{"id":"https://openalex.org/W2194234530","doi":"https://doi.org/10.1016/j.bbamcr.2015.12.005","title":"Peroxisomes in brain development and function","display_name":"Peroxisomes in brain development and function","publication_year":2015,"publication_date":"2015-12-16","ids":{"openalex":"https://openalex.org/W2194234530","doi":"https://doi.org/10.1016/j.bbamcr.2015.12.005","mag":"2194234530","pmid":"https://pubmed.ncbi.nlm.nih.gov/26686055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4880039"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbamcr.2015.12.005","doi":"https://doi.org/10.1016/j.bbamcr.2015.12.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2015.12.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0167488915004267/pdf","source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0167488915004267/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071560474","display_name":"Johannes Berger","orcid":"https://orcid.org/0000-0003-0182-2658","observed_orcids":["https://orcid.org/0000-0003-0182-2658"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Johannes Berger","raw_affiliation_strings":["Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: johannes.berger@meduniwien.ac.at","Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: johannes.berger@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013513187","display_name":"Fabian Dorninger","orcid":"https://orcid.org/0000-0003-0852-1524","observed_orcids":["https://orcid.org/0000-0003-0852-1524"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Fabian Dorninger","raw_affiliation_strings":["Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: fabian.dorninger@meduniwien.ac.at","Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: fabian.dorninger@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046468946","display_name":"Sonja Forss\u2010Petter","orcid":"https://orcid.org/0000-0002-1603-5422","observed_orcids":["https://orcid.org/0000-0002-1603-5422"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sonja Forss-Petter","raw_affiliation_strings":["Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: sonja.forss-petter@meduniwien.ac.at","Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: sonja.forss-petter@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102885856","display_name":"Markus Kunze","orcid":"https://orcid.org/0000-0002-1813-7262","observed_orcids":["https://orcid.org/0000-0002-1813-7262"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Markus Kunze","raw_affiliation_strings":["Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: markus.kunze@meduniwien.ac.at","Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria. Electronic address: markus.kunze@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071560474"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":3930,"currency":"USD","value_usd":3930},"apc_paid":{"value":3480,"currency":"EUR","value_usd":3753},"fwci":1.6255,"has_fulltext":true,"cited_by_count":202,"citation_normalized_percentile":{"value":0.83647799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"1863","issue":"5","first_page":"934","last_page":"955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peroxisome-biogenesis-disorders","display_name":"peroxisome biogenesis disorders","score":0.9039999842643738},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.9559999704360962},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9110000133514404},{"id":"https://openalex.org/keywords/axonal-integrity","display_name":"axonal integrity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9490000009536743},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.769317090511322},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.555766761302948},{"id":"https://openalex.org/C2776542497","wikidata":"https://www.wikidata.org/wiki/Q5266672","display_name":"Development (topology)","level":2,"score":0.5282983779907227},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.4669787585735321},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4139740467071533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3946850299835205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39144524931907654},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3551766574382782},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34405291080474854},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2384241223335266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14713042974472046},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09626635909080505},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074183","descriptor_name":"ATPases Associated with Diverse Cellular Activities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018901","descriptor_name":"Peroxisomal Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018901","descriptor_name":"Peroxisomal Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018901","descriptor_name":"Peroxisomal Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbamcr.2015.12.005","doi":"https://doi.org/10.1016/j.bbamcr.2015.12.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2015.12.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0167488915004267/pdf","source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},{"id":"pmid:26686055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26686055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3845830","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4880039","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4880039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4880039","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochim Biophys Acta","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.bbamcr.2015.12.005","doi":"https://doi.org/10.1016/j.bbamcr.2015.12.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2015.12.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0167488915004267/pdf","source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2520728831","display_name":"Characterization of immune cells in X-linked adrenoleukodystrophy","funder_award_id":"P26112","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G2999247784","display_name":null,"funder_award_id":"P26112-B19,","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5510306833","display_name":"Neurotransmitter Alterations in Ether Lipid Deficiency","funder_award_id":"P 24843","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5897162852","display_name":"Overcoming plasmalogen deficiency in peroxisomal disorders (PERescue)","funder_award_id":"I 2738","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2194234530.pdf","grobid_xml":"https://content.openalex.org/works/W2194234530.grobid-xml"},"referenced_works_count":343,"referenced_works":["https://openalex.org/W93365652","https://openalex.org/W177272458","https://openalex.org/W223368339","https://openalex.org/W607611259","https://openalex.org/W1480038774","https://openalex.org/W1483242733","https://openalex.org/W1488851638","https://openalex.org/W1503104627","https://openalex.org/W1522739755","https://openalex.org/W1526781454","https://openalex.org/W1534988304","https://openalex.org/W1560871346","https://openalex.org/W1564394754","https://openalex.org/W1584834830","https://openalex.org/W1586314603","https://openalex.org/W1605199145","https://openalex.org/W1629328346","https://openalex.org/W1652963135","https://openalex.org/W1666654406","https://openalex.org/W1736640447","https://openalex.org/W1771754722","https://openalex.org/W1838358999","https://openalex.org/W1878769090","https://openalex.org/W1891483234","https://openalex.org/W1936036018","https://openalex.org/W1948224189","https://openalex.org/W1954397360","https://openalex.org/W1958683634","https://openalex.org/W1963970055","https://openalex.org/W1964164432","https://openalex.org/W1964697500","https://openalex.org/W1965373646","https://openalex.org/W1966172270","https://openalex.org/W1966355534","https://openalex.org/W1966833346","https://openalex.org/W1967190893","https://openalex.org/W1968528268","https://openalex.org/W1968679005","https://openalex.org/W1970097553","https://openalex.org/W1970512854","https://openalex.org/W1971365801","https://openalex.org/W1971817019","https://openalex.org/W1971855284","https://openalex.org/W1972562258","https://openalex.org/W1972767996","https://openalex.org/W1973887123","https://openalex.org/W1974358702","https://openalex.org/W1975522242","https://openalex.org/W1978192168","https://openalex.org/W1978365047","https://openalex.org/W1979269349","https://openalex.org/W1980347624","https://openalex.org/W1983488487","https://openalex.org/W1983882766","https://openalex.org/W1984907362","https://openalex.org/W1985032084","https://openalex.org/W1985487919","https://openalex.org/W1986724957","https://openalex.org/W1986783906","https://openalex.org/W1987049546","https://openalex.org/W1987179081","https://openalex.org/W1991079717","https://openalex.org/W1991812607","https://openalex.org/W1992716449","https://openalex.org/W1993029928","https://openalex.org/W1993125822","https://openalex.org/W1993630867","https://openalex.org/W1994238431","https://openalex.org/W1994635594","https://openalex.org/W1995426334","https://openalex.org/W1995958714","https://openalex.org/W1997140762","https://openalex.org/W1999662771","https://openalex.org/W1999667491","https://openalex.org/W1999919904","https://openalex.org/W2000485285","https://openalex.org/W2000631247","https://openalex.org/W2000758650","https://openalex.org/W2000849147","https://openalex.org/W2001615993","https://openalex.org/W2001847464","https://openalex.org/W2001882267","https://openalex.org/W2002943544","https://openalex.org/W2004186568","https://openalex.org/W2004215030","https://openalex.org/W2005093647","https://openalex.org/W2006120283","https://openalex.org/W2006135287","https://openalex.org/W2006421135","https://openalex.org/W2006924544","https://openalex.org/W2006978272","https://openalex.org/W2007492904","https://openalex.org/W2007820585","https://openalex.org/W2007899228","https://openalex.org/W2009136708","https://openalex.org/W2009192911","https://openalex.org/W2009505899","https://openalex.org/W2010022610","https://openalex.org/W2010597258","https://openalex.org/W2011179863","https://openalex.org/W2012130380","https://openalex.org/W2012428359","https://openalex.org/W2013220761","https://openalex.org/W2014581910","https://openalex.org/W2014664955","https://openalex.org/W2014879410","https://openalex.org/W2015768321","https://openalex.org/W2015987971","https://openalex.org/W2016626029","https://openalex.org/W2018171395","https://openalex.org/W2022316151","https://openalex.org/W2025104020","https://openalex.org/W2025783037","https://openalex.org/W2026539650","https://openalex.org/W2026625413","https://openalex.org/W2027414612","https://openalex.org/W2027562091","https://openalex.org/W2027614771","https://openalex.org/W2028844909","https://openalex.org/W2029425513","https://openalex.org/W2029513452","https://openalex.org/W2031022721","https://openalex.org/W2033634439","https://openalex.org/W2034749536","https://openalex.org/W2035026471","https://openalex.org/W2035260979","https://openalex.org/W2037024442","https://openalex.org/W2037167329","https://openalex.org/W2037650763","https://openalex.org/W2038200717","https://openalex.org/W2038506810","https://openalex.org/W2038764117","https://openalex.org/W2039160682","https://openalex.org/W2039294355","https://openalex.org/W2039943620","https://openalex.org/W2041202040","https://openalex.org/W2041247858","https://openalex.org/W2042023245","https://openalex.org/W2043395915","https://openalex.org/W2044397707","https://openalex.org/W2045631219","https://openalex.org/W2045810250","https://openalex.org/W2046742140","https://openalex.org/W2047710690","https://openalex.org/W2048834133","https://openalex.org/W2048836955","https://openalex.org/W2049457697","https://openalex.org/W2049792249","https://openalex.org/W2050410337","https://openalex.org/W2050837335","https://openalex.org/W2050882661","https://openalex.org/W2051176321","https://openalex.org/W2053095537","https://openalex.org/W2054026377","https://openalex.org/W2054650077","https://openalex.org/W2055692289","https://openalex.org/W2055974481","https://openalex.org/W2056156479","https://openalex.org/W2057289315","https://openalex.org/W2059473317","https://openalex.org/W2059575974","https://openalex.org/W2059610924","https://openalex.org/W2059884244","https://openalex.org/W2060819989","https://openalex.org/W2060840571","https://openalex.org/W2061053247","https://openalex.org/W2062298313","https://openalex.org/W2064245163","https://openalex.org/W2065260095","https://openalex.org/W2065461128","https://openalex.org/W2066556435","https://openalex.org/W2067007546","https://openalex.org/W2067047063","https://openalex.org/W2067446209","https://openalex.org/W2068836467","https://openalex.org/W2070334570","https://openalex.org/W2070759421","https://openalex.org/W2070923978","https://openalex.org/W2071214531","https://openalex.org/W2071249409","https://openalex.org/W2071713047","https://openalex.org/W2071965243","https://openalex.org/W2072066566","https://openalex.org/W2072443346","https://openalex.org/W2072558438","https://openalex.org/W2073084630","https://openalex.org/W2073437132","https://openalex.org/W2073912502","https://openalex.org/W2073937441","https://openalex.org/W2073972553","https://openalex.org/W2074571932","https://openalex.org/W2075268322","https://openalex.org/W2076517751","https://openalex.org/W2076537660","https://openalex.org/W2076598575","https://openalex.org/W2076733103","https://openalex.org/W2077052604","https://openalex.org/W2077117781","https://openalex.org/W2078576948","https://openalex.org/W2079075112","https://openalex.org/W2079807305","https://openalex.org/W2080139119","https://openalex.org/W2083416982","https://openalex.org/W2083543206","https://openalex.org/W2084146878","https://openalex.org/W2084781258","https://openalex.org/W2085693330","https://openalex.org/W2085867188","https://openalex.org/W2086448742","https://openalex.org/W2086901557","https://openalex.org/W2087204472","https://openalex.org/W2087357371","https://openalex.org/W2087601962","https://openalex.org/W2087716931","https://openalex.org/W2087747373","https://openalex.org/W2088467891","https://openalex.org/W2088496064","https://openalex.org/W2089124434","https://openalex.org/W2089714024","https://openalex.org/W2090737830","https://openalex.org/W2091429488","https://openalex.org/W2091705101","https://openalex.org/W2091842308","https://openalex.org/W2091893791","https://openalex.org/W2091937537","https://openalex.org/W2094052948","https://openalex.org/W2094238059","https://openalex.org/W2095072855","https://openalex.org/W2095313254","https://openalex.org/W2096184116","https://openalex.org/W2099001561","https://openalex.org/W2101378834","https://openalex.org/W2101641567","https://openalex.org/W2103536990","https://openalex.org/W2104127654","https://openalex.org/W2104564418","https://openalex.org/W2105817940","https://openalex.org/W2106836101","https://openalex.org/W2107506498","https://openalex.org/W2107696332","https://openalex.org/W2107757880","https://openalex.org/W2107762201","https://openalex.org/W2109302938","https://openalex.org/W2109432887","https://openalex.org/W2109795712","https://openalex.org/W2111220794","https://openalex.org/W2111369450","https://openalex.org/W2112114437","https://openalex.org/W2112423730","https://openalex.org/W2113061584","https://openalex.org/W2113083539","https://openalex.org/W2114099224","https://openalex.org/W2115298771","https://openalex.org/W2115992493","https://openalex.org/W2117388188","https://openalex.org/W2120469313","https://openalex.org/W2121085194","https://openalex.org/W2121936687","https://openalex.org/W2124546457","https://openalex.org/W2124956869","https://openalex.org/W2125381416","https://openalex.org/W2126968890","https://openalex.org/W2127003470","https://openalex.org/W2127998841","https://openalex.org/W2128846833","https://openalex.org/W2129009565","https://openalex.org/W2129045638","https://openalex.org/W2129076467","https://openalex.org/W2130891847","https://openalex.org/W2134199998","https://openalex.org/W2134676206","https://openalex.org/W2135440453","https://openalex.org/W2136011227","https://openalex.org/W2136316795","https://openalex.org/W2136674380","https://openalex.org/W2138229358","https://openalex.org/W2138312139","https://openalex.org/W2138369511","https://openalex.org/W2138708884","https://openalex.org/W2138878645","https://openalex.org/W2141570423","https://openalex.org/W2142167590","https://openalex.org/W2142448303","https://openalex.org/W2142516061","https://openalex.org/W2142612491","https://openalex.org/W2143020603","https://openalex.org/W2143790242","https://openalex.org/W2144186776","https://openalex.org/W2144822024","https://openalex.org/W2144827316","https://openalex.org/W2146084049","https://openalex.org/W2147357144","https://openalex.org/W2147536089","https://openalex.org/W2147955643","https://openalex.org/W2148277974","https://openalex.org/W2148839621","https://openalex.org/W2150001025","https://openalex.org/W2150643970","https://openalex.org/W2150885810","https://openalex.org/W2151945423","https://openalex.org/W2152692214","https://openalex.org/W2152977496","https://openalex.org/W2153279033","https://openalex.org/W2154712332","https://openalex.org/W2155109894","https://openalex.org/W2155911957","https://openalex.org/W2156139165","https://openalex.org/W2158228840","https://openalex.org/W2158603948","https://openalex.org/W2158944859","https://openalex.org/W2160256928","https://openalex.org/W2160464289","https://openalex.org/W2161217553","https://openalex.org/W2161518810","https://openalex.org/W2163556869","https://openalex.org/W2163581659","https://openalex.org/W2163628182","https://openalex.org/W2164666271","https://openalex.org/W2165723638","https://openalex.org/W2166036638","https://openalex.org/W2166691293","https://openalex.org/W2166772109","https://openalex.org/W2167261850","https://openalex.org/W2167702038","https://openalex.org/W2168163415","https://openalex.org/W2168472266","https://openalex.org/W2171686853","https://openalex.org/W2172145085","https://openalex.org/W2264406512","https://openalex.org/W2287261134","https://openalex.org/W2320665909","https://openalex.org/W2396068173","https://openalex.org/W2398594000","https://openalex.org/W2465216792","https://openalex.org/W2886024925","https://openalex.org/W3021437023","https://openalex.org/W3209992856","https://openalex.org/W4213100601","https://openalex.org/W4242270522","https://openalex.org/W4251305217","https://openalex.org/W4253936898","https://openalex.org/W4301052166","https://openalex.org/W4318471337"],"related_works":["https://openalex.org/W4213100601","https://openalex.org/W3120129890","https://openalex.org/W7155357834","https://openalex.org/W1980497976","https://openalex.org/W2161217553","https://openalex.org/W2913781266","https://openalex.org/W2152692214","https://openalex.org/W7128467723","https://openalex.org/W2095132920","https://openalex.org/W1988797576"],"abstract_inverted_index":{"Peroxisomes":[0],"contain":[1],"numerous":[2],"enzymatic":[3],"activities":[4],"that":[5],"are":[6],"important":[7],"for":[8],"mammalian":[9],"physiology.":[10],"Patients":[11],"lacking":[12,64],"either":[13],"all":[14,65],"peroxisomal":[15,50,68,75],"functions":[16],"or":[17,21,44,66],"a":[18,53],"single":[19],"enzyme":[20],"transporter":[22],"function":[23],"typically":[24],"develop":[25],"severe":[26],"neurological":[27,137],"deficits,":[28],"which":[29],"originate":[30],"from":[31],"aberrant":[32],"development":[33],"of":[34,40,55,74,98,113,122],"the":[35,72,84,93,109,129],"brain,":[36],"demyelination":[37],"and":[38,61,77,79,95,144],"loss":[39],"axonal":[41],"integrity,":[42],"neuroinflammation":[43],"other":[45],"neurodegenerative":[46],"processes.":[47],"Whilst":[48],"correlating":[49],"properties":[51],"with":[52,118],"compilation":[54],"pathologies":[56],"observed":[57,85],"in":[58,116],"human":[59],"patients":[60],"mouse":[62],"models":[63],"individual":[67,99],"functions,":[69],"we":[70,127],"discuss":[71],"importance":[73],"metabolites":[76],"tissue-":[78],"cell":[80],"type-specific":[81],"contributions":[82],"to":[83,91,102,134],"brain":[86,104],"pathologies.":[87],"This":[88],"enables":[89],"us":[90],"deconstruct":[92],"local":[94],"systemic":[96],"contribution":[97],"metabolic":[100],"pathways":[101],"specific":[103],"functions.":[105],"We":[106],"also":[107],"review":[108],"recently":[110],"discovered":[111],"variability":[112],"pathological":[114],"symptoms":[115],"cases":[117],"unexpectedly":[119],"mild":[120],"presentation":[121],"peroxisome":[123],"biogenesis":[124],"disorders.":[125],"Finally,":[126],"explore":[128],"emerging":[130],"evidence":[131],"linking":[132],"peroxisomes":[133],"more":[135],"common":[136],"disorders":[138],"such":[139],"as":[140],"Alzheimer's":[141],"disease,":[142],"autism":[143],"amyotrophic":[145],"lateral":[146],"sclerosis.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}