{"id":"https://openalex.org/W2197489357","doi":"https://doi.org/10.1371/journal.pone.0139564","title":"The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts","display_name":"The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2197489357","doi":"https://doi.org/10.1371/journal.pone.0139564","mag":"2197489357","pmid":"https://pubmed.ncbi.nlm.nih.gov/26426806","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4591016"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0139564","doi":"https://doi.org/10.1371/journal.pone.0139564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139564","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139564&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2197489357"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139564&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043211508","display_name":"Bas ten Harkel","orcid":"https://orcid.org/0000-0002-9463-3989","observed_orcids":["https://orcid.org/0000-0002-9463-3989"]},"institutions":[{"id":"https://openalex.org/I2898155008","display_name":"Academic Center for Dentistry Amsterdam","ror":"https://ror.org/04x5wnb75","country_code":"NL","type":"education","lineage":["https://openalex.org/I2898155008"]},{"id":"https://openalex.org/I4405256582","display_name":"Amsterdam Movement Sciences","ror":"https://ror.org/04atb9h07","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405256582"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Bas ten Harkel","raw_affiliation_strings":["Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I4405256582","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034837461","display_name":"Ton Schoenmaker","orcid":"https://orcid.org/0000-0001-6649-374X","observed_orcids":["https://orcid.org/0000-0001-6649-374X"]},"institutions":[{"id":"https://openalex.org/I2898155008","display_name":"Academic Center for Dentistry Amsterdam","ror":"https://ror.org/04x5wnb75","country_code":"NL","type":"education","lineage":["https://openalex.org/I2898155008"]},{"id":"https://openalex.org/I4405256582","display_name":"Amsterdam Movement Sciences","ror":"https://ror.org/04atb9h07","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405256582"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ton Schoenmaker","raw_affiliation_strings":["Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I4405256582","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042449660","display_name":"Daisy I. Picavet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387156196","display_name":"Van Leeuwenhoek Centre for Advanced Microscopy","ror":"https://ror.org/013rctf62","country_code":"NL","type":"facility","lineage":["https://openalex.org/I2898336195","https://openalex.org/I4387156196","https://openalex.org/I887064364"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daisy I. Picavet","raw_affiliation_strings":["Department of Cell Biology and Histology, Center for Advanced Microscopy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Center for Advanced Microscopy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I4387156196","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113952994","display_name":"Noel L. Davison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165959","display_name":"Xpand Biotechnology (Netherlands)","ror":"https://ror.org/04fywsz69","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210165959"]},{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Noel L. Davison","raw_affiliation_strings":["MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; Xpand Biotechnology BV, Bilthoven, The Netherlands","MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands","Xpand Biotechnology BV, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; Xpand Biotechnology BV, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Xpand Biotechnology BV, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210165959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088515138","display_name":"Teun J. de Vries","orcid":"https://orcid.org/0000-0001-6464-5172","observed_orcids":["https://orcid.org/0000-0001-6464-5172"]},"institutions":[{"id":"https://openalex.org/I2898155008","display_name":"Academic Center for Dentistry Amsterdam","ror":"https://ror.org/04x5wnb75","country_code":"NL","type":"education","lineage":["https://openalex.org/I2898155008"]},{"id":"https://openalex.org/I4405256582","display_name":"Amsterdam Movement Sciences","ror":"https://ror.org/04atb9h07","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405256582"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Teun J. de Vries","raw_affiliation_strings":["Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I4405256582","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071267729","display_name":"Vincent E. Everts","orcid":"https://orcid.org/0000-0002-8785-9824","observed_orcids":["https://orcid.org/0000-0002-8785-9824"]},"institutions":[{"id":"https://openalex.org/I2898155008","display_name":"Academic Center for Dentistry Amsterdam","ror":"https://ror.org/04x5wnb75","country_code":"NL","type":"education","lineage":["https://openalex.org/I2898155008"]},{"id":"https://openalex.org/I4405256582","display_name":"Amsterdam Movement Sciences","ror":"https://ror.org/04atb9h07","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405256582"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Vincent Everts","raw_affiliation_strings":["Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I4405256582","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5043211508"],"corresponding_institution_ids":["https://openalex.org/I2898155008","https://openalex.org/I4405256582","https://openalex.org/I887064364"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.1763,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.93354768,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"e0139564","last_page":"e0139564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foreign-body-giant-cells","display_name":"foreign body giant cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.949999988079071},{"id":"https://openalex.org/keywords/hydroxyapatite-dissolution","display_name":"hydroxyapatite dissolution","score":0.9419999718666077},{"id":"https://openalex.org/keywords/actin-rings","display_name":"actin rings","score":0.5720000267028809},{"id":"https://openalex.org/keywords/sealing-zone","display_name":"sealing zone","score":0.7699999809265137},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ruffled-border","display_name":"ruffled border","score":0.8539999723434448},{"id":"https://openalex.org/keywords/v-atpase","display_name":"V-ATPase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cathepsin-k","display_name":"cathepsin K","score":0.8899999856948853},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii","display_name":"carbonic anhydrase II","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7709004878997803},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6916454434394836},{"id":"https://openalex.org/C136403682","wikidata":"https://www.wikidata.org/wiki/Q5796041","display_name":"Multinucleate","level":2,"score":0.6877989768981934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.66922527551651},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.548092246055603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5292251110076904},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.5185849666595459},{"id":"https://openalex.org/C108657112","wikidata":"https://www.wikidata.org/wiki/Q3332118","display_name":"Foreign-body giant cell","level":2,"score":0.5103432536125183},{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.4999966621398926},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.44439759850502014},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.4375852644443512},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3631388247013092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32018786668777466},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2711981534957886},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23833218216896057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2220703363418579},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16558969020843506},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12721502780914307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0786585807800293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015743","descriptor_name":"Giant Cells, Foreign-Body","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015743","descriptor_name":"Giant Cells, Foreign-Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":15,"locations":[{"id":"doi:10.1371/journal.pone.0139564","doi":"https://doi.org/10.1371/journal.pone.0139564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139564","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139564&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3575523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4591016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26426806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26426806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/b52a1211-eb64-4f94-83e3-604bbdfc7768","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/the-foreign-body-giant-cell-cannot-resorb-bone-but-dissolves-hydroxyapatite-like-osteoclasts(b52a1211-eb64-4f94-83e3-604bbdfc7768).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ten Harkel, B, Schoenmaker, T, Picavet, D I, Davison, N L, de Vries, T J & Everts, V 2015, 'The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts', PLoS ONE, vol. 10, no. 10, e0139564. https://doi.org/10.1371/journal.pone.0139564","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4591016","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4591016/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:research.vu.nl:openaire/51b6a4c1-ce53-4afd-952f-b267bc8d406b","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/51b6a4c1-ce53-4afd-952f-b267bc8d406b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ten Harkel, B, Schoenmaker, T, Picavet, D I, Davison, N L, de Vries, T J & Everts, V 2015, 'The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts', PLoS ONE, vol. 10, no. 10, e0139564. https://doi.org/10.1371/journal.pone.0139564","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ris.utwente.nl:openaire/82796f33-66a7-44f4-b5c8-1508c4db1634","doi":null,"is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/82796f33-66a7-44f4-b5c8-1508c4db1634","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harkel, B T, Schoenmaker, T, Picavet, D I, Davison, N L, De Vries, T J & Everts, V 2015, 'The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts', PLoS ONE, vol. 10, no. 10, e0139564. https://doi.org/10.1371/journal.pone.0139564","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.3812","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.3812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0a/4e/pone.0139564.PMC4591016.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/ab4f49d2-dac9-4bfb-a336-ab346b5e3cf9","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/the-foreign-body-giant-cell-cannot-resorb-bone-but-dissolves-hydroxyapatite-like-osteoclasts(ab4f49d2-dac9-4bfb-a336-ab346b5e3cf9).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10(10). Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:openaire/b52a1211-eb64-4f94-83e3-604bbdfc7768","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/the-foreign-body-giant-cell-cannot-resorb-bone-but-dissolves-hydroxyapatite-like-osteoclasts(b52a1211-eb64-4f94-83e3-604bbdfc7768).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ten Harkel, B, Schoenmaker, T, Picavet, D I, Davison, N L, de Vries, T J & Everts, V 2015, 'The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts', PLoS ONE, vol. 10, no. 10, e0139564. https://doi.org/10.1371/journal.pone.0139564","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4c8d96da2dcd47d0a6906c16647e383d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4c8d96da2dcd47d0a6906c16647e383d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 10, p e0139564 (2015)","raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/ecb28296-3cd1-45bd-9523-549d7f7f0559","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/173149854/The-foreign-body-giant-cell-cannot-resorb-bone-but-dissolves-hydroxyapatite-like-osteoclasts.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ten Harkel, B, Schoenmaker, T, Picavet, D I, Davison, N L, de Vries, T J & Everts, V 2015, 'The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts', PLoS ONE, vol. 10, no. 10, pp. e0139564. https://doi.org/10.1371/journal.pone.0139564","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ut:oai:ris.utwente.nl:publications/82796f33-66a7-44f4-b5c8-1508c4db1634","doi":null,"is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/82796f33-66a7-44f4-b5c8-1508c4db1634","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10(10):e0139564. Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/b52a1211-eb64-4f94-83e3-604bbdfc7768","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/the-foreign-body-giant-cell-cannot-resorb-bone-but-dissolves-hydroxyapatite-like-osteoclasts(b52a1211-eb64-4f94-83e3-604bbdfc7768).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10(10):e0139564. Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/51b6a4c1-ce53-4afd-952f-b267bc8d406b","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/51b6a4c1-ce53-4afd-952f-b267bc8d406b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 10(10):e0139564. Public Library of Science","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0139564","doi":"https://doi.org/10.1371/journal.pone.0139564","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0139564","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139564&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2197489357.pdf","grobid_xml":"https://content.openalex.org/works/W2197489357.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W81993338","https://openalex.org/W105474794","https://openalex.org/W1512269824","https://openalex.org/W1680443751","https://openalex.org/W1817443571","https://openalex.org/W1827936963","https://openalex.org/W1973218003","https://openalex.org/W1976873827","https://openalex.org/W1984980924","https://openalex.org/W1996671842","https://openalex.org/W2006582030","https://openalex.org/W2012815797","https://openalex.org/W2020800101","https://openalex.org/W2024160470","https://openalex.org/W2025062557","https://openalex.org/W2031108531","https://openalex.org/W2038326581","https://openalex.org/W2040191185","https://openalex.org/W2045491514","https://openalex.org/W2045828273","https://openalex.org/W2047169413","https://openalex.org/W2054514016","https://openalex.org/W2066718836","https://openalex.org/W2071962830","https://openalex.org/W2091122219","https://openalex.org/W2094539147","https://openalex.org/W2099993797","https://openalex.org/W2100566062","https://openalex.org/W2103722820","https://openalex.org/W2107277218","https://openalex.org/W2111239144","https://openalex.org/W2114360920","https://openalex.org/W2114679118","https://openalex.org/W2123180563","https://openalex.org/W2123318646","https://openalex.org/W2129864520","https://openalex.org/W2132235989","https://openalex.org/W2138313400","https://openalex.org/W2141824025","https://openalex.org/W2160331845","https://openalex.org/W2164944202","https://openalex.org/W2169802840","https://openalex.org/W2242584790"],"related_works":["https://openalex.org/W7127626492","https://openalex.org/W6889584023","https://openalex.org/W2043555561","https://openalex.org/W2060630366","https://openalex.org/W2054514016","https://openalex.org/W2072466744","https://openalex.org/W2425227402","https://openalex.org/W2138142537","https://openalex.org/W2522157139"],"abstract_inverted_index":{"Foreign":[0],"body":[1],"multinucleated":[2,174],"giant":[3],"cells":[4,175,295],"(FBGCs)":[5],"and":[6,24,38,95,120,139,161,182,221,245,274,353],"osteoclasts":[7,36,73,96,246],"share":[8],"several":[9],"characteristics,":[10],"like":[11,59],"a":[12,136,152,184,236,300,350],"common":[13,101],"myeloid":[14],"precursor":[15,104],"cell,":[16],"multinuclearity,":[17],"expression":[18,142,242],"of":[19,43,56,85,109,131,135,165,187,208,250,258,327,342,349],"tartrate-resistant":[20],"acid":[21],"phosphatase":[22],"(TRAcP)":[23],"dendritic":[25],"cell-specific":[26],"transmembrane":[27],"protein":[28,263],"(DC-STAMP).":[29],"However,":[30,231,332],"there":[31],"is":[32,71,79,226],"an":[33,64,87],"important":[34,65],"difference:":[35],"form":[37,47,235],"reside":[39],"in":[40,97,278,304],"the":[41,54,205,211,240,256,280,293,320,324,339,347],"vicinity":[42],"bone,":[44,76,177,198,328,343],"while":[45],"FBGCs":[46,82,94,179,192,214,244,318],"only":[48],"under":[49],"pathological":[50],"conditions":[51],"or":[52],"at":[53,210],"surface":[55],"foreign":[57],"materials,":[58],"medical":[60],"implants.":[61],"Despite":[62],"similarities,":[63],"distinction":[66],"between":[67,158],"these":[68],"cell":[69,112,147,170],"types":[70,113,148,171],"that":[72,225,252,317],"can":[74],"resorb":[75,197],"but":[77,178],"it":[78],"unknown":[80],"whether":[81],"are":[83,253,334],"capable":[84],"such":[86,126],"activity.":[88,313],"To":[89],"investigate":[90],"this,":[91],"we":[92],"differentiated":[93,172],"vitro":[98],"from":[99],"their":[100],"CD14+":[102],"monocyte":[103],"cells,":[105],"using":[106],"different":[107],"sets":[108],"cytokines.":[110],"Both":[111,169],"were":[114,149,180,193,201,296],"cultured":[115,150],"on":[116,151,176],"bovine":[117],"bone":[118,128,159,209],"slices":[119],"analyzed":[121],"for":[122],"typical":[123],"osteoclast":[124],"features,":[125],"as":[127],"resorption,":[129],"presence":[130],"actin":[132,217],"rings,":[133,218],"formation":[134],"ruffled":[137,237,351],"border,":[138],"characteristic":[140],"gene":[141,241],"over":[143],"time.":[144],"Additionally,":[145],"both":[146],"biomimetic":[153,301],"hydroxyapatite":[154,302],"coating":[155,303],"to":[156,190,196,203,228,298,322,330,337,346],"discriminate":[157],"resorption":[160],"mineral":[162,206,259,325],"dissolution":[163,257],"independent":[164],"organic":[166],"matrix":[167,281,340],"proteolysis.":[168],"into":[173],"larger":[181],"had":[183],"higher":[185],"number":[186],"nuclei":[188],"compared":[189],"osteoclasts.":[191,331],"not":[194,234,335],"able":[195,202,297,336],"yet":[199],"they":[200,232,333],"dissolve":[204,299,323],"fraction":[207,341],"surface.":[212],"Remarkably,":[213],"also":[215],"expressed":[216,247,289],"podosome":[219],"belts":[220],"sealing":[222],"zones--cytoskeletal":[223],"organization":[224],"considered":[227],"be":[229],"osteoclast-specific.":[230],"did":[233],"border.":[238],"At":[239],"level,":[243],"similar":[248,329],"levels":[249],"mRNAs":[251],"associated":[254],"with":[255],"(e.g.,":[260],"anion":[261],"exchange":[262],"2":[264,268],"(AE2),":[265],"carbonic":[266],"anhydrase":[267],"(CAII),":[269],"chloride":[270],"channel":[271],"7":[272],"(CIC7),":[273],"vacuolar-type":[275],"H+-ATPase":[276],"(v-ATPase)),":[277],"contrast":[279],"degrading":[282],"enzyme":[283,312],"cathepsin":[284,354],"K,":[285],"which":[286,306],"was":[287,307],"hardly":[288],"by":[290,309],"FBGCs.":[291],"Functionally,":[292],"latter":[294],"vitro,":[305],"blocked":[308],"inhibiting":[310],"v-ATPase":[311],"These":[314],"results":[315],"show":[316],"have":[319],"capacity":[321],"phase":[326],"digest":[338],"likely":[344],"due":[345],"lack":[348],"border":[352],"K.":[355]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}