{"id":"https://openalex.org/W2194089768","doi":null,"title":"Effects of Removal of GABAergic tone in Dorsomedial Hypothalamic Nucleus on Peripheral Metabolic Responses","display_name":"Effects of Removal of GABAergic tone in Dorsomedial Hypothalamic Nucleus on Peripheral Metabolic Responses","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2194089768","mag":"2194089768"},"language":"en","primary_location":{"id":"mag:2194089768","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TONEUROEJ-3-221","pdf_url":null,"source":{"id":"https://openalex.org/S38825921","display_name":"The Open Neuroendocrinology Journal","issn_l":"1876-5289","issn":["1876-5289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Neuroendocrinology Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024100402","display_name":"Gisele Cristiane Van","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gisele Cristiane Van","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047929307","display_name":"Carlos Henrique Xavier","orcid":"https://orcid.org/0000-0003-4006-8213","observed_orcids":["https://orcid.org/0000-0003-4006-8213","https://orcid.org/0000-0002-4405-3425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Henrique Xavier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4006-8213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019675867","display_name":"C\u00e2ndido Celso Coimbra","orcid":"https://orcid.org/0000-0001-8981-6724","observed_orcids":["https://orcid.org/0000-0001-8981-6724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e2ndido Celso Coimbra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8981-6724","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008351985","display_name":"Marco Ant\u00f4nio Peliky Fontes","orcid":"https://orcid.org/0000-0003-4525-3565","observed_orcids":["https://orcid.org/0000-0003-4525-3565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Ant\u00f4nio Peliky Fontes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4525-3565","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108467614","display_name":"Elizabeth Lage Borges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizabeth Lage Borges","raw_affiliation_strings":["FEDERAL UNIVERSITY OF MINAS GERAIS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEDERAL UNIVERSITY OF MINAS GERAIS","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1272,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43077248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.13429999351501465,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dorsomedial-hypothalamic-nucleus","display_name":"dorsomedial hypothalamus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gabaergic-tone","display_name":"GABAergic tone","score":0.7630000114440918},{"id":"https://openalex.org/keywords/bicuculline-methiodide","display_name":"bicuculline methiodide","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6539999842643738},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5789999961853027},{"id":"https://openalex.org/keywords/neuroendocrine-response","display_name":"neuroendocrine response","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7875644564628601},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.7595479488372803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7557582855224609},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6389496922492981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5761009454727173},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5583493113517761},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5335619449615479},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.5207229256629944},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.45784443616867065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3037029802799225},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.15962815284729004},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1058763861656189}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2194089768","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TONEUROEJ-3-221","pdf_url":null,"source":{"id":"https://openalex.org/S38825921","display_name":"The Open Neuroendocrinology Journal","issn_l":"1876-5289","issn":["1876-5289"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Neuroendocrinology Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W18203474","https://openalex.org/W162947818","https://openalex.org/W1262613349","https://openalex.org/W1579907219","https://openalex.org/W1659220516","https://openalex.org/W1875107825","https://openalex.org/W1964717842","https://openalex.org/W1980473712","https://openalex.org/W1980741065","https://openalex.org/W1982823310","https://openalex.org/W1985166263","https://openalex.org/W1992637805","https://openalex.org/W1996960296","https://openalex.org/W2000305618","https://openalex.org/W2003436761","https://openalex.org/W2005299892","https://openalex.org/W2034563015","https://openalex.org/W2041504419","https://openalex.org/W2043196703","https://openalex.org/W2056917548","https://openalex.org/W2060534394","https://openalex.org/W2067848413","https://openalex.org/W2080397713","https://openalex.org/W2088909919","https://openalex.org/W2093538547","https://openalex.org/W2101621049","https://openalex.org/W2103194923","https://openalex.org/W2130802383","https://openalex.org/W2138196699","https://openalex.org/W2158853345","https://openalex.org/W2159306232","https://openalex.org/W2160234571","https://openalex.org/W2163815564","https://openalex.org/W2170002187","https://openalex.org/W2177821000","https://openalex.org/W2279427440"],"related_works":["https://openalex.org/W2078240819","https://openalex.org/W2997905306","https://openalex.org/W1985166263","https://openalex.org/W2006630318","https://openalex.org/W2020818453","https://openalex.org/W2096251292","https://openalex.org/W145107670","https://openalex.org/W2555862466","https://openalex.org/W2279427440","https://openalex.org/W2092951511"],"abstract_inverted_index":{"Dorsomedial":[0],"hypothalamus":[1],"(DMH)":[2],"plays":[3],"a":[4,71],"key":[5],"role":[6],"in":[7,32,120,135,151],"the":[8,39,45,97,121],"organization":[9],"of":[10,17,38,48,52,99,158],"functional":[11],"responses":[12],"to":[13,43,104],"stress.":[14,35],"Mi-":[15],"croinjection":[16],"GABAA":[18],"antagonist":[19],"bicuculline":[20],"methiodide":[21],"(BMI)":[22],"into":[23,63,76,107],"DMH":[24,108,147],"evokes":[25],"cardiovascular":[26],"and":[27,70,83,93,130,155],"neuroendocrine":[28],"changes":[29,150],"typically":[30],"seen":[31],"experimental":[33,100],"emotional":[34],"The":[36,78],"aim":[37],"present":[40],"study":[41],"was":[42,74,81],"investigate":[44],"peripheral":[46],"metabolism":[47],"glucose":[49],"following":[50],"microinjection":[51],"BMI,":[53],"(10pmol":[54],"/":[55],"100nl)":[56,62],"or":[57],"vehicle":[58],"(NaCl":[59],"0.9%":[60],"-":[61],"DMH.":[64,77],"Male":[65],"wistar":[66],"rats":[67],"were":[68,90],"anesthetized":[69],"guide":[72],"cannula":[73],"set":[75],"jejunal":[79],"loop":[80],"isolated":[82],"perfused":[84],"with":[85],"Tyrode":[86],"solution.":[87],"Blood":[88],"samples":[89],"taken":[91],"15":[92],"40":[94],"minutes":[95],"after":[96],"beginning":[98],"period.":[101],"When":[102],"compared":[103],"vehicle,":[105],"BMI":[106],"increased":[109,131],"plasma":[110,152],"insulin":[111],"(0.22\u00b10.04":[112],"vs.":[113,124,138],"0.34\u00b10.04":[114],"ng/ml;":[115],"P<0.05),":[116],"decreased":[117],"glu-":[118],"cose-6-phosphate":[119],"liver":[122],"(0.012\u00b10.003":[123],"0.004\u00b10.002":[125],"\ufffd":[126,140],"mol/g":[127,141],"tissue;":[128,142],"P<0.05)":[129],"this":[132],"same":[133],"metabolite":[134,157],"muscle":[136],"(0.14\u00b10.05":[137],"0.43\u00b10.10":[139],"P<0.05).":[143],"We":[144],"found":[145],"that":[146],"activation":[148],"caused":[149],"insu-":[153],"lin":[154],"intermediate":[156],"glycolitic":[159],"pathways.":[160]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}