{"id":"https://openalex.org/W2196246201","doi":null,"title":"Plasminogen activator inhibitor-1 4G/5G polymorphism is associated with coronary artery disease risk: a meta-analysis.","display_name":"Plasminogen activator inhibitor-1 4G/5G polymorphism is associated with coronary artery disease risk: a meta-analysis.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2196246201","mag":"2196246201","pmid":"https://pubmed.ncbi.nlm.nih.gov/25419432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238518"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100761457","display_name":"Huifeng Zhang","orcid":"https://orcid.org/0000-0002-9818-7904","observed_orcids":["https://orcid.org/0000-0002-9818-7904"]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifeng Zhang","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061194242","display_name":"Pingshuan Dong","orcid":"https://orcid.org/0000-0002-9862-7367","observed_orcids":["https://orcid.org/0000-0002-9862-7367"]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingshuan Dong","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuming Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuming Yang","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zhenghao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenghao Liu","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China","institution_ids":["https://openalex.org/I4210134906"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210134906"],"apc_list":null,"apc_paid":null,"fwci":0.3133,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.31046119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"10","first_page":"3777","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pai-1-4g-5g-polymorphism","display_name":"PAI-1 4G/5G polymorphism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9490000009536743},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7239999771118164},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/premature-coronary-artery-disease","display_name":"premature coronary artery disease","score":0.8840000033378601},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.671999990940094},{"id":"https://openalex.org/keywords/asian-populations","display_name":"Asian populations","score":0.5920000076293945},{"id":"https://openalex.org/keywords/white-population","display_name":"Caucasian population","score":0.7730000019073486},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.3499999940395355},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.3160000145435333},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5929999947547913},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.3529999852180481},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8419755697250366},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.8117032647132874},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7481679916381836},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.7221947908401489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6726922988891602},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.6706269979476929},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6308141946792603},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46879658102989197}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4238518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:25419432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:2196246201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W33124927","https://openalex.org/W162836990","https://openalex.org/W308616378","https://openalex.org/W1191700713","https://openalex.org/W1505365469","https://openalex.org/W1667162547","https://openalex.org/W1963506094","https://openalex.org/W1964393238","https://openalex.org/W1965430426","https://openalex.org/W1983538052","https://openalex.org/W1983793079","https://openalex.org/W1985578174","https://openalex.org/W1985811959","https://openalex.org/W1989072075","https://openalex.org/W1994905211","https://openalex.org/W2001619160","https://openalex.org/W2006896298","https://openalex.org/W2012366759","https://openalex.org/W2028654766","https://openalex.org/W2032021142","https://openalex.org/W2032102036","https://openalex.org/W2034888656","https://openalex.org/W2039831544","https://openalex.org/W2040990410","https://openalex.org/W2059771162","https://openalex.org/W2062801512","https://openalex.org/W2064487195","https://openalex.org/W2072699133","https://openalex.org/W2075085023","https://openalex.org/W2075311308","https://openalex.org/W2075363297","https://openalex.org/W2077943776","https://openalex.org/W2080626966","https://openalex.org/W2081430694","https://openalex.org/W2089202211","https://openalex.org/W2091984324","https://openalex.org/W2092970462","https://openalex.org/W2096504289","https://openalex.org/W2096544735","https://openalex.org/W2116284648","https://openalex.org/W2116944848","https://openalex.org/W2120303579","https://openalex.org/W2124233487","https://openalex.org/W2124671503","https://openalex.org/W2127198954","https://openalex.org/W2128529644","https://openalex.org/W2130629729","https://openalex.org/W2135565172","https://openalex.org/W2146519773","https://openalex.org/W2149501769","https://openalex.org/W2157823046","https://openalex.org/W2160074973","https://openalex.org/W2169303393","https://openalex.org/W2174849655","https://openalex.org/W2203937556","https://openalex.org/W2264592449","https://openalex.org/W2281293425","https://openalex.org/W2356450261","https://openalex.org/W2408223358","https://openalex.org/W2411331373","https://openalex.org/W2411771797","https://openalex.org/W2418202708","https://openalex.org/W2462594344","https://openalex.org/W2883545750","https://openalex.org/W4253704606"],"related_works":["https://openalex.org/W2410531015","https://openalex.org/W1994905211","https://openalex.org/W4206206428","https://openalex.org/W2080626966","https://openalex.org/W2107409286","https://openalex.org/W653121882","https://openalex.org/W3108817881","https://openalex.org/W2418202708","https://openalex.org/W2462594344","https://openalex.org/W2389963833"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,59,95,115],"aim":[2],"of":[3,12,34,43,83,117],"the":[4,10,62,163,183],"current":[5],"study":[6],"was":[7,69,99,122,130,170,191,235],"to":[8],"evaluate":[9],"association":[11,60,190],"PAI-1":[13,63,96,232],"4G/5G":[14,64,97,233],"polymorphism":[15,65,98,129,152,169,234],"with":[16,102,132,173],"coronary":[17],"artery":[18],"disease":[19],"(CAD)":[20],"risk":[21,68,104,134,156,176,237],"using":[22],"a":[23,32,187,236],"meta-analysis.":[24],"METHODS:":[25],"All":[26],"eligible":[27],"studies":[28,85],"were":[29,92],"identified":[30],"through":[31],"search":[33],"PubMed,":[35],"EMBASE,":[36],"China":[37,50],"National":[38],"Knowledge":[39],"Infrastructure":[40],"(CNKI),":[41],"Database":[42],"Chinese":[44],"Scientific":[45],"and":[46,49,66,75,89,142,205,220],"Technical":[47],"Periodicals,":[48],"Biology":[51],"Medical":[52],"literature":[53],"database":[54],"(CBM)":[55],"before":[56],"June":[57],"2014.":[58],"between":[61],"CAD":[67,103,121,133,175,195,213],"estimated":[70],"by":[71,166],"odds":[72],"ratio":[73],"(OR)":[74],"95%":[76,109,138,145,158,178,198,216,222],"confidence":[77],"interval":[78],"(CI).":[79],"RESULTS:":[80],"A":[81],"total":[82],"72":[84],"including":[86],"23557":[87],"cases":[88],"21526":[90],"controls":[91],"eventually":[93],"collected.":[94],"significant":[100,189],"associated":[101,131,172],"in":[105,135,193],"overall":[106],"population":[107],"(OR=1.19,":[108],"CI":[110,125,139,146,159,179,199,217,223],"1.10-1.28,":[111],"P":[112,148],"<":[113,149],"0.00001).":[114],"combination":[116],"adjusted":[118],"ORs":[119],"for":[120,239],"1.20":[123],"(95%":[124],"1.03-1.40,":[126],"P=0.02).":[127],"This":[128,151,228],"Caucasians":[136],"(OR=1.10,":[137,197],"1.02-1.19,":[140],"P=0.01)":[141],"Asians":[143],"(OR=1.46,":[144],"1.21-1.75,":[147],"0.0001).":[150],"significantly":[153,171],"increased":[154,212],"MI":[155],"(OR=1.15,":[157],"1.06-1.25,":[160],"P=0.001).":[161],"In":[162,182],"subgroup":[164,185],"analysis":[165],"age,":[167],"this":[168],"early-onset":[174],"(OR=1.21,":[177],"1.02-1.43,":[180],"P=0.03).":[181],"gender":[184],"analyses,":[186],"statistically":[188],"found":[192],"male":[194],"patients":[196,204,207],"1.01-1.20,":[200],"P=0.04).":[201],"Both":[202],"T2DM":[203],"non-T2DM":[206],"carrying":[208],"4G":[209],"allele":[210],"showed":[211],"risks":[214],"(OR=2.23,":[215],"1.27-3.92,":[218],"P=0.005":[219],"OR=1.64,":[221],"1.19-2.25,":[224],"P=0.002,":[225],"respectively).":[226],"CONCLUSIONS:":[227],"meta-analysis":[229],"suggested":[230],"that":[231],"factor":[238],"CAD.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
