{"id":"https://openalex.org/W2198762999","doi":null,"title":"THE ROLE OF BAX IN APOPTOSIS OF ECTOPIC PRIMORDIAL GERM CELLS IN THE MOUSE","display_name":"THE ROLE OF BAX IN APOPTOSIS OF ECTOPIC PRIMORDIAL GERM CELLS IN THE MOUSE","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2198762999","mag":"2198762999"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1046891667","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042080064","display_name":"James Patrick Stallock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James Patrick Stallock","raw_affiliation_strings":["University of Cincinnati**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati**","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042080064"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9240000247955322},{"id":"https://openalex.org/keywords/primordial-germ-cells","display_name":"primordial germ cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/germ-cell-apoptosis","display_name":"germ cell apoptosis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/germ-cell-migration","display_name":"germ cell migration","score":0.8960000276565552},{"id":"https://openalex.org/keywords/c-kit-signaling","display_name":"c-Kit signaling","score":0.6869999766349792},{"id":"https://openalex.org/keywords/germ-cell-survival","display_name":"germ cell survival","score":0.6079999804496765},{"id":"https://openalex.org/keywords/gonadal-development","display_name":"gonad development","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.894099771976471},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.6882216930389404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6754803657531738},{"id":"https://openalex.org/C2781471917","wikidata":"https://www.wikidata.org/wiki/Q213456","display_name":"Gonad","level":2,"score":0.5890987515449524},{"id":"https://openalex.org/C2910790502","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Totipotent","level":4,"score":0.5519881248474121},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5479273796081543},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5151396989822388},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.4217478632926941},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.31611377000808716},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24231821298599243},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1865917444229126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ucin1046891667","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","raw_type":"text"},{"id":"mag:2198762999","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1046891667","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2198762999.pdf","grobid_xml":"https://content.openalex.org/works/W2198762999.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W29161343","https://openalex.org/W103053889","https://openalex.org/W178183906","https://openalex.org/W347790389","https://openalex.org/W1482574930","https://openalex.org/W1484163259","https://openalex.org/W1535454769","https://openalex.org/W1539305121","https://openalex.org/W1555116693","https://openalex.org/W1577859676","https://openalex.org/W1578649908","https://openalex.org/W1665419471","https://openalex.org/W1767355390","https://openalex.org/W1829371983","https://openalex.org/W1864184149","https://openalex.org/W1894661456","https://openalex.org/W1906896043","https://openalex.org/W1913661233","https://openalex.org/W1933460820","https://openalex.org/W1950481374","https://openalex.org/W1966632935","https://openalex.org/W1967912613","https://openalex.org/W1970176101","https://openalex.org/W1976435237","https://openalex.org/W1976720365","https://openalex.org/W1976781803","https://openalex.org/W1978093163","https://openalex.org/W1980141913","https://openalex.org/W1980482182","https://openalex.org/W1981088384","https://openalex.org/W1982210988","https://openalex.org/W1985442766","https://openalex.org/W1987785848","https://openalex.org/W1987952647","https://openalex.org/W1988288108","https://openalex.org/W1989050230","https://openalex.org/W1991933996","https://openalex.org/W1996634627","https://openalex.org/W1997444723","https://openalex.org/W2000167648","https://openalex.org/W2000352412","https://openalex.org/W2000519963","https://openalex.org/W2000529918","https://openalex.org/W2000894919","https://openalex.org/W2003211543","https://openalex.org/W2003301112","https://openalex.org/W2004619982","https://openalex.org/W2005497769","https://openalex.org/W2006499356","https://openalex.org/W2008597649","https://openalex.org/W2010336249","https://openalex.org/W2013105209","https://openalex.org/W2013469964","https://openalex.org/W2018583173","https://openalex.org/W2019980431","https://openalex.org/W2020866505","https://openalex.org/W2026391442","https://openalex.org/W2026873116","https://openalex.org/W2028022342","https://openalex.org/W2030656510","https://openalex.org/W2033873142","https://openalex.org/W2036105826","https://openalex.org/W2036365433","https://openalex.org/W2042289467","https://openalex.org/W2043396979","https://openalex.org/W2044903253","https://openalex.org/W2045086385","https://openalex.org/W2045476552","https://openalex.org/W2045733786","https://openalex.org/W2049946159","https://openalex.org/W2053997148","https://openalex.org/W2056772501","https://openalex.org/W2056964530","https://openalex.org/W2059163294","https://openalex.org/W2059792351","https://openalex.org/W2060153293","https://openalex.org/W2060208377","https://openalex.org/W2061188705","https://openalex.org/W2063362926","https://openalex.org/W2069196243","https://openalex.org/W2069772488","https://openalex.org/W2072725812","https://openalex.org/W2074113757","https://openalex.org/W2074939213","https://openalex.org/W2076020247","https://openalex.org/W2077270970","https://openalex.org/W2081118239","https://openalex.org/W2083029613","https://openalex.org/W2083460129","https://openalex.org/W2083898995","https://openalex.org/W2084775418","https://openalex.org/W2085227431","https://openalex.org/W2085487017","https://openalex.org/W2086778634","https://openalex.org/W2089543169","https://openalex.org/W2096282502","https://openalex.org/W2105253445","https://openalex.org/W2107427447","https://openalex.org/W2110905385","https://openalex.org/W2111166148","https://openalex.org/W2121853087","https://openalex.org/W2123530676","https://openalex.org/W2125088406","https://openalex.org/W2125536365","https://openalex.org/W2130453712","https://openalex.org/W2134872883","https://openalex.org/W2134979684","https://openalex.org/W2140967934","https://openalex.org/W2140987025","https://openalex.org/W2142189637","https://openalex.org/W2143755436","https://openalex.org/W2144701362","https://openalex.org/W2145182226","https://openalex.org/W2146332504","https://openalex.org/W2146965545","https://openalex.org/W2150014745","https://openalex.org/W2151827847","https://openalex.org/W2152247516","https://openalex.org/W2152594753","https://openalex.org/W2156483686","https://openalex.org/W2158343596","https://openalex.org/W2159650080","https://openalex.org/W2161575933","https://openalex.org/W2162504561","https://openalex.org/W2163011434","https://openalex.org/W2165135585","https://openalex.org/W2165892496","https://openalex.org/W2167234515","https://openalex.org/W2167918176","https://openalex.org/W2168056910","https://openalex.org/W2168436056","https://openalex.org/W2170477710","https://openalex.org/W2180762163","https://openalex.org/W2182720429","https://openalex.org/W2187959282","https://openalex.org/W2188651990","https://openalex.org/W2188804251","https://openalex.org/W2188914906","https://openalex.org/W2189305529","https://openalex.org/W2197911224","https://openalex.org/W2233325915","https://openalex.org/W2241084762","https://openalex.org/W2279323582","https://openalex.org/W2331736295","https://openalex.org/W2395939399","https://openalex.org/W4229985088"],"related_works":["https://openalex.org/W2109680952","https://openalex.org/W2529741927","https://openalex.org/W2050793594","https://openalex.org/W2019980431","https://openalex.org/W2092028353","https://openalex.org/W2092886140","https://openalex.org/W2086778634","https://openalex.org/W2053484275","https://openalex.org/W1985765271","https://openalex.org/W1989027475"],"abstract_inverted_index":{"Primordial":[0],"germ":[1,249],"cells":[2,23,250],"(PGCs)":[3],"are":[4,24,84,124,141,169,179],"the":[5,20,36,41,57,65,79,89,94,101,155,159,163,225,235,270,273],"mothers":[6],"of":[7,12,103,112,162,218,231,237,243,258,272,293],"all":[8],"stem":[9],"cells,":[10],"capable":[11],"giving":[13],"rise":[14],"to":[15,35,39,76,174,187,207,224],"every":[16],"other":[17,70],"cell":[18,166,193,226,276],"in":[19,28,86,93,128,158,176,181],"body.These":[21],"totipotent":[22],"set":[25],"aside":[26],"early":[27,246],"development":[29],"via":[30],"locational":[31],"cues,":[32],"and":[33,74,92,98,118,138,147,185,199,245,299],"migrate":[34,62],"genital":[37],"ridges":[38],"form":[40],"gonad":[42,80],"proper.The":[43],"migration":[44,58,105],"process":[45],"for":[46],"PGCs":[47,53,60,83,121,140,149,178,209,238,260,296],"is":[48,297,301],"not":[49],"overly":[50],"efficient,":[51],"with":[52,69],"migrating":[54],"aberrantly":[55],"throughout":[56],"process.The":[59],"that":[61,168,241,303],"successfully":[63],"into":[64],"gonadal":[66,177],"anlagen":[67],"aggregate":[68],"PGCs,":[71,117,184],"become":[72],"non-motile,":[73],"continue":[75],"proliferate":[77,198],"within":[78],"proper.Ectopic":[81],"post-migratory":[82,247],"present":[85,180],"mice":[87,134],"near":[88,154],"developing":[90,164],"gonads":[91],"midline":[95,137],"mesenchymal":[96],"tissue":[97],"hindgut":[99],"along":[100],"route":[102],"PGC":[104,113,290],"up":[106],"until":[107],"E13.5,":[108],"when":[109,205],"a":[110,220,253,266,286],"wave":[111,307],"apoptosis":[114,281],"eliminates":[115],"intragonadal":[116,305],"possibly":[119],"ectopic":[120,148,183,248,259,295],"as":[122,143,145],"none":[123],"found":[125],"at":[126,152,190,262,282,309],"E14.5":[127,175,182],"wild-type":[129,208],"embryos.In":[130],"Bax":[131,196,213,232],"homozygous":[132],"mutant":[133],"(Bax":[135],"-/-),":[136],"capsular":[139],"seen":[142],"late":[144],"E15.5,":[146],"were":[150],"observed":[151,308],"E18.5":[153],"dorsal":[156],"aorta":[157],"lumbar":[160],"region":[161],"embryo.Germ":[165],"markers":[167],"normally":[170],"turned":[171],"off":[172],"prior":[173],"begin":[186],"decrease":[188],"expression":[189],"~E15.5.In":[191],"crude":[192],"cultures,":[194],"E10.5":[195],"-/-PGCs":[197,214],"have":[200],"an":[201,304],"increased":[202],"shortterm":[203],"survival":[204,230,278],"compared":[206],"from":[210],"littermates,":[211],"however":[212,234],"do":[215],"eventually":[216],"die.Addition":[217],"ACK2,":[219],"c-kit":[221],"blocking":[222],"antibody,":[223],"cultures":[227],"partially":[228,284],"reduced":[229],"-/-PGCs,":[233],"majority":[236],"survive.I":[239],"propose":[240],"removal":[242,257,292],"migratory":[244],"proceeds":[251],"through":[252,265,285],"Bax-dependent":[254],"pathway,":[255],"whereas":[256],"beginning":[261],"E15.5":[263],"operates":[264],"Bax-independent":[267],"mechanism.In":[268],"addition,":[269],"loss":[271],"Steel/c-kit":[274],"iii":[275],"signaling":[277],"pathway":[279],"promotes":[280],"least":[283],"Baxdependent":[287],"mechanism":[288],"during":[289],"migration.The":[291],"E13.5":[294,310],"Bax-dependent,":[298],"it":[300],"possible":[302],"apoptotic":[306],"may":[311],"also":[312],"be":[313],"Bax-dependent.iv":[314]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}