{"id":"https://openalex.org/W2190170967","doi":null,"title":"The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats.","display_name":"The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats.","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2190170967","mag":"2190170967","pmid":"https://pubmed.ncbi.nlm.nih.gov/27307951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636881"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4636881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Clin Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044086416","display_name":"Behrooz Khakpour-Taleghani","orcid":"https://orcid.org/0000-0002-9468-4276","observed_orcids":["https://orcid.org/0000-0002-9468-4276","https://orcid.org/0000-0002-8192-0188"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Behrooz Khakpour-Taleghani","raw_affiliation_strings":["Cellular & Molecular Research Center and Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular & Molecular Research Center and Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041423729","display_name":"Zahra Reisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Reisi","raw_affiliation_strings":["Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053172178","display_name":"Abbas Haghparast","orcid":"https://orcid.org/0000-0003-1084-180X","observed_orcids":["https://orcid.org/0000-0003-1084-180X"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abbas Haghparast","raw_affiliation_strings":["Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, P.O. Box 19615, 1178 Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, P.O. Box 19615, 1178 Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.374,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.51340975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"2","first_page":"73","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.9430000185966492},{"id":"https://openalex.org/keywords/reinstatement","display_name":"reinstatement","score":0.8859999775886536},{"id":"https://openalex.org/keywords/extinction","display_name":"extinction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sch-23390","display_name":"SCH 23390","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sulpiride","display_name":"sulpiride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dopamine-d1-receptor-antagonist","display_name":"dopamine D1 receptor antagonist","score":0.6700000166893005},{"id":"https://openalex.org/keywords/dopamine-d2-receptor-antagonists","display_name":"dopamine D2 receptor antagonists","score":0.9700000286102295},{"id":"https://openalex.org/keywords/opioid-reward","display_name":"opioid reward","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.8287209272384644},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.7221917510032654},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6073318719863892},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5956992506980896},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.5550876259803772},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.5522741675376892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.519071638584137},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.49991464614868164},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4703540802001953},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4605748653411865},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.45641428232192993},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4174368381500244},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.400948166847229},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.38368889689445496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37227118015289307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3569009304046631},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34528011083602905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3351376950740814}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4636881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Clin Neurosci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3872591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4636881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27307951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27307951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and clinical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.829.2646","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.829.2646","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bcn.iums.ac.ir/browse.php?a_id%3D612%26ftxt%3D1%26sid%3D1%26slc_lang%3Den","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.852.3603","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.852.3603","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bcn.iums.ac.ir/files/site1/user_files_c424bc/zahrareisi-A-10-744-1-987ab64.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c670b6f7cbb74daf9ae2e42b2a669eab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c670b6f7cbb74daf9ae2e42b2a669eab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 6, Iss 2, Pp 73-82 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4636881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4636881/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Clin Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2190170967.pdf","grobid_xml":"https://content.openalex.org/works/W2190170967.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W104238112","https://openalex.org/W1512701253","https://openalex.org/W1574751342","https://openalex.org/W1817985333","https://openalex.org/W1977247384","https://openalex.org/W1982436434","https://openalex.org/W1984848419","https://openalex.org/W1991933576","https://openalex.org/W1996599661","https://openalex.org/W2001074583","https://openalex.org/W2006780539","https://openalex.org/W2008605050","https://openalex.org/W2023504580","https://openalex.org/W2034179063","https://openalex.org/W2055372210","https://openalex.org/W2088844388","https://openalex.org/W2092706697","https://openalex.org/W2113204002","https://openalex.org/W2121007598","https://openalex.org/W2125765644","https://openalex.org/W2139882380","https://openalex.org/W2162244617","https://openalex.org/W2163815564","https://openalex.org/W2164730568","https://openalex.org/W2166988967","https://openalex.org/W4244161634"],"related_works":["https://openalex.org/W2475211332","https://openalex.org/W2883607404","https://openalex.org/W3088290632","https://openalex.org/W2968696739","https://openalex.org/W3035786282","https://openalex.org/W3006311717","https://openalex.org/W2890292556","https://openalex.org/W2164730568","https://openalex.org/W2092706697","https://openalex.org/W2166988967"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,104,139],"hippocampus":[2],"(HIP),":[3],"the":[4,50,65,76,82,102,129,133,176],"primary":[5],"brain":[6],"structure":[7],"related":[8],"to":[9],"learning":[10],"and":[11,19,54,111,152,161,165],"memory,":[12],"receives":[13],"sparse":[14],"but":[15],"comprehensive":[16],"dopamine":[17,21,28,57],"innervations":[18],"contains":[20],"D1/D2-like":[22,79,193],"receptors.":[23],"It":[24,188],"is":[25,47],"demonstrated":[26],"that":[27,142,192],"receptors":[29,58,80,194],"in":[30,41,59,64,84,202,205],"dentate":[31],"gyrus":[32],"(DG)":[33],"region":[34,197],"of":[35,52,78,145,148,183],"HIP":[36,53],"have":[37,198],"a":[38,99,156,169],"remarkable":[39],"function":[40],"spatial":[42],"reward":[43],"processing.":[44],"Much":[45],"less":[46],"known":[48],"about":[49],"involvement":[51],"its":[55],"D1/D2":[56],"drug-seeking":[60],"behaviors,":[61,86],"more":[62],"particularly,":[63],"morphine":[66,184],"extinguished":[67,206],"conditioned":[68],"place":[69],"preference":[70],"(CPP).":[71],"METHODS:":[72],"To":[73],"find":[74],"out":[75],"role":[77,201],"within":[81,195],"DG":[83,134],"morphine-seeking":[85,203],"forty":[87],"adult":[88],"male":[89],"albino":[90],"Wistar":[91],"rats":[92],"weighing":[93],"220-280g":[94],"were":[95,114,121],"unilaterally":[96],"implanted":[97],"by":[98,116,180],"cannula":[100],"into":[101,132],"DG.":[103],"CPP":[105,130,178],"paradigm":[106],"was":[107],"done;":[108],"conditioning":[109],"score":[110],"locomotors":[112],"activity":[113],"recorded":[115],"Ethovision":[117],"software.":[118],"All":[119],"drugs/vehicles":[120],"microinjected":[122],"one":[123],"day":[124],"after":[125],"extinction":[126],"(just":[127],"before":[128],"test)":[131],"as":[135,155,168],"reinstatement":[136],"day.":[137],"RESULTS:":[138],"results":[140],"showed":[141],"intra-DG":[143],"administration":[144],"different":[146],"dose":[147],"SCH23390":[149],"(0.25,":[150,163],"1":[151,164],"4\u03bcg/0.5\u03bcl":[153,166],"saline),":[154],"selective":[157,170],"D1-like":[158],"receptor":[159,172],"antagonist":[160,173],"sulpiride":[162],"DMSO),":[167],"D2-like":[171],"dose-dependently":[174],"attenuated":[175],"morphine-extinguished":[177],"reinstated":[179],"priming":[181],"injection":[182],"(1":[185],"mg/kg;sc).":[186],"DISCUSSION:":[187],"can":[189],"be":[190],"concluded":[191],"this":[196],"an":[199],"important":[200],"behaviors":[204],"rats.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}