{"id":"https://openalex.org/W2194716111","doi":null,"title":"Effect of omega-3 fatty acids supplementation on testosterone levels in women with polycystic ovary syndrome: Meta-analysis of randomized controlled trials","display_name":"Effect of omega-3 fatty acids supplementation on testosterone levels in women with polycystic ovary syndrome: Meta-analysis of randomized controlled trials","publication_year":2015,"publication_date":"2015-12-07","ids":{"openalex":"https://openalex.org/W2194716111","mag":"2194716111"},"language":"en","primary_location":{"id":"mag:2194716111","doi":null,"is_oa":false,"landing_page_url":"http://jnsd.tums.ac.ir/index.php/jnsd/article/download/35/24","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nutritional Sciences and Dietetics","raw_type":null},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032731002","display_name":"Neda Forouhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Neda Forouhi","raw_affiliation_strings":["Department of Clinical nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086077722","display_name":"Sakineh Shab\u2010Bidar","orcid":"https://orcid.org/0000-0002-0167-7174","observed_orcids":["https://orcid.org/0000-0002-0167-7174","https://orcid.org/0000-0002-2248-8698","https://orcid.org/0000-0001-8630-6155"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sakineh Shab\u2010Bidar","raw_affiliation_strings":["Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran, University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-0167-7174","affiliations":[{"raw_affiliation_string":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran, University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012645385","display_name":"Kurosh Djafarian","orcid":"https://orcid.org/0000-0002-9134-7178","observed_orcids":["https://orcid.org/0000-0002-9134-7178"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kurosh Djafarian","raw_affiliation_strings":["Department of Clinical nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9134-7178","affiliations":[{"raw_affiliation_string":"Department of Clinical nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I70640408"],"apc_list":null,"apc_paid":null,"fwci":0.0461,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.04551539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"3","first_page":"165","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9549999833106995},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antiandrogenic-effects","display_name":"antiandrogenic effects","score":0.781000018119812},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8351566791534424},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.815151572227478},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.7895089387893677},{"id":"https://openalex.org/C136524200","wikidata":"https://www.wikidata.org/wiki/Q3136977","display_name":"Jadad scale","level":4,"score":0.7564889192581177},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.6321462392807007},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6156024932861328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5953717231750488},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5943912267684937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5905675292015076},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5525330901145935},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.551631510257721},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.504986584186554},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3300181031227112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.199662983417511},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1282234787940979},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.11642074584960938},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.10810589790344238},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.06368717551231384}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2194716111","doi":null,"is_oa":false,"landing_page_url":"http://jnsd.tums.ac.ir/index.php/jnsd/article/download/35/24","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nutritional Sciences and Dietetics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W120108033","https://openalex.org/W171370963","https://openalex.org/W1157773366","https://openalex.org/W1902475818","https://openalex.org/W1964346766","https://openalex.org/W1986215651","https://openalex.org/W1989689562","https://openalex.org/W1995158816","https://openalex.org/W2064000729","https://openalex.org/W2073745414","https://openalex.org/W2085908723","https://openalex.org/W2100338186","https://openalex.org/W2106165408","https://openalex.org/W2106731425","https://openalex.org/W2109968049","https://openalex.org/W2110600772","https://openalex.org/W2125091322","https://openalex.org/W2130340425","https://openalex.org/W2133007882","https://openalex.org/W2149580176","https://openalex.org/W2266844806","https://openalex.org/W2407765934","https://openalex.org/W2418309287","https://openalex.org/W2616656233"],"related_works":["https://openalex.org/W171370963","https://openalex.org/W6999899287","https://openalex.org/W2336350264","https://openalex.org/W2130340425","https://openalex.org/W3088124743","https://openalex.org/W3197297734","https://openalex.org/W4294285938","https://openalex.org/W2995388486","https://openalex.org/W2796048673","https://openalex.org/W2266844806"],"abstract_inverted_index":{"B":[0],"a":[2,59,219],"ckground:\u00a0":[4],"Scientific":[5],"literature":[6],"has":[7],"shown":[8],"evidence":[9],"that":[10],"omega-3":[11,104,181,205],"polyunsaturated":[12],"\u00a0fatty":[13],"\u00a0acids":[14],"\u00a0(PUFA)":[15],"\u00a0have":[16],"\u00a0anti-androgenic\u00a0":[17],"action,":[18],"\u00a0and":[19,97],"\u00a0for":[20],"\u00a0this":[21],"reason":[22],"could":[23],"be":[24],"useful":[25],"as":[26],"an":[27],"adjuvant":[28],"in":[29,70,111,138],"hyperandrogenism":[30],"conditions":[31],"including":[32],"polycystic":[33],"ovarian":[34],"syndrome":[35],"(PCOS).":[36],"However,":[37],"the":[38,126,202],"possible":[39],"effect":[40],"of":[41,64,180,193,204,222],"eicosapentaenoic":[42],"acid":[43,47],"(EPA)":[44],"and":[45,115,146],"docosahexaenoic":[46],"(DHA)":[48],"supplementation":[49],"on":[50,67,158,198,208],"testosterone":[51,68,159,200],"concentration":[52],"still":[53],"remains":[54],"undetermined.":[55],"Therefore,":[56],"we":[57],"performed":[58],"meta-analysis":[60,120],"to":[61,154,216],"investigate":[62],"effects":[63],"EPA/DHA":[65],"supplements":[66,107,207],"hormone":[69],"PCOS":[71,114,185,209],"women.":[72],"M":[75],"ethods":[77],":":[78,133,190],"Randomized":[79],"controlled":[80],"trials":[81],"(RCTs)":[82],"published":[83],"until":[84],"end":[85],"May":[86],"2015":[87],"were":[88,136],"\u00a0searched":[89],"\u00a0through":[90],"\u00a0a":[91],"\u00a0comprehensive":[92],"\u00a0search":[93],"\u00a0of":[94],"\u00a0the":[95],"\u00a0PubMed":[96],"\u00a0Scopus":[98],"electronic":[99],"databases.":[100],"Included":[101],"RCTs":[102,135,213],"evaluated":[103],"fatty":[105,182],"acids":[106,183],"compared":[108],"with":[109,113,201],"control":[110],"patients":[112],"reported":[116],"circulatory":[117],"androgens.":[118],"The":[119,141,191],"quality":[121],"assessment":[122],"was":[123,148],"conducted":[124],"by":[125],"Jadad":[127],"scoring":[128],"criteria.":[129],"Results":[132],"Four":[134],"analyzed":[137],"this":[139],"meta-analysis.":[140],"dose":[142],"range":[143],"for":[144,184],"EPA":[145],"DHA":[147],"0.9-3.6.":[149],"Follow-up":[150],"ranged":[151],"from":[152],"6":[153],"8":[155],"weeks.":[156],"Meta-analysis":[157],"\u00a0levels\u00a0":[160],"\u00a0revealed\u00a0":[161],"\u00a0a\u00a0":[162],"\u00a0significant":[163],"\u00a0lowering\u00a0":[164],"\u00a0effect\u00a0":[165],"\u00a0(weighted\u00a0":[166],"\u00a0mean":[167],"difference":[168],"-":[169],"0.264;":[170],"95%":[171],"confidence":[172],"interval":[173],"=":[174],"\u22120.39,":[175],"0.14;":[176],"p":[177],"<":[178],"0.001)":[179],"subjects.":[186],"Conclusion":[189],"results":[192],"our":[194,223],"study":[195],"revealed":[196],"benefits":[197],"total":[199],"use":[203],"PUFA":[206],"patients.":[210],"Further,":[211],"high-quality":[212],"are":[214],"required":[215],"definitively":[217],"draw":[218],"causal":[220],"interpretation":[221],"finding.":[224]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
