{"id":"https://openalex.org/W2198345596","doi":"https://doi.org/10.1093/annonc/mdu435.120","title":"Efficacy and Safety of Gemcitabine as First-Line Therapy in Patients Aged 65 and Older with Advanced Pancreatic Cancer","display_name":"Efficacy and Safety of Gemcitabine as First-Line Therapy in Patients Aged 65 and Older with Advanced Pancreatic Cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2198345596","doi":"https://doi.org/10.1093/annonc/mdu435.120","mag":"2198345596"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdu435.120","doi":"https://doi.org/10.1093/annonc/mdu435.120","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu435.120","pdf_url":"https://doi.org/10.1093/annonc/mdu435.120","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/annonc/mdu435.120","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044702819","display_name":"Yosuke Kito","orcid":"https://orcid.org/0000-0003-3677-9880","observed_orcids":["https://orcid.org/0000-0003-3677-9880"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Kito","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015481734","display_name":"Akiko Todaka","orcid":"https://orcid.org/0000-0002-7308-5960","observed_orcids":["https://orcid.org/0000-0002-7308-5960"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Todaka","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004637658","display_name":"Akira Fukutomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Fukutomi","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198101","display_name":"Kenji Kunieda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Kunieda","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464446","display_name":"Takahiro Tsushima","orcid":"https://orcid.org/0000-0003-3551-7504","observed_orcids":["https://orcid.org/0000-0003-3551-7504"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Tsushima","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000636193","display_name":"Tomoya Yokota","orcid":"https://orcid.org/0000-0001-7327-7949","observed_orcids":["https://orcid.org/0000-0001-7327-7949"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Yokota","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069631984","display_name":"Nozomu Machida","orcid":"https://orcid.org/0000-0001-9570-3670","observed_orcids":["https://orcid.org/0000-0001-9570-3670"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nozomu Machida","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038655401","display_name":"Kentaro Yamazaki","orcid":"https://orcid.org/0000-0001-6269-9345","observed_orcids":["https://orcid.org/0000-0001-6269-9345"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Yamazaki","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069640225","display_name":"Yusuke Onozawa","orcid":"https://orcid.org/0009-0003-1019-7564","observed_orcids":["https://orcid.org/0009-0003-1019-7564"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Onozawa","raw_affiliation_strings":["Division of Medical Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101921121","display_name":"Hirofumi Yasui","orcid":"https://orcid.org/0000-0002-7176-8354","observed_orcids":["https://orcid.org/0000-0002-7176-8354"]},"institutions":[{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Yasui","raw_affiliation_strings":["Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisiont of Gastrointestinal Oncology, Shizuoka Cancer Center","institution_ids":["https://openalex.org/I4210088324"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210088324"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19725935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":null,"first_page":"v73","last_page":"v73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7720000147819519},{"id":"https://openalex.org/keywords/relative-dose-intensity","display_name":"relative dose intensity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6930000185966492},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7590000033378601},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.984000027179718},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.6990000009536743},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.671999990940094},{"id":"https://openalex.org/keywords/biliary-tract-infection","display_name":"biliary tract infection","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/biliary-obstruction","display_name":"biliary obstruction","score":0.43700000643730164},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9633182883262634},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8962874412536621},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7081971764564514},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6142295002937317},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5594621300697327},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40066394209861755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdu435.120","doi":"https://doi.org/10.1093/annonc/mdu435.120","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu435.120","pdf_url":"https://doi.org/10.1093/annonc/mdu435.120","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdu435.120","doi":"https://doi.org/10.1093/annonc/mdu435.120","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu435.120","pdf_url":"https://doi.org/10.1093/annonc/mdu435.120","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2198345596.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001891495","https://openalex.org/W2064894357","https://openalex.org/W1979444138","https://openalex.org/W2039360554","https://openalex.org/W2809615793","https://openalex.org/W4391095729","https://openalex.org/W1982609675","https://openalex.org/W2978377284","https://openalex.org/W2979014789","https://openalex.org/W7162190921"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}