{"id":"https://openalex.org/W2190856024","doi":null,"title":"Effects of human herpesvirus 7 infection on expression levels of human immunodeficiency virus type 1 receptors on Cd4+ T cells Among Hiv-1 highly exposed Sero-Negative persons in Nairobi Kenya","display_name":"Effects of human herpesvirus 7 infection on expression levels of human immunodeficiency virus type 1 receptors on Cd4+ T cells Among Hiv-1 highly exposed Sero-Negative persons in Nairobi Kenya","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2190856024","mag":"2190856024"},"language":"en","primary_location":{"id":"pmh:oai:http://erepository.uonbi.ac.ke:11295/93263","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11295/93263","pdf_url":null,"source":{"id":"https://openalex.org/S4306402107","display_name":"University of Nairobi Research Archive (University of Nairobi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12859529","host_organization_name":"University of Nairobi","host_organization_lineage":["https://openalex.org/I12859529"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001685003","display_name":"Matrona Akiso","orcid":"https://orcid.org/0000-0002-3665-9304","observed_orcids":["https://orcid.org/0000-0002-3665-9304"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matrona Akiso","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3665-9304","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001685003"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-herpesvirus-7","display_name":"human herpesvirus 7","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hiv-discordant-couples","display_name":"HIV discordant couples","score":0.7870000004768372},{"id":"https://openalex.org/keywords/genital-mucosa","display_name":"genital mucosa","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.3449999988079071},{"id":"https://openalex.org/keywords/viral-coinfection","display_name":"viral coinfection","score":0.5180000066757202},{"id":"https://openalex.org/keywords/nairobi","display_name":"Nairobi","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.7372178435325623},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6579497456550598},{"id":"https://openalex.org/C3018958071","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Human herpesvirus","level":3,"score":0.5828230977058411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49907636642456055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4828127324581146},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42853814363479614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35374557971954346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15322062373161316}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:http://erepository.uonbi.ac.ke:11295/93263","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11295/93263","pdf_url":null,"source":{"id":"https://openalex.org/S4306402107","display_name":"University of Nairobi Research Archive (University of Nairobi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12859529","host_organization_name":"University of Nairobi","host_organization_lineage":["https://openalex.org/I12859529"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2190856024","doi":null,"is_oa":false,"landing_page_url":"http://erepository.uonbi.ac.ke/handle/11295/93263","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W119849496","https://openalex.org/W401676589","https://openalex.org/W1496541437","https://openalex.org/W1984929752","https://openalex.org/W2000147682","https://openalex.org/W2004729775","https://openalex.org/W2009589728","https://openalex.org/W2017324951","https://openalex.org/W2023354986","https://openalex.org/W2028693547","https://openalex.org/W2040896751","https://openalex.org/W2047872303","https://openalex.org/W2052134648","https://openalex.org/W2063139767","https://openalex.org/W2085904942","https://openalex.org/W2089178114","https://openalex.org/W2102070104","https://openalex.org/W2106015647","https://openalex.org/W2116227626","https://openalex.org/W2125065061","https://openalex.org/W2126339385","https://openalex.org/W2133420484","https://openalex.org/W2207266486"],"related_works":["https://openalex.org/W2089178114","https://openalex.org/W2169618276","https://openalex.org/W2085904942","https://openalex.org/W2051737346","https://openalex.org/W2207266486","https://openalex.org/W7098688019","https://openalex.org/W2061950958","https://openalex.org/W1557355868","https://openalex.org/W1496541437","https://openalex.org/W2387187635"],"abstract_inverted_index":{"Background:":[0],"Remaining":[1],"as":[2,96],"one":[3],"of":[4,33,114,136,141,186,224,254,300,361],"the":[5,24,31,34,84,91,101,134,153,175,220,225,232,244,251,265,301,365,374,382,388,395,398,403,407],"infectious":[6],"agents":[7],"associated":[8],"with":[9,122],"major":[10],"global":[11],"health":[12],"\\nburdens,":[13],"to":[14,21,38,46,89,110,213],"date,":[15],"there":[16],"is":[17,83],"no":[18,50],"effective":[19],"vaccine/drug":[20],"HIV":[22,39,69,123,149,165,200,203,256,399],"and":[23,171,202,210,215,219,243,280,292,318,329,342],"available":[25],"anti-retroviral":[26],"\\ntherapy":[27],"(ART)":[28],"only":[29,85],"prolongs":[30],"lives":[32],"infected":[35,57],"people.":[36],"Exposure":[37],"has":[40,58,107],"been":[41,60,108],"shown":[42,109],"\\nto":[43],"either":[44],"lead":[45],"established":[47],"infection":[48,70,124,138,363,400],"or":[49],"infection.":[51],"Why":[52],"some":[53,73],"people":[54],"don\u2019t":[55],"get":[56],"\\nnot":[59],"fully":[61],"understood.":[62],"Studies":[63],"on":[64,75,139],"other":[65,86],"viruses":[66],"that":[67,274,391],"modulate":[68],"may":[71],"shed":[72],"\\nlight":[74],"this":[76],"unique":[77],"phenomenon.":[78],"Human":[79],"herpesvirus":[80],"7":[81],"(HHV7)":[82],"virus":[87],"known":[88],"\\nuse":[90],"CD4":[92,302,319],"surface":[93,112,145,221,229],"glycoprotein":[94],"exclusively":[95],"its":[97],"primary":[98],"receptors":[99,116,146,230,303],"into":[100,125,152,195,364],"CD4+":[102,226,258,293,366,375],"T":[103,143,227,259,294,367,376],"cells.":[104,127,155,368],"This":[105,157,268],"\\nvirus":[106],"down-regulate":[111],"expression":[113,140,323,344],"these":[115,126],"in":[117,174,231,241,250,264,272,306,326,373,381,406],"in-vitro":[118,354],"studies":[119,355],"\\nhence":[120],"interfere":[121],"\\nObjectives:":[128],"The":[129,297,347],"study":[130,163,188,348,389,408],"aimed":[131],"at":[132],"assessing":[133],"impact":[135],"HHV7":[137,217,237,279,289,315,339,358,392],"\\nCD4+":[142],"cell":[144,228,260,295,377],"used":[147],"by":[148],"for":[150,277],"entry":[151],"host":[154],"\\nMethodology:":[156],"was":[158,190,238,269,283,324,336,379],"a":[159,333],"cross":[160],"sectional":[161],"cohort":[162,179],"where":[164],"discordant":[166,177],"couples":[167],"aged":[168],"\\nbetween":[169,338],"18":[170],"50":[172],"years":[173],"Pumwani":[176],"couples\u2019":[178],"were":[180,193,247,262,275,304],"recruited.":[181],"A":[182,309],"calculated":[183],"\\nsample":[184],"size":[185],"125":[187],"participants":[189],"used.":[191],"Participants":[192],"categorized":[194],"Highly":[196],"\\nexposed":[197],"seronegative":[198],"(HESN),":[199],"positive":[201,286],"negative":[204,276,310,334],"controls.":[205],"Laboratory":[206],"procedures":[207],"\\nincluded":[208],"PCR":[209],"Flow":[211],"cytometry":[212],"detect":[214],"quantify":[216],"genome":[218],"\\nexpression":[222,298],"levels":[223,299],"genital":[233],"mucosa":[234],"respectively.":[235],"\\nResults:":[236],"more":[239],"prevalent":[240],"males":[242],"viral":[245,290,316,340],"loads":[246,291,317,341],"significantly":[248],"higher":[249,263],"\\nmales":[252],"regardless":[253],"their":[255],"status.":[257],"frequencies":[261,378],"HHV7+":[266,307,328,383],"\\ncontrols.":[267],"also":[270],"observed":[271,313,337,380],"cases":[273],"both":[278,327],"HIV.":[281],"There":[282],"\\na":[284],"strong":[285],"correlation":[287,311,335],"between":[288,314],"frequencies.":[296],"reduced":[305],"subjects.":[308,331],"\\nwas":[312],"receptor":[320],"expression.":[321],"CCR5":[322,343],"\\nhigher":[325],"HIV+":[330],"However,":[332],"levels.":[345],"\\nConclusion:":[346],"results":[349],"support":[350],"findings":[351],"from":[352],"previous":[353],"which":[356],"\\ndemonstrated":[357],"induced":[359],"inhibition":[360],"HIV-1":[362],"In":[369,386],"addition,":[370],"an":[371],"\\nincrease":[372],"control":[384],"population.":[385],"\\nconclusion,":[387],"proposes":[390],"could":[393],"be":[394],"agent":[396],"behind":[397],"resistance":[401],"\\nof":[402],"HESN":[404],"group":[405],"population":[409]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
