{"id":"https://openalex.org/W2193603221","doi":null,"title":"Effect of Pomegranate Extract Consumption on Cardiovascular Disease RiskFactors, Stress Hormones, and Quality of Life in Human Volunteers: An Exploratory Randomised, Double-Blind, Placebo-Controlled Trial","display_name":"Effect of Pomegranate Extract Consumption on Cardiovascular Disease RiskFactors, Stress Hormones, and Quality of Life in Human Volunteers: An Exploratory Randomised, Double-Blind, Placebo-Controlled Trial","publication_year":2015,"publication_date":"2015-10-15","ids":{"openalex":"https://openalex.org/W2193603221","mag":"2193603221"},"language":"en","primary_location":{"id":"pmh:oai:eresearch.qmu.ac.uk:4144","doi":null,"is_oa":false,"landing_page_url":"http://eresearch.qmu.ac.uk/4144/1/Published%20paper_ECNU-02-000057.pdf","pdf_url":"http://eresearch.qmu.ac.uk/4144/1/Published%20paper_ECNU-02-000057.pdf","source":{"id":"https://openalex.org/S4306402028","display_name":"Queen Margaret University Publications Repository (Queen Margaret University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181656237","host_organization_name":"Queen Margaret University","host_organization_lineage":["https://openalex.org/I181656237"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/4144","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047038967","display_name":"Angela V.E. Stockton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Stockton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083177962","display_name":"Emad A. S. Al\u2010Dujaili","orcid":"https://orcid.org/0000-0002-0985-7217","observed_orcids":["https://orcid.org/0000-0002-0985-7217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emad A.S. Al\u2010Dujaili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0985-7217","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054865905","display_name":"Gordon J. McDougall","orcid":"https://orcid.org/0000-0002-2285-0124","observed_orcids":["https://orcid.org/0000-0002-2285-0124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon J. McDougall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2285-0124","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111843175","display_name":"Isobel Davidson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isobel Davidson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109213954","display_name":"Sandra Drummond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Drummond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030569133","display_name":"L. Wyness","orcid":"https://orcid.org/0009-0003-5222-2908","observed_orcids":["https://orcid.org/0009-0003-5222-2908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Wyness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5781,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68552779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pomegranate-extract","display_name":"pomegranate extract","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9160000085830688},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.949999988079071},{"id":"https://openalex.org/keywords/salivary-cortisol","display_name":"salivary cortisol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stress-hormones","display_name":"stress hormones","score":0.9079999923706055},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8920000195503235},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.7519999742507935},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.41200000047683716},{"id":"https://openalex.org/keywords/ellagitannins","display_name":"ellagitannins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.8460000157356262},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5559999942779541},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/biophenols","display_name":"biophenols","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cortisol-cortisone-ratio","display_name":"cortisol/cortisone ratio","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7338162064552307},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6694291830062866},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6383118629455566},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5320134162902832},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5051212906837463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45022979378700256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.384198933839798},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3504517674446106},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:eresearch.qmu.ac.uk:4144","doi":null,"is_oa":false,"landing_page_url":"http://eresearch.qmu.ac.uk/4144/1/Published%20paper_ECNU-02-000057.pdf","pdf_url":"http://eresearch.qmu.ac.uk/4144/1/Published%20paper_ECNU-02-000057.pdf","source":{"id":"https://openalex.org/S4306402028","display_name":"Queen Margaret University Publications Repository (Queen Margaret University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181656237","host_organization_name":"Queen Margaret University","host_organization_lineage":["https://openalex.org/I181656237"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eresearch.qmu.ac.uk:20.500.12289/4144","doi":null,"is_oa":true,"landing_page_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/4144","pdf_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/4144","source":{"id":"https://openalex.org/S4306402028","display_name":"Queen Margaret University Publications Repository (Queen Margaret University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181656237","host_organization_name":"Queen Margaret University","host_organization_lineage":["https://openalex.org/I181656237"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"mag:2193603221","doi":null,"is_oa":false,"landing_page_url":"https://eresearch.qmu.ac.uk/bitstream/20.500.12289/4144/1/Published%2520paper_ECNU-02-000057.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:eresearch.qmu.ac.uk:20.500.12289/4144","doi":null,"is_oa":true,"landing_page_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/4144","pdf_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/4144","source":{"id":"https://openalex.org/S4306402028","display_name":"Queen Margaret University Publications Repository (Queen Margaret University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181656237","host_organization_name":"Queen Margaret University","host_organization_lineage":["https://openalex.org/I181656237"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2193603221.pdf","grobid_xml":"https://content.openalex.org/works/W2193603221.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W203629605","https://openalex.org/W1914148979","https://openalex.org/W1966962224","https://openalex.org/W1983366955","https://openalex.org/W1984447537","https://openalex.org/W1986371908","https://openalex.org/W1988975966","https://openalex.org/W2010120018","https://openalex.org/W2014230992","https://openalex.org/W2019500301","https://openalex.org/W2020932917","https://openalex.org/W2022333851","https://openalex.org/W2031825421","https://openalex.org/W2036187997","https://openalex.org/W2046715719","https://openalex.org/W2047475718","https://openalex.org/W2058745518","https://openalex.org/W2073216076","https://openalex.org/W2074021923","https://openalex.org/W2083501577","https://openalex.org/W2084038315","https://openalex.org/W2091538011","https://openalex.org/W2101571252","https://openalex.org/W2104695445","https://openalex.org/W2107135234","https://openalex.org/W2107987708","https://openalex.org/W2110040410","https://openalex.org/W2114004260","https://openalex.org/W2114691160","https://openalex.org/W2117023932","https://openalex.org/W2117801971","https://openalex.org/W2118029826","https://openalex.org/W2120080228","https://openalex.org/W2123712628","https://openalex.org/W2131742409","https://openalex.org/W2135565392","https://openalex.org/W2141462478","https://openalex.org/W2142317953","https://openalex.org/W2157739430","https://openalex.org/W2165292984","https://openalex.org/W2167854858","https://openalex.org/W2170182466","https://openalex.org/W2329504255","https://openalex.org/W2999510508"],"related_works":["https://openalex.org/W6981427931","https://openalex.org/W1508911424","https://openalex.org/W4307948032","https://openalex.org/W2744546937","https://openalex.org/W6903985493","https://openalex.org/W2955041345","https://openalex.org/W4409043021","https://openalex.org/W2468358264","https://openalex.org/W6959898872","https://openalex.org/W2062379130"],"abstract_inverted_index":{"Background:":[0],"Pomegranate":[1],"extract":[2],"(PE)":[3],"provides":[4,378],"a":[5,81,104,109,195,232,384],"rich":[6,341],"and":[7,24,26,63,74,116,118,131,136,141,147,154,162,209,212,245,279,293,308,352],"varied":[8],"source":[9],"of":[10,49,65,123,235,311,358],"biophenols,":[11],"which":[12],"can":[13],"act":[14],"as":[15],"powerful":[16],"antioxidants.":[17],"The":[18,252,326,360],"most":[19],"abundant":[20],"being":[21],"ellagitannins,":[22],"anthocyanins,":[23],"ellagic":[25],"gallic":[27],"acid":[28,214],"derivatives..":[29],"Evidence":[30],"suggests":[31],"that":[32,338],"pomegranate":[33],"juice":[34],"consumption":[35,51,230],"may":[36,344,366],"alleviate":[37],"cardiovascular":[38,346],"disease":[39],"(CVD)":[40],"risk":[41,347],"factors.":[42],"This":[43,375],"exploratory":[44,85,376],"study":[45,86,172,377],"investigates":[46],"the":[47,119,171,174,198,227,323],"effect":[48],"PE":[50,100,182,229,324,339],"on":[52],"blood":[53,149],"pressure":[54],"(BP),":[55],"insulin":[56,161,163,211],"resistance":[57,164],"(HOMA-IR),":[58],"stress":[59,350],"hormone":[60],"levels":[61,138,200,238,351,365],"(cortisol/cortisone)":[62],"quality":[64,357],"life":[66],"in":[67,80,170,197,224,320,342,362],"healthy":[68],"human":[69],"volunteers.":[70],"Methods:":[71],"Seven":[72],"males":[73],"22":[75],"females(n":[76],"=":[77,191,207,250,287,291,297,301,306,315],"29)":[78],"participated":[79],"double-blind,":[82],"randomised,":[83],"placebo-controlled":[84],"(BMI:":[87],"25.05":[88],"3.91":[89],"kg/m_,":[90],"age:":[91],"34.5":[92],"13.7":[93],"years).":[94],"All":[95,167],"participants":[96,168],"consumed":[97],"either":[98],"one":[99],"(Pomanox,":[101],"Pomegreat)":[102],"or":[103],"placebo":[105],"capsule":[106],"daily,":[107],"after":[108,155],"meal,":[110],"for":[111,369],"4":[112,156],"weeks.":[113],"Dietary":[114],"history":[115],"habits":[117],"health":[120,304,355],"related":[121,356],"Quality":[122,310],"Life":[124,312],"questionnaire":[125],"(Rand":[126],"36)":[127],"were":[128,143,222,317],"recorded":[129,223],"pre-":[130],"post-intervention.":[132],"BP,":[133],"salivary":[134,236,253,363],"cortisol":[135,237,364],"cortisone":[137],"(am,":[139],"noon,":[140],"pm)":[142],"assessed":[144],"by":[145],"ELISAs,":[146],"fasting":[148],"was":[150,178,194,256,328],"obtained":[151],"at":[152],"baseline":[153],"weeks":[157],"to":[158,186,203,264,273,283,382],"compare":[159],"glucose,":[160,210],"parameters.":[165],"Results:":[166],"randomised":[169],"completed":[173],"intervention.":[175],"Systolic":[176],"BP":[177],"significantly":[179,258,318],"reduced":[180,259],"following":[181],"from":[183,217,261,372],"120.3":[184],"13.3":[185],"115.6":[187],"13.1":[188],"mmHg":[189],"(P":[190,206],"0.012).":[192],"There":[193],"reduction":[196,361],"HOMA-IR":[199],"from2.22":[201],"2.62":[202],"1.61":[204],"1.88":[205],"0.045),":[208],"uric":[213],"all":[215],"decreased":[216],"baseline.":[218],"No":[219],"significant":[220,233],"changes":[221],"volunteers":[225],"taking":[226,322],"placebo.":[228],"caused":[231],"drop":[234],"(am;":[239],"39.5":[240],"19.6%,":[241],"p":[242,249,267,276,286],"<":[243,268,277],"0.001":[244,278],"noon;":[246],"43.1":[247],"32.3%,":[248],"0.016).":[251],"cortisol/cortisone":[254],"ratio":[255],"also":[257],"(am":[260],"1.11":[262],"0.51":[263],"0.55":[265],"0.26,":[266],"0.001,":[269],"noon":[270],"1.57":[271],"0.85":[272],"0.75":[274],"0.72,":[275],"pm;":[280],"1.22":[281],"0.90":[282],"0.74":[284],"0.59,":[285],"0.011).":[288],"Physical":[289],"(p":[290,296,300,305,314],"0.018)":[292],"social":[294],"functioning":[295],"0.021),":[298],"pain":[299],"0.003),":[302],"general":[303],"0.008)":[307],"overall":[309],"score":[313],"0.007)":[316],"improved":[319],"those":[321],"capsules.":[325],"intervention":[327],"delivered":[329],"successfully":[330],"with":[331],"no":[332],"withdrawals.":[333],"Conclusions:":[334],"These":[335],"results":[336],"suggest":[337],"intake":[340],"biophenols":[343],"ameliorate":[345],"factors,":[348],"reduce":[349],"improve":[353],"perceived":[354],"life.":[359],"prove":[367],"beneficial":[368],"people":[370],"suffering":[371],"chronic":[373],"stress.":[374],"useful":[379],"information":[380],"required":[381],"conduct":[383],"definitive":[385],"trial.":[386]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
