{"id":"https://openalex.org/W2195658564","doi":"https://doi.org/10.1016/j.nano.2015.09.010","title":"3D printed nanocomposite matrix for the study of breast cancer bone metastasis","display_name":"3D printed nanocomposite matrix for the study of breast cancer bone metastasis","publication_year":2015,"publication_date":"2015-10-25","ids":{"openalex":"https://openalex.org/W2195658564","doi":"https://doi.org/10.1016/j.nano.2015.09.010","mag":"2195658564","pmid":"https://pubmed.ncbi.nlm.nih.gov/26472048"},"language":"en","primary_location":{"id":"doi:10.1016/j.nano.2015.09.010","doi":"https://doi.org/10.1016/j.nano.2015.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nano.2015.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101415381","display_name":"Wei Zhu","orcid":"https://orcid.org/0000-0003-1809-3578","observed_orcids":["https://orcid.org/0000-0003-1809-3578"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhu","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034515374","display_name":"Benjamin B. Holmes","orcid":"https://orcid.org/0009-0005-5664-6454","observed_orcids":["https://orcid.org/0009-0005-5664-6454"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Holmes","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079126152","display_name":"Robert I. Glazer","orcid":"https://orcid.org/0000-0001-6936-2980","observed_orcids":["https://orcid.org/0000-0001-6936-2980"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert I. Glazer","raw_affiliation_strings":["Department of Oncology, and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082297222","display_name":"Lijie Grace Zhang","orcid":"https://orcid.org/0000-0003-3009-045X","observed_orcids":["https://orcid.org/0000-0003-3009-045X"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lijie Grace Zhang","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA; Department of Medicine, The George Washington University, Washington, DC, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC, USA. Electronic address: lgzhang@gwu.edu","Department of Biomedical Engineering, The George Washington University, Washington, DC, USA","Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA","Department of Medicine, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA; Department of Medicine, The George Washington University, Washington, DC, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC, USA. Electronic address: lgzhang@gwu.edu","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Medicine, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082297222"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":6.4593,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.97412967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"69","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/stereolithography","display_name":"stereolithography","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nano-hydroxyapatite","display_name":"hydroxyapatite nanoparticles","score":0.984000027179718},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.7289999723434448},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anticancer-drug-screening","display_name":"anticancer drug screening","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6767323613166809},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.625611424446106},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5892894268035889},{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.5578902363777161},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.49817633628845215},{"id":"https://openalex.org/C2993697008","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Bone matrix","level":3,"score":0.48859912157058716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48001331090927124},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4306037425994873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4185323715209961},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3886547386646271},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3821484446525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.290370911359787},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2578349709510803},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08032932877540588},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061249","descriptor_name":"Batch Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.nano.2015.09.010","doi":"https://doi.org/10.1016/j.nano.2015.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nano.2015.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:26472048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26472048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine : nanotechnology, biology, and medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1582847607","https://openalex.org/W1858524504","https://openalex.org/W1967240031","https://openalex.org/W1967265143","https://openalex.org/W1967293289","https://openalex.org/W1969128375","https://openalex.org/W1979700784","https://openalex.org/W1980754327","https://openalex.org/W1982036031","https://openalex.org/W1985133253","https://openalex.org/W1986471913","https://openalex.org/W1986578949","https://openalex.org/W1991073285","https://openalex.org/W1997813585","https://openalex.org/W2004403900","https://openalex.org/W2006434892","https://openalex.org/W2008658133","https://openalex.org/W2010251891","https://openalex.org/W2010560182","https://openalex.org/W2010835587","https://openalex.org/W2013133290","https://openalex.org/W2016802225","https://openalex.org/W2017894359","https://openalex.org/W2033474014","https://openalex.org/W2041772625","https://openalex.org/W2067324501","https://openalex.org/W2070385313","https://openalex.org/W2086103746","https://openalex.org/W2086294121","https://openalex.org/W2086542098","https://openalex.org/W2087324367","https://openalex.org/W2087658248","https://openalex.org/W2092517018","https://openalex.org/W2093369423","https://openalex.org/W2093913323","https://openalex.org/W2107924152","https://openalex.org/W2110048188","https://openalex.org/W2125170987","https://openalex.org/W2132311567","https://openalex.org/W2151565572","https://openalex.org/W2166383248","https://openalex.org/W2332921353"],"related_works":["https://openalex.org/W2461545510","https://openalex.org/W52835445","https://openalex.org/W2326896535","https://openalex.org/W2533859605","https://openalex.org/W4387849419","https://openalex.org/W3127033909","https://openalex.org/W2994821877","https://openalex.org/W3117659685","https://openalex.org/W4379390748","https://openalex.org/W7165524123"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
