{"id":"https://openalex.org/W2194892136","doi":"https://doi.org/10.1038/srep17981","title":"RETRACTED ARTICLE: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia","display_name":"RETRACTED ARTICLE: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia","publication_year":2015,"publication_date":"2015-12-10","ids":{"openalex":"https://openalex.org/W2194892136","doi":"https://doi.org/10.1038/srep17981","mag":"2194892136","pmid":"https://pubmed.ncbi.nlm.nih.gov/26656460","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4674709"},"language":"en","primary_location":{"id":"doi:10.1038/srep17981","doi":"https://doi.org/10.1038/srep17981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep17981","pdf_url":"https://www.nature.com/articles/srep17981.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep17981.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063370384","display_name":"Guang\u2010Xia Shi","orcid":"https://orcid.org/0000-0002-8834-2085","observed_orcids":["https://orcid.org/0000-0002-8834-2085"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Xia Shi","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012483706","display_name":"Xuerui Wang","orcid":"https://orcid.org/0000-0001-8938-3420","observed_orcids":["https://orcid.org/0000-0001-8938-3420"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-Rui Wang","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076741740","display_name":"Chao-Qun Yan","orcid":"https://orcid.org/0000-0001-7921-3057","observed_orcids":["https://orcid.org/0000-0001-7921-3057"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao-Qun Yan","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101889384","display_name":"Tian He","orcid":"https://orcid.org/0000-0001-6319-9860","observed_orcids":["https://orcid.org/0000-0001-6319-9860"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian He","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018026807","display_name":"Jing\u2010Wen Yang","orcid":"https://orcid.org/0000-0002-7031-3446","observed_orcids":["https://orcid.org/0000-0002-7031-3446"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Wen Yang","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102148566","display_name":"Xianghong Zeng","orcid":"https://orcid.org/0000-0001-9383-6576","observed_orcids":["https://orcid.org/0000-0001-9383-6576"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Hong Zeng","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755654","display_name":"Qian Xu","orcid":"https://orcid.org/0000-0001-8291-8728","observed_orcids":["https://orcid.org/0000-0001-8291-8728"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xu","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111614336","display_name":"Wen Xian Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhu","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112951152","display_name":"Siqi Du","orcid":"https://orcid.org/0009-0001-2082-8273","observed_orcids":["https://orcid.org/0009-0001-2082-8273"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Qi Du","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016706609","display_name":"Cun\u2010Zhi Liu","orcid":"https://orcid.org/0000-0001-8031-5667","observed_orcids":["https://orcid.org/0000-0001-8031-5667"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210148966","display_name":"Beijing Hospital of Traditional Chinese Medicine","ror":"https://ror.org/057vq6e26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148966"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cun-Zhi Liu","raw_affiliation_strings":["Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210148966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":12.9853,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.98823209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"17981","last_page":"17981"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":1.0},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9350000023841858},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8050000071525574},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gp91phox","display_name":"gp91phox","score":0.9710000157356262},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bilateral-common-carotid-artery-occlusion","display_name":"bilateral common carotid artery occlusion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8289999961853027},{"id":"https://openalex.org/keywords/apocynin","display_name":"apocynin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2777209548","wikidata":"https://www.wikidata.org/wiki/Q414754","display_name":"Apocynin","level":4,"score":0.9660979509353638},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7569445371627808},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6352546811103821},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.5751513838768005},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5713574290275574},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.564192533493042},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5566410422325134},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.49410465359687805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4732045531272888},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.46882909536361694},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.4572548270225525},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.44397497177124023},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4199710786342621},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.4131351411342621},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3921360969543457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3210906982421875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3164711892604828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.314785897731781},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25512266159057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2344057857990265},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19485583901405334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12647545337677002},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026881","descriptor_name":"Acupuncture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep17981","doi":"https://doi.org/10.1038/srep17981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep17981","pdf_url":"https://www.nature.com/articles/srep17981.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:26656460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26656460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4674709","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4674709/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep17981","doi":"https://doi.org/10.1038/srep17981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep17981","pdf_url":"https://www.nature.com/articles/srep17981.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8240191246","display_name":null,"funder_award_id":"2014B063","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"}],"funders":[{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2194892136.pdf","grobid_xml":"https://content.openalex.org/works/W2194892136.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1913726112","https://openalex.org/W1965891907","https://openalex.org/W1971556924","https://openalex.org/W1974997758","https://openalex.org/W1983124954","https://openalex.org/W1994253596","https://openalex.org/W1995994561","https://openalex.org/W1996562399","https://openalex.org/W1998703225","https://openalex.org/W2003321649","https://openalex.org/W2003993264","https://openalex.org/W2006823958","https://openalex.org/W2007066669","https://openalex.org/W2018022526","https://openalex.org/W2021658296","https://openalex.org/W2027895734","https://openalex.org/W2046879748","https://openalex.org/W2054790952","https://openalex.org/W2058445386","https://openalex.org/W2060817651","https://openalex.org/W2068214990","https://openalex.org/W2068872788","https://openalex.org/W2070325134","https://openalex.org/W2071252381","https://openalex.org/W2079159302","https://openalex.org/W2079551412","https://openalex.org/W2080189649","https://openalex.org/W2081417591","https://openalex.org/W2082582644","https://openalex.org/W2102182027","https://openalex.org/W2121875633","https://openalex.org/W2140211254","https://openalex.org/W2142790005","https://openalex.org/W2142978584","https://openalex.org/W2149227217","https://openalex.org/W2152940644","https://openalex.org/W2157368934","https://openalex.org/W2161948816","https://openalex.org/W2166711131","https://openalex.org/W2511859509"],"related_works":["https://openalex.org/W2015633568","https://openalex.org/W2058445386","https://openalex.org/W1993059590","https://openalex.org/W2102242603","https://openalex.org/W2335021952","https://openalex.org/W2032423144","https://openalex.org/W2767669313","https://openalex.org/W7097154194","https://openalex.org/W2022940103","https://openalex.org/W2900375675"],"abstract_inverted_index":{"In":[0],"the":[1,18,60,70,158,174,184],"current":[2],"study,":[3],"we":[4],"aimed":[5],"to":[6,172],"investigate":[7],"whether":[8],"NADPH":[9,44,75,185],"oxidase,":[10],"a":[11],"major":[12],"ROS-producing":[13],"enzyme,":[14],"was":[15,95],"involved":[16],"in":[17,47,69,92,118,177,192],"antioxidant":[19],"effect":[20,83,159],"of":[21,38,43,49,65,74,84,107,123,138,160,183,200],"acupuncture":[22,85,133,161],"on":[23,86],"cognitive":[24,30,61,87,112,164,196],"impairment":[25,113,176,197],"after":[26,56,89,127,132],"cerebral":[27,90],"ischaemia.":[28],"The":[29,82,121],"function,":[31],"infract":[32],"size,":[33,104],"neuron":[34,115],"cell":[35,116],"loss,":[36],"level":[37],"superoxide":[39],"anion":[40],"and":[41,63,72,79,109,114,125,166],"expression":[42],"oxidase":[45,76,186],"subunit":[46],"hippocampus":[48],"two-vessel":[50],"occlusion":[51],"(2VO)":[52],"rats":[53],"were":[54,67,129,141,151],"determined":[55,68],"2-week":[57],"acupuncture.":[58],"Furthermore,":[59,147],"function":[62,88,165,182],"production":[64],"O2(-)":[66,168],"presence":[71],"absence":[73],"agonist":[77],"(TBCA)":[78],"antagonist":[80],"(Apocynin).":[81],"ischaemia":[91],"gp91phox-KO":[93],"mice":[94],"evaluated":[96],"by":[97,153,162],"Morris":[98],"water":[99],"maze.":[100],"Acupuncture":[101,170],"reduced":[102],"infarct":[103],"attenuated":[105],"overproduction":[106],"O2(-),":[108],"reversed":[110,152],"consequential":[111],"loss":[117],"2VO":[119,128],"rats.":[120],"elevations":[122],"gp91phox":[124,139,178],"p47phox":[126],"significantly":[130],"decreased":[131],"treatment.":[134],"However,":[135],"no":[136],"differences":[137],"mRNA":[140],"found":[142],"among":[143],"any":[144],"experimental":[145],"groups.":[146],"these":[148],"beneficial":[149],"effects":[150,194],"TBCA,":[154],"whereas":[155],"apocynin":[156],"mimicked":[157],"improving":[163],"decreasing":[167],"generation.":[169],"failed":[171],"improve":[173],"memory":[175],"KO":[179],"mice.":[180],"Full":[181],"enzyme":[187],"plays":[188],"an":[189],"important":[190],"role":[191],"neuroprotective":[193],"against":[195],"via":[198],"inhibition":[199],"NAPDH":[201],"oxidase-mediated":[202],"oxidative":[203],"stress.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}