{"id":"https://openalex.org/W2192016206","doi":"https://doi.org/10.1016/j.pharmthera.2015.10.009","title":"Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer","display_name":"Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer","publication_year":2015,"publication_date":"2015-11-04","ids":{"openalex":"https://openalex.org/W2192016206","doi":"https://doi.org/10.1016/j.pharmthera.2015.10.009","mag":"2192016206","pmid":"https://pubmed.ncbi.nlm.nih.gov/26542362"},"language":"en","primary_location":{"id":"doi:10.1016/j.pharmthera.2015.10.009","doi":"https://doi.org/10.1016/j.pharmthera.2015.10.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2015.10.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725815002016/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0163725815002016/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075511892","display_name":"Mari Masuda","orcid":"https://orcid.org/0000-0003-2311-8696","observed_orcids":["https://orcid.org/0000-0003-2311-8696"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Masuda","raw_affiliation_strings":["Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011509062","display_name":"Masaaki Sawa","orcid":"https://orcid.org/0000-0002-0077-2188","observed_orcids":["https://orcid.org/0000-0002-0077-2188"]},"institutions":[{"id":"https://openalex.org/I4405285453","display_name":"Carna Biosciences (Japan)","ror":"https://ror.org/05fw9gc86","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405285453"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Sawa","raw_affiliation_strings":["Carna Biosciences, Inc., Kobe 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carna Biosciences, Inc., Kobe 650-0047, Japan","institution_ids":["https://openalex.org/I4405285453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049388697","display_name":"Tesshi Yamada","orcid":"https://orcid.org/0000-0002-6843-7482","observed_orcids":["https://orcid.org/0000-0002-6843-7482"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tesshi Yamada","raw_affiliation_strings":["Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan. Electronic address: tyamada@ncc.go.jp","Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104\u20130045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan. Electronic address: tyamada@ncc.go.jp","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104\u20130045, Japan","institution_ids":["https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049388697"],"corresponding_institution_ids":["https://openalex.org/I4405287541"],"apc_list":{"value":5660,"currency":"USD","value_usd":5660},"apc_paid":{"value":5660,"currency":"USD","value_usd":5660},"fwci":0.9317,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.66294643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"156","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnik","display_name":"TNIK","score":0.9169999957084656},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/t-cell-factor-4","display_name":"T-cell factor 4","score":0.7599999904632568},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.49000000953674316},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9030690789222717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7024558782577515},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.6361178159713745},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.5982092618942261},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5813474059104919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5626125931739807},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.5594545602798462},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.547105610370636},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5306668877601624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41922903060913086},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.41737446188926697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29685908555984497},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21593338251113892}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pharmthera.2015.10.009","doi":"https://doi.org/10.1016/j.pharmthera.2015.10.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2015.10.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725815002016/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:26542362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26542362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.pharmthera.2015.10.009","doi":"https://doi.org/10.1016/j.pharmthera.2015.10.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pharmthera.2015.10.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0163725815002016/pdf","source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324144","display_name":"National Institute of Biomedical Innovation","ror":"https://ror.org/001rkbe13"},{"id":"https://openalex.org/F4320335039","display_name":"Narodowe Centrum Bada\u0144 i Rozwoju","ror":"https://ror.org/05pwfyy15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2192016206.pdf","grobid_xml":"https://content.openalex.org/works/W2192016206.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W38102763","https://openalex.org/W64959330","https://openalex.org/W1018331845","https://openalex.org/W1524824145","https://openalex.org/W1575128272","https://openalex.org/W1593333298","https://openalex.org/W1963521777","https://openalex.org/W1965700826","https://openalex.org/W1966121721","https://openalex.org/W1967137553","https://openalex.org/W1969867759","https://openalex.org/W1970195787","https://openalex.org/W1971085650","https://openalex.org/W1975423168","https://openalex.org/W1975993620","https://openalex.org/W1976359234","https://openalex.org/W1982804269","https://openalex.org/W1985158921","https://openalex.org/W1986168751","https://openalex.org/W1986724654","https://openalex.org/W1988856936","https://openalex.org/W1990423062","https://openalex.org/W1994029539","https://openalex.org/W1999157957","https://openalex.org/W1999999470","https://openalex.org/W2000991161","https://openalex.org/W2001181621","https://openalex.org/W2001459623","https://openalex.org/W2002803432","https://openalex.org/W2006307101","https://openalex.org/W2006419043","https://openalex.org/W2007145040","https://openalex.org/W2008773040","https://openalex.org/W2009117004","https://openalex.org/W2009134460","https://openalex.org/W2011517124","https://openalex.org/W2011532943","https://openalex.org/W2014886648","https://openalex.org/W2018348035","https://openalex.org/W2022083755","https://openalex.org/W2023206317","https://openalex.org/W2026041152","https://openalex.org/W2032355637","https://openalex.org/W2034030391","https://openalex.org/W2034373020","https://openalex.org/W2042992682","https://openalex.org/W2045031715","https://openalex.org/W2045828622","https://openalex.org/W2051055358","https://openalex.org/W2055845643","https://openalex.org/W2057257265","https://openalex.org/W2059114286","https://openalex.org/W2059813946","https://openalex.org/W2062006728","https://openalex.org/W2065504774","https://openalex.org/W2069561533","https://openalex.org/W2069750786","https://openalex.org/W2071506358","https://openalex.org/W2078591745","https://openalex.org/W2078628823","https://openalex.org/W2079554604","https://openalex.org/W2086487946","https://openalex.org/W2095579742","https://openalex.org/W2096175781","https://openalex.org/W2097959454","https://openalex.org/W2101889783","https://openalex.org/W2104452138","https://openalex.org/W2105953048","https://openalex.org/W2105986617","https://openalex.org/W2107261560","https://openalex.org/W2108981351","https://openalex.org/W2112140640","https://openalex.org/W2113995806","https://openalex.org/W2115001053","https://openalex.org/W2119032770","https://openalex.org/W2126002765","https://openalex.org/W2127396827","https://openalex.org/W2132477203","https://openalex.org/W2132705689","https://openalex.org/W2133267962","https://openalex.org/W2133992767","https://openalex.org/W2147834058","https://openalex.org/W2148074532","https://openalex.org/W2154142433","https://openalex.org/W2154966824","https://openalex.org/W2155978263","https://openalex.org/W2158079348","https://openalex.org/W2171080110","https://openalex.org/W2184814767","https://openalex.org/W2262414037","https://openalex.org/W3083236858","https://openalex.org/W4322700126","https://openalex.org/W6661789891","https://openalex.org/W6679771922","https://openalex.org/W6679934118","https://openalex.org/W6683167697","https://openalex.org/W6849789077","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W2588274259","https://openalex.org/W2168244837","https://openalex.org/W2401566442","https://openalex.org/W4307423229","https://openalex.org/W2506489222","https://openalex.org/W2332898336","https://openalex.org/W2042992682","https://openalex.org/W2071506358","https://openalex.org/W3115939134","https://openalex.org/W2072573412"],"abstract_inverted_index":{"The":[0],"genetic":[1,71,90],"and":[2,60,123,126,138,151,167,188],"epigenetic":[3],"alterations":[4],"occurring":[5],"during":[6],"the":[7,18,24,30,40,69,115,164,181,186,195,211],"course":[8],"of":[9,23,33,49,56,66,88,95,114,140,163,185,210],"multistage":[10],"colorectal":[11,34,74,106,199],"carcinogenesis":[12],"have":[13,37,135],"been":[14,99,136,157],"extensively":[15],"studied":[16],"in":[17,39,54,146,180,198],"last":[19],"few":[20],"decades.":[21],"One":[22],"most":[25,182],"notable":[26],"findings":[27],"is":[28,68,191],"that":[29],"great":[31],"majority":[32],"cancers":[35],"(>80%)":[36],"mutations":[38],"adenomatous":[41],"polyposis":[42],"coli":[43],"(APC)":[44],"tumor":[45],"suppressor":[46],"gene.":[47],"Loss":[48],"functional":[50],"APC":[51,67,203],"protein":[52,131,133,153],"results":[53],"activation":[55,84],"canonical":[57],"Wnt/\u03b2-catanin":[58],"signaling":[59,97,117,179],"initiates":[61],"intestinal":[62],"carcinogenesis.":[63],"Mutational":[64],"inactivation":[65],"first":[70],"event,":[72],"but":[73],"cancer":[75,200],"cells":[76,201],"retain":[77],"their":[78],"dependency":[79],"on":[80],"constitutive":[81],"Wnt":[82,96,116,178],"signal":[83,196],"even":[85,197],"after":[86],"accumulation":[87],"other":[89],"events.":[91],"Accordingly,":[92],"pharmacological":[93],"blocking":[94],"has":[98,156],"considered":[100],"an":[101],"attractive":[102],"therapeutic":[103],"approach":[104],"for":[105],"cancer.":[107],"Several":[108],"therapeutics":[109],"targeting":[110],"various":[111],"molecular":[112],"components":[113],"pathway,":[118,187],"including":[119],"porcupine,":[120],"frizzled":[121],"receptors":[122],"co-receptor,":[124],"tankyrases,":[125],"cAMP":[127],"response":[128],"element":[129],"binding":[130],"(CREB)-binding":[132],"(CBP),":[134],"developed,":[137],"some":[139,209],"those":[141],"are":[142],"currently":[143],"being":[144],"evaluated":[145],"early-phase":[147],"clinical":[148],"trials.":[149],"Traf2-":[150],"Nck-interacting":[152],"kinase":[154],"(TNIK)":[155],"identified":[158],"as":[159],"a":[160],"regulatory":[161],"component":[162],"T-cell":[165],"factor-4":[166],"\u03b2-catenin":[168],"transcriptional":[169],"complex":[170],"independently":[171],"by":[172],"two":[173],"research":[174],"groups.":[175],"TNIK":[176,212],"regulates":[177],"downstream":[183],"part":[184],"its":[189],"inhibition":[190],"expected":[192],"to":[193],"block":[194],"with":[202],"gene":[204],"mutation.":[205],"Here":[206],"we":[207],"discuss":[208],"inhibitors":[213],"under":[214],"preclinical":[215],"development.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}