{"id":"https://openalex.org/W2190886353","doi":null,"title":"Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.","display_name":"Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.","publication_year":1990,"publication_date":"1990-12-01","ids":{"openalex":"https://openalex.org/W2190886353","mag":"2190886353","pmid":"https://pubmed.ncbi.nlm.nih.gov/1701964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877741"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1545015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"W G Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W G Zhou","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W Chao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Chao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B A Levine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Levine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062485460","display_name":"Merle S. Olson","orcid":"https://orcid.org/0000-0003-3654-7692","observed_orcids":["https://orcid.org/0000-0003-3654-7692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4712,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91088315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"137","issue":"6","first_page":"1501","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":1.0},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/obstructive-pancreatitis","display_name":"obstructive pancreatitis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pancreatic-duct-ligation","display_name":"pancreatic duct ligation","score":0.984000027179718},{"id":"https://openalex.org/keywords/paf-receptor-antagonist","display_name":"PAF receptor antagonists","score":0.824999988079071},{"id":"https://openalex.org/keywords/bn-52021","display_name":"BN 52021","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pancreatic-regeneration","display_name":"pancreatic regeneration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/exocrine-pancreatic-function","display_name":"pancreatic exocrine function","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pancreatic-fibrosis","display_name":"pancreatic fibrosis","score":0.703000009059906},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7506568431854248},{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.7308989763259888},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6545355319976807},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6327469944953918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6206415891647339},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5920570492744446},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.547698438167572},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5109519362449646},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5033311247825623},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.48325687646865845},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48160430788993835},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4163965880870819},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27815625071525574}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D046934","descriptor_name":"Ginkgolides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1545015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:1701964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1701964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1877741","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1877741/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:2190886353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1701964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1545015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3852952164","display_name":"REGULATORY MECHANISMS IN KETOGENESIS AND GLUCONEOGENESIS","funder_award_id":"5r01am019473-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W149350379","https://openalex.org/W1515846068","https://openalex.org/W1600041070","https://openalex.org/W1799056643","https://openalex.org/W1893528652","https://openalex.org/W1964258168","https://openalex.org/W1969829366","https://openalex.org/W1971924515","https://openalex.org/W1974936938","https://openalex.org/W1988154111","https://openalex.org/W1991537460","https://openalex.org/W1994287166","https://openalex.org/W2010132397","https://openalex.org/W2013527644","https://openalex.org/W2015152562","https://openalex.org/W2020223826","https://openalex.org/W2020358486","https://openalex.org/W2046504225","https://openalex.org/W2052412773","https://openalex.org/W2060507826","https://openalex.org/W2062271937","https://openalex.org/W2068244101","https://openalex.org/W2071406689","https://openalex.org/W2073105849","https://openalex.org/W2077482915","https://openalex.org/W2082331610","https://openalex.org/W2090557058","https://openalex.org/W2098906642","https://openalex.org/W2101720275","https://openalex.org/W2106170607","https://openalex.org/W2152311269","https://openalex.org/W2153489208","https://openalex.org/W2166376385","https://openalex.org/W2252056675","https://openalex.org/W2260101877","https://openalex.org/W2315590091","https://openalex.org/W2332522473","https://openalex.org/W2398294620","https://openalex.org/W2407037778","https://openalex.org/W2412751280","https://openalex.org/W2417982496","https://openalex.org/W4290428850"],"related_works":["https://openalex.org/W1972280862","https://openalex.org/W2050973855","https://openalex.org/W977196248","https://openalex.org/W2419398697","https://openalex.org/W7217634257","https://openalex.org/W2036507797","https://openalex.org/W2031944053","https://openalex.org/W158091812","https://openalex.org/W1530317158","https://openalex.org/W1979822356"],"abstract_inverted_index":{"The":[0],"role":[1,278],"of":[2,9,21,26,43,47,68,85,93,127,152,155,197,208,233,243,246,255,263],"platelet-activating":[3],"factor":[4],"(PAF)":[5],"as":[6,28,281],"a":[7,70,97,206,276,282],"mediator":[8,285],"pancreatic":[10,17,101,136,162,168,188,216,224,256,268],"inflammation":[11,191],"was":[12,36,60,108,150,184],"examined":[13],"in":[14,49,100,130,176,194,218,266,286,289],"the":[15,50,64,73,83,91,118,124,153,230,244],"rat":[16],"duct":[18,115,142,238],"ligation":[19,116,143],"model":[20],"obstructive":[22,234],"pancreatitis.":[23],"Pancreatic":[24],"generation":[25],"PAF,":[27,247],"measured":[29],"by":[30,237],"bioassay":[31],"(ie,":[32],"platelet":[33],"[3H]serotonin":[34],"secretion),":[35],"determined":[37],"at":[38],"various":[39],"times":[40,105],"after":[41,114,141],"induction":[42],"inflammation.":[44],"Tissue":[45],"levels":[46,103,146,226],"PAF":[48,59,102,145,156,199,225,264,280],"normal":[51],"pancreas":[52],"averaged":[53],"600":[54],"+/-":[55],"49":[56],"pg/g,":[57],"but":[58],"not":[61],"detectable":[62],"during":[63,82,117,229],"initial":[65],"24":[66],"hours":[67],"pancreatitis,":[69],"time":[71],"when":[72,144],"inflammatory":[74,284],"reaction":[75],"would":[76],"be":[77],"considered":[78],"acute,":[79],"that":[80,223,241,260],"is,":[81],"period":[84],"maximal":[86],"serum":[87],"amylase":[88,213],"release":[89,214],"and":[90,135,159,172,190,212,258,270],"development":[92],"interstitial":[94],"edema.":[95],"However":[96],"substantial":[98],"increase":[99],"(12":[104],"control":[106],"levels)":[107],"observed":[109],"7":[110,203],"to":[111,123,186],"14":[112],"days":[113],"late-phase":[119,283],"response":[120],"interval":[121],"similar":[122],"situation":[125],"characteristic":[126],"chronic":[128,231,261,287],"pancreatitis":[129,235,288],"which":[131],"parenchymal":[132],"atrophy,":[133],"fibrosis,":[134],"insufficiency":[137],"evolve.":[138],"One":[139],"week":[140],"peaked,":[147],"an":[148,253],"evaluation":[149],"made":[151],"effects":[154],"antagonists":[157],"(BN52021":[158],"WEB2170)":[160],"on":[161],"lesions":[163],"using":[164],"Evan's":[165],"blue":[166],"extravasation,":[167],"myeloperoxidase":[169],"(MPO)":[170],"activity,":[171],"acid":[173],"phosphatase":[174],"activity":[175],"peritoneal":[177],"lavage":[178],"fluid.":[179],"BN52021":[180],"or":[181],"WEB2170":[182],"treatment":[183],"shown":[185],"reduce":[187],"damage":[189],"significantly.":[192],"Long-term":[193],"vivo":[195],"administration":[196,262],"exogenous":[198],"(20":[200],"micrograms/kg/hr":[201],"for":[202,279],"days)":[204],"exhibited":[205],"reduction":[207],"[3H]thymidine":[209],"uptake":[210],"into":[211],"from":[215],"acini":[217],"vitro.":[219],"Our":[220],"observations":[221],"1)":[222],"increased":[227],"significantly":[228],"phase":[232],"induced":[236],"ligation;":[239],"2)":[240],"inhibition":[242],"action":[245],"through":[248],"specific":[249],"receptor":[250],"antagonism,":[251],"caused":[252],"attenuation":[254],"lesions;":[257],"3)":[259],"resulted":[265],"decreased":[267],"regeneration":[269],"exocrine":[271],"function":[272],"are":[273],"consistent":[274],"with":[275],"pivotal":[277],"rats.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}