{"id":"https://openalex.org/W2199811752","doi":"https://doi.org/10.1177/106002807801200707","title":"Simplified Regimens for Hypertension","display_name":"Simplified Regimens for Hypertension","publication_year":1978,"publication_date":"1978-07-01","ids":{"openalex":"https://openalex.org/W2199811752","doi":"https://doi.org/10.1177/106002807801200707","mag":"2199811752"},"language":"en","primary_location":{"id":"doi:10.1177/106002807801200707","doi":"https://doi.org/10.1177/106002807801200707","is_oa":true,"landing_page_url":"https://doi.org/10.1177/106002807801200707","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/106002807801200707","source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Intelligence & Clinical Pharmacy","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/106002807801200707","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043324333","display_name":"William A. Miller","orcid":"https://orcid.org/0000-0002-7290-6501","observed_orcids":["https://orcid.org/0000-0002-7290-6501"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Miller","raw_affiliation_strings":["Professor and Chairman, Department of Pharmacy Practice, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman, Department of Pharmacy Practice, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076509098","display_name":"Timothy H. Self","orcid":"https://orcid.org/0000-0002-1344-5602","observed_orcids":["https://orcid.org/0000-0002-1344-5602"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy H. Self","raw_affiliation_strings":["Associate Professor of Pharmacy Practice, Department of Pharmacy Practice, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Pharmacy Practice, Department of Pharmacy Practice, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076838586","display_name":"Stephen T. Miller","orcid":"https://orcid.org/0000-0003-2207-7159","observed_orcids":["https://orcid.org/0000-0003-2207-7159"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen T. Miller","raw_affiliation_strings":["Departments of Medicine and, Community Medicine, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and, Community Medicine, University of Tennessee Center for, the Health Sciences, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I160606119"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"7","first_page":"424","last_page":"424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3790000081062317},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4776650369167328},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39309558272361755},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3877548575401306},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3644225299358368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3489837050437927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/106002807801200707","doi":"https://doi.org/10.1177/106002807801200707","is_oa":true,"landing_page_url":"https://doi.org/10.1177/106002807801200707","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/106002807801200707","source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Intelligence & Clinical Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1177/106002807801200707","doi":"https://doi.org/10.1177/106002807801200707","is_oa":true,"landing_page_url":"https://doi.org/10.1177/106002807801200707","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/106002807801200707","source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Intelligence & Clinical Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6399999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2199811752.pdf","grobid_xml":"https://content.openalex.org/works/W2199811752.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W182657878","https://openalex.org/W1967047470","https://openalex.org/W1973783057","https://openalex.org/W2008826192","https://openalex.org/W2058454315","https://openalex.org/W2070018946","https://openalex.org/W2079551104","https://openalex.org/W2117387175","https://openalex.org/W2170170246","https://openalex.org/W2181582113","https://openalex.org/W2396072514","https://openalex.org/W2414691370","https://openalex.org/W2417652499","https://openalex.org/W2434411827"],"related_works":["https://openalex.org/W2416405083","https://openalex.org/W4243258074","https://openalex.org/W1970247434","https://openalex.org/W4235339780","https://openalex.org/W614418717","https://openalex.org/W4250192920","https://openalex.org/W4230249955","https://openalex.org/W4291204043","https://openalex.org/W4299861895","https://openalex.org/W2423965836"],"abstract_inverted_index":{"HYPERTENSION,":[0],"One":[1],"of":[2,113,141,149,166,199,207,224,230,258,271,276,280],"the":[3,31,73,105,139,173,178,222,253,267,272],"more":[4],"difficult":[5],"problems":[6],"is":[7,28,170,210,235],"patient":[8,233],"medication":[9,17],"compliance.Although":[10],"there":[11],"are":[12,44,128],"several":[13,35],"mechanisms":[14],"to":[15,29,57,68,219,238,247],"improve":[16,220],"compliance,":[18],"one":[19],"effective":[20,208,228],"mechanism":[21],"that":[22,81,103],"has":[23,157],"not":[24,106],"been":[25,158],"adequately":[26],"stressed":[27],"simplify":[30],"patient's":[32],"drug":[33],"regimen.While":[34],"antihypertensive":[36,250],"agents,":[37],"including":[38],"reserpine,":[39],"guanethidine":[40],"and":[41,62,86,95,118,152,168,187,204,240,261,274,282],"thiazide":[42],"diuretics,":[43],"usually":[45],"given":[46,59],"in":[47,66,104,134,154,172,185,201],"single":[48,110,135,163,186,277],"doses,":[49],"other":[50],"agents":[51],"(e.g.,":[52],"hydralazine,":[53,150,259],"propranolol,":[54,151],"methyldopa)":[55],"continue":[56,218],"be":[58,92,124,183,264,285],"by":[60,288],"many,":[61],"probably":[63],"most,":[64],"practitioners":[65,216],"three":[67],"four":[69],"divided":[70],"daily":[71,111,136,147,164,189,256,278],"doses.Over":[72],"past":[74],"few":[75],"years,":[76],"numerous":[77],"authors":[78],"have":[79],"reported":[80],"methyldopa,":[82],"1-5":[83],"propranolol":[84,119,167,262,283],"6-10":[85],"hydralazine":[87],"11":[88],"\u2022":[89,116],"12":[90],"can":[91],"administered":[93],"safely":[94],"effectively":[96],"twice":[97,146,188,255],"daily.In":[98],"addition,":[99],"recent":[100],"investigations":[101],"indicate":[102],"too":[107],"distant":[108],"future,":[109,268],"dosing":[112,148,165,251,257],"methyldopa":[114,153,169,260,281],"13":[115],"14":[117],"15":[120],"\"":[121],"18":[122],"will":[123,182],"feasible.In":[125],"Sweden,":[126],"beta-blockers":[127],"now":[129],"officially":[130],"approved":[131],"for":[132,138,236],"administration":[133],"doses":[137,190,279],"treatment":[140],"hypertension.19":[142],".Clinical":[143],"experience":[144],"with":[145,245],"our":[155],"clinics":[156],"quite":[159],"encouraging.More":[160],"investigation":[161],"on":[162],"needed":[171],"United":[174],"States.However,":[175],"we":[176],"envision":[177],"time":[179],"when":[180],"antihypertensives":[181],"prescribed":[184],"almost":[191],"exclusively.Since":[192],"hypertension":[193],"affects":[194],"such":[195],"a":[196],"large":[197],"number":[198],"people":[200],"this":[202],"country,":[203],"since":[205],"lack":[206],"therapy":[209],"often":[211],"catastrophic,":[212],"all":[213,289],"health":[214],"care":[215,223,234],"should":[217,263,284],"further":[221,269],"hypertensive":[225,232],"patients.One":[226],"potentially":[227],"means":[229],"improving":[231],"pharmacists":[237],"educate":[239],"encourage":[241],"their":[242],"physician":[243],"colleagues":[244],"regard":[246],"prescribing":[248],"simplified":[249],"regimens.For":[252],"moment,":[254],"strongly":[265],"encouraged.For":[266],"documentation":[270],"efficacy":[273],"safety":[275],"eagerly":[286],"anticipated":[287],"practitioners.":[290]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}