{"id":"https://openalex.org/W2195992255","doi":"https://doi.org/10.3389/fvets.2015.00055","title":"Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells","display_name":"Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells","publication_year":2015,"publication_date":"2015-11-16","ids":{"openalex":"https://openalex.org/W2195992255","doi":"https://doi.org/10.3389/fvets.2015.00055","mag":"2195992255","pmid":"https://pubmed.ncbi.nlm.nih.gov/26664982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4672282"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2015.00055","doi":"https://doi.org/10.3389/fvets.2015.00055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2015.00055","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2015.00055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fvets.2015.00055/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073471902","display_name":"Emma P. Bavin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335290417","display_name":"Animal Health Trust","ror":"https://ror.org/04npk0q16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1335290417"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma P. Bavin","raw_affiliation_strings":["Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK","institution_ids":["https://openalex.org/I1335290417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078442375","display_name":"Olivia Eilers Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Olivia Smith","raw_affiliation_strings":["D\u00e9partement de biom\u00e9decine v\u00e9t\u00e9rinaire, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de biom\u00e9decine v\u00e9t\u00e9rinaire, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060936908","display_name":"Arabella Baird","orcid":"https://orcid.org/0000-0003-2689-1481","observed_orcids":["https://orcid.org/0000-0003-2689-1481"]},"institutions":[{"id":"https://openalex.org/I1335290417","display_name":"Animal Health Trust","ror":"https://ror.org/04npk0q16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1335290417"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arabella E. G. Baird","raw_affiliation_strings":["Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK","institution_ids":["https://openalex.org/I1335290417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074833069","display_name":"Lawrence Charles Smith","orcid":"https://orcid.org/0000-0001-8766-0148","observed_orcids":["https://orcid.org/0000-0001-8766-0148"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lawrence C. Smith","raw_affiliation_strings":["D\u00e9partement de biom\u00e9decine v\u00e9t\u00e9rinaire, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de biom\u00e9decine v\u00e9t\u00e9rinaire, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000535977","display_name":"Deborah Jane Guest","orcid":"https://orcid.org/0000-0002-0034-3332","observed_orcids":["https://orcid.org/0000-0002-0034-3332"]},"institutions":[{"id":"https://openalex.org/I1335290417","display_name":"Animal Health Trust","ror":"https://ror.org/04npk0q16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1335290417"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Deborah J. Guest","raw_affiliation_strings":["Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Preventive Medicine, Animal Health Trust, Newmarket, UK","institution_ids":["https://openalex.org/I1335290417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000535977"],"corresponding_institution_ids":["https://openalex.org/I1335290417"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.9529,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.70655982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2","issue":null,"first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tendon-differentiation","display_name":"tendon differentiation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tendon-regeneration","display_name":"tendon regeneration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.5879999995231628},{"id":"https://openalex.org/keywords/tendon-injury","display_name":"tendon injury","score":0.8289999961853027},{"id":"https://openalex.org/keywords/artificial-tendons","display_name":"artificial tendons","score":0.7450000047683716},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta3","display_name":"transforming growth factor-beta3","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.625},{"id":"https://openalex.org/keywords/epigenetic-variation","display_name":"epigenetic variation","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8295843601226807},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7366030216217041},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6837546825408936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6154406666755676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5219449400901794},{"id":"https://openalex.org/C23416140","wikidata":"https://www.wikidata.org/wiki/Q6335239","display_name":"KOSR","level":5,"score":0.4349888265132904},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33180806040763855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14044374227523804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0915290117263794}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fvets.2015.00055","doi":"https://doi.org/10.3389/fvets.2015.00055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2015.00055","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2015.00055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3652237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4672282","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26664982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26664982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4672282","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4672282/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:33498bbf478f4fc5baa62d72677c65e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33498bbf478f4fc5baa62d72677c65e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 2 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2015.00055","doi":"https://doi.org/10.3389/fvets.2015.00055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2015.00055","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2015.00055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2870617797","display_name":null,"funder_award_id":"vet/prj/762","funder_id":"https://openalex.org/F4320320638","funder_display_name":"Horserace Betting Levy Board"}],"funders":[{"id":"https://openalex.org/F4320320638","display_name":"Horserace Betting Levy Board","ror":"https://ror.org/02z2a9w02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2195992255.pdf","grobid_xml":"https://content.openalex.org/works/W2195992255.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W198588021","https://openalex.org/W1437092813","https://openalex.org/W1486827600","https://openalex.org/W1519238448","https://openalex.org/W1540921601","https://openalex.org/W1913280318","https://openalex.org/W1966292190","https://openalex.org/W1972334415","https://openalex.org/W1982752306","https://openalex.org/W1987774343","https://openalex.org/W1993314665","https://openalex.org/W1995346025","https://openalex.org/W1996076770","https://openalex.org/W2022015256","https://openalex.org/W2023507189","https://openalex.org/W2025589346","https://openalex.org/W2028103767","https://openalex.org/W2030742673","https://openalex.org/W2033685719","https://openalex.org/W2044848017","https://openalex.org/W2045771535","https://openalex.org/W2052082578","https://openalex.org/W2053911973","https://openalex.org/W2075136524","https://openalex.org/W2078457908","https://openalex.org/W2082059162","https://openalex.org/W2102560467","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2119177157","https://openalex.org/W2126580353","https://openalex.org/W2144868856","https://openalex.org/W2148240349","https://openalex.org/W2152580977","https://openalex.org/W2158594279","https://openalex.org/W2160394785","https://openalex.org/W2164884088","https://openalex.org/W2166599552"],"related_works":["https://openalex.org/W6930426379","https://openalex.org/W2033685719","https://openalex.org/W2019046863","https://openalex.org/W2175337291","https://openalex.org/W3209697066","https://openalex.org/W2231065089","https://openalex.org/W3129030522","https://openalex.org/W1519238448","https://openalex.org/W2973133231","https://openalex.org/W2397940680"],"abstract_inverted_index":{"Tendon":[0],"injuries":[1],"occur":[2],"commonly":[3],"in":[4,71,170,196],"horses":[5,14,87],"and":[6,35,64,141,157,184,204,219],"their":[7,96,221,229],"repair":[8],"through":[9,144],"scar":[10],"tissue":[11,33],"formation":[12],"predisposes":[13],"to":[15,30,73,89,98,135,178,211,217,228],"a":[16,26,114],"high":[17],"rate":[18],"of":[19,39,118,126,131,165,193],"re-injury.":[20,40],"Pluripotent":[21],"stem":[22,48,79],"cells":[23,49,70,80,119,183],"may":[24],"provide":[25,113],"cell":[27,55,110],"replacement":[28],"therapy":[29],"improve":[31],"tendon":[32,54,63,69,101,137,182,198,202],"regeneration":[34],"lower":[36],"the":[37,53,60,124,152,163,175,191,194,205],"frequency":[38],"We":[41],"have":[42,82],"previously":[43],"demonstrated":[44],"that":[45],"equine":[46,215],"embryonic":[47],"(ESCs)":[50],"differentiate":[51,66,99,179],"into":[52,59,67,100,180],"lineage":[56],"upon":[57],"injection":[58],"damaged":[61],"horse":[62,127],"can":[65,105],"functional":[68,181],"vitro":[72,197],"generate":[74,185],"artificial":[75,186],"tendons.":[76,187],"Induced":[77],"pluripotent":[78,225],"(iPSCs)":[81],"now":[83],"been":[84],"derived":[85],"from":[86,108,224],"but,":[88],"date,":[90],"there":[91],"are":[92],"no":[93],"reports":[94],"on":[95,214],"ability":[97],"cells.":[102],"As":[103],"iPSCs":[104,142,153,176,216],"be":[106,212],"produced":[107,143],"adult":[109],"types,":[111],"they":[112],"more":[115,208],"accessible":[116],"source":[117],"than":[120],"ESCs,":[121],"which":[122,159],"require":[123],"use":[125],"embryos.":[128],"The":[129],"aim":[130],"this":[132],"study":[133],"was":[134],"compare":[136],"differentiation":[138,150,173,203],"by":[139,162],"ESCs":[140,226],"two":[145],"independent":[146],"methods.":[147],"In":[148],"two-dimensional":[149],"assays,":[151,174],"expressed":[154],"tendon-associated":[155],"genes":[156],"proteins,":[158],"were":[160],"enhanced":[161],"presence":[164],"transforming":[166],"growth":[167],"factor-\u03b23.":[168],"However,":[169],"three-dimensional":[171],"(3D)":[172],"failed":[177],"These":[188],"results":[189],"demonstrate":[190],"utility":[192],"3D":[195],"assay":[199],"for":[200,207],"measuring":[201],"need":[206],"detailed":[209],"studies":[210],"performed":[213],"identify":[218],"understand":[220],"epigenetic":[222],"differences":[223],"prior":[227],"clinical":[230],"application.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}