{"id":"https://openalex.org/W2190771027","doi":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","title":"Pemberian Kombinasi 5FU-Leucovorin dengan Phaleria macrocarpa terhadap Proliferasi Sel dan Diameter Adenokarsinoma Kolon Tikus Sprague dawley","display_name":"Pemberian Kombinasi 5FU-Leucovorin dengan Phaleria macrocarpa terhadap Proliferasi Sel dan Diameter Adenokarsinoma Kolon Tikus Sprague dawley","publication_year":2016,"publication_date":"2016-12-29","ids":{"openalex":"https://openalex.org/W2190771027","doi":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","mag":"2190771027"},"language":"id","primary_location":{"id":"doi:10.21776/ub.jkb.2017.029.03.7","doi":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","pdf_url":"https://www.jkb.ub.ac.id/index.php/jkb/article/download/1205/541","source":{"id":"https://openalex.org/S4210224216","display_name":"Jurnal Kedokteran Brawijaya","issn_l":"0216-9347","issn":["0216-9347","2338-0772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kedokteran Brawijaya","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jkb.ub.ac.id/index.php/jkb/article/download/1205/541","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087916912","display_name":"Luqman Alwi","orcid":"https://orcid.org/0009-0000-2740-3406","observed_orcids":["https://orcid.org/0009-0000-2740-3406"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Luqman Alwi","raw_affiliation_strings":["Diponegoro University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diponegoro University","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000003650","display_name":"Selamat Budijitno","orcid":"https://orcid.org/0000-0003-1171-5979","observed_orcids":["https://orcid.org/0000-0003-1171-5979"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Selamat Budijitno","raw_affiliation_strings":["Diponegoro University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diponegoro University","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034579841","display_name":"Edwin Basyar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Edwin Basyar","raw_affiliation_strings":["Diponegoro University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diponegoro University","institution_ids":["https://openalex.org/I11855966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I11855966"],"apc_list":null,"apc_paid":null,"fwci":0.3468,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63721725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"223","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.3041999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8769999742507935},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phaleria-macrocarpa","display_name":"Phaleria macrocarpa","score":0.9940000176429749},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/ki67-cell-proliferation","display_name":"Ki-67 cell proliferation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.626141369342804},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.41075512766838074},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.40271368622779846},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36243772506713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15862417221069336}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21776/ub.jkb.2017.029.03.7","doi":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","pdf_url":"https://www.jkb.ub.ac.id/index.php/jkb/article/download/1205/541","source":{"id":"https://openalex.org/S4210224216","display_name":"Jurnal Kedokteran Brawijaya","issn_l":"0216-9347","issn":["0216-9347","2338-0772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kedokteran Brawijaya","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21776/ub.jkb.2017.029.03.7","doi":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.jkb.2017.029.03.7","pdf_url":"https://www.jkb.ub.ac.id/index.php/jkb/article/download/1205/541","source":{"id":"https://openalex.org/S4210224216","display_name":"Jurnal Kedokteran Brawijaya","issn_l":"0216-9347","issn":["0216-9347","2338-0772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Kedokteran Brawijaya","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2190771027.pdf","grobid_xml":"https://content.openalex.org/works/W2190771027.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W53831954","https://openalex.org/W3204701664","https://openalex.org/W2461362430","https://openalex.org/W1501930010","https://openalex.org/W164840116","https://openalex.org/W2724272475","https://openalex.org/W3097649702","https://openalex.org/W2332776249","https://openalex.org/W2055109849","https://openalex.org/W1987881820"],"abstract_inverted_index":{"Insidensi":[0],"kanker":[1],"kolon":[2,73,209],"di":[3],"seluruh":[4],"dunia":[5],"masih":[6],"tinggi":[7],"dan":[8,28,68,116,132,156,205],"menjadi":[9,54],"penyebab":[10],"kematian":[11],"terbanyak":[12],"kategori":[13],"penyakit":[14],"tidak":[15,185],"menular.":[16],"Pembedahan":[17],"tetap":[18],"merupakan":[19],"pilihan":[20],"utama":[21],"dengan":[22,37,41,75,93,102,179],"modalitas":[23],"lainnya":[24],"berupa":[25],"kemoterapi,":[26],"radiasi":[27],"imunoterapi":[29],"seperti":[30],"P.":[31,66,90,188,216],"macrocarpa":[32,91,189],"(Mahkota":[33],"Dewa).":[34],"Penelitian":[35],"dilakukan":[36],"desain":[38,42],"eksperimental":[39],"laboratorik":[40],"post":[43],"test":[44],"only":[45],"menggunakan":[46,111],"tikus":[47,210],"putih":[48],"betina":[49],"strain":[50],"Sprague":[51,211],"dawley":[52],"dibagi":[53],"4":[55],"kelompok":[56,58,122,147,162],"yaitu":[57],"K":[59,148,163,167],"(kontrol),":[60],"P1":[61,165],"(kelompok":[62,65],"kemoterapi),":[63],"P2":[64,152,171],"macrocarpa),":[67],"P3":[69,126,150,154,169,173],"(Kelompok":[70],"kombinasi).":[71],"Tumor":[72],"diperoleh":[74],"induksi":[76],"1,2-DMH":[77],"subkutan.":[78],"Kemoterapi":[79],"yang":[80,194],"diberikan":[81,92],"5FU-Leucovorin":[82,199],"sebanyak":[83],"6":[84],"siklus":[85],"sesuai":[86],"Rosswell":[87],"Park":[88],"Regiment.":[89],"dosis":[94],"0,495mg/hari":[95],"(0,99mL/hari)":[96],"per":[97],"oral.":[98],"Proliferasi":[99,114],"sel":[100,115,145,178,204,219],"dinilai":[101],"pengecatan":[103],"IHC":[104],"Ki-67":[105],"sedangkan":[106],"diameter":[107,117,158,180,207],"massa":[108,118,159,181],"tumor":[109,119,160,182],"diukur":[110],"caliper":[112],"tumor.":[113],"didapatkan":[120,183],"rerata":[121],"K,":[123],"P1,":[124],"P2,":[125],"berturut-turut":[127],"37,150\u00b18,878,":[128],"28,567\u00b112,531,":[129],"35,533\u00b18,982,":[130],"22,567\u00b13,445":[131],"1,403\u00b10,265,":[133],"1,135\u00b10,154,":[134],"1,339\u00b10,111,":[135],"1,074\u00b10,164.":[136],"Analisis":[137,175],"statistik":[138],"menunjukkan":[139],"terdapat":[140],"perbedaan":[141],"bermakna":[142,186],"pada":[143,157],"proliferasi":[144,177,203,218],"antara":[146,161],"vs":[149,153,164,168,172],"(p=0,011),":[151],"(p=0,022)":[155],"(p=0,020),":[166],"(p=0,005),":[170],"(0,021).":[174],"korelasi":[176,184],"(p=0,405).":[187],"mempunyai":[190],"potensi":[191],"sebagai":[192],"imunostimulator":[193],"dapat":[195],"meningkatkan":[196],"efektivitas":[197],"kemoterapi":[198],"dalam":[200],"hal":[201],"penurunan":[202,206],"adenokarsinoma":[208],"dawley.Kata":[212],"Kunci:":[213],"Adenokarsinoma":[214],"kolon,":[215],"macrocarpa,":[217]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-07T09:17:50.787605","created_date":"2016-06-24T00:00:00"}
