{"id":"https://openalex.org/W2199433167","doi":null,"title":"Effects of iron on the absorption and retention of lead.","display_name":"Effects of iron on the absorption and retention of lead.","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2199433167","mag":"2199433167","pmid":"https://pubmed.ncbi.nlm.nih.gov/712193"},"language":"en","primary_location":{"id":"pmid:712193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/712193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077060961","display_name":"James C. Barton","orcid":"https://orcid.org/0000-0003-2876-8276","observed_orcids":["https://orcid.org/0000-0003-2876-8276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Barton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800678","display_name":"Marcel E. Conrad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Conrad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001634742","display_name":"Sue Nuby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nuby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L Harrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Harrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2559,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.97527395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"92","issue":"4","first_page":"536","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-uptake","display_name":"lead uptake","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lead-retention","display_name":"lead retention","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dietary-iron","display_name":"dietary iron","score":0.9399999976158142},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.6570000052452087},{"id":"https://openalex.org/keywords/metal-binding-sites","display_name":"metal binding sites","score":0.7889999747276306},{"id":"https://openalex.org/keywords/metal-competition","display_name":"metal competition","score":0.3580000102519989},{"id":"https://openalex.org/keywords/lead-excretion","display_name":"lead excretion","score":0.7450000047683716},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.5040000081062317},{"id":"https://openalex.org/keywords/thermostable-proteins","display_name":"thermostable proteins","score":0.5929999947547913},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6921199560165405},{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.6515880823135376},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.6355829834938049},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.6051210761070251},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5866104960441589},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5568674802780151},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.5099896192550659},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.45377641916275024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4298282861709595},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4292868375778198},{"id":"https://openalex.org/C3017702006","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Dietary iron","level":4,"score":0.41690513491630554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4155206084251404},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.37061506509780884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3642493486404419},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3550255298614502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.178569495677948},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.16455170512199402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13386082649230957},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.07557165622711182},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07469058036804199},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012156","descriptor_name":"Reticulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:712193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/712193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2199433167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/712193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W103499828","https://openalex.org/W127371064","https://openalex.org/W1579514899","https://openalex.org/W1600933472","https://openalex.org/W1607046039","https://openalex.org/W1775749144","https://openalex.org/W1787418246","https://openalex.org/W1909985675","https://openalex.org/W1975360643","https://openalex.org/W1979942205","https://openalex.org/W2010528248","https://openalex.org/W2019488951","https://openalex.org/W2048724996","https://openalex.org/W2063269290","https://openalex.org/W2076445806","https://openalex.org/W2111301002","https://openalex.org/W2122560378","https://openalex.org/W2150259559","https://openalex.org/W2154135162","https://openalex.org/W2319902388","https://openalex.org/W2416568728","https://openalex.org/W4205256840"],"related_works":["https://openalex.org/W1966798642","https://openalex.org/W1858517515","https://openalex.org/W1971783424","https://openalex.org/W4252017492","https://openalex.org/W2028848405","https://openalex.org/W1485337880","https://openalex.org/W1787418246","https://openalex.org/W2021500680","https://openalex.org/W2440387258","https://openalex.org/W2082281919"],"abstract_inverted_index":{"An":[0],"inverse":[1],"relationship":[2],"between":[3],"lead":[4,39,44,55,92,113,119,140,155],"retention":[5],"and":[6,93,141,157],"dietary":[7,152],"iron":[8,30,47,94,108,153,158],"content":[9],"has":[10],"been":[11],"suspected":[12],"for":[13,19,74],"many":[14],"years,":[15],"but":[16,40],"the":[17,26,36,49,57,70,86,103,116,122],"reasons":[18],"this":[20,67,129,147],"association":[21],"remained":[22],"unknown.":[23],"In":[24,89],"rats,":[25],"state":[27],"of":[28,38,51,54,107,112,118,135],"body":[29],"repletion":[31],"had":[32],"significant":[33],"effects":[34],"on":[35,43,78,146],"absorption":[37,50,156],"no":[41],"effect":[42],"excretion.":[45],"Intraluminal":[46],"decreased":[48,154],"test":[52,110],"doses":[53,111],"from":[56],"small":[58],"intestine":[59],"in":[60,85],"a":[61,132],"dose-related":[62],"manner.":[63],"We":[64],"postulated":[65],"that":[66,128],"occurred":[68],"because":[69],"two":[71,97],"metals":[72],"competed":[73],"similar":[75],"binding":[76,144],"sites":[77,145],"intestinal":[79,99],"mucosal":[80,100],"proteins":[81],"which":[82],"were":[83],"important":[84],"absorptive":[87],"process.":[88],"vivo,":[90],"both":[91,139],"bound":[95,120,138],"to":[96,109],"heat-stable":[98],"fractions,":[101],"particularly":[102],"higher-molecular-weight":[104],"fraction.":[105,124],"Addition":[106],"markedly":[114],"diminished":[115],"amount":[117],"by":[121],"high-molecular-weight":[123],"Further":[125],"investigation":[126],"revealed":[127],"fraction,":[130],"with":[131],"molecular":[133],"weight":[134],"approximately":[136],"370,000,":[137],"iron.":[142],"Shared":[143],"protein":[148],"may":[149],"explain":[150],"why":[151],"deficiency":[159],"increased":[160],"it.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}