{"id":"https://openalex.org/W2190830971","doi":"https://doi.org/10.1186/s13075-015-0877-x","title":"The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid","display_name":"The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2190830971","doi":"https://doi.org/10.1186/s13075-015-0877-x","mag":"2190830971","pmid":"https://pubmed.ncbi.nlm.nih.gov/26643105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4672561"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-015-0877-x","doi":"https://doi.org/10.1186/s13075-015-0877-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0877-x","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13075-015-0877-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074318066","display_name":"Ali Alquraini","orcid":"https://orcid.org/0000-0003-4216-572X","observed_orcids":["https://orcid.org/0000-0003-4216-572X"]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Alquraini","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. ali.alquraini@my.mcphs.edu","Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. ali.alquraini@my.mcphs.edu","institution_ids":["https://openalex.org/I165817395"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113493273","display_name":"Steven Garguilo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Garguilo","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. steven.garguilo@my.mcphs.edu","Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. steven.garguilo@my.mcphs.edu","institution_ids":["https://openalex.org/I165817395"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090380505","display_name":"Gerard G. M. D\u2019Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard D\u2019Souza","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091761821","display_name":"Ling X. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"id":"https://openalex.org/I4210151747","display_name":"Lifespan","ror":"https://ror.org/04yt1rh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling X. Zhang","raw_affiliation_strings":["Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA. lzhang1@lifespan.org","Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA. lzhang1@lifespan.org","institution_ids":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]},{"raw_affiliation_string":"Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010138020","display_name":"Tannin A. Schmidt","orcid":"https://orcid.org/0000-0001-7140-254X","observed_orcids":["https://orcid.org/0000-0001-7140-254X"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tannin A. Schmidt","raw_affiliation_strings":["Faculty of Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, Canada. tschmidt@ucalgary.ca","Faculty of Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, Canada. tschmidt@ucalgary.ca","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Faculty of Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086926","display_name":"Gregory D. Jay","orcid":"https://orcid.org/0000-0003-1517-8488","observed_orcids":["https://orcid.org/0000-0003-1517-8488"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Jay","raw_affiliation_strings":["Department of Biomedical Engineering, Brown University, Providence, RI, USA. gjay@lifespan.org","Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA. gjay@lifespan.org","Department of Biomedical Engineering, Brown University, Providence, RI, USA","Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Brown University, Providence, RI, USA. gjay@lifespan.org","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA. gjay@lifespan.org","institution_ids":["https://openalex.org/I2800446032"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086816730","display_name":"Khaled A. Elsaid","orcid":"https://orcid.org/0000-0002-8925-4255","observed_orcids":["https://orcid.org/0000-0002-8925-4255"]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khaled A. Elsaid","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. Khaled.elsaid@mcphs.edu","Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA, 02115, USA. Khaled.elsaid@mcphs.edu","institution_ids":["https://openalex.org/I165817395"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 179 Longwood Ave, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I165817395"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086816730"],"corresponding_institution_ids":["https://openalex.org/I165817395"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":6.9359,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.97589569,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"353","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.18539999425411224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteoglycan-4","display_name":"proteoglycan 4","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9660000205039978},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pam3csk4","display_name":"Pam3CSK4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.800000011920929},{"id":"https://openalex.org/keywords/glycoprotein-binding","display_name":"glycoprotein binding","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.8095859289169312},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.751922607421875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.578918993473053},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5685873031616211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5180497169494629},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5156930088996887},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.5136758685112},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.45838114619255066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4519774615764618},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44538652896881104},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37203675508499146},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.3362518846988678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.329756498336792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19734805822372437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14048618078231812},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.0810151994228363},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000099158","descriptor_name":"Proteoglycan 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s13075-015-0877-x","doi":"https://doi.org/10.1186/s13075-015-0877-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0877-x","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4672561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4672561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:26643105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26643105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s13075-015-0877-x","doi":"https://doi.org/10.1186/s13075-015-0877-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0877-x","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3719481456","display_name":"COBRE for Skeletal Health and Repair","funder_award_id":"P20RR024484","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7602562168","display_name":"Nanocarriers for intra-articular drug delivery following ACL injury","funder_award_id":"R15AR061722","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G826715835","display_name":"Lubricin function in articulating joints","funder_award_id":"R01AR050180","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G979675260","display_name":"Tribosupplementation of Injured Joints","funder_award_id":"R42AR057276","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W79431883","https://openalex.org/W1239091656","https://openalex.org/W1488112431","https://openalex.org/W1494185187","https://openalex.org/W1601585257","https://openalex.org/W1679604700","https://openalex.org/W1963996129","https://openalex.org/W1967443177","https://openalex.org/W1969307566","https://openalex.org/W1970446320","https://openalex.org/W1973204863","https://openalex.org/W1976996315","https://openalex.org/W1982523597","https://openalex.org/W1987383242","https://openalex.org/W1989995073","https://openalex.org/W1991119452","https://openalex.org/W1991731944","https://openalex.org/W1992773045","https://openalex.org/W1994108614","https://openalex.org/W2010453472","https://openalex.org/W2014415867","https://openalex.org/W2015769931","https://openalex.org/W2024778783","https://openalex.org/W2028985265","https://openalex.org/W2033248229","https://openalex.org/W2035242925","https://openalex.org/W2035464830","https://openalex.org/W2040390440","https://openalex.org/W2045092981","https://openalex.org/W2046429196","https://openalex.org/W2059996143","https://openalex.org/W2061163173","https://openalex.org/W2064741792","https://openalex.org/W2079022347","https://openalex.org/W2086276639","https://openalex.org/W2090816971","https://openalex.org/W2092926936","https://openalex.org/W2097511131","https://openalex.org/W2123665246","https://openalex.org/W2131626977","https://openalex.org/W2135654846","https://openalex.org/W2143092625","https://openalex.org/W2149878776","https://openalex.org/W2152827658","https://openalex.org/W2157488005","https://openalex.org/W2163959124","https://openalex.org/W2478270278","https://openalex.org/W4254025084"],"related_works":["https://openalex.org/W2321560488","https://openalex.org/W2412034636","https://openalex.org/W2613643891","https://openalex.org/W1679604700","https://openalex.org/W2902753267","https://openalex.org/W4362667191","https://openalex.org/W4387435733","https://openalex.org/W7130506697","https://openalex.org/W7161232827","https://openalex.org/W7208061777"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lubricin/proteoglycan-4":[1],"(PRG4)":[2],"is":[3,42],"a":[4,17,71,100,222,295],"mucinous":[5],"glycoprotein":[6],"secreted":[7],"by":[8,122,133,159,190,270,276],"synovial":[9,76],"fibroblasts":[10],"and":[11,52,61,64,66,84,90,95,112,128,136,151,157,162,165,183,187,193,205,212,218,230,233,252,257,259,279,289,291],"superficial":[12],"zone":[13],"chondrocytes.":[14],"PRG4":[15,24,50,55,72,177,199,268,285],"has":[16],"homeostatic":[18],"multifaceted":[19],"role":[20,74,298],"in":[21,32,75,141,221],"the":[22,45,142,166],"joint.":[23],"intra-articular":[25],"treatment":[26,171,261],"retards":[27],"progression":[28],"of":[29,39,47,108,126,146,155,168,226],"cartilage":[30],"degeneration":[31],"pre-clinical":[33],"posttraumatic":[34],"osteoarthritis":[35,82],"models.":[36],"The":[37],"objective":[38],"this":[40,68,292],"study":[41],"to":[43,57,93,210,243,287],"evaluate":[44],"binding":[46,92,209,293],"recombinant":[48],"human":[49,54,115],"(rhPRG4)":[51],"native":[53],"(nhPRG4)":[56],"toll-like":[58],"receptors":[59],"2":[60],"4":[62],"(TLR2":[63],"TLR4)":[65],"whether":[67],"interaction":[69],"underpins":[70],"anti-inflammatory":[73,297],"fluid":[77],"(SF)":[78],"from":[79,180],"patients":[80],"with":[81,110,196,216],"(OA)":[83],"rheumatoid":[85],"arthritis":[86],"(RA).":[87],"METHODS:":[88],"rhPRG4":[89,109,204,214],"nhPRG4":[91,147,169,206,227,260],"TLR2":[94,111,127,156,186,211,238,256,274,288],"TLR4":[96,113,129,158,188,240,258,290],"was":[97,120,139,175,178,201],"evaluated":[98],"using":[99],"direct":[101],"enzyme":[102],"linked":[103],"immunosorbent":[104],"assay":[105],"(ELISA).":[106],"Association":[107],"overexpressing":[114],"embryonic":[116],"kidney":[117],"(HEK)":[118],"cells":[119,132,220],"studied":[121,140],"flow":[123],"cytometry.":[124],"Activation":[125,154],"on":[130,172],"HEK":[131],"agonists":[134],"Pam3CSK4":[135,234,244],"lipopolysaccharide":[137],"(LPS)":[138],"absence":[143],"or":[144,197,235,239,245],"presence":[145],"at":[148],"50,":[149],"100":[150,229],"150":[152,231],"\u03bcg/ml.":[153],"OA":[160,182,192,250,277],"SF":[161,164,170,195,251,254,278,281],"RA":[163,184,194,253,280],"effect":[167],"receptor":[173,264],"activation":[174,189,241,265,275],"assessed.":[176],"immunoprecipitated":[179],"pooled":[181,191],"SF.":[185],"without":[198],"immunoprecipitation":[200,271],"compared.":[202],"RESULTS:":[203],"exhibited":[207],"concentration-dependent":[208],"TLR4.":[213],"associated":[215],"TLR2-":[217],"TLR4-HEK":[219],"time-dependent":[223],"manner.":[224],"Co-incubation":[225],"(50,":[228],"\u03bcg/ml)":[232],"LPS":[236,246],"reduced":[237,262],"compared":[242],"alone":[247],"(p":[248,266,282],"<0.05).":[249],"activated":[255],"SF-induced":[263],"<0.001).":[267,283],"depletion":[269],"significantly":[272],"increased":[273],"CONCLUSION:":[284],"binds":[286],"mediates":[294],"novel":[296],"for":[299],"PRG4.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}