{"id":"https://openalex.org/W21944081","doi":"https://doi.org/10.21236/ada420863","title":"Structure-Based Design of CSDK4-Specific Inhibitors","display_name":"Structure-Based Design of CSDK4-Specific Inhibitors","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W21944081","doi":"https://doi.org/10.21236/ada420863","mag":"21944081"},"language":"en","primary_location":{"id":"doi:10.21236/ada420863","doi":"https://doi.org/10.21236/ada420863","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada420863","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061620397","display_name":"Ronen Marmorstein","orcid":"https://orcid.org/0000-0003-4373-4752","observed_orcids":["https://orcid.org/0000-0003-4373-4752","https://orcid.org/0000-0002-9755-7838"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ronen Marmorstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061620397"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.781000018119812},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.9729999899864197},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.8199999928474426},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.7509999871253967},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/p16ink4","display_name":"p16INK4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4067867398262024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3256160616874695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23304811120033264}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada420863","doi":"https://doi.org/10.21236/ada420863","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada420863","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA420863","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA420863","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2219817965","https://openalex.org/W3184076058","https://openalex.org/W2775259666","https://openalex.org/W4220955524","https://openalex.org/W2887177266","https://openalex.org/W2404490516","https://openalex.org/W4286638082","https://openalex.org/W4323059695","https://openalex.org/W7118177763","https://openalex.org/W2935187964"],"abstract_inverted_index":{"Distinct":[0],"cancer":[1,123,173],"types":[2],"have":[3],"been":[4],"correlated":[5],"with":[6],"several":[7,171],"proteins":[8],"that":[9,151,176],"are":[10,44],"involved":[11],"in":[12,46,71,98,115,136,180],"the":[13,19,29,33,36,59,62,72,154,160,168,177,190],"G1":[14,155],"to":[15,31,92,118,121,156,167],"S":[16,157],"transition":[17,158],"of":[18,35,50,74,112,140,153,159,170,192],"mammalian":[20,161],"cell":[21,162],"cycle":[22,163],"(Funk,":[23],"1999;":[24],"Molinari,":[25],"2000).":[26],"In":[27],"particular,":[28,181],"inability":[30],"inhibit":[32],"activity":[34],"paralogs":[37],"cyclin-dependent":[38],"kinases":[39],"4":[40],"and":[41,78,103,110,175],"6":[42],"(CDK4/6)":[43],"implicated":[45],"more":[47],"than":[48],"80%":[49],"human":[51],"neoplasias":[52],"(Ortega":[53,143],"et":[54,107,125,144],"al.,":[55,108,126,145],"2002).":[56,146],"For":[57],"example,":[58],"gene":[60,96,134],"encoding":[61],"CDK4/6":[63,84,178],"inhibitory":[64],"protein,":[65,179],"p16INK4,":[66],"is":[67,89,131,164,182],"deleted":[68],"or":[69,95,133],"mutated":[70],"majority":[73],"leukemias,":[75],"bladder":[76],"cancers":[77,101,142],"familial":[79],"melanomas":[80],"(Roussel,":[81],"1999).":[82],"The":[83],"stimulatory":[85],"subunit,":[86],"cyclin":[87,113],"Dl,":[88],"commonly":[90],"found":[91],"be":[93],"overexpressed":[94,132],"amplified":[97,135],"spontaneous":[99],"breast":[100,122,141,193],"(Donnellan":[102],"Chetty,":[104],"1998;":[105],"Khoo":[106],"2002),":[109],"overexpression":[111],"Dl":[114],"mice":[116],"leads":[117],"death":[119],"due":[120],"(Wang":[124],"1994).":[127],"Finally,":[128],"CDK4":[129],"itself":[130],"about":[137],"one":[138],"third":[139],"Together,":[147],"these":[148],"observations":[149],"indicate":[150],"deregulation":[152],"tightly":[165],"linked":[166],"onset":[169],"different":[172],"types,":[174],"an":[183],"excellent":[184],"candidate":[185],"for":[186,189],"targeted":[187],"inhibition":[188],"treatment":[191],"cancer.":[194]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}