoma":[42,95,100,138],"B16F10":[43],"CD133(+)CD44(+)":[44,84,163],"cancer":[45],"stem":[46],"cell":[47],"(CSC)":[48],"vaccine":[49,86,135,165],"expressing":[50],"6":[51],"kDa":[52],"early":[53],"secreted":[54],"antigenic":[55],"target":[56],"(ESAT-6)":[57],"in":[58,76],"glycosylphosphatidylinositol":[60],"(GPI)-anchored":[61],"form":[62],"and":[63,72,114,128,174],"secreting":[64],"interleukin":[65],"(IL)-21":[66],"was":[67,106],"developed.":[68],"Its":[69],"anti-melanoma":[70,89,104],"efficacy":[71,90],"mechanisms":[73],"were":[74],"investigated":[75],"mice.":[77,102],"The":[78,103],"results":[79],"demonstrated":[80],"B16F10-ESAT-6-gpi/IL-21":[83,162],"CSC":[85,164],"exhibited":[87],"enhanced":[88],"as":[91,117,119],"determined":[92],"by":[93,141],"inhibited":[94,137,156],"growth,":[96],"prolonged":[97],"survival":[98],"bearing":[101],"immunity":[105,173],"associated":[107],"with":[108],"elevated":[109],"levels":[110],"serum":[112],"anti-ESAT-6":[113],"interferon":[115],"(IFN)-\u03b3":[116],"well":[118],"increased":[120],"cytotoxic":[121],"activities":[122],"natural":[124],"killer":[125],"cells,":[126],"splenocytes,":[127],"complement":[129],"dependent":[130],"cytotoxicity.":[131],"Furthermore,":[132],"CSC-based":[134],"apparently":[136],"lung":[139],"metastasis":[140],"decreasing":[142],"level":[144,150],"Vimentin":[146],"while":[147],"increasing":[148],"E-cadherin":[152],"expression,":[153],"suggesting":[154],"an":[155],"epithelial":[157],"mesenchymal":[158],"transition.":[159],"Thus,":[160],"be":[167],"used":[168],"to":[169],"reactivate":[170],"anti-tumor":[172],"treatment":[176],"melanoma.":[178]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}