{"id":"https://openalex.org/W2199178706","doi":"https://doi.org/10.1016/j.ygyno.2015.12.011","title":"Sequential combination therapy of ovarian cancer with cisplatin and \u03b3-secretase inhibitor MK-0752","display_name":"Sequential combination therapy of ovarian cancer with cisplatin and \u03b3-secretase inhibitor MK-0752","publication_year":2015,"publication_date":"2015-12-16","ids":{"openalex":"https://openalex.org/W2199178706","doi":"https://doi.org/10.1016/j.ygyno.2015.12.011","mag":"2199178706","pmid":"https://pubmed.ncbi.nlm.nih.gov/26704638"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygyno.2015.12.011","doi":"https://doi.org/10.1016/j.ygyno.2015.12.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2015.12.011","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076992217","display_name":"Xiuxiu Chen","orcid":"https://orcid.org/0000-0001-8873-2350","observed_orcids":["https://orcid.org/0000-0001-8873-2350"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XiuXiu Chen","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101921199","display_name":"Li-Hua Gong","orcid":"https://orcid.org/0000-0001-7385-4961","observed_orcids":["https://orcid.org/0000-0001-7385-4961"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LiHua Gong","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007412273","display_name":"Rongying Ou","orcid":"https://orcid.org/0000-0002-1100-6497","observed_orcids":["https://orcid.org/0000-0002-1100-6497","https://orcid.org/0000-0003-0174-7088"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RongYing Ou","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819519","display_name":"Zhenzhen Zheng","orcid":"https://orcid.org/0000-0002-0290-7293","observed_orcids":["https://orcid.org/0000-0002-0290-7293"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZhenZhen Zheng","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085798045","display_name":"Jinyan Chen","orcid":"https://orcid.org/0000-0003-3743-2707","observed_orcids":["https://orcid.org/0000-0003-3743-2707"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JinYan Chen","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109486941","display_name":"Fengfeng Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FengFeng Xie","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033809681","display_name":"Xiaoxiu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XiaoXiu Huang","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027816847","display_name":"Jian-Ge Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JianGe Qiu","raw_affiliation_strings":["Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101905420","display_name":"Wenji Zhang","orcid":"https://orcid.org/0000-0003-1500-6627","observed_orcids":["https://orcid.org/0000-0003-1500-6627"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WenJi Zhang","raw_affiliation_strings":["Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006758431","display_name":"Qiwei Jiang","orcid":"https://orcid.org/0000-0002-3940-7276","observed_orcids":["https://orcid.org/0000-0002-3940-7276"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QiWei Jiang","raw_affiliation_strings":["Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":"https://orcid.org/0000-0002-3940-7276","affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397588","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0002-4123-4888","observed_orcids":["https://orcid.org/0000-0002-4123-4888","https://orcid.org/0000-0002-7740-7293","https://orcid.org/0009-0003-5078-2450"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101630432","display_name":"Hua Zhu","orcid":"https://orcid.org/0000-0001-9318-3659","observed_orcids":["https://orcid.org/0000-0001-9318-3659"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhu","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048003025","display_name":"Zhi Shi","orcid":"https://orcid.org/0000-0002-8328-0305","observed_orcids":["https://orcid.org/0000-0002-8328-0305"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi Shi","raw_affiliation_strings":["Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address: tshizhi@jnu.edu.cn","Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address: tshizhi@jnu.edu.cn","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210098034"]},{"raw_affiliation_string":"Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082985248","display_name":"Xiaojian Yan","orcid":"https://orcid.org/0000-0002-5306-4484","observed_orcids":["https://orcid.org/0000-0002-5306-4484"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"XiaoJian Yan","raw_affiliation_strings":["Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: yxjbetter@126.com","Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: yxjbetter@126.com","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048003025","https://openalex.org/A5082985248"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I2801769982","https://openalex.org/I4210098034"],"apc_list":{"value":4380,"currency":"USD","value_usd":4380},"apc_paid":null,"fwci":2.5937,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.91578369,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"140","issue":"3","first_page":"537","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9900000095367432},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.7860000133514404},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8596731424331665},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.720759391784668},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6638890504837036},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5420937538146973},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47670572996139526},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44532740116119385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4086650609970093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29941636323928833},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16578122973442078}],"mesh":[{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ygyno.2015.12.011","doi":"https://doi.org/10.1016/j.ygyno.2015.12.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2015.12.011","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},{"id":"pmid:26704638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26704638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G245777456","display_name":null,"funder_award_id":"31271444","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3680897474","display_name":null,"funder_award_id":"81503293","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4183564348","display_name":null,"funder_award_id":"81373075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6660685099","display_name":null,"funder_award_id":"81201726","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8842907609","display_name":null,"funder_award_id":"20124401120007","funder_id":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W172561760","https://openalex.org/W1547041557","https://openalex.org/W1810100663","https://openalex.org/W1840112861","https://openalex.org/W1856716148","https://openalex.org/W1970820847","https://openalex.org/W1971429606","https://openalex.org/W1974567048","https://openalex.org/W1976078324","https://openalex.org/W1977342376","https://openalex.org/W1977962361","https://openalex.org/W1987604182","https://openalex.org/W1994253118","https://openalex.org/W2001799702","https://openalex.org/W2006827588","https://openalex.org/W2010521246","https://openalex.org/W2014952486","https://openalex.org/W2017316771","https://openalex.org/W2017592327","https://openalex.org/W2019708706","https://openalex.org/W2037810620","https://openalex.org/W2043412419","https://openalex.org/W2052872355","https://openalex.org/W2053833210","https://openalex.org/W2058792931","https://openalex.org/W2064111887","https://openalex.org/W2066452505","https://openalex.org/W2086604490","https://openalex.org/W2088720735","https://openalex.org/W2096237102","https://openalex.org/W2099293048","https://openalex.org/W2107400278","https://openalex.org/W2111923995","https://openalex.org/W2130470865","https://openalex.org/W2136321415","https://openalex.org/W2139881001","https://openalex.org/W2153293603","https://openalex.org/W2154861644","https://openalex.org/W2169961966","https://openalex.org/W2415141331","https://openalex.org/W3035130918","https://openalex.org/W4210987384","https://openalex.org/W6607032200","https://openalex.org/W6715944805"],"related_works":["https://openalex.org/W2053833210","https://openalex.org/W3010868496","https://openalex.org/W2109487929","https://openalex.org/W3027454220","https://openalex.org/W3173533075","https://openalex.org/W2050677695","https://openalex.org/W6939696316","https://openalex.org/W2971337387","https://openalex.org/W1810100663","https://openalex.org/W1984382302"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}