{"id":"https://openalex.org/W2190674101","doi":"https://doi.org/10.1007/bf03256308","title":"Successful Translation of Pharmacogenetics into the Clinic","display_name":"Successful Translation of Pharmacogenetics into the Clinic","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2190674101","doi":"https://doi.org/10.1007/bf03256308","mag":"2190674101","pmid":"https://pubmed.ncbi.nlm.nih.gov/19351209"},"language":"en","primary_location":{"id":"doi:10.1007/bf03256308","doi":"https://doi.org/10.1007/bf03256308","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03256308","pdf_url":null,"source":{"id":"https://openalex.org/S206038947","display_name":"Molecular Diagnosis & Therapy","issn_l":"1177-1062","issn":["1177-1062","1179-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diagnosis & Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Elizabeth Phillips","raw_affiliation_strings":["Institute for Immunology and Infectious Diseases, Murdoch University and Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital, Perth, Western Australia, Australia. e.phillips@iiid.com.au","Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Infectious Diseases, Murdoch University and Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital, Perth, Western Australia, Australia. e.phillips@iiid.com.au","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]},{"raw_affiliation_string":"Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I176790772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Mallal","raw_affiliation_strings":["Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I176790772"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080985934"],"corresponding_institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":1.2378,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.76112026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-b-57-01","display_name":"HLA-B*57:01","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacogenetic-screening","display_name":"pharmacogenetic screening","score":0.828000009059906},{"id":"https://openalex.org/keywords/skin-patch-testing","display_name":"skin patch testing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.621999979019165},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.5210000276565552},{"id":"https://openalex.org/keywords/negative-predictive-value","display_name":"negative predictive value","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.8378685712814331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6562227010726929},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.41823694109916687},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3802902400493622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3508913218975067},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.16870656609535217},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.14268356561660767},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.09611254930496216},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.07914042472839355}],"mesh":[{"descriptor_ui":"D000099227","descriptor_name":"Abacavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010328","descriptor_name":"Patch Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf03256308","doi":"https://doi.org/10.1007/bf03256308","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03256308","pdf_url":null,"source":{"id":"https://openalex.org/S206038947","display_name":"Molecular Diagnosis & Therapy","issn_l":"1177-1062","issn":["1177-1062","1179-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diagnosis & Therapy","raw_type":"journal-article"},{"id":"pmid:19351209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19351209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular diagnosis & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:alma.61MUN_INST:11137289360007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Successful-translation-of-pharmacogenetics-into-the/991005546365907891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:2837","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/2837/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phillips, E.J. <http://researchrepository.murdoch.edu.au/view/author/Phillips, Elizabeth.html> and Mallal, S. <http://researchrepository.murdoch.edu.au/view/author/Mallal, Simon.html> (2009) Successful translation of pharmacogenetics into the clinic: The abacavir example. Molecular Diagnosis and Therapy, 13 (1). pp. 1-9.","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W71091497","https://openalex.org/W381968275","https://openalex.org/W1553222122","https://openalex.org/W1898025448","https://openalex.org/W1964499538","https://openalex.org/W1968439455","https://openalex.org/W1970924226","https://openalex.org/W1972242699","https://openalex.org/W1984051973","https://openalex.org/W1991088839","https://openalex.org/W1994872511","https://openalex.org/W2009516154","https://openalex.org/W2009674096","https://openalex.org/W2010897078","https://openalex.org/W2015329000","https://openalex.org/W2021318193","https://openalex.org/W2026666645","https://openalex.org/W2032039529","https://openalex.org/W2035312251","https://openalex.org/W2035476310","https://openalex.org/W2036030829","https://openalex.org/W2040846047","https://openalex.org/W2049501844","https://openalex.org/W2049902892","https://openalex.org/W2051736603","https://openalex.org/W2052332986","https://openalex.org/W2053896303","https://openalex.org/W2055128986","https://openalex.org/W2061631865","https://openalex.org/W2082126453","https://openalex.org/W2083508836","https://openalex.org/W2089378839","https://openalex.org/W2091436708","https://openalex.org/W2101761365","https://openalex.org/W2102942667","https://openalex.org/W2103213111","https://openalex.org/W2110868212","https://openalex.org/W2111047626","https://openalex.org/W2112182958","https://openalex.org/W2117678059","https://openalex.org/W2118621632","https://openalex.org/W2122329447","https://openalex.org/W2128338622","https://openalex.org/W2130470659","https://openalex.org/W2131240259","https://openalex.org/W2135068975","https://openalex.org/W2137146513","https://openalex.org/W2137422676","https://openalex.org/W2140055542","https://openalex.org/W2148750104","https://openalex.org/W2151936813","https://openalex.org/W2160393449","https://openalex.org/W2168733361","https://openalex.org/W2169362147","https://openalex.org/W2170804912","https://openalex.org/W2182777591","https://openalex.org/W2410517707","https://openalex.org/W2471343115","https://openalex.org/W4232532733"],"related_works":["https://openalex.org/W602754563","https://openalex.org/W1984773683","https://openalex.org/W1976076283","https://openalex.org/W2023117847","https://openalex.org/W2156404814","https://openalex.org/W139992993","https://openalex.org/W1994897757","https://openalex.org/W6923437558","https://openalex.org/W2065600450","https://openalex.org/W2055357102"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}