{"id":"https://openalex.org/W2198005345","doi":null,"title":"DIET, BACTERIA AND INFLAMMATION: THE INTESTINAL MUCOSA AND METABOLIC SYNDROME","display_name":"DIET, BACTERIA AND INFLAMMATION: THE INTESTINAL MUCOSA AND METABOLIC SYNDROME","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2198005345","mag":"2198005345"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:nutrisci_etds-1005","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/nutrisci_etds/4","pdf_url":"https://uknowledge.uky.edu/nutrisci_etds/4","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Nutritional Sciences","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/nutrisci_etds/4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002275685","display_name":"Nadeem Mohammed","orcid":"https://orcid.org/0000-0001-7035-7441","observed_orcids":["https://orcid.org/0000-0001-7035-7441"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nadeem Mohammed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7035-7441","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002275685"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1049,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39526234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9610000252723694},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/intestinal-immunity","display_name":"intestinal immunity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fecal-iga","display_name":"fecal IgA","score":0.8019999861717224},{"id":"https://openalex.org/keywords/plasma-igg","display_name":"plasma IgG","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9269999861717224},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6745479106903076},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.6234678030014038},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6144255995750427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5911360383033752},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5708402395248413},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.5363918542861938},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5310205817222595},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5301048755645752},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.47925662994384766},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4511614441871643},{"id":"https://openalex.org/C2777221637","wikidata":"https://www.wikidata.org/wiki/Q132644","display_name":"Lactobacillus acidophilus","level":4,"score":0.4494943618774414},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4441053867340088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4329659938812256},{"id":"https://openalex.org/C2909437661","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli infection","level":4,"score":0.4242556691169739},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4216788113117218},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4214571714401245},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.41951999068260193},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.3947353959083557},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3866795599460602},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38018956780433655},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.36707618832588196},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.31700098514556885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3148552179336548},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2479027807712555},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.17323940992355347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:nutrisci_etds-1005","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/nutrisci_etds/4","pdf_url":"https://uknowledge.uky.edu/nutrisci_etds/4","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Nutritional Sciences","raw_type":"text"},{"id":"mag:2198005345","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1005&context=nutrisci_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:nutrisci_etds-1005","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/nutrisci_etds/4","pdf_url":"https://uknowledge.uky.edu/nutrisci_etds/4","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Nutritional Sciences","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2198005345.pdf","grobid_xml":"https://content.openalex.org/works/W2198005345.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W40771570","https://openalex.org/W77623388","https://openalex.org/W82467273","https://openalex.org/W108736017","https://openalex.org/W158779872","https://openalex.org/W1494780959","https://openalex.org/W1500864024","https://openalex.org/W1529674879","https://openalex.org/W1533523963","https://openalex.org/W1533876739","https://openalex.org/W1548367056","https://openalex.org/W1566458213","https://openalex.org/W1567420244","https://openalex.org/W1576852720","https://openalex.org/W1586799661","https://openalex.org/W1596765116","https://openalex.org/W1618175032","https://openalex.org/W1642457845","https://openalex.org/W1646170356","https://openalex.org/W1661544713","https://openalex.org/W1663895113","https://openalex.org/W1670573097","https://openalex.org/W1684647427","https://openalex.org/W1750136410","https://openalex.org/W1764140709","https://openalex.org/W1902894571","https://openalex.org/W1939007604","https://openalex.org/W1963639967","https://openalex.org/W1967251205","https://openalex.org/W1967971775","https://openalex.org/W1968973375","https://openalex.org/W1971205306","https://openalex.org/W1971349333","https://openalex.org/W1971349971","https://openalex.org/W1971737706","https://openalex.org/W1972614771","https://openalex.org/W1972745528","https://openalex.org/W1974599416","https://openalex.org/W1974744480","https://openalex.org/W1975319022","https://openalex.org/W1977772456","https://openalex.org/W1979859398","https://openalex.org/W1981270981","https://openalex.org/W1983819140","https://openalex.org/W1984004823","https://openalex.org/W1986349550","https://openalex.org/W1987772295","https://openalex.org/W1987907874","https://openalex.org/W1988870963","https://openalex.org/W1990946950","https://openalex.org/W1992442610","https://openalex.org/W1994684051","https://openalex.org/W1995337037","https://openalex.org/W1996106963","https://openalex.org/W1996901896","https://openalex.org/W1999523219","https://openalex.org/W2004465286","https://openalex.org/W2004993550","https://openalex.org/W2005006373","https://openalex.org/W2007058937","https://openalex.org/W2007503046","https://openalex.org/W2008869160","https://openalex.org/W2010399378","https://openalex.org/W2011006768","https://openalex.org/W2017646214","https://openalex.org/W2019279852","https://openalex.org/W2022671594","https://openalex.org/W2025114863","https://openalex.org/W2031484324","https://openalex.org/W2032186105","https://openalex.org/W2035965693","https://openalex.org/W2036125357","https://openalex.org/W2036188131","https://openalex.org/W2038389691","https://openalex.org/W2040024879","https://openalex.org/W2040253720","https://openalex.org/W2041136224","https://openalex.org/W2041729015","https://openalex.org/W2042074642","https://openalex.org/W2044236841","https://openalex.org/W2046859247","https://openalex.org/W2048041034","https://openalex.org/W2048058913","https://openalex.org/W2049323213","https://openalex.org/W2055833760","https://openalex.org/W2057180728","https://openalex.org/W2057198053","https://openalex.org/W2057248065","https://openalex.org/W2058686993","https://openalex.org/W2061319589","https://openalex.org/W2064119981","https://openalex.org/W2065201220","https://openalex.org/W2065761991","https://openalex.org/W2066281446","https://openalex.org/W2068592334","https://openalex.org/W2069125860","https://openalex.org/W2069219892","https://openalex.org/W2073132923","https://openalex.org/W2077296632","https://openalex.org/W2077732595","https://openalex.org/W2078807483","https://openalex.org/W2079482620","https://openalex.org/W2084814184","https://openalex.org/W2084825289","https://openalex.org/W2086648828","https://openalex.org/W2086778308","https://openalex.org/W2087370309","https://openalex.org/W2088697466","https://openalex.org/W2091940253","https://openalex.org/W2093329141","https://openalex.org/W2094834014","https://openalex.org/W2094882027","https://openalex.org/W2096668238","https://openalex.org/W2097822651","https://openalex.org/W2098268087","https://openalex.org/W2099224474","https://openalex.org/W2100719344","https://openalex.org/W2101508556","https://openalex.org/W2102683312","https://openalex.org/W2103540095","https://openalex.org/W2103760724","https://openalex.org/W2103831817","https://openalex.org/W2104439753","https://openalex.org/W2104600979","https://openalex.org/W2104722369","https://openalex.org/W2104890139","https://openalex.org/W2104942758","https://openalex.org/W2108021940","https://openalex.org/W2109796699","https://openalex.org/W2111900042","https://openalex.org/W2112785138","https://openalex.org/W2115207445","https://openalex.org/W2115848892","https://openalex.org/W2116286418","https://openalex.org/W2118352951","https://openalex.org/W2121800587","https://openalex.org/W2124303495","https://openalex.org/W2124334818","https://openalex.org/W2125309974","https://openalex.org/W2127157976","https://openalex.org/W2127187614","https://openalex.org/W2127642399","https://openalex.org/W2128890658","https://openalex.org/W2129316761","https://openalex.org/W2129374849","https://openalex.org/W2129754316","https://openalex.org/W2130766522","https://openalex.org/W2131395371","https://openalex.org/W2131536322","https://openalex.org/W2132935604","https://openalex.org/W2133449490","https://openalex.org/W2133966719","https://openalex.org/W2134293572","https://openalex.org/W2135388445","https://openalex.org/W2140157151","https://openalex.org/W2141440140","https://openalex.org/W2147802195","https://openalex.org/W2148624349","https://openalex.org/W2149625542","https://openalex.org/W2150464859","https://openalex.org/W2151335106","https://openalex.org/W2151485670","https://openalex.org/W2153049426","https://openalex.org/W2153905079","https://openalex.org/W2156280702","https://openalex.org/W2157898656","https://openalex.org/W2158796091","https://openalex.org/W2161914374","https://openalex.org/W2163270865","https://openalex.org/W2164824982","https://openalex.org/W2165282564","https://openalex.org/W2165528446","https://openalex.org/W2165741907","https://openalex.org/W2165922813","https://openalex.org/W2166558587","https://openalex.org/W2167062509","https://openalex.org/W2167927725","https://openalex.org/W2169330513","https://openalex.org/W2171742795","https://openalex.org/W2175262016","https://openalex.org/W2241432584","https://openalex.org/W2253744705","https://openalex.org/W2267980504","https://openalex.org/W2325164321","https://openalex.org/W2339773943","https://openalex.org/W2396037506","https://openalex.org/W2404854108","https://openalex.org/W2412274443","https://openalex.org/W2429814667","https://openalex.org/W2470975179","https://openalex.org/W4234615218","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2049145926","https://openalex.org/W55471973","https://openalex.org/W7095605191","https://openalex.org/W2086648828","https://openalex.org/W2603846067","https://openalex.org/W4280646502","https://openalex.org/W2519073022","https://openalex.org/W2519717771","https://openalex.org/W2993542661","https://openalex.org/W2095717717"],"abstract_inverted_index":{"Long":[0],"term":[1,27,49,245],"consumption":[2,29,51,141,149,265],"of":[3,12,47,147,180,206,217],"a":[4,62,89],"high":[5],"fat":[6,66],"diet":[7,67],"(HFD)":[8],"increases":[9],"the":[10,34,45,53,137,154,177,203,215],"risk":[11],"developing":[13],"Metabolic":[14],"Syndrome":[15],"and":[16,64,83,95,102,115,128,142,167,191,256],"type":[17],"2":[18],"diabetes.":[19],"This":[20],"led":[21],"us":[22],"to":[23,33,135,252],"hypothesize":[24],"that":[25,223,238,263],"long":[26,48,244],"HFD":[28,50,63,103,140,148,165,170,218,224,246,264],"impairs":[30],"immune":[31,55,151,250],"tolerance":[32],"intestinal":[35,143,220,254,268],"bacteria.":[36],"Our":[37,131,233],"studies":[38,260],"had":[39,172,198,226],"two":[40],"goals.":[41],"First,":[42],"we":[43],"characterized":[44],"effect":[46,146,216],"on":[52,150,214,219],"systemic":[54,248],"response":[56],"by":[57,88,159],"comparing":[58],"C57BL6":[59],"mice":[60,101,166,171,225],"fed":[61],"low":[65],"(LFD).":[68],"Plasma":[69],"immunoglobulin":[70],"G":[71],"(IgG)":[72],"against":[73,176,202],"Escherichia":[74,181],"coli":[75,78,182,208],"(LF-82),":[76],"E.":[77,207],"(Nissle":[79],"1917),":[80],"Bacteroides":[81],"thetaiotaomicron":[82],"Lactobacillus":[84],"acidophilus":[85],"were":[86,97,110,117],"measured":[87,98,118],"lab-developed":[90],"ELISA.":[91],"Fasting":[92],"blood":[93,193],"glucose":[94,194],"inflammation":[96],"in":[99,119,153,164,237],"LFD":[100,168,231],"mice.":[104,169,232],"To":[105],"test":[106],"whether":[107],"our":[108],"findings":[109,234],"clinically":[111],"relevant,":[112],"anti-bacterial":[113],"IgG":[114,175,201],"TNF-\u03b1":[116],"plasma":[120,174,187,200],"samples":[121],"from":[122],"lean":[123,210],"healthy":[124,211],"individuals,":[125],"obese":[126,129],"non-diabetics":[127],"diabetics.":[130],"second":[132],"aim":[133],"was":[134,157],"investigate":[136],"relationship":[138],"between":[139,243],"immunity.":[144,269],"The":[145],"responses":[152,251],"GI":[155],"tract":[156],"assessed":[158],"measuring":[160],"fecal":[161,228],"IgA":[162,229],"levels":[163],"higher":[173,186,199],"LF82":[178,204],"strain":[179,205],"as":[183,185],"well":[184],"TNF-\u03b1,":[188],"neutrophil":[189],"percentage":[190],"fasting":[192],"levels.":[195],"Obese":[196],"diabetics":[197],"than":[209,230],"controls.":[212],"Studies":[213],"immunity":[221],"revealed":[222],"lower":[227],"are":[235],"novel":[236],"they":[239],"show":[240],"an":[241],"association":[242],"consumption,":[247],"inflammatory":[249],"pathogenic":[253],"bacteria":[255],"insulin":[257],"resistance.":[258],"These":[259],"also":[261],"showed":[262],"may":[266],"impair":[267]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
