{"id":"https://openalex.org/W2199845508","doi":"https://doi.org/10.1124/mol.115.101154","title":"Voltage-Gated R-Type Calcium Channel Inhibition via Human \u03bc-, \u03b4-, and \u03ba-opioid Receptors Is Voltage-Independently Mediated by G\u03b2\u03b3 Protein Subunits","display_name":"Voltage-Gated R-Type Calcium Channel Inhibition via Human \u03bc-, \u03b4-, and \u03ba-opioid Receptors Is Voltage-Independently Mediated by G\u03b2\u03b3 Protein Subunits","publication_year":2015,"publication_date":"2015-10-22","ids":{"openalex":"https://openalex.org/W2199845508","doi":"https://doi.org/10.1124/mol.115.101154","mag":"2199845508","pmid":"https://pubmed.ncbi.nlm.nih.gov/26490245"},"language":"en","primary_location":{"id":"doi:10.1124/mol.115.101154","doi":"https://doi.org/10.1124/mol.115.101154","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.115.101154","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046089021","display_name":"G\u00e9za Berecki","orcid":"https://orcid.org/0000-0002-8664-6325","observed_orcids":["https://orcid.org/0000-0002-8664-6325"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G\u00e9za Berecki","raw_affiliation_strings":["Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia geza.berecki@rmit.edu.au","Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia geza.berecki@rmit.edu.au","institution_ids":["https://openalex.org/I82951845"]},{"raw_affiliation_string":"Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110039922","display_name":"Leonid G. Motin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Leonid Motin","raw_affiliation_strings":["Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025386235","display_name":"David J. Adams","orcid":"https://orcid.org/0000-0002-7030-2288","observed_orcids":["https://orcid.org/0000-0002-7030-2288"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David J. Adams","raw_affiliation_strings":["Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I82951845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I82951845"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.7411,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64819809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"89","issue":"1","first_page":"187","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/r-type-calcium-channels","display_name":"R-type calcium channels","score":0.878000020980835},{"id":"https://openalex.org/keywords/cav2-3","display_name":"Cav2.3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/n-type-calcium-channels","display_name":"N-type calcium channels","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cav2-2","display_name":"CaV2.2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gbetagamma-subunits","display_name":"G\u03b2\u03b3 subunits","score":0.8119999766349792},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pain-perception","display_name":"pain perception","score":0.640999972820282},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.722000002861023},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinase-2","display_name":"G protein-coupled receptor kinase 2","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.6290000081062317},{"id":"https://openalex.org/keywords/gtpase-inhibitors","display_name":"GTPase inhibitors","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.650075376033783},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6227288842201233},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.6021819710731506},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.524130642414093},{"id":"https://openalex.org/C92645518","wikidata":"https://www.wikidata.org/wiki/Q26916851","display_name":"N-type calcium channel","level":5,"score":0.5236901044845581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5000042915344238},{"id":"https://openalex.org/C37088560","wikidata":"https://www.wikidata.org/wiki/Q354550","display_name":"Voltage-gated ion channel","level":4,"score":0.49936819076538086},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.4746844470500946},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.45736536383628845},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.43449950218200684},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4338931441307068},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4319412410259247},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.42116305232048035},{"id":"https://openalex.org/C174293024","wikidata":"https://www.wikidata.org/wiki/Q3001149","display_name":"R-type calcium channel","level":5,"score":0.4132015109062195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41159695386886597},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3581090569496155},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.34992942214012146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.316670298576355},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.30813533067703247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25763264298439026},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D020875","descriptor_name":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020908","descriptor_name":"Calcium Channels, R-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044387","descriptor_name":"GTP-Binding Protein beta Subunits","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044388","descriptor_name":"GTP-Binding Protein gamma Subunits","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1124/mol.115.101154","doi":"https://doi.org/10.1124/mol.115.101154","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.115.101154","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:26490245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26490245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:alma61RMIT.INST:11247258400001341","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1124/mol.115.101154","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27488964","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Voltage-gated_R-type_calcium_channel_inhibition_via_human_mu-_delta-_and_kappa-opioid_receptors_is_voltage-independently_mediated_by_G_beta_gamma_protein_subunits/27488964","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1546091073","https://openalex.org/W1549637041","https://openalex.org/W1611357344","https://openalex.org/W1617876476","https://openalex.org/W1972211504","https://openalex.org/W1982797011","https://openalex.org/W1985069323","https://openalex.org/W1995607463","https://openalex.org/W2004736949","https://openalex.org/W2020834991","https://openalex.org/W2023331798","https://openalex.org/W2029226095","https://openalex.org/W2036111495","https://openalex.org/W2038223161","https://openalex.org/W2042526378","https://openalex.org/W2043647387","https://openalex.org/W2048793794","https://openalex.org/W2064748241","https://openalex.org/W2069268149","https://openalex.org/W2075338922","https://openalex.org/W2075466332","https://openalex.org/W2085879736","https://openalex.org/W2086323174","https://openalex.org/W2091694654","https://openalex.org/W2094754857","https://openalex.org/W2102408597","https://openalex.org/W2105445497","https://openalex.org/W2108364148","https://openalex.org/W2113130197","https://openalex.org/W2123379447","https://openalex.org/W2127472321","https://openalex.org/W2144728851","https://openalex.org/W2149674899","https://openalex.org/W2155765257","https://openalex.org/W2351484114","https://openalex.org/W2469712714","https://openalex.org/W2913636289","https://openalex.org/W4299956327","https://openalex.org/W4318355239"],"related_works":["https://openalex.org/W2332181020","https://openalex.org/W2291652420","https://openalex.org/W2063483515","https://openalex.org/W2023503411","https://openalex.org/W2336434130","https://openalex.org/W1975087779","https://openalex.org/W2094908852","https://openalex.org/W1527273445","https://openalex.org/W2416914837","https://openalex.org/W1908503105"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}