{"id":"https://openalex.org/W2192590399","doi":"https://doi.org/10.4049/jimmunol.1501888","title":"Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation","display_name":"Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation","publication_year":2015,"publication_date":"2015-12-08","ids":{"openalex":"https://openalex.org/W2192590399","doi":"https://doi.org/10.4049/jimmunol.1501888","mag":"2192590399","pmid":"https://pubmed.ncbi.nlm.nih.gov/26643479","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4707069"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1501888","doi":"https://doi.org/10.4049/jimmunol.1501888","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1501888","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/2/668.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jimmunol.org/content/jimmunol/196/2/668.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071685336","display_name":"Christine D. Palmer","orcid":"https://orcid.org/0000-0003-3213-0398","observed_orcids":["https://orcid.org/0000-0003-3213-0398"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine D Palmer","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070000407","display_name":"Marisol Romero\u2010Tejeda","orcid":"https://orcid.org/0000-0003-3624-1976","observed_orcids":["https://orcid.org/0000-0003-3624-1976"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisol Romero-Tejeda","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074882409","display_name":"Michael N. Sirignano","orcid":"https://orcid.org/0000-0001-9209-0901","observed_orcids":["https://orcid.org/0000-0001-9209-0901"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Sirignano","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102910857","display_name":"Siddhartha M. Sharma","orcid":"https://orcid.org/0000-0001-8597-7547","observed_orcids":["https://orcid.org/0000-0001-8597-7547","https://orcid.org/0000-0002-8799-388X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siddhartha Sharma","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027975124","display_name":"Todd M. Allen","orcid":"https://orcid.org/0000-0002-6609-1318","observed_orcids":["https://orcid.org/0000-0002-6609-1318"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd M Allen","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042817775","display_name":"Marcus A. Altfeld","orcid":"https://orcid.org/0000-0001-5972-2997","observed_orcids":["https://orcid.org/0000-0001-5972-2997"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Marcus Altfeld","raw_affiliation_strings":["Department of Viral Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , 20251 Hamburg ,","Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","\u2020Department of Viral Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Viral Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , 20251 Hamburg ,","institution_ids":["https://openalex.org/I137251492"]},{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]},{"raw_affiliation_string":"\u2020Department of Viral Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I137251492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079514697","display_name":"St\u00e9phanie Jost","orcid":"https://orcid.org/0000-0003-2100-3262","observed_orcids":["https://orcid.org/0000-0003-2100-3262"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephanie Jost","raw_affiliation_strings":["Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139","institution_ids":["https://openalex.org/I2802422659"]},{"raw_affiliation_string":"*Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042817775","https://openalex.org/A5074882409","https://openalex.org/A5079514697","https://openalex.org/A5102910857"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I137251492","https://openalex.org/I2802422659","https://openalex.org/I63966007"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.5943,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.6591889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"196","issue":"2","first_page":"668","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.578000009059906},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.640999972820282},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hla-dr-expression","display_name":"HLA-DR expression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autocrine-cytokine-signaling","display_name":"autocrine cytokine signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hiv-negative-men","display_name":"HIV-negative men","score":0.7310000061988831},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7077997326850891},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6603133678436279},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6079564094543457},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.6025609374046326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5928770303726196},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5280935168266296},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4642421007156372},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.45599788427352905},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4157862961292267},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.12797027826309204},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1501888","doi":"https://doi.org/10.4049/jimmunol.1501888","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1501888","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/2/668.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:26643479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26643479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4127265","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4707069","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4707069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4707069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.1501888","doi":"https://doi.org/10.4049/jimmunol.1501888","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1501888","pdf_url":"https://www.jimmunol.org/content/jimmunol/196/2/668.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5375337232","display_name":"Acute HIV Infection:  Implications for vaccine design","funder_award_id":"P01AI074415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6780903929","display_name":"TLR-mediated gender differences in HIV-1 pathogenesis","funder_award_id":"R01AI078784","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320313818","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2192590399.pdf","grobid_xml":"https://content.openalex.org/works/W2192590399.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1489590226","https://openalex.org/W1544940894","https://openalex.org/W1569758706","https://openalex.org/W1889825709","https://openalex.org/W1911554866","https://openalex.org/W1925993589","https://openalex.org/W1945510071","https://openalex.org/W1990583388","https://openalex.org/W1993197717","https://openalex.org/W1994176403","https://openalex.org/W1996005331","https://openalex.org/W1997739963","https://openalex.org/W2005141763","https://openalex.org/W2007701278","https://openalex.org/W2024576717","https://openalex.org/W2024992082","https://openalex.org/W2026616659","https://openalex.org/W2029466803","https://openalex.org/W2038939047","https://openalex.org/W2052997401","https://openalex.org/W2056548679","https://openalex.org/W2068365384","https://openalex.org/W2072344266","https://openalex.org/W2092079568","https://openalex.org/W2092617134","https://openalex.org/W2093170083","https://openalex.org/W2100820895","https://openalex.org/W2108596257","https://openalex.org/W2110558548","https://openalex.org/W2116797415","https://openalex.org/W2117170739","https://openalex.org/W2122378910","https://openalex.org/W2122483069","https://openalex.org/W2122708604","https://openalex.org/W2123912956","https://openalex.org/W2130603879","https://openalex.org/W2136072463","https://openalex.org/W2140876277","https://openalex.org/W2149612654","https://openalex.org/W2156013098","https://openalex.org/W2313606964","https://openalex.org/W2323083683"],"related_works":["https://openalex.org/W4313356889","https://openalex.org/W2059740732","https://openalex.org/W1989429351","https://openalex.org/W2045380875","https://openalex.org/W2158957145","https://openalex.org/W2313606964","https://openalex.org/W1998131107","https://openalex.org/W2162723667","https://openalex.org/W7097357688","https://openalex.org/W2017327685"],"abstract_inverted_index":{"Multiple":[0],"studies":[1,33],"have":[2,34,200],"shown":[3],"correlates":[4],"of":[5,38,43,54,70,101,117,131,155,165,178],"immune":[6,47,96,197],"activation":[7,22,177],"with":[8,73],"microbial":[9],"translocation":[10],"and":[11,84,145,148],"plasma":[12,85,104,119,132,172],"LPS":[13,44,105,120,133,173],"during":[14],"HIV":[15],"infection.":[16],"It":[17],"is":[18,23],"unclear":[19],"whether":[20],"this":[21,160],"due":[24],"to":[25,77,93,175,193],"LPS,":[26],"residual":[27],"viral":[28,56,111],"replication,":[29],"or":[30,58],"both.":[31],"Few":[32],"addressed":[35],"the":[36,52,99],"effects":[37],"persistent":[39],"in":[40,49,51,79,98,134,162,188,196],"vivo":[41,108,135,163],"levels":[42,106,121,130],"on":[45,67],"specific":[46],"functions":[48,97],"humans":[50],"absence":[53],"chronic":[55],"infection":[57],"pathological":[59],"settings":[60],"such":[61],"as":[62],"sepsis.":[63],"We":[64],"previously":[65],"reported":[66],"a":[68],"cohort":[69,90],"HIV-negative":[71,89],"men":[72],"subclinical":[74,103,129,166,186],"endotoxemia":[75,187],"linked":[76],"alterations":[78],"CD4/CD8":[80],"T":[81,138],"cell":[82,139],"ratio":[83],"cytokine":[86,143,182],"levels.":[87],"This":[88],"allowed":[91],"us":[92],"assess":[94],"cellular":[95],"context":[100],"different":[102],"ex":[107],"without":[109],"confounding":[110],"effects.":[112],"By":[113],"comparing":[114],"two":[115],"samples":[116],"differing":[118],"from":[122],"each":[123],"individual,":[124],"we":[125,168],"now":[126],"show":[127,170],"that":[128,171,185,199],"significantly":[136],"alter":[137],"proliferative":[140],"capacity,":[141],"monocyte":[142],"release,":[144],"HLA-DR":[146],"expression,":[147],"induce":[149],"TLR":[150],"cross-tolerance":[151],"by":[152],"decreased":[153],"phosphorylation":[154],"MAPK":[156],"pathway":[157],"components.":[158],"Using":[159],"human":[161],"model":[164],"endotoxemia,":[167],"furthermore":[169],"leads":[174],"constitutive":[176],"STAT1":[179],"through":[180],"autocrine":[181],"signaling,":[183],"suggesting":[184],"healthy":[189],"individuals":[190],"might":[191],"lead":[192],"significant":[194],"changes":[195],"function":[198],"thus":[201],"far":[202],"not":[203],"been":[204],"appreciated.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}