{"id":"https://openalex.org/W2196739769","doi":"https://doi.org/10.1074/jbc.m115.661819","title":"Pore Hydration States of KcsA Potassium Channels in Membranes","display_name":"Pore Hydration States of KcsA Potassium Channels in Membranes","publication_year":2015,"publication_date":"2015-09-15","ids":{"openalex":"https://openalex.org/W2196739769","doi":"https://doi.org/10.1074/jbc.m115.661819","mag":"2196739769","pmid":"https://pubmed.ncbi.nlm.nih.gov/26370089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646329"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.661819","doi":"https://doi.org/10.1074/jbc.m115.661819","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.661819","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m115.661819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109235672","display_name":"Joseph R. Blasic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4389425230","display_name":"Institute for Bioscience and Biotechnology Research","ror":"https://ror.org/02zs3hb12","country_code":"US","type":"facility","lineage":["https://openalex.org/I126744593","https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4389425230","https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Blasic","raw_affiliation_strings":["From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","institution_ids":["https://openalex.org/I4389425230"]},{"raw_affiliation_string":"Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","institution_ids":["https://openalex.org/I4389425230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038259930","display_name":"David L. Worcester","orcid":"https://orcid.org/0000-0002-6140-9606","observed_orcids":["https://orcid.org/0000-0002-6140-9606"]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210159838","display_name":"NIST Center for Neutron Research","ror":"https://ror.org/05qgcra83","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210159838"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Worcester","raw_affiliation_strings":["the Department of Physiology and Biophysics, University of California, Irvine, California 92697, the National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, Maryland 20899","Department of Physiology and Biophysics, University of California, Irvine, California 92697","the National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, Maryland 20899"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Physiology and Biophysics, University of California, Irvine, California 92697, the National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, Maryland 20899","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I204250578","https://openalex.org/I4210159838"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"the National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, Maryland 20899","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I4210159838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052880769","display_name":"Klaus Gawrisch","orcid":"https://orcid.org/0000-0002-0841-1539","observed_orcids":["https://orcid.org/0000-0002-0841-1539"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus Gawrisch","raw_affiliation_strings":["the Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056043768","display_name":"Philip A. Gurnev","orcid":"https://orcid.org/0000-0001-9247-5027","observed_orcids":["https://orcid.org/0000-0001-9247-5027"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"id":"https://openalex.org/I4389425230","display_name":"Institute for Bioscience and Biotechnology Research","ror":"https://ror.org/02zs3hb12","country_code":"US","type":"facility","lineage":["https://openalex.org/I126744593","https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4389425230","https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Gurnev","raw_affiliation_strings":["the Physics Department, University of Massachusetts, Amherst, Massachusetts 01003, and From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","the Physics Department, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Physics Department, University of Massachusetts, Amherst, Massachusetts 01003, and From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","institution_ids":["https://openalex.org/I24603500","https://openalex.org/I4389425230"]},{"raw_affiliation_string":"the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"the Physics Department, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065541160","display_name":"Mihaela Mihailescu","orcid":"https://orcid.org/0000-0002-9788-5655","observed_orcids":["https://orcid.org/0000-0002-9788-5655"]},"institutions":[{"id":"https://openalex.org/I4389425230","display_name":"Institute for Bioscience and Biotechnology Research","ror":"https://ror.org/02zs3hb12","country_code":"US","type":"facility","lineage":["https://openalex.org/I126744593","https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4389425230","https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mihaela Mihailescu","raw_affiliation_strings":["From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850, emihailescu@ibbr.umd.edu","Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850, emihailescu@ibbr.umd.edu","institution_ids":["https://openalex.org/I4389425230"]},{"raw_affiliation_string":"Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850","institution_ids":["https://openalex.org/I4389425230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5065541160"],"corresponding_institution_ids":["https://openalex.org/I4389425230"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.2893,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.59161165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"290","issue":"44","first_page":"26765","last_page":"26775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcsa-potassium-channel","display_name":"KcsA potassium channel","score":0.9350000023841858},{"id":"https://openalex.org/keywords/proton-channel","display_name":"proton channel","score":0.515999972820282},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.6000000238418579},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tetrabutylammonium","display_name":"tetrabutylammonium","score":0.8349999785423279},{"id":"https://openalex.org/keywords/selectivity-filter","display_name":"selectivity filter","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neutron-diffraction","display_name":"neutron diffraction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/solid-state-nmr","display_name":"solid-state NMR","score":0.75},{"id":"https://openalex.org/keywords/hydrophobic-cavity","display_name":"hydrophobic cavity","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C45516822","wikidata":"https://www.wikidata.org/wiki/Q6382011","display_name":"KcsA potassium channel","level":4,"score":0.9461218118667603},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6095607280731201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5851162075996399},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5177375674247742},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4549632966518402},{"id":"https://openalex.org/C73585123","wikidata":"https://www.wikidata.org/wiki/Q910499","display_name":"Neutron diffraction","level":3,"score":0.4511132538318634},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.4133446514606476},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3844265937805176},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.37185898423194885},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.10515791177749634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09632551670074463},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010715","descriptor_name":"Phosphatidylglycerols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048170","descriptor_name":"Streptomyces lividans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048170","descriptor_name":"Streptomyces lividans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m115.661819","doi":"https://doi.org/10.1074/jbc.m115.661819","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.661819","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4030992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4646329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4646329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:26370089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26370089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.661819","doi":"https://doi.org/10.1074/jbc.m115.661819","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.661819","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5930657035","display_name":null,"funder_award_id":"GM-86685","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7984663305","display_name":"Making Sense of Voltage Sensors","funder_award_id":"P01GM086685","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000209648","display_name":null,"funder_award_id":"GM86685","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1517714742","https://openalex.org/W1947778485","https://openalex.org/W1963480981","https://openalex.org/W1969129798","https://openalex.org/W1970960203","https://openalex.org/W1980318325","https://openalex.org/W1988901585","https://openalex.org/W1989764838","https://openalex.org/W1990551042","https://openalex.org/W1990866743","https://openalex.org/W1997048904","https://openalex.org/W2006090981","https://openalex.org/W2006177920","https://openalex.org/W2021801729","https://openalex.org/W2026733600","https://openalex.org/W2028505648","https://openalex.org/W2032734987","https://openalex.org/W2037991961","https://openalex.org/W2051894265","https://openalex.org/W2054864208","https://openalex.org/W2057990041","https://openalex.org/W2065818918","https://openalex.org/W2066070661","https://openalex.org/W2067177623","https://openalex.org/W2068636421","https://openalex.org/W2069888185","https://openalex.org/W2070206101","https://openalex.org/W2070607949","https://openalex.org/W2077082977","https://openalex.org/W2084307938","https://openalex.org/W2091775757","https://openalex.org/W2105120291","https://openalex.org/W2106260465","https://openalex.org/W2109258309","https://openalex.org/W2124653618","https://openalex.org/W2138980535","https://openalex.org/W2143070723","https://openalex.org/W2143125286","https://openalex.org/W2144860443","https://openalex.org/W2156008447","https://openalex.org/W2160498055","https://openalex.org/W2162314649","https://openalex.org/W2164829352","https://openalex.org/W2950069625","https://openalex.org/W4211151288","https://openalex.org/W4255370921"],"related_works":["https://openalex.org/W2051163971","https://openalex.org/W2025418098","https://openalex.org/W2144070114","https://openalex.org/W1999929223","https://openalex.org/W2729302170","https://openalex.org/W1999026764","https://openalex.org/W2134855730","https://openalex.org/W2111208593","https://openalex.org/W2167437483","https://openalex.org/W4391312457"],"abstract_inverted_index":{"Water-filled":[0],"hydrophobic":[1],"cavities":[2],"in":[3,29,34,58,68,76,150,173,182],"channel":[4,41,57,91,101,116,183],"proteins":[5],"serve":[6],"as":[7],"gateways":[8],"for":[9],"transfer":[10],"of":[11,47,50,64,71,96,136,143,171,179],"ions":[12],"across":[13,122],"membranes,":[14],"but":[15],"their":[16,151],"properties":[17],"are":[18,146],"largely":[19],"unknown.":[20],"We":[21],"determined":[22,162],"water":[23,65,75,86,97,120,144,158],"distributions":[24],"along":[25],"the":[26,44,55,59,62,69,72,77,82,90,100,113,123,130,133,154,176],"conduction":[27],"pores":[28],"two":[30,141],"tetrameric":[31],"channels":[32,172],"embedded":[33],"lipid":[35],"bilayers":[36],"using":[37,104],"neutron":[38,105],"diffraction:":[39],"potassium":[40],"KcsA":[42,56],"and":[43,107,159,169,175],"transmembrane":[45],"domain":[46],"M2":[48,114],"protein":[49,160],"influenza":[51],"A":[52],"virus.":[53],"For":[54],"closed":[60],"state,":[61],"distribution":[63,145],"is":[66,87],"peaked":[67],"middle":[70],"membrane,":[73,124],"showing":[74],"central":[78],"cavity":[79],"adjacent":[80],"to":[81,153],"selectivity":[83],"filter.":[84],"This":[85],"displaced":[88],"by":[89],"blocker":[92],"tetrabutyl-ammonium.":[93],"The":[94,157],"amount":[95],"associated":[98],"with":[99,125],"was":[102],"quantified,":[103],"diffraction":[106],"solid":[108],"state":[109],"NMR.":[110],"In":[111],"contrast,":[112],"proton":[115],"shows":[117],"a":[118,126],"V-shaped":[119],"profile":[121],"narrow":[127],"constriction":[128],"at":[129],"center,":[131],"like":[132],"hourglass":[134],"shape":[135],"its":[137],"internal":[138],"surface.":[139],"These":[140],"types":[142],"therefore":[147],"very":[148],"different":[149],"connectivity":[152],"bulk":[155],"water.":[156],"profiles":[161],"here":[163],"provide":[164],"important":[165],"evidence":[166],"concerning":[167],"conformation":[168],"hydration":[170,181],"membranes":[174],"potential":[177],"role":[178],"pore":[180],"gating.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
