{"id":"https://openalex.org/W2199776704","doi":null,"title":"The role of vasopressin in chronic stress studied in a chronic mild stress model of depression.","display_name":"The role of vasopressin in chronic stress studied in a chronic mild stress model of depression.","publication_year":2007,"publication_date":"2007-03-30","ids":{"openalex":"https://openalex.org/W2199776704","mag":"2199776704","pmid":"https://pubmed.ncbi.nlm.nih.gov/17451068"},"language":"en","primary_location":{"id":"pmid:17451068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083154152","display_name":"D\u00f3ra Zelena","orcid":"https://orcid.org/0000-0001-5616-1100","observed_orcids":["https://orcid.org/0000-0001-5616-1100"]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"D\u00f3ra Zelena","raw_affiliation_strings":["Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest. zelena@koki.hu","Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest. zelena@koki.hu","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]},{"raw_affiliation_string":"Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071692670","display_name":"\u00c1gnes Domokos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Agnes Domokos","raw_affiliation_strings":["Hungarian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Academy of Sciences","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113540258","display_name":"Istv\u00e1n Barna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istv\u00e1n Barna","raw_affiliation_strings":["Hungarian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Academy of Sciences","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054824318","display_name":"Katalin Csabail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Katalin Csabail","raw_affiliation_strings":["Hungarian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Academy of Sciences","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011181373","display_name":"Gy\u00f6rgy Bagdy","orcid":"https://orcid.org/0000-0001-8141-3410","observed_orcids":["https://orcid.org/0000-0001-8141-3410"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy Bagdy","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044651066","display_name":"G\u00e1bor B. Makara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor B Makara","raw_affiliation_strings":["Hungarian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Academy of Sciences","institution_ids":["https://openalex.org/I7597260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2483,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51083591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"3-4","first_page":"196","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chronic-mild-stress","display_name":"chronic mild stress","score":0.9309999942779541},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/brattleboro-rats","display_name":"Brattleboro rats","score":0.9100000262260437},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8859999775886536},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pomc-mrna","display_name":"POMC mRNA","score":0.8320000171661377},{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.8349999785423279},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7459999918937683},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.9103646278381348},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.8934342861175537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8326497077941895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8274867534637451},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.7361965775489807},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6466190814971924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5506604313850403},{"id":"https://openalex.org/C2779146795","wikidata":"https://www.wikidata.org/wiki/Q1369123","display_name":"Hypothalamic\u2013pituitary\u2013adrenal axis","level":3,"score":0.43834632635116577},{"id":"https://openalex.org/C2781409172","wikidata":"https://www.wikidata.org/wiki/Q17056802","display_name":"Involution (esoterism)","level":3,"score":0.41982007026672363},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22729241847991943},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21912625432014465},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08017969131469727},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011910","descriptor_name":"Rats, Brattleboro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17451068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Comparative Study"},{"id":"mag:2199776704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031499575","https://openalex.org/W2104838175","https://openalex.org/W4247950900","https://openalex.org/W2018450379","https://openalex.org/W2143606608","https://openalex.org/W2160928673","https://openalex.org/W2077851881","https://openalex.org/W2004974597","https://openalex.org/W2124599923","https://openalex.org/W2014142101"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Vasopressin":[3],"plays":[4],"an":[5],"important":[6,30],"role":[7,25],"in":[8,16,111,139,170,204],"the":[9,24,37,47,143,146,186,193],"hypothalamo-pituitary-adrenal":[10,51,187],"axis":[11,52,188],"regulation":[12],"as":[13,15],"well":[14],"stress-related":[17],"disorders.":[18],"A":[19],"common":[20],"view":[21],"suggested":[22],"that":[23,39,178],"of":[26,49,75,113,142,148,164,195],"vasopressin":[27,60,149,173,180,196],"is":[28,181,197],"especially":[29],"during":[31],"chronic":[32,50,55,107,114,154,165,190],"stresses.":[33],"Here":[34],"we":[35],"tested":[36],"hypothesis":[38],"vasopressin-deficient":[40],"rats":[41,63],"may":[42],"be":[43],"more":[44],"resistant":[45],"to":[46,66],"development":[48],"hyperactivity":[53],"after":[54],"mild":[56,72,77,108,155,166],"stress.":[57],"METHODS:":[58],"Male":[59],"deficient":[61,174],"Brattleboro":[62,205],"were":[64,89,99],"compared":[65],"their":[67],"heterozygous":[68],"litter":[69],"mates.":[70],"Chronic":[71],"stress":[73,109,115,167,191],"consisted":[74],"different":[76],"stimuli":[78],"(e.g.":[79,202],"wet":[80],"cages,":[81],"restraint)":[82],"for":[83,184],"6":[84],"week.":[85],"The":[86],"corticosterone":[87,133],"changes":[88,128,160],"followed":[90],"by":[91,118,189,199],"repeated":[92],"tail":[93],"cutting":[94],"and":[95,97,126,132,135,161,172],"organs":[96],"blood":[98],"collected":[100],"from":[101],"decapitated":[102],"rats.":[103,206],"RESULTS:":[104],"In":[105],"controls,":[106],"resulted":[110],"symptoms":[112],"state":[116],"characterized":[117],"typical":[119],"somatic":[120],"(body":[121],"weight":[122],"reduction,":[123],"thymus":[124],"involution)":[125],"endocrine":[127,162],"(resting":[129],"plasma":[130],"ACTH":[131],"elevation":[134,138],"POMC":[136],"mRNA":[137],"anterior":[140],"lobe":[141],"pituitary).":[144],"Unexpectedly,":[145],"lack":[147],"could":[150],"not":[151,182],"influence":[152],"any":[153],"stress-induced":[156],"changes.":[157],"CONCLUSION:":[158],"Somatic":[159],"effects":[163],"are":[168],"similar":[169],"control":[171],"animals.":[175],"This":[176],"suggests":[177],"either":[179],"indispensable":[183],"activating":[185],"or":[192],"absence":[194],"compensated":[198],"other":[200],"mediators":[201],"CRH)":[203]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}