{"id":"https://openalex.org/W2196509347","doi":null,"title":"Beta-blockers for heart failure: an evidence based review answering practical therapeutic questions.","display_name":"Beta-blockers for heart failure: an evidence based review answering practical therapeutic questions.","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2196509347","mag":"2196509347","pmid":"https://pubmed.ncbi.nlm.nih.gov/22582541"},"language":"en","primary_location":{"id":"pmid:22582541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22582541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical journal of Malaysia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077039848","display_name":"Hean Teik Ong","orcid":"https://orcid.org/0000-0001-8429-7670","observed_orcids":["https://orcid.org/0000-0001-8429-7670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H T Ong","raw_affiliation_strings":["HT Ong Heart Clinic, Cardiology, 251C Burma Road, Georgetown, Penang 10350, Malaysia. ongheanteik@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HT Ong Heart Clinic, Cardiology, 251C Burma Road, Georgetown, Penang 10350, Malaysia. ongheanteik@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109419461","display_name":"L M Ong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Ong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089253870","display_name":"F P Kow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P Kow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0323,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78724814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"67","issue":"1","first_page":"7","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisoprolol","display_name":"bisoprolol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/metoprolol-succinate","display_name":"metoprolol succinate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metoprolol-tartrate","display_name":"metoprolol tartrate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nebivolol","display_name":"nebivolol","score":1.0},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8149999976158142},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.8339999914169312},{"id":"https://openalex.org/keywords/acute-decompensated-heart-failure","display_name":"acute decompensated heart failure","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bronchospasm","display_name":"bronchospasm","score":0.9929999709129333},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2779670145","wikidata":"https://www.wikidata.org/wiki/Q412515","display_name":"Bisoprolol","level":3,"score":0.9745594263076782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9563145637512207},{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.9480891227722168},{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.8408054709434509},{"id":"https://openalex.org/C2777537511","wikidata":"https://www.wikidata.org/wiki/Q418130","display_name":"Nebivolol","level":3,"score":0.8205684423446655},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.758739709854126},{"id":"https://openalex.org/C2909447574","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol Tartrate","level":3,"score":0.6498275399208069},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.6386191844940186},{"id":"https://openalex.org/C2778088044","wikidata":"https://www.wikidata.org/wiki/Q279330","display_name":"Bronchospasm","level":3,"score":0.580451250076294},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5736613869667053},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4293522834777832},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.41020750999450684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39690566062927246},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38548287749290466},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32896992564201355},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1418505609035492},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22582541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22582541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical journal of Malaysia","raw_type":"Journal Article"},{"id":"mag:2196509347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22582541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W52877415","https://openalex.org/W136210392","https://openalex.org/W172609984","https://openalex.org/W1509404622","https://openalex.org/W1548375036","https://openalex.org/W1964744163","https://openalex.org/W1974194776","https://openalex.org/W1975704641","https://openalex.org/W1980649708","https://openalex.org/W1981932764","https://openalex.org/W1982266755","https://openalex.org/W1983059396","https://openalex.org/W1985431801","https://openalex.org/W1989247444","https://openalex.org/W2009930118","https://openalex.org/W2016102355","https://openalex.org/W2016736407","https://openalex.org/W2023044098","https://openalex.org/W2027114537","https://openalex.org/W2034324117","https://openalex.org/W2035674932","https://openalex.org/W2041444364","https://openalex.org/W2044178472","https://openalex.org/W2058169534","https://openalex.org/W2069685451","https://openalex.org/W2071149967","https://openalex.org/W2074247530","https://openalex.org/W2077272643","https://openalex.org/W2094174373","https://openalex.org/W2096910942","https://openalex.org/W2109712401","https://openalex.org/W2112650958","https://openalex.org/W2114333967","https://openalex.org/W2122290203","https://openalex.org/W2122559873","https://openalex.org/W2124282595","https://openalex.org/W2129967926","https://openalex.org/W2130738558","https://openalex.org/W2134169764","https://openalex.org/W2134212326","https://openalex.org/W2136145230","https://openalex.org/W2136642260","https://openalex.org/W2140348725","https://openalex.org/W2146157538","https://openalex.org/W2147892763","https://openalex.org/W2154143064","https://openalex.org/W2164324917","https://openalex.org/W2167760816","https://openalex.org/W2170601562","https://openalex.org/W2172025889","https://openalex.org/W2185647118","https://openalex.org/W2296998040","https://openalex.org/W2413991898","https://openalex.org/W2501742968","https://openalex.org/W2582861166","https://openalex.org/W2586400969","https://openalex.org/W2992490956","https://openalex.org/W2998034180","https://openalex.org/W3001949083","https://openalex.org/W4230893588"],"related_works":["https://openalex.org/W7098901707","https://openalex.org/W2413266036","https://openalex.org/W3210782531","https://openalex.org/W2335755823","https://openalex.org/W2078234204","https://openalex.org/W31155387","https://openalex.org/W7044131560","https://openalex.org/W4327850730","https://openalex.org/W4389448818","https://openalex.org/W1964221588"],"abstract_inverted_index":{"Beta-blockers":[0],"are":[1,14,24,115],"underutilised":[2],"in":[3,26,43,105,144],"heart":[4,50,89,107,148],"failure":[5,108],"because":[6],"clinicians":[7,135],"may":[8,121],"be":[9,19,64,97,124],"unsure":[10],"whether":[11,22],"all":[12],"beta-blockers":[13,23,114],"useful,":[15],"how":[16],"therapy":[17],"should":[18,63,96,133],"initiated":[20],"and":[21,31,41,59,77,92,136],"contraindicated":[25,117],"some":[27],"patients.":[28],"Bisoprolol,":[29],"carvedilol":[30],"metoprolol":[32,57,75],"succinate":[33],"have":[34,122],"been":[35],"clearly":[36],"proven":[37],"to":[38,48,86,123,139],"reduce":[39],"mortality":[40],"hospitalisation":[42],"patients":[44,145],"with":[45,111,146],"Class":[46],"II":[47],"IV":[49],"failure;":[51],"limited":[52],"evidence":[53],"also":[54],"support":[55],"short-acting":[56],"tartrate":[58],"nebivolol.":[60],"Initiating":[61],"dose":[62,95,120],"very":[65],"low":[66],"(1.25":[67],"mg":[68,71,74],"bisoprolol,":[69],"3.125":[70],"carvedilol,":[72],"12.5":[73],"succinate)":[76],"increased":[78],"gradually":[79],"over":[80],"weeks.":[81],"Treatment":[82],"benefit":[83],"appears":[84],"proportional":[85],"magnitude":[87],"of":[88],"rate":[90],"reduction":[91],"thus":[93],"target":[94],"the":[98,119],"maximum":[99],"tolerated":[100],"for":[101],"adequate":[102],"bradycardia.":[103],"Even":[104],"decompensated":[106],"or":[109,126],"those":[110],"coexisting":[112],"bronchospasm,":[113],"not":[116],"although":[118],"reduced":[125],"withheld":[127],"temporarily.":[128],"The":[129],"consistent":[130],"trial":[131],"data":[132],"reassure":[134],"encourage":[137],"them":[138],"confidently":[140],"initiate":[141],"beta":[142],"blockers":[143],"systolic":[147],"failure.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}