{"id":"https://openalex.org/W2194080025","doi":"https://doi.org/10.1111/and.12504","title":"mTOR expression in human testicular seminoma","display_name":"mTOR expression in human testicular seminoma","publication_year":2015,"publication_date":"2015-12-09","ids":{"openalex":"https://openalex.org/W2194080025","doi":"https://doi.org/10.1111/and.12504","mag":"2194080025","pmid":"https://pubmed.ncbi.nlm.nih.gov/26648340"},"language":"en","primary_location":{"id":"doi:10.1111/and.12504","doi":"https://doi.org/10.1111/and.12504","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12504","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12504","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12504","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039555328","display_name":"Aylin Yaba","orcid":"https://orcid.org/0000-0001-6781-9983","observed_orcids":["https://orcid.org/0000-0001-6781-9983"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"A. Yaba","raw_affiliation_strings":["Institute of Health Sciences; Yeditepe University; \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Sciences; Yeditepe University; \u0130stanbul Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021443623","display_name":"Erol R\u00fc\u015ft\u00fc Bozkurt","orcid":"https://orcid.org/0000-0002-1349-2206","observed_orcids":["https://orcid.org/0000-0002-1349-2206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. R. Bozkurt","raw_affiliation_strings":["Department of Pathology; \u0130stanbul Samatya Education and Research Hospital; \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology; \u0130stanbul Samatya Education and Research Hospital; \u0130stanbul Turkey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101925949","display_name":"Necdet Dem\u0131r","orcid":"https://orcid.org/0000-0002-8166-5535","observed_orcids":["https://orcid.org/0000-0002-8166-5535"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"N. Demir","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey","institution_ids":["https://openalex.org/I197907453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039555328"],"corresponding_institution_ids":["https://openalex.org/I100072489"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.4235,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.53809684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"6","first_page":"702","last_page":"707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.9070000052452087},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/seminiferous-tubules","display_name":"seminiferous tubules","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.703000009059906},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.8209999799728394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2778074268","wikidata":"https://www.wikidata.org/wiki/Q1786953","display_name":"Seminoma","level":3,"score":0.8868275880813599},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8314100503921509},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.5506830811500549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5190020799636841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.50909823179245},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.449344277381897},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36864519119262695},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.3519483506679535},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3417440354824066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3079211115837097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2788175344467163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27353328466415405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2712833881378174},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018239","descriptor_name":"Seminoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018239","descriptor_name":"Seminoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/and.12504","doi":"https://doi.org/10.1111/and.12504","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12504","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12504","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},{"id":"pmid:26648340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26648340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/and.12504","doi":"https://doi.org/10.1111/and.12504","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12504","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12504","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2194080025.pdf","grobid_xml":"https://content.openalex.org/works/W2194080025.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W104690111","https://openalex.org/W193603262","https://openalex.org/W1791416231","https://openalex.org/W1965955251","https://openalex.org/W1980048146","https://openalex.org/W1984736455","https://openalex.org/W1995197723","https://openalex.org/W1997499008","https://openalex.org/W2003570540","https://openalex.org/W2006436316","https://openalex.org/W2017018900","https://openalex.org/W2020773732","https://openalex.org/W2031132185","https://openalex.org/W2064549366","https://openalex.org/W2077453272","https://openalex.org/W2082171685","https://openalex.org/W2085457454","https://openalex.org/W2108608698","https://openalex.org/W2144254428","https://openalex.org/W2159481926","https://openalex.org/W2189466444","https://openalex.org/W6649721139"],"related_works":["https://openalex.org/W2625967112","https://openalex.org/W4313488134","https://openalex.org/W1997499008","https://openalex.org/W4323860351","https://openalex.org/W2583038916","https://openalex.org/W2931119222","https://openalex.org/W4404844173","https://openalex.org/W2613383557","https://openalex.org/W2974492941","https://openalex.org/W4415585854"],"abstract_inverted_index":{"The":[0],"mammalian":[1],"target":[2,39],"of":[3,12,24,61,75,127,148,186],"rapamycin":[4],"(TOR)":[5],"has":[6],"been":[7],"implicated":[8],"in":[9,21,40,53,79,124,130,140,163,170,193],"the":[10,22,125,131,146,164,167,194],"control":[11,23,101],"different":[13],"stressors,":[14],"growth":[15],"factors,":[16],"nutrients":[17],"and":[18,98,111,118,121,152,190],"hormones,":[19],"participating":[20],"key":[25],"cellular":[26],"functions.":[27],"Controlling":[28],"this":[29],"many":[30],"pathways":[31],"poses":[32],"mTOR":[33,48,76,110,149,159,176],"signalling":[34,62,150,177],"as":[35],"a":[36],"potential":[37],"new":[38,41,181],"treatment":[42,185],"strategies":[43],"for":[44,166,184],"multiple":[45],"cancer":[46],"types.":[47],"components":[49,178],"could":[50,57,179],"potentially":[51],"mislocated":[52],"tumour":[54],"cells,":[55],"which":[56],"lead":[58],"to":[59,72,95],"activation":[60],"pathway":[63,151,160],"that":[64,175],"should":[65],"not":[66],"be":[67],"active.":[68],"Therefore,":[69,172],"we":[70,108,173],"aimed":[71],"show":[73],"localisation":[74],"signal":[77],"proteins":[78,123,161],"testicular":[80,83,103,153,187],"seminoma.":[81],"Tumoural":[82],"tissues":[84],"were":[85],"obtained":[86],"from":[87],"10":[88],"patients":[89,189],"with":[90,100],"unilateral":[91],"classic":[92],"seminoma":[93,141,154,188],"undergoing":[94],"therapeutic":[96],"orchidectomy":[97],"compared":[99],"human":[102],"tissues.":[104],"Upon":[105],"immunohistochemical":[106],"evaluation,":[107],"detected":[109],"p-mTOR":[112],"(serine":[113],"2448),":[114],"P70S6K,":[115],"p-P70S6K,":[116],"PKCalpha":[117],"p-PKCalpha,":[119],"CD36":[120],"MAPLC3":[122],"cytoplasm":[126],"Sertoli":[128],"cells":[129],"seminiferous":[132],"tubules.":[133],"We":[134],"also":[135],"showed":[136],"cytoplasmic":[137,158],"perinuclear":[138],"staining":[139],"cells.":[142],"This":[143],"study":[144],"demonstrated":[145],"interaction":[147],"by":[155],"showing":[156],"intense":[157],"immunoreactivity":[162],"seminoma,":[165],"first":[168],"time":[169],"humans.":[171],"suggested":[174],"create":[180],"clinical":[182],"targets":[183],"male":[191],"infertility":[192],"future.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}