{"id":"https://openalex.org/W2190339596","doi":"https://doi.org/10.1136/thoraxjnl-2015-207428","title":"Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD","display_name":"Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD","publication_year":2015,"publication_date":"2015-12-08","ids":{"openalex":"https://openalex.org/W2190339596","doi":"https://doi.org/10.1136/thoraxjnl-2015-207428","mag":"2190339596","pmid":"https://pubmed.ncbi.nlm.nih.gov/26645414"},"language":"en","primary_location":{"id":"doi:10.1136/thoraxjnl-2015-207428","doi":"https://doi.org/10.1136/thoraxjnl-2015-207428","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2015-207428","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/71/2/126.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/71/2/126.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013878034","display_name":"Kristoffer Ostridge","orcid":"https://orcid.org/0000-0001-8910-3900","observed_orcids":["https://orcid.org/0000-0001-8910-3900"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kristoffer Ostridge","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0001-8910-3900","affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102719692","display_name":"Nicholas P. Williams","orcid":"https://orcid.org/0000-0002-2866-682X","observed_orcids":["https://orcid.org/0000-0002-2866-682X"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Williams","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Viktoriya Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Viktoriya Kim","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021102644","display_name":"Michael John Bennett","orcid":"https://orcid.org/0000-0002-2930-4900","observed_orcids":["https://orcid.org/0000-0002-2930-4900"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Bennett","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103097808","display_name":"Stephen P. Harden","orcid":"https://orcid.org/0000-0002-9995-6058","observed_orcids":["https://orcid.org/0000-0002-9995-6058"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Harden","raw_affiliation_strings":["Department of Radiology, University Hospital Southampton, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Hospital Southampton, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033556510","display_name":"Lindsay Welch","orcid":"https://orcid.org/0000-0001-5564-2252","observed_orcids":["https://orcid.org/0000-0001-5564-2252"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lindsay Welch","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041935340","display_name":"Simon C. Bourne","orcid":"https://orcid.org/0000-0002-6753-6948","observed_orcids":["https://orcid.org/0000-0002-6753-6948"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Bourne","raw_affiliation_strings":["Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030769630","display_name":"Ngaire A. Coombs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ngaire A Coombs","raw_affiliation_strings":["Department of Primary Care & Population Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Primary Care & Population Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082043968","display_name":"Paul T. Elkington","orcid":"https://orcid.org/0000-0003-0390-0613","observed_orcids":["https://orcid.org/0000-0003-0390-0613"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul T Elkington","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010011502","display_name":"Karl J. Staples","orcid":"https://orcid.org/0000-0003-3844-6457","observed_orcids":["https://orcid.org/0000-0003-3844-6457"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karl J Staples","raw_affiliation_strings":["Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069988933","display_name":"Tom M. A. Wilkinson","orcid":"https://orcid.org/0000-0003-1771-3851","observed_orcids":["https://orcid.org/0000-0003-1771-3851"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210110707","display_name":"NIHR Southampton Respiratory Biomedical Research Unit","ror":"https://ror.org/01yg3ff09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805","https://openalex.org/I34931013","https://openalex.org/I4210110707","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tom MA Wilkinson","raw_affiliation_strings":["Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Clinical & Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707"]},{"raw_affiliation_string":"Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069988933"],"corresponding_institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I4210110707","https://openalex.org/I43439940"],"apc_list":null,"apc_paid":null,"fwci":6.4323,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.9718778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"71","issue":"2","first_page":"126","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.800000011920929},{"id":"https://openalex.org/keywords/small-airway-disease","display_name":"small airway disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bronchial-wall-thickening","display_name":"bronchial wall thickening","score":0.859000027179718},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.5730000138282776},{"id":"https://openalex.org/keywords/air-trapping","display_name":"air trapping","score":0.6439999938011169},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8659999966621399},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.921999990940094},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8667528629302979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7947174310684204},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7325810194015503},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7268989682197571},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6292423605918884},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5676391124725342},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5661590695381165},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.46856051683425903},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4549228549003601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15359428524971008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08508908748626709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1136/thoraxjnl-2015-207428","doi":"https://doi.org/10.1136/thoraxjnl-2015-207428","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2015-207428","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/71/2/126.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmid:26645414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26645414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:385040","doi":null,"is_oa":true,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/385040/","pdf_url":"https://eprints.soton.ac.uk/385040/1/Relationship_20between_20Pulmonary_20Matrix_20Metalloproteinases_20and_20Quantitative_20CT_20Markers_20of_20Small_20Airways_20Disease_20and_20Emphysema_20in_20COPD_20accepted.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:thoraxjnl:71/2/126","doi":null,"is_oa":false,"landing_page_url":"http://thorax.bmj.com/cgi/content/short/71/2/126","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pure.atira.dk:publications/213f99db-4fd9-4a08-9ab8-c06858942bf3","doi":null,"is_oa":true,"landing_page_url":"https://pure.solent.ac.uk/en/publications/213f99db-4fd9-4a08-9ab8-c06858942bf3","pdf_url":null,"source":{"id":"https://openalex.org/S4306402589","display_name":"Solent University Research Portal (Solent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I156118397","host_organization_name":"Southampton Solent University","host_organization_lineage":["https://openalex.org/I156118397"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ostridge , K , Williams , N , Kim , V , Bennett , M , Harden , S , Welch , L , Bourne , S , Coombs , N A , Elkington , P T , Staples , K J & Wilkinson , T M A 2016 , ' Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD ' , Thorax , vol. 71 , no. 2 , pp. 126-132 . https://doi.org/10.1136/thoraxjnl-2015-207428","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/thoraxjnl-2015-207428","doi":"https://doi.org/10.1136/thoraxjnl-2015-207428","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thoraxjnl-2015-207428","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/71/2/126.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2190339596.pdf","grobid_xml":"https://content.openalex.org/works/W2190339596.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W207268442","https://openalex.org/W1754220768","https://openalex.org/W1850182854","https://openalex.org/W1976728831","https://openalex.org/W1982530769","https://openalex.org/W2004556227","https://openalex.org/W2016073678","https://openalex.org/W2020863153","https://openalex.org/W2040099837","https://openalex.org/W2042364910","https://openalex.org/W2050237494","https://openalex.org/W2056888987","https://openalex.org/W2061471588","https://openalex.org/W2063445653","https://openalex.org/W2066968375","https://openalex.org/W2072649524","https://openalex.org/W2096759470","https://openalex.org/W2099042792","https://openalex.org/W2099969611","https://openalex.org/W2104333455","https://openalex.org/W2111536145","https://openalex.org/W2116875982","https://openalex.org/W2117214391","https://openalex.org/W2122078978","https://openalex.org/W2124272888","https://openalex.org/W2124698558","https://openalex.org/W2125078269","https://openalex.org/W2127951128","https://openalex.org/W2132128793","https://openalex.org/W2143604872","https://openalex.org/W2145562112","https://openalex.org/W2153997368","https://openalex.org/W2154239113","https://openalex.org/W2162313829","https://openalex.org/W2167070869","https://openalex.org/W2171649568","https://openalex.org/W2319554819","https://openalex.org/W3215332570","https://openalex.org/W4211263216","https://openalex.org/W6608381377"],"related_works":["https://openalex.org/W2523465603","https://openalex.org/W7062135267","https://openalex.org/W2124698558","https://openalex.org/W2477303889","https://openalex.org/W1975240324","https://openalex.org/W2416966318","https://openalex.org/W2145562112","https://openalex.org/W7098605687","https://openalex.org/W1976728831","https://openalex.org/W2107157359"],"abstract_inverted_index":{"BACKGROUND:":[0],"Matrix":[1],"metalloproteinases":[2],"(MMPs)":[3],"are":[4,196],"proteolytic":[5],"enzymes":[6],"that":[7,216],"can":[8],"degrade":[9],"the":[10,20,38,45,58,66,75,189,200,230],"extracellular":[11],"matrix":[12],"and":[13,62,71,83,92,101,109,120,132,134,139,154,174,184,205],"drive":[14],"tissue":[15],"remodelling,":[16,225],"key":[17,76,227],"processes":[18],"in":[19,37,49,65,81,95,143,222,229],"pathogenesis":[21,231],"of":[22,26,41,47,60,79,90,145,162,188,202,232],"COPD.":[23,148,233],"The":[24],"development":[25,40],"small":[27,121,163,206,223],"airway":[28],"disease":[29,51,208],"has":[30],"been":[31],"identified":[32,209],"as":[33],"a":[34,219,226],"critical":[35],"mechanism":[36],"early":[39],"airflow":[42],"obstruction":[43],"but":[44],"contribution":[46],"MMPs":[48,61,91,126,183,217],"human":[50],"is":[52],"poorly":[53],"characterised.":[54],"OBJECTIVES:":[55],"We":[56,87],"investigated":[57],"role":[59,221],"inflammatory":[63,93],"cytokines":[64,94,135],"lung":[67],"by":[68],"quantifying":[69],"levels":[70,89],"determining":[72],"relationships":[73,181],"with":[74,147,159,171,199],"pathological":[77],"components":[78],"COPD":[80,100],"patients":[82],"healthy":[84],"controls.":[85],"METHODS:":[86],"analysed":[88],"bronchoalveolar":[96],"lavage":[97],"from":[98],"24":[99],"8":[102],"control":[103],"subjects.":[104],"Each":[105],"subject":[106],"underwent":[107],"spirometry":[108],"high-resolution":[110],"CT.":[111],"Image":[112],"analysis":[113],"quantitatively":[114],"assessed":[115],"emphysema,":[116],"bronchial":[117,185],"wall":[118,186],"thickening":[119],"airways":[122,164,207,224],"disease.":[123,165],"RESULTS:":[124],"Multiple":[125],"(MMP-1,":[127],"-2,":[128],"-3,":[129],"-8,":[130,151],"-9":[131],"-10)":[133],"(interleukin":[136],"(IL)":[137],"6":[138],"IL-8)":[140],"were":[141,178],"elevated":[142],"lungs":[144],"subjects":[146],"MMP-3,":[149,172],"-7,":[150],"-9,":[152],"-10":[153],"-12":[155],"concentrations":[156,195],"closely":[157],"associated":[158,170,198],"CT":[160,211],"markers":[161],"Emphysema":[166],"severity":[167],"was":[168],"also":[169],"-7":[173],"-10.":[175],"However,":[176],"there":[177],"no":[179],"strong":[180],"between":[182],"thickness":[187],"larger":[190],"airways.":[191],"CONCLUSIONS:":[192],"Pulmonary":[193],"MMP":[194],"directly":[197],"extent":[201],"gas":[203],"trapping":[204],"on":[210],"scan.":[212],"This":[213],"study":[214],"suggests":[215],"play":[218],"significant":[220],"feature":[228],"TRIAL":[234],"REGISTRATION":[235],"NUMBER:":[236],"NCT01701869.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}