{"id":"https://openalex.org/W2195039102","doi":null,"title":"Glycididazole sodium combined with radioiodine therapy for patients with differentiated thyroid carcinoma (DTC).","display_name":"Glycididazole sodium combined with radioiodine therapy for patients with differentiated thyroid carcinoma (DTC).","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2195039102","mag":"2195039102","pmid":"https://pubmed.ncbi.nlm.nih.gov/26550375","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4613060"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3610517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4613060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4613060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110527778","display_name":"Qiang Wen","orcid":"https://orcid.org/0000-0001-8784-5855","observed_orcids":["https://orcid.org/0000-0001-8784-5855"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Wen","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101737211","display_name":"Qingjie Ma","orcid":"https://orcid.org/0000-0002-2164-9955","observed_orcids":["https://orcid.org/0000-0002-2164-9955"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingjie Ma","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Bai","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687963","display_name":"Tongtong Wang","orcid":"https://orcid.org/0000-0001-7621-7781","observed_orcids":["https://orcid.org/0000-0001-7621-7781"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongtong Wang","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055660553","display_name":"Yuping Han","orcid":"https://orcid.org/0000-0002-1329-8542","observed_orcids":["https://orcid.org/0000-0002-1329-8542"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuping Han","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101404508","display_name":"Haishan Zhang","orcid":"https://orcid.org/0009-0000-0378-6975","observed_orcids":["https://orcid.org/0009-0000-0378-6975","https://orcid.org/0009-0004-7264-1066","https://orcid.org/0000-0003-3411-4332"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haishan Zhang","raw_affiliation_strings":["China-Japan Union Hospital, Jilin University Changchun 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital, Jilin University Changchun 130033, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"8","first_page":"14095","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/iodine-131","display_name":"iodine-131","score":0.9240000247955322},{"id":"https://openalex.org/keywords/differentiated-thyroid-cancer","display_name":"differentiated thyroid cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cervical-lymph-node-metastasis","display_name":"cervical lymph node metastasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.8199999928474426},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chromosome-mutations","display_name":"chromosomal mutations","score":0.675000011920929},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585368633270264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5219987630844116},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5106688141822815},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.4828977584838867},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45699092745780945},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4475274980068207},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4282878041267395},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4109892249107361}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3610517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4613060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26550375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26550375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4613060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4613060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2195039102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26550375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3610517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4613060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W118304598","https://openalex.org/W1546616948","https://openalex.org/W1966715409","https://openalex.org/W1967624469","https://openalex.org/W2019328052","https://openalex.org/W2044828595","https://openalex.org/W2074484141","https://openalex.org/W2088238681","https://openalex.org/W2091842393","https://openalex.org/W2108279483","https://openalex.org/W2108696043","https://openalex.org/W2123838717","https://openalex.org/W2129749079","https://openalex.org/W2158773893","https://openalex.org/W2184194630","https://openalex.org/W2190971767"],"related_works":["https://openalex.org/W3151669979","https://openalex.org/W2355327945","https://openalex.org/W2351614036","https://openalex.org/W2369788915","https://openalex.org/W2746031957","https://openalex.org/W4402701197","https://openalex.org/W2371305730","https://openalex.org/W2360503543","https://openalex.org/W2793446879","https://openalex.org/W3110372768"],"abstract_inverted_index":{"The":[0,96],"aim":[1],"of":[2,13,29,49,59,65,79,101,132,174,181,188],"the":[3,130],"present":[4],"study":[5],"was":[6],"to":[7,76],"evaluate":[8],"efficacy":[9,187],"and":[10,73,93,158,163],"side":[11,193],"effects":[12],"glycididazole":[14],"sodium":[15],"(CMNa)":[16],"combined":[17,61,107,124,177],"with":[18,23,46,56,62,108,125,178],"radioiodine":[19,109,118],"therapy":[20],"for":[21],"patients":[22,28,190],"DTC":[24,30,189],"cervical":[25,31],"metastases.":[26],"53":[27],"lymph":[32],"node":[33],"metastasis":[34],"were":[35,44,54,70,112],"randomly":[36],"divided":[37],"into":[38],"2":[39],"groups,":[40],"where":[41],"24":[42],"cases":[43,53],"treated":[45,55],"4.44":[47,63,172],"GBq":[48,64,173],"(131)I":[50,175],"alone,":[51],"29":[52],"800":[57,179],"mg/m(2)":[58,180],"CMNa":[60,106,123,182],"(131)I.":[66],"Peripheral":[67],"blood":[68,81,148],"samples":[69],"collected":[71],"before":[72,162],"after":[74,139,166],"treatment":[75,127,140,167,176],"perform":[77],"measurements":[78],"routine":[80],"test,":[82],"liver":[83,150],"function,":[84,86,151,153],"renal":[85,152],"parathyroid":[87],"hormone":[88],"(PTH),":[89],"lymphocyte":[90,155],"micronucleus":[91,156],"rates":[92,100,157,161],"chromosome":[94,159],"mutation.":[95],"results":[97,170],"showed":[98],"that":[99,116],"complete":[102],"response":[103],"(CR)":[104],"in":[105,117,147],"group":[110,120],"(65.5%)":[111],"significantly":[113,128,184],"higher":[114],"than":[115],"monotherapy":[119],"(37.5%).":[121],"Furthermore,":[122],"adioiodine":[126],"increased":[129],"percentage":[131],"thyroglobulin":[133],"(Tg)":[134],"reduction":[135],"at":[136],"12":[137,164],"weeks":[138,165],"(P<0.05).":[141],"There":[142],"is":[143],"no":[144],"significant":[145],"difference":[146],"routine,":[149],"PTH,":[154],"mutation":[160],"(P>0.05).":[168],"These":[169],"indicate":[171],"could":[183],"improve":[185],"clinical":[186],"without":[191],"increasing":[192],"effects.":[194]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}