{"id":"https://openalex.org/W2196366477","doi":null,"title":"Autoinducer 2-based quorum sensing response of Escherichia coli to sub-therapeutic tetracycline exposure","display_name":"Autoinducer 2-based quorum sensing response of Escherichia coli to sub-therapeutic tetracycline exposure","publication_year":2006,"publication_date":"2006-10-30","ids":{"openalex":"https://openalex.org/W2196366477","mag":"2196366477"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/4198","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/bitstreams/ac15f50b-0145-417c-bea8-e27a063af25e/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101569049","display_name":"Lingeng Lu","orcid":"https://orcid.org/0000-0001-9871-0809","observed_orcids":["https://orcid.org/0000-0001-9871-0809"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lingeng Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9871-0809","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101569049"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoinducer-2","display_name":"autoinducer-2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.9909999966621399},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antimicrobial-resistance-plasmids","display_name":"antibiotic resistance plasmids","score":0.8500000238418579},{"id":"https://openalex.org/keywords/plasmid-conjugation","display_name":"plasmid conjugation","score":0.796999990940094},{"id":"https://openalex.org/keywords/rp4-plasmid","display_name":"RP4 plasmid","score":0.8799999952316284},{"id":"https://openalex.org/keywords/transconjugation","display_name":"transconjugation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/food-safety","display_name":"food safety","score":0.5730000138282776},{"id":"https://openalex.org/keywords/meat-samples","display_name":"meat samples","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.9420548677444458},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.877758800983429},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.8774916529655457},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6260486841201782},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6248507499694824},{"id":"https://openalex.org/C95282255","wikidata":"https://www.wikidata.org/wiki/Q4826353","display_name":"Autoinducer","level":5,"score":0.5518874526023865},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5061787962913513},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4776947796344757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.413519024848938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36183083057403564},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.324546217918396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28908252716064453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15837064385414124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09065890312194824},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.05398571491241455}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/4198","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/bitstreams/ac15f50b-0145-417c-bea8-e27a063af25e/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2196366477","doi":null,"is_oa":false,"landing_page_url":"http://oaktrust.library.tamu.edu/bitstream/handle/1969.1/4198/etd-tamu-2004B-FSTC-Lu.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W34287084","https://openalex.org/W58688778","https://openalex.org/W73930336","https://openalex.org/W1483156815","https://openalex.org/W1505015935","https://openalex.org/W1519243375","https://openalex.org/W1532877272","https://openalex.org/W1538744213","https://openalex.org/W1553714112","https://openalex.org/W1561161356","https://openalex.org/W1563057536","https://openalex.org/W1565218818","https://openalex.org/W1570512758","https://openalex.org/W1571835453","https://openalex.org/W1576056687","https://openalex.org/W1578180068","https://openalex.org/W1579174902","https://openalex.org/W1581591524","https://openalex.org/W1602956225","https://openalex.org/W1671649413","https://openalex.org/W1703657909","https://openalex.org/W1730089026","https://openalex.org/W1791865039","https://openalex.org/W1802959093","https://openalex.org/W1827772617","https://openalex.org/W1851276803","https://openalex.org/W1858588481","https://openalex.org/W1864068949","https://openalex.org/W1869672696","https://openalex.org/W1895584462","https://openalex.org/W1895988065","https://openalex.org/W1897512913","https://openalex.org/W1899978364","https://openalex.org/W1922086601","https://openalex.org/W1927570869","https://openalex.org/W1934181521","https://openalex.org/W1945265201","https://openalex.org/W1956569867","https://openalex.org/W1959548112","https://openalex.org/W1967016876","https://openalex.org/W1967056998","https://openalex.org/W1967446141","https://openalex.org/W1969286524","https://openalex.org/W1969395262","https://openalex.org/W1971289275","https://openalex.org/W1973091470","https://openalex.org/W1973805672","https://openalex.org/W1975393437","https://openalex.org/W1978541321","https://openalex.org/W1985393441","https://openalex.org/W1986125183","https://openalex.org/W1987835005","https://openalex.org/W1993616876","https://openalex.org/W1993678265","https://openalex.org/W1994064950","https://openalex.org/W1994462493","https://openalex.org/W1996135784","https://openalex.org/W1996505314","https://openalex.org/W1996872292","https://openalex.org/W2003837616","https://openalex.org/W2005009733","https://openalex.org/W2005874691","https://openalex.org/W2008119892","https://openalex.org/W2008477522","https://openalex.org/W2009828459","https://openalex.org/W2010203249","https://openalex.org/W2012635468","https://openalex.org/W2013719025","https://openalex.org/W2014580856","https://openalex.org/W2014871293","https://openalex.org/W2016402044","https://openalex.org/W2018206858","https://openalex.org/W2020135617","https://openalex.org/W2024711659","https://openalex.org/W2024799321","https://openalex.org/W2027659554","https://openalex.org/W2033647833","https://openalex.org/W2035639577","https://openalex.org/W2035890664","https://openalex.org/W2035999312","https://openalex.org/W2040274713","https://openalex.org/W2040386900","https://openalex.org/W2040641257","https://openalex.org/W2041695050","https://openalex.org/W2042544884","https://openalex.org/W2043668977","https://openalex.org/W2045643333","https://openalex.org/W2051108092","https://openalex.org/W2054016534","https://openalex.org/W2056932987","https://openalex.org/W2057474502","https://openalex.org/W2057802070","https://openalex.org/W2060182791","https://openalex.org/W2060779329","https://openalex.org/W2064612941","https://openalex.org/W2064758115","https://openalex.org/W2065212787","https://openalex.org/W2065327814","https://openalex.org/W2065641899","https://openalex.org/W2067527532","https://openalex.org/W2068371158","https://openalex.org/W2068873942","https://openalex.org/W2069275673","https://openalex.org/W2073944837","https://openalex.org/W2074553810","https://openalex.org/W2074726414","https://openalex.org/W2075135844","https://openalex.org/W2075241168","https://openalex.org/W2078327104","https://openalex.org/W2079698171","https://openalex.org/W2080014614","https://openalex.org/W2080357982","https://openalex.org/W2080597593","https://openalex.org/W2081211831","https://openalex.org/W2085360512","https://openalex.org/W2090401452","https://openalex.org/W2091446851","https://openalex.org/W2091880741","https://openalex.org/W2093245072","https://openalex.org/W2095048146","https://openalex.org/W2095349490","https://openalex.org/W2095960226","https://openalex.org/W2097393614","https://openalex.org/W2098064749","https://openalex.org/W2098159838","https://openalex.org/W2099131077","https://openalex.org/W2099245280","https://openalex.org/W2099321243","https://openalex.org/W2100257322","https://openalex.org/W2101222303","https://openalex.org/W2101376032","https://openalex.org/W2103359264","https://openalex.org/W2104688104","https://openalex.org/W2105920155","https://openalex.org/W2106586422","https://openalex.org/W2107308945","https://openalex.org/W2108281648","https://openalex.org/W2109277022","https://openalex.org/W2109568293","https://openalex.org/W2110951528","https://openalex.org/W2111472993","https://openalex.org/W2112927109","https://openalex.org/W2113177287","https://openalex.org/W2113790776","https://openalex.org/W2115130110","https://openalex.org/W2115315875","https://openalex.org/W2115808190","https://openalex.org/W2120473134","https://openalex.org/W2120846931","https://openalex.org/W2123616171","https://openalex.org/W2123974237","https://openalex.org/W2123991121","https://openalex.org/W2126055663","https://openalex.org/W2126922170","https://openalex.org/W2126945584","https://openalex.org/W2126979693","https://openalex.org/W2127799152","https://openalex.org/W2128311206","https://openalex.org/W2129623714","https://openalex.org/W2129935647","https://openalex.org/W2132758784","https://openalex.org/W2133972092","https://openalex.org/W2134097765","https://openalex.org/W2134153749","https://openalex.org/W2134382101","https://openalex.org/W2135132182","https://openalex.org/W2135452372","https://openalex.org/W2136731386","https://openalex.org/W2137479184","https://openalex.org/W2138579964","https://openalex.org/W2138595033","https://openalex.org/W2139391134","https://openalex.org/W2142596421","https://openalex.org/W2142764066","https://openalex.org/W2142817071","https://openalex.org/W2144569522","https://openalex.org/W2144640625","https://openalex.org/W2146292204","https://openalex.org/W2146646703","https://openalex.org/W2152710136","https://openalex.org/W2153015702","https://openalex.org/W2154819662","https://openalex.org/W2155417932","https://openalex.org/W2157092031","https://openalex.org/W2157706491","https://openalex.org/W2157722878","https://openalex.org/W2157907007","https://openalex.org/W2158083899","https://openalex.org/W2159237341","https://openalex.org/W2161366746","https://openalex.org/W2162483759","https://openalex.org/W2162507824","https://openalex.org/W2165499943","https://openalex.org/W2165611106","https://openalex.org/W2166662833","https://openalex.org/W2167637231","https://openalex.org/W2167748399","https://openalex.org/W2167808578","https://openalex.org/W2168788018","https://openalex.org/W2169029990","https://openalex.org/W2171785935","https://openalex.org/W2263995505","https://openalex.org/W2343208818","https://openalex.org/W2416989861","https://openalex.org/W2419494840","https://openalex.org/W2896771875"],"related_works":["https://openalex.org/W7137862659","https://openalex.org/W2993307133","https://openalex.org/W2127377673","https://openalex.org/W2158083899","https://openalex.org/W2186331897","https://openalex.org/W2099245280","https://openalex.org/W3211493864","https://openalex.org/W2527342783","https://openalex.org/W2960851214","https://openalex.org/W2609229377"],"abstract_inverted_index":{"Autoinducer":[0],"2":[1],"(AI-2)":[2],"is":[3,140],"a":[4],"quorum":[5,214],"sensing":[6,215],"signal":[7],"employed":[8],"by":[9],"bacteria":[10],"to":[11,14,23,32,102,109,113,121,146,155,201,225],"coordinate\\ntheir":[12],"response":[13,221],"environmental":[15,226],"stresses.":[16],"The":[17,56,79,91],"objective":[18],"of":[19,28,36,43,50,69,81,134,151,161,175,212,222,232,240],"this":[20],"study":[21],"was":[22],"determine":[24],"the\\nrelationship":[25],"between":[26],"presence":[27,68,80,150,174],"AI-2":[29,59,82,103,114,147,176,203,219],"molecules,":[30],"exposure":[31],"sub-therapeutic":[33,152],"tetracycline,\\nthe":[34],"expression":[35,133],"genes":[37],"associated":[38],"with":[39],"the":[40,47,67,95,110,132,162,166,173,209,229,236],"conjugal":[41,48],"transfer":[42,49],"antibiotic":[44],"resistance\\nplasmids,":[45],"and":[46,75,189,228,238],"these":[51,206],"plasmids":[52],"in":[53,62,66,87,143,172,184,235],"Escherichia":[54],"coli.":[55,90],"studies":[57,92],"showed\\nthat":[58],"activity":[60,182],"increased":[61,141,169],"Tets":[63,88,98],"E.":[64,89,99],"coli":[65,100],"tetracycline":[70,153],"(2":[71],"\u00b5g/mL)":[72],"under\\nboth":[73],"batch":[74],"continuous":[76],"culture":[77],"conditions.":[78],"molecules":[83,104,115,148],"induced\\ntetracycline":[84],"tolerance":[85],"development":[86],"showed":[93],"that":[94,118,131,199],"survival":[96],"rates\\nof":[97],"exposed":[101,120,145],"were":[105,119],"significantly":[106],"higher":[107],"compared":[108,154],"cells":[111,117,144,224],"not\\nexposed":[112],"or":[116],"only":[122],"LB":[123],"(Lauria-Bertani)":[124],"broth.\\nMolecular":[125],"analyses":[126],"using":[127],"real-time":[128],"PCR":[129],"indicate":[130],"at":[135],"least":[136],"one\\nconjugation-associated":[137],"gene":[138,168],"(trbC)":[139],"9-fold":[142],"in\\nthe":[149,220],"its":[156],"negative":[157],"controls.":[158],"The\\ntransconjugation":[159],"frequency":[160],"plasmid":[163],"RP4":[164],"carrying":[165],"tet(A)":[167],"between\\n10-100":[170],"fold":[171],"molecules.":[177],"In":[178],"companion":[179],"studies,":[180],"AI-2-like":[181],"was\\ndetected":[183],"fish,":[185],"tomatoes,":[186],"cantaloupes,":[187],"carrots":[188],"milk":[190],"samples.":[191],"Interestingly,":[192],"ground":[193],"beef\\nand":[194],"poultry":[195],"meat":[196],"contained":[197],"substances":[198],"appear":[200],"inhibit":[202],"activity.":[204],"Collectively,":[205],"results":[207],"highlight":[208],"potential":[210],"importance":[211],"bacterial":[213,223],"signals":[216,234],"such":[217],"as":[218],"stimuli":[227],"possible":[230],"role":[231],"quorum\\nsensing":[233],"quality":[237],"safety":[239],"foods.":[241]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}