{"id":"https://openalex.org/W2190832897","doi":"https://doi.org/10.1007/s00726-015-2134-7","title":"Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate","display_name":"Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate","publication_year":2015,"publication_date":"2015-12-10","ids":{"openalex":"https://openalex.org/W2190832897","doi":"https://doi.org/10.1007/s00726-015-2134-7","mag":"2190832897","pmid":"https://pubmed.ncbi.nlm.nih.gov/26660760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4752965"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-015-2134-7","doi":"https://doi.org/10.1007/s00726-015-2134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-015-2134-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00726-015-2134-7.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs00726-015-2134-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027318709","display_name":"Chad N. Hancock","orcid":"https://orcid.org/0000-0003-0285-0829","observed_orcids":["https://orcid.org/0000-0003-0285-0829"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad N. Hancock","raw_affiliation_strings":["Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA. chad.hancock@nih.gov","Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA. chad.hancock@nih.gov","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431690","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0001-8430-0497","observed_orcids":["https://orcid.org/0000-0001-8430-0497"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012473434","display_name":"W. Gregory Alvord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Gregory Alvord","raw_affiliation_strings":["Data Management Services, National Cancer Institute at Frederick, Frederick, MD, 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Management Services, National Cancer Institute at Frederick, Frederick, MD, 21702, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041646089","display_name":"James Ming Phang","orcid":"https://orcid.org/0000-0001-6707-0693","observed_orcids":["https://orcid.org/0000-0001-6707-0693"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James M. Phang","raw_affiliation_strings":["Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA. phangj@mail.nih.gov","Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA. phangj@mail.nih.gov","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NCI-Frederick, 1050 Boyles Street, Bldg. 538, Rm. 144, Frederick, MD, 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027318709","https://openalex.org/A5041646089"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":1.4458,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.81585781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"48","issue":"3","first_page":"859","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9869999885559082},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8629999756813049},{"id":"https://openalex.org/keywords/respiratory-fitness","display_name":"respiratory fitness","score":0.6389999985694885},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.7020000219345093},{"id":"https://openalex.org/keywords/dhp","display_name":"DHP","score":0.4779999852180481},{"id":"https://openalex.org/keywords/nac","display_name":"NAC","score":0.8600000143051147},{"id":"https://openalex.org/keywords/proline-metabolism","display_name":"proline metabolism","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2781132150","wikidata":"https://www.wikidata.org/wiki/Q1157009","display_name":"Proline dehydrogenase","level":4,"score":0.8746422529220581},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6297690272331238},{"id":"https://openalex.org/C2778858093","wikidata":"https://www.wikidata.org/wiki/Q24721080","display_name":"Alternative oxidase","level":3,"score":0.5853226780891418},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5818185210227966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5485579967498779},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.4792482852935791},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.41821348667144775},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.4122905135154724},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.3964647054672241},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09042420983314514}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011394","descriptor_name":"Proline Oxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011394","descriptor_name":"Proline Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00726-015-2134-7","doi":"https://doi.org/10.1007/s00726-015-2134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-015-2134-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00726-015-2134-7.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4752965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4752965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"Text"},{"id":"pmid:26660760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26660760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino acids","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00726-015-2134-7","doi":"https://doi.org/10.1007/s00726-015-2134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-015-2134-7","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00726-015-2134-7.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2190832897.pdf","grobid_xml":"https://content.openalex.org/works/W2190832897.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W7827006","https://openalex.org/W75870934","https://openalex.org/W1431301684","https://openalex.org/W1505439087","https://openalex.org/W1513618424","https://openalex.org/W1528834211","https://openalex.org/W1657827244","https://openalex.org/W1851039006","https://openalex.org/W1970710520","https://openalex.org/W1972777699","https://openalex.org/W1975517035","https://openalex.org/W1977015709","https://openalex.org/W1977019840","https://openalex.org/W1985382030","https://openalex.org/W1989332295","https://openalex.org/W1989447705","https://openalex.org/W1995675594","https://openalex.org/W2009951450","https://openalex.org/W2011400718","https://openalex.org/W2016653480","https://openalex.org/W2018179312","https://openalex.org/W2019864664","https://openalex.org/W2023005251","https://openalex.org/W2025719835","https://openalex.org/W2027977649","https://openalex.org/W2035171388","https://openalex.org/W2037605125","https://openalex.org/W2044414180","https://openalex.org/W2045484875","https://openalex.org/W2062126666","https://openalex.org/W2070779353","https://openalex.org/W2081200438","https://openalex.org/W2083162774","https://openalex.org/W2086360089","https://openalex.org/W2090161375","https://openalex.org/W2098387216","https://openalex.org/W2101411068","https://openalex.org/W2102715863","https://openalex.org/W2109000902","https://openalex.org/W2116622745","https://openalex.org/W2118936759","https://openalex.org/W2122372918","https://openalex.org/W2124567452","https://openalex.org/W2126511952","https://openalex.org/W2135414906","https://openalex.org/W2137140571","https://openalex.org/W2144828013","https://openalex.org/W2152430532","https://openalex.org/W2157167939","https://openalex.org/W2160304978","https://openalex.org/W2166213418","https://openalex.org/W2169335055","https://openalex.org/W2224940506","https://openalex.org/W4237877335"],"related_works":["https://openalex.org/W2082242607","https://openalex.org/W2088374643","https://openalex.org/W2514430610","https://openalex.org/W2898849930","https://openalex.org/W4225401898","https://openalex.org/W1881081860","https://openalex.org/W1967896144","https://openalex.org/W1799768544","https://openalex.org/W6908672578","https://openalex.org/W4221040533"],"abstract_inverted_index":{"Proline":[0],"dehydrogenase/oxidase":[1],"(PRODH/POX)":[2],"is":[3],"a":[4,40,118,188],"mitochondrial":[5,26,199],"protein":[6],"critical":[7],"to":[8,24,56],"multiple":[9],"stress":[10],"pathways.":[11],"Because":[12],"of":[13,16,47,81,121,124,136,148,198],"the":[14,25,30,48,125,134],"roles":[15],"PRODH/POX":[17,44,53,61,70,82,114,149,158,193],"in":[18,73,84,88,117,173,196],"signaling,":[19],"and":[20,45,58,67,99,127,138,156,170,175,194],"its":[21],"shared":[22],"localization":[23],"inner":[27],"membrane":[28],"with":[29],"electron":[31],"transport":[32],"chain":[33],"(ETC),":[34],"we":[35],"investigated":[36],"whether":[37],"there":[38],"was":[39,130,144],"direct":[41],"relationship":[42],"between":[43,168,192],"regulation":[46,197],"ETC.":[49],"We":[50,140],"found":[51,141],"that":[52,59,102,142],"binds":[54],"directly":[55],"CoQ1":[57],"CoQ1-dependent":[60],"activity":[62],"required":[63],"functional":[64],"Complex":[65,68],"III":[66],"IV.":[69],"supported":[71],"respiration":[72,172],"living":[74],"cells":[75],"during":[76],"nutrient":[77],"stress;":[78],"however,":[79],"expression":[80,115],"resulted":[83,116],"an":[85,145],"overall":[86],"decrease":[87],"respiratory":[89,93,161],"fitness.":[90,162],"Effects":[91],"on":[92,160],"fitness":[94],"were":[95,105],"inhibited":[96,151],"by":[97,107,133,154],"DHP":[98,137],"NAC,":[100],"indicating":[101],"these":[103],"effects":[104,159],"mediated":[106],"PRODH/POX-dependent":[108],"reactive":[109],"oxygen":[110],"species":[111],"(ROS)":[112],"generation.":[113],"dose-dependent":[119],"down-regulation":[120],"Complexes":[122],"I-IV":[123],"ETC,":[126],"this":[128],"effect":[129],"also":[131],"mitigated":[132],"addition":[135],"NAC.":[139],"succinate":[143,171,195],"uncompetitive":[146],"inhibitor":[147],"activity,":[150],"ROS":[152],"generation":[153],"PRODH/POX,":[155],"alleviated":[157],"The":[163],"findings":[164],"demonstrate":[165],"novel":[166],"cross-talk":[167],"proline":[169],"vivo":[174],"provide":[176],"mechanistic":[177],"insights":[178],"into":[179],"observations":[180],"from":[181],"previous":[182],"animal":[183],"studies.":[184],"Our":[185],"results":[186],"suggest":[187],"potential":[189],"regulatory":[190],"loop":[191],"respiration.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
