{"id":"https://openalex.org/W219926017","doi":null,"title":"Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos Lonicerae on macrophage.","display_name":"Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos Lonicerae on macrophage.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W219926017","mag":"219926017","pmid":"https://pubmed.ncbi.nlm.nih.gov/15569416"},"language":"en","primary_location":{"id":"pmid:15569416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15569416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060994942","display_name":"He-zhenWU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He-zhen Wu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091278210","display_name":"JingLUO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059622835","display_name":"Yan-xiaYIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-xia Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002003466","display_name":"QunWEI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qun Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1999,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92988275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"12","first_page":"1685","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":1.0},{"id":"https://openalex.org/keywords/lonicerae-flos","display_name":"Flos Lonicerae","score":0.9670000076293945},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.9810000061988831},{"id":"https://openalex.org/keywords/macrophage-mediated-cytotoxicity","display_name":"macrophage cytotoxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.9469367265701294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7268571257591248},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7187129855155945},{"id":"https://openalex.org/C2778711105","wikidata":"https://www.wikidata.org/wiki/Q1767381","display_name":"Flos","level":4,"score":0.5963215827941895},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.5947482585906982},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5832597017288208},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5309789776802063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5257281064987183},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40495800971984863},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2492089569568634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14568081498146057},{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.11028960347175598},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.08864632248878479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07595166563987732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05787721276283264},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.05455285310745239},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002726","descriptor_name":"Chlorogenic Acid","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002726","descriptor_name":"Chlorogenic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031239","descriptor_name":"Lonicera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15569416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15569416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:2188585525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15569416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:219926017","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/95561A/200412/11621268.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1496728073","https://openalex.org/W1509995036","https://openalex.org/W1619162897","https://openalex.org/W1975107946","https://openalex.org/W1983612298","https://openalex.org/W1984754431","https://openalex.org/W1988304711","https://openalex.org/W1997020265","https://openalex.org/W2018348216","https://openalex.org/W2043064344","https://openalex.org/W2048007715","https://openalex.org/W2048399816","https://openalex.org/W2067807708","https://openalex.org/W2080169144","https://openalex.org/W2081549493","https://openalex.org/W2083692829","https://openalex.org/W2091718809","https://openalex.org/W2118293908","https://openalex.org/W2140927361","https://openalex.org/W2172196619","https://openalex.org/W2360910193","https://openalex.org/W2410058530"],"related_works":["https://openalex.org/W2365398016","https://openalex.org/W2353621564","https://openalex.org/W2390328789","https://openalex.org/W2359670515","https://openalex.org/W1999526715","https://openalex.org/W2384159060","https://openalex.org/W2354843658","https://openalex.org/W2049241173","https://openalex.org/W1967529408","https://openalex.org/W1603149479"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,29,38,77,88,99,112,132,146,159,176],"activation":[4,61],"of":[5,62,81,90,101,114,148,179],"chlorogenic":[6],"acid":[7],"(CHA)":[8],"purified":[9,46],"from":[10,47],"Flos":[11,33,48],"Lonicerae":[12,34,49],"to":[13,28,92,97,150],"calcineurin":[14,44,65,119,156],"and":[15,23,56,72,87,111,141,157,164,167],"its":[16,168],"effects":[17,100],"on":[18,53,64,103,116],"macrophage":[19,104,133,160],"functions":[20,134,161,169],"in":[21,24,84,135,162,165,170],"vivo":[22,163,171],"vitro.":[25],"METHODS:":[26],"According":[27],"screening":[30],"results":[31],"that":[32],"could":[35,42,108,154],"activate":[36,43,109,155],"calcineurin,":[37,110],"active":[39],"component":[40],"which":[41],"was":[45,120],"by":[50],"column":[51],"chromatography":[52],"silica":[54],"gel":[55],"identified":[57],"as":[58,76],"CHA.":[59],"The":[60,79],"CHA":[63,102,107,115,123,138,153],"had":[66],"been":[67],"validated":[68],"with":[69],"both":[70],"p-NPP":[71],"32P-labeled":[73],"RII":[74],"peptide":[75],"substrates.":[78],"clearance":[80],"charcoal":[82],"particles":[83],"normal":[85,136],"mice":[86],"cytotoxicity":[89,147],"U937":[91,149],"MCF-7":[93],"were":[94],"used":[95],"together":[96],"determine":[98],"functions.":[105],"RESULTS:":[106],"concentration":[113],"maximal":[117],"activating":[118],"282.5":[121,142],"micromol/L.":[122],"administration":[124],"(10":[125],"mg/kg,":[126],"ig,":[127],"7":[128],"d)":[129],"significantly":[130],"enhanced":[131],"mice.":[137],"(70.6,":[139],"141.2,":[140],"micromol/L)":[143],"obviously":[144],"increased":[145],"MCF-7.":[151],"CONCLUSION:":[152],"enhance":[158],"vitro,":[166],"may":[172],"be":[173],"realized":[174],"via":[175],"signal":[177],"pathways":[178],"calcineurin.":[180]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}