{"id":"https://openalex.org/W2196957880","doi":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","title":"Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method","display_name":"Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method","publication_year":1956,"publication_date":"1956-09-30","ids":{"openalex":"https://openalex.org/W2196957880","doi":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","mag":"2196957880","pmid":"https://pubmed.ncbi.nlm.nih.gov/13362583"},"language":"en","primary_location":{"id":"doi:10.1152/ajplegacy.1956.187.1.15","doi":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109411487","display_name":"R. Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Steele","raw_affiliation_strings":["From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City","institution_ids":["https://openalex.org/I200870766","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047776495","display_name":"J. S. Wall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. S. Wall","raw_affiliation_strings":["From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City","institution_ids":["https://openalex.org/I200870766","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018234469","display_name":"R. C. de Bodo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. C. de Bodo","raw_affiliation_strings":["From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City","institution_ids":["https://openalex.org/I200870766","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047916998","display_name":"NORMAN ALTSZULER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Altszuler","raw_affiliation_strings":["From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Brookhaven National Laboratory, Upton, New York, and the Department of Pharmacology, New York University College of Medicine, New York City","institution_ids":["https://openalex.org/I200870766","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7752,"has_fulltext":false,"cited_by_count":811,"citation_normalized_percentile":{"value":0.96851734,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"187","issue":"1","first_page":"15","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.44600000977516174,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.44600000977516174,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.35350000858306885,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotope-dilution","display_name":"isotope dilution","score":0.906000018119812},{"id":"https://openalex.org/keywords/carbon-14-labeled-glucose","display_name":"carbon-14 labeled glucose","score":0.847000002861023},{"id":"https://openalex.org/keywords/compartmental-analysis","display_name":"compartmental analysis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/postabsorptive-state","display_name":"postabsorptive state","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glucose-kinetics","display_name":"glucose kinetics","score":0.40400001406669617},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6854504346847534},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.6570613384246826},{"id":"https://openalex.org/C86132830","wikidata":"https://www.wikidata.org/wiki/Q3308838","display_name":"Outflow","level":2,"score":0.5037979483604431},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.4990346431732178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4426172077655792},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42087316513061523},{"id":"https://openalex.org/C2776132308","wikidata":"https://www.wikidata.org/wiki/Q11070850","display_name":"Inflow","level":2,"score":0.4140959680080414},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2634887099266052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1972876489162445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12867668271064758},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007554","descriptor_name":"Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplegacy.1956.187.1.15","doi":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1956.187.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},{"id":"pmid:13362583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13362583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1511288226","https://openalex.org/W2181947976","https://openalex.org/W2032848796","https://openalex.org/W2281375185","https://openalex.org/W6995294845","https://openalex.org/W2153716175","https://openalex.org/W1826779723","https://openalex.org/W331151755","https://openalex.org/W2232394738","https://openalex.org/W1963150643"],"abstract_inverted_index":{"Glucose":[0],"uniformly":[1],"labeled":[2],"with":[3,83,113,241,247],"C14":[4,28],"was":[5,34,47,120,178],"administered":[6],"intravenously":[7],"in":[8,14,72,99,130,238],"minute":[9],"amounts":[10,96],"to":[11,44,123,154,191,205,212,221],"unanesthetized":[12],"dogs":[13,244],"the":[15,31,39,49,58,62,66,76,84,95,103,114,125,128,162,173,196],"postabsorptive":[16],"state":[17],"as":[18],"an":[19,183],"initial":[20,189],"dose":[21,43,153,190],"followed":[22],"by":[23,253,262],"a":[24,73,89,215,223],"continuous":[25],"infusion.":[26],"The":[27,255],"content":[29],"of":[30,41,61,78,92,97,109,127,151,186,188,228,258],"plasma":[32,50,85,115],"glucose":[33,51,82,86,98,110,116,132,175,230,234],"determined":[35],"at":[36,105,148],"intervals.":[37],"When":[38],"ratio":[40],"priming":[42,152],"infusion":[45,155,192],"rate":[46,139,193,236],"suitable,":[48],"specific":[52],"activity":[53],"remained":[54],"relatively":[55],"constant":[56],"during":[57,65],"60\u2013180-minute":[59],"period":[60],"infusion,":[63],"whereas":[64],"first":[67],"60":[68],"minutes":[69],"it":[70,208],"decreased":[71],"manner":[74],"indicating":[75],"presence":[77],"two":[79],"compartments":[80,101],"exchanging":[81],"compartment.":[87],"For":[88],"typical":[90],"experiment":[91,217],"this":[93],"kind,":[94],"these":[100,107,259],"and":[102,135,233],"rates":[104],"which":[106,140,195,249],"bodies":[108],"underwent":[111],"mixing":[112,170],"were":[117],"calculated.":[118],"It":[119,177],"then":[121],"possible":[122],"determine":[124],"magnitude":[126],"errors":[129,158,197],"body":[131,174,229],"pool":[133,231],"size":[134,232],"inflow-outflow":[136,235],"(i.e.,":[137],"turnover)":[138],"are":[141,145,159,198,245],"made":[142,167],"when":[143,161],"measurements":[144],"carried":[146],"out":[147,214],"various":[149],"ratios":[150,187],"rate.":[156],"These":[157],"incurred":[160],"usual":[163],"simplifying":[164],"assumption":[165],"is":[166,182,209,265],"that":[168,180],"instantaneous":[169],"occurs":[171],"throughout":[172],"pool.":[176],"found":[179],"there":[181],"extensive":[184],"range":[185],"over":[194],"small":[199],"enough":[200],"(less":[201],"than":[202],"\u00b1":[203],"5%)":[204],"be":[206],"ignored;":[207],"not":[210],"necessary":[211],"carry":[213],"preliminary":[216],"on":[218],"each":[219],"dog":[220],"establish":[222],"desirable":[224],"ratio.":[225],"Average":[226],"values":[227,248],"obtained":[237],"10":[239],"experiments":[240],"seven":[242],"normal":[243],"compared":[246],"have":[250],"been":[251],"reported":[252],"others.":[254],"physiological":[256],"significance":[257],"parameters":[260],"measured":[261],"isotope":[263],"dilution":[264],"discussed.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}