{"id":"https://openalex.org/W2199228452","doi":null,"title":"The Change of Mitochondrial Fusion and Fission in human Skeletal Muscle with Aging","display_name":"The Change of Mitochondrial Fusion and Fission in human Skeletal Muscle with Aging","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2199228452","mag":"2199228452"},"language":"en","primary_location":{"id":"mag:2199228452","doi":null,"is_oa":false,"landing_page_url":"http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01897148","pdf_url":null,"source":{"id":"https://openalex.org/S4210201443","display_name":"Journal of Experimental & Biomedical Sciences/Biomedical Science Letters","issn_l":"1738-3226","issn":["1738-3226","2288-7415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uc758\uc0dd\uba85\uacfc\ud559\ud68c\uc9c0","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030498031","display_name":"HyungJun Cho","orcid":"https://orcid.org/0000-0003-0844-9948","observed_orcids":["https://orcid.org/0000-0003-0844-9948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HyungJun Cho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0844-9948","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101841474","display_name":"Soo Yeon Park","orcid":"https://orcid.org/0000-0003-0710-8316","observed_orcids":["https://orcid.org/0000-0003-0710-8316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo Yeon Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0710-8316","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1411254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"2","first_page":"112","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-aging","display_name":"skeletal muscle aging","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gracilis-muscle","display_name":"gracilis muscle","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fis1","display_name":"Fis1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mfn2","display_name":"mitofusin 2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/opa1","display_name":"OPA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2777755479","wikidata":"https://www.wikidata.org/wiki/Q18039927","display_name":"FIS1","level":5,"score":0.9560006856918335},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.9510380029678345},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.8418764472007751},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.697723388671875},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6497758626937866},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5937438607215881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4872190058231354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4245396554470062},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4210616946220398},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.41762980818748474},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3389178514480591},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2443697154521942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19345906376838684},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1759689748287201},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13826951384544373},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.06120160222053528},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2199228452","doi":null,"is_oa":false,"landing_page_url":"http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01897148","pdf_url":null,"source":{"id":"https://openalex.org/S4210201443","display_name":"Journal of Experimental & Biomedical Sciences/Biomedical Science Letters","issn_l":"1738-3226","issn":["1738-3226","2288-7415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uc758\uc0dd\uba85\uacfc\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2171282815"],"related_works":["https://openalex.org/W2057864018","https://openalex.org/W4411661406","https://openalex.org/W1512819323","https://openalex.org/W2624469129","https://openalex.org/W2028043977","https://openalex.org/W2809326196","https://openalex.org/W3173642030","https://openalex.org/W2066734635","https://openalex.org/W2119516920","https://openalex.org/W1985139869"],"abstract_inverted_index":{"A":[0],"gradual":[1],"change":[2,36],"of":[3,34,50,73,90,109,134,143,145,157,164],"molecules":[4],"that":[5,31,162],"are":[6,25],"related":[7,170],"in":[8,37,54,62,83,87,97,154],"fission":[9,24,41,59,135,146,168],"and":[10,23,40,58,111,119,122,136,140,167],"fusion":[11,22,39,55,137,151,166],"is":[12,28],"occurred":[13],"during":[14],"aging":[15,18,172],"process.":[16],"Although":[17],"effects":[19],"on":[20],"mitochondrial":[21,51,165],"investigated,":[26],"it":[27],"still":[29],"unclear":[30],"the":[32,35,48,63,88,120,141,155],"extent":[33],"mitochondria":[38],"periodically.":[42],"In":[43],"this":[44],"study":[45],"we":[46],"investigated":[47],"changes":[49,86,163],"proteins":[52,169],"involved":[53],"(Mfn2,":[56],"Opa1)":[57],"(Drp1,":[60],"Fis1)":[61],"human":[64],"gracilis":[65,77],"muscle":[66,78,84,177],"ranging":[67],"from":[68,129],"10":[69],"to":[70,175],"50":[71],"years":[72],"age":[74,89,156],"(n=40).":[75],"The":[76,106,132],"showed":[79],"a":[80],"significant":[81],"increase":[82],"apoptotic":[85],"50s":[91],"compared":[92],"with":[93,171],"10s":[94],"by":[95],"using":[96],"situ":[98],"terminal":[99],"deoxynucleotidyl":[100],"transferase-mediated":[101],"dUTP":[102],"nick":[103],"end-labeling":[104],"(TUNEL).":[105],"expression":[107],"levels":[108,126],"Drp1":[110],"Fis1":[112],"(P<0.01,":[113,124],"P<0.05)":[114,125],"mRNA":[115],"were":[116,127],"significantly":[117],"elevated":[118],"Mfn2":[121],"Opa1":[123],"decreased":[128],"older":[130],"individuals.":[131],"ratio":[133],"was":[138,148],"altered":[139],"level":[142],"increment":[144],"gene":[147,152],"greater":[149],"than":[150],"decrement":[153],"50s.":[158],"These":[159],"findings":[160],"suggest":[161],"might":[173],"contribute":[174],"aged":[176],"apoptosis.":[178]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}