{"id":"https://openalex.org/W2192963340","doi":"https://doi.org/10.1016/j.trci.2015.08.002","title":"A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects","display_name":"A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects","publication_year":2015,"publication_date":"2015-10-02","ids":{"openalex":"https://openalex.org/W2192963340","doi":"https://doi.org/10.1016/j.trci.2015.08.002","mag":"2192963340","pmid":"https://pubmed.ncbi.nlm.nih.gov/29854937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975062"},"language":"en","primary_location":{"id":"doi:10.1016/j.trci.2015.08.002","doi":"https://doi.org/10.1016/j.trci.2015.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.trci.2015.08.002","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.trci.2015.08.002","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.trci.2015.08.002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112007704","display_name":"Inge Lues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Inge Lues","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Frank Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Weber","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027238188","display_name":"Antje Meyer","orcid":"https://orcid.org/0000-0003-1675-4512","observed_orcids":["https://orcid.org/0000-0003-1675-4512"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antje Meyer","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033895656","display_name":"Uli B","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uli B\u00fchring","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113705413","display_name":"Torsten Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Hoffmann","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058824118","display_name":"Kerstin K\u00fchn\u2010Wache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin K\u00fchn\u2010Wache","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040786000","display_name":"Susanne Manhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Manhart","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040602339","display_name":"Ulrich F. Heiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Heiser","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087154649","display_name":"Rolf Pokorny","orcid":"https://orcid.org/0000-0002-3681-6007","observed_orcids":["https://orcid.org/0000-0002-3681-6007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolf Pokorny","raw_affiliation_strings":["Covance Clinical Research Unit AG, Allschwil, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Covance Clinical Research Unit AG, Allschwil, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022359281","display_name":"Joseph Chiesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166171","display_name":"Covance (United Kingdom)","ror":"https://ror.org/059vag305","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210166171","https://openalex.org/I60638368"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Chiesa","raw_affiliation_strings":["Covance Clinical Research Unit Ltd, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Covance Clinical Research Unit Ltd, Leeds, UK","institution_ids":["https://openalex.org/I4210166171"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106672603","display_name":"Konrad Glund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Konrad Glund","raw_affiliation_strings":["Probiodrug AG, Halle, Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Probiodrug AG, Halle, Saale, Germany","institution_ids":["https://openalex.org/I4210144058"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112007704"],"corresponding_institution_ids":["https://openalex.org/I4210144058"],"apc_list":{"value":2540,"currency":"USD","value_usd":2540},"apc_paid":{"value":2540,"currency":"USD","value_usd":2540},"fwci":1.1221,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.71097058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"3","first_page":"182","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroglutamate-amyloid-beta","display_name":"pyroglutamate amyloid-beta","score":0.8259999752044678},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.46799999475479126},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.6769999861717224},{"id":"https://openalex.org/keywords/elderly-subjects","display_name":"elderly subjects","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.9326014518737793},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7371596097946167},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6648672223091125},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5575404167175293},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5048843026161194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4798154830932617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3273860216140747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24673661589622498},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1505926251411438},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.trci.2015.08.002","doi":"https://doi.org/10.1016/j.trci.2015.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.trci.2015.08.002","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.trci.2015.08.002","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},{"id":"pmid:29854937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29854937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia (New York, N. Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5975062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5975062/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement (N Y)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.trci.2015.08.002","doi":"https://doi.org/10.1016/j.trci.2015.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.trci.2015.08.002","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.trci.2015.08.002","source":{"id":"https://openalex.org/S2898321583","display_name":"Alzheimer s & Dementia Translational Research & Clinical Interventions","issn_l":"2352-8737","issn":["2352-8737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia: Translational Research & Clinical Interventions","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2192963340.pdf","grobid_xml":"https://content.openalex.org/works/W2192963340.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1514539285","https://openalex.org/W1518422193","https://openalex.org/W1552912270","https://openalex.org/W1587774683","https://openalex.org/W1603385476","https://openalex.org/W1861771638","https://openalex.org/W1963773666","https://openalex.org/W1964747897","https://openalex.org/W1974145718","https://openalex.org/W1977175607","https://openalex.org/W1978635035","https://openalex.org/W1979109833","https://openalex.org/W1980804249","https://openalex.org/W1990632702","https://openalex.org/W1993324769","https://openalex.org/W1993756815","https://openalex.org/W2012337892","https://openalex.org/W2013827779","https://openalex.org/W2039833241","https://openalex.org/W2055775253","https://openalex.org/W2076742349","https://openalex.org/W2080592458","https://openalex.org/W2082429191","https://openalex.org/W2082452187","https://openalex.org/W2083166775","https://openalex.org/W2089862851","https://openalex.org/W2096410114","https://openalex.org/W2097338951","https://openalex.org/W2103440561","https://openalex.org/W2116211664","https://openalex.org/W2170543101","https://openalex.org/W2399749275"],"related_works":["https://openalex.org/W2485000086","https://openalex.org/W1993324769","https://openalex.org/W2609307726","https://openalex.org/W2895816045","https://openalex.org/W7052540796","https://openalex.org/W1982724245","https://openalex.org/W6977321244","https://openalex.org/W4382683742","https://openalex.org/W2334708421","https://openalex.org/W2897925330"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Pyroglutamate-amyloid-\u03b2":[1],"(pE-A\u03b2)":[2],"peptides":[3],"are":[4,12],"major":[5],"components":[6],"of":[7,17,27,37,57,79,111,134,142,147],"A\u03b2-oligomers":[8],"and":[9,46,55,62,70,92,117,120],"A\u03b2-plaques,":[10],"which":[11],"regarded":[13],"as":[14],"key":[15],"culprits":[16],"Alzheimer's":[18],"disease":[19],"(AD)":[20],"pathology.":[21],"PQ912":[22,58,66,143],"is":[23],"a":[24,127,135],"competitive":[25],"inhibitor":[26],"the":[28,35,52,112,145],"enzyme":[29],"glutaminyl":[30],"cyclase":[31],"(QC),":[32],"essential":[33],"for":[34,144],"formation":[36],"pE-A\u03b2":[38],"peptides.":[39],"METHODS:":[40],"A":[41],"randomized,":[42],"double-blind,":[43],"placebo-controlled,":[44],"single-":[45],"multiple-ascending":[47],"oral":[48],"dose":[49],"study":[50,133],"investigated":[51],"safety,":[53],"pharmacokinetics,":[54],"pharmacodynamics":[56],"in":[59,94,104,115,126],"healthy":[60],"nonelderly":[61],"elderly":[63,95],"subjects.":[64],"RESULTS:":[65],"was":[67,90,97,108,124],"considered":[68],"safe":[69],"well":[71],"tolerated":[72],"with":[73],"dose-proportional":[74],"pharmacokinetics":[75],"up":[76,85],"to":[77,86,100],"doses":[78,84],"200":[80],"mg.":[81],"At":[82],"higher":[83],"1800":[87],"mg,":[88],"exposure":[89,93],"supraproportional":[91],"subjects":[96],"approximately":[98,109],"1.5-":[99],"2.1-fold":[101],"higher.":[102],"Exposure":[103],"cerebrospinal":[105],"fluid":[106],"(CSF)":[107],"20%":[110],"unbound":[113],"drug":[114],"plasma,":[116],"both":[118],"serum":[119],"CSF":[121],"QC":[122,137],"activity":[123],"inhibited":[125],"dose-related":[128],"manner.":[129],"DISCUSSION:":[130],"This":[131],"first-in-man":[132],"compound-targeting":[136],"inhibition":[138],"justifies":[139],"further":[140],"development":[141],"treatment":[146],"AD.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}