{"id":"https://openalex.org/W2190384249","doi":null,"title":"Did inappropriate delivery systems hamper therapeutic efficacy of di-sodium-cromo-glycate (DSCG)? Time for a reappraisal","display_name":"Did inappropriate delivery systems hamper therapeutic efficacy of di-sodium-cromo-glycate (DSCG)? Time for a reappraisal","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2190384249","mag":"2190384249"},"language":"en","primary_location":{"id":"mag:2190384249","doi":null,"is_oa":false,"landing_page_url":"http://erj.ersjournals.com/content/38/Suppl_55/p4829","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086596169","display_name":"Manfred Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099916","display_name":"PARI (Germany)","ror":"https://ror.org/011pcrd91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099916"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Keller","raw_affiliation_strings":["Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany","institution_ids":["https://openalex.org/I4210099916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004605323","display_name":"Oliver Denk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099916","display_name":"PARI (Germany)","ror":"https://ror.org/011pcrd91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099916"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Denk","raw_affiliation_strings":["Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany","institution_ids":["https://openalex.org/I4210099916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050812375","display_name":"Albert Bucholski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099916","display_name":"PARI (Germany)","ror":"https://ror.org/011pcrd91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099916"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Bucholski","raw_affiliation_strings":["Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany","institution_ids":["https://openalex.org/I4210099916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011599933","display_name":"Martin Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099916","display_name":"PARI (Germany)","ror":"https://ror.org/011pcrd91","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099916"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Knoch","raw_affiliation_strings":["Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerosol Research Institute, PARI Pharma GmbH, Graefelfing, Germany","institution_ids":["https://openalex.org/I4210099916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210099916"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":null,"first_page":"4829","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5820000171661377},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.6010000109672546},{"id":"https://openalex.org/keywords/nebulizer","display_name":"nebulizer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dry-powder-inhaler","display_name":"dry powder inhaler","score":0.8450000286102295},{"id":"https://openalex.org/keywords/metered-dose-inhaler","display_name":"MDI","score":0.902999997138977},{"id":"https://openalex.org/keywords/lung-deposition","display_name":"lung deposition","score":0.671999990940094},{"id":"https://openalex.org/keywords/relative-humidity","display_name":"relative humidity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.7289999723434448},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8860647678375244},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5782574415206909},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5393106937408447},{"id":"https://openalex.org/C77056095","wikidata":"https://www.wikidata.org/wiki/Q543183","display_name":"Isotonic","level":2,"score":0.5106926560401917},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.44593971967697144},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.4219544231891632},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3559364676475525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31913238763809204},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.2389051616191864},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.18732628226280212}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2190384249","doi":null,"is_oa":false,"landing_page_url":"http://erj.ersjournals.com/content/38/Suppl_55/p4829","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160994784","https://openalex.org/W2328045745","https://openalex.org/W2408802422","https://openalex.org/W1554448134","https://openalex.org/W2014449320","https://openalex.org/W2599930269","https://openalex.org/W2321621098","https://openalex.org/W2073533621","https://openalex.org/W2332422800","https://openalex.org/W2319323431"],"abstract_inverted_index":{"Chymase-positive":[0],"mast":[1],"cells":[2],"located":[3],"in":[4,11,75,149,165],"distal":[5],"airways":[6],"play":[7],"a":[8,76,162,215,222],"crucial":[9],"role":[10],"asthma":[12,219],"(Balzar":[13],"2005":[14],"&":[15,24,132],"2010).":[16,206],"A":[17],"review":[18],"on":[19,140],"inhaled":[20,193,203],"DSCG":[21,33,46,183,213,246],"by":[22,70,143,154,250],"Keller":[23],"Schierholz":[25],"(2011)":[26],"provided":[27,103],"evidence":[28],"that":[29,212,242],"poor":[30],"efficacy":[31,107,201,244],"of":[32,45,245],"is":[34,214,230,247],"most":[35],"probably":[36],"linked":[37],"with":[38,51,197],"sub-therapeutic":[39],"lung":[40,53],"doses.":[41],"The":[42],"hygroscopic":[43],"nature":[44],"causes":[47],"particle":[48,72],"growth":[49],"associated":[50],"reduced":[52],"deposition":[54],"(Hiller":[55],"1980)":[56],"which":[57],"may":[58],"explain":[59],"insufficient":[60],"therapeutic":[61,243],"efficacy.":[62],"Significantly":[63],"higher":[64],"in-vitro":[65],"respirable":[66],"doses":[67],"were":[68,121,146],"found":[69],"aerodynamic":[71],"size":[73,227],"assessments":[74],"next":[77],"generation":[78],"impactor":[79],"operated":[80],"at":[81,235],"50%":[82,236],"and":[83,96,106,118,128,138,217,237],"95%":[84,238],"rel.":[85,239],"humid.,":[86],"respectively":[87],"using":[88],"small":[89,225],"droplet":[90,226],"nebulisers":[91,124],"compared":[92,125],"to":[93,126,202],"Intal\u00ae":[94],"MDI":[95,196],"DPI":[97],"(Keller":[98],"2007).":[99],"Nebulised":[100],"isotonic":[101,182],"solutions":[102],"better":[104],"tolerability":[105],"than":[108],"hypotonic":[109],"Intal":[110],"solution":[111],"(Weiner":[112],"1988,":[113],"Soferman":[114],"1990).":[115],"Higher":[116],"Cmax":[117],"AUC":[119],"values":[120],"obtained":[122,234],"for":[123,174],"MDIs":[127],"DPIs":[129],"(Patel":[130],"1986":[131],"Kato":[133],"1999).":[134],"Above":[135],"mentioned":[136],"aspects":[137],"critisism":[139],"earlier":[141],"meta-analyses":[142],"Stevens":[144],"2007":[145],"still":[147],"ignored":[148],"the":[150,251],"latest":[151],"Cochrane":[152],"meta-analysis":[153],"van":[155],"der":[156],"Wouden":[157],"2009.":[158],"Recent":[159],"data":[160,210,233],"from":[161],"clinical":[163],"trial":[164],"48":[166],"asthmatic":[167],"children":[168],"(10.3\u00b12.8":[169],"yrs,":[170],"19":[171],"girls)":[172],"inhaling":[173],"6":[175],"months":[176],"either":[177],"3\u00d7":[178],"daily":[179,192],"20":[180],"mg":[181],"via":[184,195],"an":[185],"investigational":[186],"eFlow\u00ae":[187],"electronic":[188],"nebuliser":[189,229],"or":[190],"twice":[191],"steroids":[194,204],"spacer":[198],"showed":[199],"comparable":[200],"(Basek":[205],"In":[207],"conclusion,":[208],"in-vivo":[209],"suggest":[211],"safe":[216],"effective":[218],"controller":[220],"when":[221],"highly":[223],"efficient,":[224],"generating":[228],"used.":[231],"Impactor":[232],"humidity":[240],"show":[241],"strongly":[248],"affected":[249],"delivery":[252],"system.":[253]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}